Нарушение рецепторопосредованных механизмов регуляции тонуса сосудов при травматическом и геморрагическом шоке.
Пути их коррекции (экспериментальное исследование)
![Диссертация: Нарушение рецепторопосредованных механизмов регуляции тонуса сосудов при травматическом и геморрагическом шоке. Пути их коррекции (экспериментальное исследование)](https://westud.ru/work/3421811/cover.png)
Диссертация
На модели травматического шока было исследовано, как изменяются рецепторуправляемые механизмы регуляции сосудистого тонуса в динамике развития данного патологического процесса. Установлено, что в первые часы после нанесения травмы развиваются различные по степени выраженности и направленности по отношению к отдельным вазоконстрикторным гормонам и нейротрансмиттерам изменения сосудистой… Читать ещё >
Содержание
- Глава 1. ОБЗОР ЛИТЕРАТУРЫ
- 1. 1. Структурные и функциональные свойства сопряженных с G-белками мембранных рецепторов
- 1. 2. Структурные и функциональные свойства цитоплазматиче-ских глюкокортикоидных рецепторов
- 1. 3. Функциональная активность и экспрессия цитоплазматиче-ских и мембранных рецепторов при шоке
- 1. 4. Воздействие на рецепторный аппарат клетки как способ коррекции шокового состояния
- Глава 2. МАТЕРИАЛЫ И МЕТОДЫ ИССЛЕДОВАНИЯ
- 2. 1. Экспериментальные модели шока
- 2. 2. Оценка показателей системной гемодинамики
- 2. 3. Изучение реакции сосудов на вазоконстрикторные гормоны и нейротрансмиттеры в условиях целостного организма
- 2. 4. Измерение силы изометрического сокращения изолированных фрагментов аорты крысы
- 2. 5. Методы адаптации к стрессу и гипоксии
- 2. 6. Биохимические методы исследования
- 2. 7. Оценка функциональной активности цитозольных глюкокортикоидных рецепторов
- 2. 8. Эксперименты на культуре гладкомышечных клеток аорты крысы
- 2. 9. Молекулярно-биологические методы исследования
- Глава 3. ОСОБЕННОСТИ ТЕЧЕНИЯ ТРАВМАТИЧЕСКОГО И ГЕМОРРАГИЧЕСКОГО ШОКА В ЭКСПЕРИМЕНТЕ
- 3. 1. Изучение гемодинамики и метаболизма при травматическом шоке
- 3. 2. Изучение гемодинамики и метаболизма при геморрагическом шоке
- Обсуждение результатов
- Глава 4. ИЗУЧЕНИЕ ФУНКЦИОНАЛЬНОЙ АКТИВНОСТИ И ЭКСПРЕССИИ ГЛЮКОКОРТИКОИДНЫХ РЕЦЕПТОРОВ ПРИ ШОКЕ
- 4. 1. Изучение влияния травматического и геморрагического шока на свойства глюкокортикоидных рецепторов
- 4. 2. Влияние адаптации к стрессу и гипоксии на функциональное состояние глюкокортикоидных рецепторов при геморрагическом шоке
- Обсуждение результатов
- Глава 5. ВЛИЯНИЕ ДЕКСАМЕТАЗОНА НА ЭКСПРЕССИЮ РЕЦЕПТОРОВ ВАЗОКОНСТРИКТОРНЫХ ГОРМОНОВ В ГЛАДКОМЫШЕЧНЫХ КЛЕТКАХ АОРТЫ КРЫСЫ
- Глава 6. НАРУШЕНИЕ ФУНКЦИОНАЛЬНОЙ АКТИВНОСТИ G-БЕЛОК СВЯЗАННЫХ РЕЦЕПТОРОВ ПРИ ТРАВМАТИЧЕСКОМ ШОКЕ
- 6. 1. Влияние травматического шока на чувствительность сосудов к действию вазоконстрикторных гормонов и нейротрансмиттеров
- Обсуждение результатов
- 6. 2. Влияние длительного применения дексаметазона на чувствительность сосудов к действию вазоконстрикторных гормонов и нейротрансмиттеров
- Обсуждение результатов
- 6. 3. Влияние длительного применения циклоспорина, А на чувствительность сосудов к действию вазоконстрикторных гормонов и нейротрансмиттеров
- Выводы
- Глава 7. НЕСТЕРОИДНАЯ МОДУЛЯЦИЯ ФУНКЦИИ ГЛЮКОКОРТИКО-ИДНЫХ РЕЦЕПРОРОВ ПРИ ТРАВМАТИЧЕСКОМ ШОКЕ С ПОМОЩЬЮ ПРЕПАРАТОВ МОРФИНОВОГО РЯДА
- 7. 1. Изучение модулирующего влияния производных морфино-вого ряда на функцию глюкокортикоидных рецепторов II и III типа цитозоля печени в опытах in vitro
- 7. 2. Изучение влияния буторфанола на функцию глюкокортикоидных рецепторов при травматическом шоке и оценка его противошоковой эффективности
- 7. 3. Изучение противошоковой эффективности производных морфинового ряда даларгина, налоксона и бупренорфина
- Обсуждение результатов
- Глава 8. ВЛИЯНИЕ АНТАГОНИСТОВ КАЛЬЦИЯ НА ФУНКЦИЮ ГЛЮКОКОРТИКОИДНЫХ РЕЦЕПТОРОВ ПРИ ТРАВМАТИЧЕСКОМ И ГЕМОРРАГИЧЕСКОМ ШОКЕ И ОЦЕНКА ИХ ПРОТИВОШОКОВОЙ ЭФФЕКТИВНОСТИ
- 8. 1. Влияние нифедипина и верапамила на функцию глюкокортикоидных рецепторов и течение геморрагического шока
- 8. 2. Влияние антагониста кальция А-1 на функцию глюкокортикоидных рецепторов при геморрагическом шоке и оценка его противошоковой эффективности
- Обсуждение результатов
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