Ультраструктурный анализ методом объёмной реконструкции обратимой ретракции дендритных шипиков в поле САЗ гиппокампа гибернирующих сусликов
Диссертация
Данная работа связана с такой фундаментальной проблемой нейробиологии, как изучение нейрональной пластичности синапсов, лежащей в основе исследования механизмов памяти у млекопитающих. Результаты настоящей работы свидетельствуют о том, что даже при глубоком охлаждении головного мозга, происходят обратимые изменения в синапсах центральной нервной системы млекопитающих. Полученные результаты могут… Читать ещё >
Содержание
- СПИСОК СОКРАЩЕНИЙ
- Глава I. ОБЗОР ЛИТЕРАТУРЫ
- 1. Функциональная роль и строение гиппокампа
- 1. 1. Строение гиппокампа
- 1. 2. Связи нейронов в различных полях гиппокампа
- 1. 2. 1. Связь между клетками зубчатой фасции и полем САЗ/СА
- 1. 2. 2. Связи нейронов полей СА2, САЗ/СА
- 1. 2. 3. Проекции нейронов в хилусе
- 1. 2. 4. Связи полиморфных клеток
- 1. 2. 5. Афферентные пути
- 1. 2. 6. Эфферентные пути
- 1. 3. Функциональная роль гиппокампа
- 2. Строение дендритных шипиков в поле САЗ
- 2. 1. Классификации дендритных шипиков
- 2. 2. Структура синаптического комплекса
- 2. 2. 1. Постсинаптическое уплотнение
- 2. 2. 2. Цитоскелет и цитоплазма
- 2. 2. 3. Эндоплазматический ретикулум
- 2. 2. 4. Белок синтезирующие компоненты шипиков
- 2. 2. 5. Митохондрии
- 2. 2. 6. Мультивезикулярные тельца
- 2. 2. 7. Пресинаптические везикулы
- 2. 2. 8. Астроциты
- 2. 2. 9. Химический синапс и синаптическая щель
- 2. 3. Функциональная роль дендритных шипиков
- 2. 3. 1. Большинство синапсов гиппокампа располагаются на дендритных шипиках
- 2. 3. 2. Шипики увеличивают плотность синапсов на дендрите
- 2. 3. 3. Шипики — сайты возбуждающих входов гиппокампа
- 2. 3. 4. Шипики могут модулировать активность синапсов
- 2. 3. 5. Шипики обеспечивают специфичность синапсов через молекулярную компартментализацию и локальный синтез белков
- 2. 3. 6. Защитная функция шипиков
- 1. Функциональная роль и строение гиппокампа
- 3. Пластичность дендритных шипиков
- 3. 1. Длительная потенциация
- 3. 2. Обучение
- 3. 3. Патологии нервной системы
- 3. 4. Циклические изменения дендритных шипиков
- 3. 5. Генезис дендритных шипиков
- 3. 6. Предполагаемый механизм пластичности шипиков
- 4. Гибернация и гипотермия как естественные модели для 53 изучения синапсов в различных функциональных состояниях
- 5. Современные методы анализа дендритных шипиков
- 5. 1. Окраска по Гольджи
- 5. 2. Электронная микроскопия
- 5. 3. Конфокальная микроскопия и молекулярно-биологические методы
- 5. 4. Объёмная реконструкция и стереологический анализ
- 1. Подготовка животных
- 2. Приготовление образцов для световой и электронной микроскопии
- 3. Метод получения серийных ультратонких срезов
- 4. Электронная микроскопия
- 5. Трехмерная реконструкция синаптических структур
- 6. Измеряемые параметры
- 7. Методы статистической обработки количественных данных
- 8. Разработка программного обеспечения
- 1. Организация синапсов образуемых апикальными дендритами пирамидных нейронов и мшистыми волокнами в поле САЗ гиппокампа
- 2. Обратимые изменения колючих шишек в различных функциональных состояниях
- 3. Количественные изменения морфологических параметров активных зон синапсов в различных функциональных состояниях
- 4. Характеристика белоксинтезирующего аппарата в различных функциональных состояниях
- 5. Улучшение метода объёмной реконструкции
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