Характер изменения активности сфингомиелиназы в условиях ингибирования и активации пероксидного окисления липидов в печени животных
Научно-практическая значимость. Результаты исследования имеют важное теоретическое и практическое значение для понимания механизмов регуляции дифференцировки, пролиферации и апоптоза клеток с помощью сигнальной системы сфингомиелинового цикла. Выявленная нами коррелятивная взаимосвязь между активностью сфингомиелиназы и интенсивностью процесса пероксидного окисления липидов может… Читать ещё >
Содержание
- 1. Введение
- 2. Обзор литературы
- 2. 1. Общие сведения о сфингомиелиновом цикле
- 2. 1. 1. Метаболизм сфингомиелина
- 2. 1. 2. Изоформы сфингомиелиназ
- 2. 1. 3. Механизмы регуляции сфингомиелиназ в клетке
- 2. 1. 3. 1. Регуляция липидами
- 2. 1. 3. 2. Регуляция протеинкиназой С
- 2. 1. 3. 3. Регуляция протеазами
- 2. 1. 3. 4. Регуляция Вс
- 2. 1. 3. 5. Регуляция р
- 2. 1. 3. 6. Регуляция другими белками
- 2. 1. 3. 7. Регуляция глутатионом
- 2. 1. Общие сведения о сфингомиелиновом цикле
- 2. 2. Сфингомиелиновый цикл как сигнальная система
- 2. 2. 1. Участие сфингомиелиназы в передаче внеклеточных сигналов
- 2. 2. 2. Участие церамида в передаче внеклеточных сигналов
- 2. 2. 3. Участие сфингозина в передаче внеклеточных сигналов. 2.2.4. Участие сфингозин-1-фосфата в передаче внеклеточных сигналов
- 2. 3. Сигнальные системы окислительного стресса
- 2. 3. 1. Пути генерации активных форм кислорода в ^ клетках
- 2. 3. 2. Оксиданты регулируют клеточные сигнальные системы
- 2. 3. 2. 1. Протеинтирозинкиназы и фосфатазы
- 2. 3. 2. 2. Серин/треонинкиназы и фосфатазы
- 2. 3. 2. 3. Липидный метаболизм
- 2. 3. 2. 4. Транскрипционные факторы
- 2. 3. 2. 4. 1. АР
- 2. 3. 2. 4. 2. NFkB
- 2. 3. 2. 4. 3. Myb
- 2. 4. 1. Общие активаторы и ингибиторы
- 2. 4. 2. АФК активируют образование церамида
- 2. 4. 3. Митохондриальная электронная транспортная ф цепь — мишень церамида
- 2. 4. 4. Церамид и N0 при проведении сигнала апоптоза
- 2. 4. 5. Роль антиоксидантов в регуляции образования церамида
- 2. 4. 6. Церамид, другие сфинголипиды и окислительный стресс
- 3. 1. Биофизические и биохимические методы
- 3. 2. Работа с животными
- 3. 3. Статистическая обработка результатов
4.1. Изучение взаимосвязи между активностью нейтральной сфингомиелиназы и интенсивностью процесса пероксидного окисления липидов в печени мышей при действии глутатиона в восстановленной и окисленной формах.
4.1.1. Изменение активности нейтральной сфингомиелиназы и содержания сфингомиелина в печени мышей при внутрибрюшинном введении восстановленного и окисленного глутатиона.
4.1.2 Влияние восстановленного и окисленного глутатиона на содержание продуктов пероксидного окисления липидов в печени мышей.
4.2. Изучение взаимосвязи между активностью нейтральной сфингомиелиназы и интенсивностью процесса пероксидного окисления липидов в печени и сердце мышей при действии билирубина.
4.2.1. Изменение активности нейтральной сфингомиелиназы в печени и сердце мышей при внутрибрюшинном введении билирубина.
4.2.2. Влияние билирубина на содержание продуктов пероксидного окисления липидов в печени и сердце мышей.
4.3. Влияние церамида на интенсивность пероксидного окисления липидов в печени мышей.
4.4. Изучение взаимосвязи между активностью нейтральной сфингомиелиназы и интенсивностью процесса пероксидного окисления липидов в печени мышей при действии гепатотоксина а-нафтилизотиоцианата.
4.4.1. Изменение активности нейтральной сфингомиелиназы в печени мышей при внутрибрюшинном введении а-нафтилизотиоцианата.
4.4.2. Влияние а-нафтилизотиоцианата на содержание продуктов пероксидного окисления липидов в печени мышей.
4.5. Изучение взаимосвязи между активностью нейтральной (сфингомиелиназы, уровнем ФНО-а и интенсивностью процесса пероксидного окисления липидов в печени крыс при перевязке общего желчного протока с последующим восстановлением оттока желчи.
4.5.1. Изменение активности нейтральной сфингомиелиназы в печени крыс при перевязке общего желчного протока.
4.5.2. Изменение содержания ФНО-а в печени крыс при перевязке общего желчного протока.
4.5.3. Влияние перевязки общего желчного протока на интенсивность пероксидного окисления липидов в печени крыс.
4.5.4. Изменение активности нейтральной сфингомиелиназы в печени крыс при восстановлении оттока желчи после перевязки общего желчного протока.
4.5.5. Изменение содержания ФНО-а в печени крыс при восстановлении оттока желчи после перевязки общего желчного протока.
4.5.6. Влияние восстановления оттока желчи после перевязки общего желчного протока на интенсивность пероксидного окисления липидов в печени крыс.
5. Обсуждение результатов исследования. 1Ю
6. Выводы.
7. Список аббревиатур.
I 8. Литература.
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