Структура и динамика ряда P, N-содержащих каркасных соединений и макроциклических производных пиримидиновых оснований в растворах
Диссертация
Показано, что в макроциклах, состоящих из трех пиримидиновых оснований, может реализовываться «свернутая» конформация. Однако возможность образования такой структуры существенно зависит от: 1) длины полиметил еновых спейсеров (структурный фактор) — 2) наличия нековалентных взаимодействий (водородное связывание) — 3) среды (кислотность, природа растворителя). Установлено, что «свернутая… Читать ещё >
Содержание
- ОСНОВНЫЕ ОБОЗНАЧЕНИЯ И СОКРАЩЕНИЯ
- Глава 1. Литературный обзор
- 1. 1. Ведение — концепция «жесткие-гибкие»
- 1. 2. Р, N содержащие криптанды
- 1. 3. Р, N содержащие парациклофаны
- 1. 4. Пиримидинофаны
- Глава 2. Экспериментальная часть
- 2. 1. Соединения
- 2. 2. Методология эксперимента
- 2. 3. Обработка экспериментальных данных
- 2. 4. Расчеты
- Глава 3. Р, N — содержащие макроциклы
- 3. 1. Криптанды
- 3. 2. Р, N содержащий 16-членный макроцикл (аналог криптанда без «якорного» спейсера)
- 3. 3. Парациклофаны
- Глава 4. Структура и динамика макроциклических соединений, содержащих три пиримидиновых фрагмента
- 4. 1. Предварительный анализ ЯМР данных. Комнатная температура
- 4. 2. ЯМР эксперименты с вариацией температуры
- 4. 3. Второй процесс, обмен с протонированной формой
- 4. 4. ЗИ структура макроциклов
- 4. 5. Нековалентные взаимодействия в макроциклах
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