ΠΠ»Π΅ΡΠΊΠΈ Π²ΠΎΠ»ΠΎΡΡΠ½ΠΎΠ³ΠΎ ΡΠΎΠ»Π»ΠΈΠΊΡΠ»Π° in vitro
ΠΠ΅ΡΠΌΠΎΡΡΡ Π½Π° Π±ΠΎΠ»ΡΡΠΎΠ΅ ΡΠΈΡΠ»ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π² ΠΎΠ±Π»Π°ΡΡΠΈ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ ΡΠΏΠΈΠ΄Π΅ΡΠΌΠ°Π»ΡΠ½ΡΡ I ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ, ΡΡΡΠΎΠ³ΠΈΡ ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² Π΄Π»Ρ ΠΈΡ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ Π΄ΠΎ ΡΠΈΡ ΠΏΠΎΡ Π½Π΅ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π½ΡΡ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΡ ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² ΠΏΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡ ΡΠΏΠΎΡΠ½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π ΡΠ°ΡΡΠ½ΠΎΡΡΠΈ, ΠΌΠ½ΠΎΠ³ΠΎΠ΅ ΠΎΡΡΠ°Π΅ΡΡΡ Π½Π΅ΡΡΠ½ΡΠΌ ΠΈ Π² ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»Π°Π³Π°Π΅ΠΌΠΎΠ³ΠΎ ΠΌΠ°ΡΠΊΠ΅ΡΠ° ΡΠΏΠΈΠ΄Π΅ΡΠΌΠ°Π»ΡΠ½ΡΡ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ — ΠΊΠ΅ΡΠ°ΡΠΈΠ½Π° 19. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ… Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- Π‘ΠΏΠΈΡΠΎΠΊ ΡΠΎΠΊΡΠ°ΡΠ΅Π½ΠΈΠΉ
- I. ΠΠ±Π·ΠΎΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ. Ρ
- 1. 1. Π‘ΡΡΡΠΊΡΡΡΠ° ΡΠΏΠΈΠ΄Π΅ΡΠΌΠΈΡΠ°
- 1. 1. 1. ΠΠΏΠΈΠ΄Π΅ΡΠΌΠ°Π»ΡΠ½Π°Ρ ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ²Π½Π°Ρ Π΅Π΄ΠΈΠ½ΠΈΡΠ°
- 1. 1. 2. ΠΠ°Π·Π°Π»ΡΠ½Π°Ρ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π°
- 1. 1. 3. Π¦ΠΈΡΠΎΠΊΠ²ΡΠ°ΡΠΈΠ½Ρ
- 1. 2. ΠΠ»Π΅ΡΠΎΡΠ½ΡΠ΅ ΠΊΠΎΠ½ΡΠ°ΠΊΡΡ ΠΊΠ΅ΡΠ°ΡΠΈΠ½ΠΎΡΠΈΡΠΎΠ²
- 1. 2. 1. ΠΠ»ΠΎΡΠ½ΡΠ΅ ΠΊΠΎΠ½ΡΠ°ΠΊΡΡ
- 1. 2. 2. ΠΠ°ΡΠΊΠΎΡΠΈΠ²Π°ΡΡΠΈΠ΅ ΠΊΠΎΠ½ΡΠ°ΠΊΡΡ
- 1. 2. 3. ΠΠΎΠΌΠΌΡΠ½ΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΠ΅ ΠΊΠΎΠ½ΡΠ°ΠΊΡΡ
- 1. 3. ΠΠΎΠ»ΠΎΡΡΠ½ΠΎΠΉ ΡΠΎΠ»Π»ΠΈΠΊΡΠ» ΠΊΠ°ΠΊ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΠΎΠ΅ ΠΊΠΎΠΆΠΈ
- 1. 4. Π‘ΡΠ²ΠΎΠ»ΠΎΠ²Π°Ρ ΡΠΏΠΈΠ΄Π΅ΡΠΌΠ°Π»ΡΠ½Π°Ρ ΠΊΠ»Π΅ΡΠΊΠ°
- 1. 4. 1. ΠΠΈΡΠ° ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ
- 1. 4. 2. Π₯Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ
- 1. 4. 3. ΠΠ΅ΡΠ°ΡΠΈΠ½ 19-ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ
- 1. 5. ΠΠ΅Π·Π΅Π½Ρ ΠΈΠΌΠ½ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ Π²ΠΎΠ»ΠΎΡΡΠ½ΠΎΠ³ΠΎ ΡΠΎΠ»Π»ΠΈΠΊΡΠ»Π°
- 1. 6. ΠΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΊΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠΏΠΈΠ΄Π΅ΡΠΌΠΈΡΠ°
- 1. 6. 1. Π€ΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΡΠ»ΡΡΡΡΡ ΠΊΠ΅ΡΠ°ΡΠΈΠ½ΠΎΡΠΈΡΠΎΠ²
- 1. 6. 2. ΠΠ΄Π³Π΅Π·ΠΈΡ ΠΊΠ΅ΡΠ°ΡΠΈΠ½ΠΎΡΠΈΡΠΎΠ² ΠΊ ΡΡΠ±ΡΡΡΠ°ΡΡ
