Капсулирование биологически активных веществ в матрицы на основе биосовместимых полимеров и их использование для биомедицины
Диссертация
Среди прочих биологически активных веществ, способных ускорить процесс заживления ран, повышенное внимание в последнее время уделяется белкам и пептидам (гормонам, различным факторам роста др.). Особое место среди них занимает тромбин (сериновая протеаза семейства трипсина), который, являясь фактором роста, не только регулирует свертывающие и противосвертывающие механизмы и ангиогенез, но также… Читать ещё >
Содержание
- Список сокращений
- Глава 1. ОБЗОР ЛИТЕРАТУРЫ
- 1. 1. Механизмы регенерации тканей
- 1. 1. 1. Особенности заживления кожных ран
- 1. 1. 2. Особенности заживления язвы желудка
- 1. 2. Покрытия для терапии ран
- 1. 3. Биологически активные вещества, ускоряющие репарацию тканей
- 1. 3. 1. Факторы роста
- 1. 3. 2. Тромбин
- 1. 3. 3. Пептиды, имитирующие действие тромбина
- 1. 4. Системы доставки БАВ и методы их получения
- 1. 4. 1. Микрочастицы и микрокапсулы
- 1. 4. 2. Методы капсулирования БАВ в биосовместимые полимерные микрочастицы и микрокапсулы
- 1. 4. 2. 1. Метод простой эмульсии (В/М)
- 1. 4. 2. 2. Метод двойной эмульсии (ТВ/М/В)
- 1. 4. 2. 3. Метод двойной эмульсии (В1/М/В2)
- 1. 4. 3. Полимерные материалы для капсулирования БАВ
- 1. 4. 3. 1. Сополимеры молочной и гликолевой кислот
- 1. 4. 3. 1. 1. Основные характеристики Р1ЛА
- 1. 4. 3. 1. 2. Механизм и особенности деструкции РЬОА
- 1. 4. 3. 1. 3. Механизм выделения БАВ из РЬОА микрочастиц
- 1. 1. Механизмы регенерации тканей
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