- 1. 6. 3. ΠΠ΅ΠΉΡΡΠ²ΠΈΠ΅ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΡΡΠ±ΡΡΡΠ°ΡΠΎΠ² ΠΈ ΠΈΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΈ ΠΊΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ ΠΊΠ΅ΡΠ°ΡΠΈΠ½ΠΎΡΠΈΡΠΎΠ²
- 1. 6. 4. Π’ΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΡ Π²ΡΡΠ°ΡΠ΅Π½Π½ΡΡ Π² ΠΊΡΠ»ΡΡΡΡΠ΅ ΡΠΏΠΈΠ΄Π΅ΡΠΌΠ°Π»ΡΠ½ΡΡ ΠΏΠ»Π°ΡΡΠΎΠ²
- 1. 6. 5. ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΡΠΎΡΡΠ°
- 1. 6. 6. Π‘ΠΎΡ ΡΠ°Π½Π΅Π½ΠΈΠ΅ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ Π² ΠΊΡΠ»ΡΡΡΡΠ΅
- 1. 6. 7. ΠΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠ΅Ρ ΠΌΠ΅ΡΠ½ΡΡ Π³Π΅Π»Π΅ΠΉ Π² ΠΊΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ ΡΠΏΠΈΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ
- 1. 7. ΠΠ·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΊΠ΅ΡΠ°ΡΠΈΠ½ΠΎΡΠΈΡΠΎΠ² ΠΈ ΡΠΈΠ±ΡΠΎΠ±Π»Π°ΡΡΠΎΠ²
- 1. 8. ΠΠΎΡΡΠΎΠ³Π΅Π½Π΅Π· ΡΠΏΠΈΡΠ΅Π»ΠΈΡ
- 1. 8. 1. Π’ΡΠ±ΡΠ»ΠΎΠ³Π΅Π½Π΅Π· ΠΊΠ°ΠΊ ΠΏΡΠΈΠΌΠ΅Ρ ΠΌΠΎΡΡΠΎΠ³Π΅Π½Π΅Π·Π°
- 1. 8. 2. ΠΠ΅Ρ Π°Π½ΠΈΠ·ΠΌ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΡΠ±ΡΠ»ΡΡΠ½ΡΡ ΡΡΡΡΠΊΡΡΡ
- 1. 8. 3. ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΡΠ°ΠΊΡΠΎΡΠΎΠ² Π½Π° ΠΌΠΎΡΡΠΎΠ³Π΅Π½Π΅Π·
- 1. 8. 4. ΠΠΎΠ΄Π΅Π»Ρ Π΄Π»Ρ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΌΠΎΡΡΠΎΠ³Π΅Π½Π΅Π·Π° ΡΠΏΠΈΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ
- 1. 1. Π‘ΡΡΡΠΊΡΡΡΠ° ΡΠΏΠΈΠ΄Π΅ΡΠΌΠΈΡΠ°
- II. 1. ΠΠΠ’ΠΠ ΠΠΠΠ«
- II. 2. ΠΠΠ’ΠΠΠ«
- 11. 2. 1. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΡΡ ΠΊΠ΅ΡΠ°ΡΠΈΠ½ΠΎΡΠΈΡΠΎΠ² ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°
- 11. 2. 2. ΠΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠ΅ΡΠ°ΡΠΈΠ½ΠΎΡΠΈΡΠΎΠ² Π½Π° ΠΏΠ»Π°ΡΡΠΈΠΊΠ΅
- 11. 2. 4. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΈΠ½ΡΠ΅ΡΡΠΎΠ»Π»ΠΈΠΊΡΠ»ΡΡΠ½ΠΎΠ³ΠΎ ΡΠΏΠΈΠ΄Π΅ΡΠΌΠΈΡΠ°
- 11. 2. 5. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΈ ΠΊΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎΡΡΠ½Π°ΡΠ°Π»ΡΠ½ΡΡ ΡΠΈΠ±ΡΠΎΠ±Π»Π°ΡΡΠΎΠ² ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°
- 11. 2. 10. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΠ΅Π΄, ΠΊΠΎΠ½Π΄ΠΈΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΡΠΈΠ±ΡΠΎΠ±Π»Π°ΡΡΠ°ΠΌΠΈ
- 11. 2. 11. ΠΠΈΡΡΠΎΡ ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΎΠΊΡΠ°ΡΠΈΠ²Π°Π½ΠΈΠ΅
- 11. 2. 12. ΠΠ½Π΄ΡΠΊΡΠΈΡ ΠΈ Π΄Π΅ΡΠ΅ΠΊΡΠΈΡ ΠΎΡΡΠ΅ΠΎ- ΠΈ Π°Π΄ΠΈΠΏΠΎΠ³Π΅Π½Π½ΠΎΠΉ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΎΠΊ
- 11. 2. 13. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΊΠΎΠ»Π»Π°Π³Π΅Π½Π° ΠΈΠ· Ρ Π²ΠΎΡΡΠΎΠ² ΠΊΡΡΡ
- 11. 2. 14. ΠΠ±ΡΠ°Π±ΠΎΡΠΊΠ° ΡΡΠ΅ΠΊΠΎΠ» ΡΡΠ±ΡΡΡΠ°ΡΠ°ΠΌΠΈ
- 11. 2. 16. ΠΡΠΈΠ³ΠΎΡΠΎΠ²Π»Π΅Π½ΠΈΠ΅ ΠΊΠΎΠ»Π»Π°Π³Π΅Π½ΠΎΠ²ΠΎΠ³ΠΎ Π³Π΅Π»Ρ
- 11. 2. 17. ΠΠΌΠΌΡΠ½ΠΎΠ³ΠΈΡΡΠΎΡ ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅
- 11. 2. 18. ΠΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠ΅ΡΠ°ΡΠΈΠ½ΠΎΡΠΈΡΠΎΠ² Π½Π° ΠΏΠΎΠ²Π΅ΡΡ Π½ΠΎΡΡΠΈ ΠΊΠΎΠ»Π»Π°Π³Π΅Π½ΠΎΠ²ΠΎΠ³ΠΎ Π³Π΅Π»Ρ
- 11. 2. 19. ΠΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠ΅ΡΠ°ΡΠΈΠ½ΠΎΡΠΈΡΠΎΠ² Π² ΠΊΠΎΠ»Π»Π°Π³Π΅Π½ΠΎΠ²ΠΎΠΌ Π³Π΅Π»Π΅
- 11. 2. 20. ΠΠ»Π΅ΠΊΡΡΠΎΠ½Π½Π°Ρ ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠΈΡ
- 11. 2. 21. ΠΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΊΠ»Π΅ΡΠΎΠΊ Π»Π΅Π½ΡΠΈΠ²ΠΈΡΡΡΠΎΠΌ
- 11. 2. 22. Π’ΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΈΠΌΠΌΡΠ½ΠΎΠ΄Π΅ΡΠΈΡΠΈΡΠ½ΡΠΌ ΠΌΡΡΠ°ΠΌ
- 11. 2. 23. ΠΡΡΠ²Π»Π΅Π½ΠΈΠ΅ BrdU-ΠΌΠ΅ΡΠ΅Π½Π½ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ
- 11. 2. 25. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ Π²Π»ΠΈΡΠ½ΠΈΡ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΡΠ°ΠΊΡΠΎΡΠΎΠ² Π½Π° ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ Π±Π°Π·Π°Π»ΡΠ½ΡΡ ΠΊΠ΅ΡΠ°ΡΠΈΠ½ΠΎΡΠΈΡΠΎΠ²
- 11. 2. 26. Π‘ΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΎΠ±ΡΠ°Π±ΠΎΡΠΊΠ° ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ²
- III. 1. Π‘ΡΠ²ΠΎΠ»ΠΎΠ²ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ
- 111. 1. 1. ΠΠΊΡΠΏΡΠ΅ΡΡΠΈΡ ΠΊΠ΅ΡΠ°ΡΠΈΠ½Π°
- 111. 1. 2. ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΠΊΠ°Π»ΡΡΠΈΡ Π½Π° ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ ΠΊΠ΅ΡΠ°ΡΠΈΠ½Π°
- 111. 1. 4. ΠΠΊΡΠΏΡΠ΅ΡΡΠΈΡ ΠΊΠ΅ΡΠ°ΡΠΈΠ½Π° 19 Π² Π±Π°Π·Π°Π»ΡΠ½ΡΡ ΠΊΠ΅ΡΠ°ΡΠΈΠ½ΠΎΡΠΈΡΠ°Ρ
- 111. 1. 5. ΠΠ½Π³ΠΈΠ±ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠΈ ΠΊΠ΅ΡΠ°ΡΠΈΠ½ΠΎΡΠΈΡΠΎΠ² ΠΌΠΈΡΠΎΠΌΠΈΡΠΈΠ½ΠΎΠΌ Π‘
- 111. 1. 6. ΠΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΈΠ½ΡΠ΅ΡΡΠΎΠ»Π»ΠΈΠΊΡΠ»ΡΡΠ½ΠΎΠ³ΠΎ ΡΠΏΠΈΠ΄Π΅ΡΠΌΠΈΡΠ°
- 111. 2. ΠΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° ΠΊΠ»Π΅ΡΠΎΠΊ ΠΠ
- 111. 3. Π‘ΡΡΡΠΊΡΡΡΠ° ΡΠΏΠΈΠ΄Π΅ΡΠΌΠ°Π»ΡΠ½ΡΡ Π²ΡΡΠΎΡΡΠΎΠ²
- 111. 4. Π‘ΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ ΠΊΠ΅ΡΠ°ΡΠΈΠ½ΠΎΡΠΈΡΠΎΠ² ΠΊ ΡΠ°ΠΌΠΎΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΠΈ
- 111. 5. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ Π²ΡΡΡΠ°ΠΈΠ²Π°ΡΡΡΡ Π² ΡΡΠ΅Ρ ΠΌΠ΅ΡΠ½ΡΠ΅. ΡΡΡΡΠΊΡΡΡΡ ΠΊΠΎΠΆΠΈ in vivo
Π‘ΠΏΠΈΡΠΎΠΊ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
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