ΠΠΏΠΈΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ Π² ΠΎΠΏΡΡ ΠΎΠ»ΡΡ ΡΠ΅ΠΉΠΊΠΈ ΠΌΠ°ΡΠΊΠΈ: Π³ΠΈΠΏΠ΅Ρ-ΠΈ Π³ΠΈΠΏΠΎΠΌΠ΅ΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎΠ²ΡΠΎΡΡΡΡΠΈΡ ΡΡ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠ² ΠΠΠ
![ΠΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΡ: ΠΠΏΠΈΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ Π² ΠΎΠΏΡΡ
ΠΎΠ»ΡΡ
ΡΠ΅ΠΉΠΊΠΈ ΠΌΠ°ΡΠΊΠΈ: Π³ΠΈΠΏΠ΅Ρ-ΠΈ Π³ΠΈΠΏΠΎΠΌΠ΅ΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎΠ²ΡΠΎΡΡΡΡΠΈΡ
ΡΡ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠ² ΠΠΠ](https://westud.ru/work/2523268/cover.png)
ΠΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΡ
Π’ΡΠ°Π½ΡΠΊΡΠΈΠΏΡΡ, Π²ΡΡΠΎΠΊΠΎΠ³ΠΎΠΌΠΎΠ»ΠΎΠ³ΠΈΡΠ½ΡΠ΅ Π³Π΅Π½Π°ΠΌ DUX4 ΠΈ DUX10, ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Ρ Π² Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΡΡ ΡΠΊΠ°Π½ΡΡ ΡΠ΅ΠΉΠΊΠΈ ΠΌΠ°ΡΠΊΠΈΠΏΠΎΠ΄Π°Π²Π»Π΅Π½ΠΈΠ΅ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΈ Π³Π΅Π½ΠΎΠ² DUX ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ Π² 68% ΠΎΠΏΡΡ ΠΎΠ»Π΅ΠΉ ΡΠ΅ΠΉΠΊΠΈ ΠΌΠ°ΡΠΊΠΈ ΠΊΠ°ΠΊ Ρ Π³ΠΈΠΏΠ΅ΡΠΌΠ΅ΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ 3,3-kb ΠΏΠΎΠ²ΡΠΎΡΠΎΠ², ΡΠ°ΠΊ ΠΈ Π±Π΅Π· Π½Π΅Π³ΠΎ. ΠΠΏΠ΅ΡΠ²ΡΠ΅ Π² ΠΊΠ»Π΅ΡΠΊΠ°Ρ ΡΠ°ΠΊΠ° ΡΠ΅ΠΉΠΊΠΈ ΠΌΠ°ΡΠΊΠΈ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΡΡΠ°ΡΡΡΠ° ΠΌΠ΅ΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΡΠΌΠΈ ΡΠΊΠ°Π½ΡΠΌΠΈ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΡΠ°ΡΡΠΊΠ° ΠΠΠ S/MAR, ΡΠ°ΡΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½ΠΎΠ³ΠΎ… Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- Π‘ΠΠΠ‘ΠΠ Π‘ΠΠΠ ΠΠ©ΠΠΠΠ
- ΠΠΠΠΠ 1. ΠΠΠΠΠ ΠΠΠ’ΠΠ ΠΠ’Π£Π Π«
- 1. 1. ΠΠ²Π΅Π΄Π΅Π½ΠΈ Π΅
- 1. 2. Π Π΅ΡΡΠΎΡΡΠ°Π½ΡΠΏΠΎΠ·ΠΎΠ½Ρ
- 1. 2. 1. ΠΠ΅ ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΠ΅ LTR ΡΠ΅ΡΡΠΎΡΡΠ°Π½ΡΠΏΠΎΠ·ΠΎΠ½Ρ
- 1. 2. 2. LTR-ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΠ΅ ΡΠ΅ΡΡΠΎΡΡΠ°Π½ΡΠΏΠΎΠ·ΠΎΠ½Ρ
- 1. 3. Π‘Π°ΡΠ΅Π»Π»ΠΈΡΠ½ΡΠ΅ ΠΏΠΎΠ²ΡΠΎΡΡ
- 1. 4. ΠΠ°ΠΊΡΠΎΡΠ°ΡΠ΅Π»Π»ΠΈΡΠ½ΡΠ΅ 3,3-kb ΠΏΠΎΠ²ΡΠΎΡΡ
Π‘ΠΏΠΈΡΠΎΠΊ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
- ΠΡΡΡΠ΅Π²Π° Π. Π., ΠΠ·ΠΈΠ·ΠΎΠ², Π., ΠΈ ΠΠ°Π½ΡΡΠΈΠ½, Π. Π€. (1979Π°). ΠΠΈΠΎΡ ΠΈΠΌΠΈΡ, 44,1690−1696.
- ΠΡΡΡΠ΅Π²Π° Π. Π., ΠΠ·ΠΈΠ·ΠΎΠ², Π., ΠΡΠΊΠΈΠ½, Π. 3., ΠΈ ΠΠ°Π½ΡΡΠΈΠ½, Π. Π€. (1977). ΠΠΈΠΎΡ ΠΈΠΌΠΈΡ 42,1296−1302.
- ΠΡΡΡΠ΅Π²Π° Π. Π., Π ΠΎΠΌΠ°Π½ΠΎΠ², Π. Π., ΠΠ·ΠΈΠ·ΠΎΠ², Π., ΠΈ ΠΠ°Π½ΡΡΠΈΠ½, Π. Π€. (1979b). ΠΠΈΠΎΡ ΠΈΠΌΠΈΡ 44, 2066−2072.
- Π£ΡΠΌΠ°Π½ΠΎΠ²Π°, Π. Π., ΠΠ°Π·Π°ΠΊΠΎΠ², Π. Π., ΠΈ Π’ΠΎΠΌΠΈΠ»ΠΈΠ½, Π. Π. (2008). Π Π΅ΡΡΠΎΠΏΠΎΠ·ΠΎΠ½Ρ AIu-ΡΠ΅ΠΌΠ΅ΠΉΡΡΠ²Π° ΠΈΠ· ΡΠΈΡ-ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ½ΡΡ ΠΌΠΎΠ΄ΡΠ»Π΅ΠΉ ΠΏΡΠΎΠΌΠΎΡΠΎΡΠΎΠ² Π³Π΅Π½ΠΎΠ² DNASE II ΠΈ CAML Π²Π»ΠΈΡΡΡ Π½Π° Π³Π΅Π½Π½ΡΡ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ Π² ΠΊΠ»Π΅ΡΠΊΠ°Ρ Π549 ΠΈ ΠΠΠ293. Π¦ΠΈΡΠΎΠ»ΠΎΠ³ΠΈΡ, 249−255.
- Π€Π΅Π΄ΠΎΡΠΎΠ² Π. Π. (2008). Π Π΅Π³ΡΠ»ΡΡΠΈΡ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΈ ΡΠ΅ΡΡΠΎΡΡΠ°Π½ΡΠΏΠΎΠ·ΠΎΠ½ΠΎΠ² LINE-1 ΠΌΠ»Π΅ΠΊΠΎΠΏΠΈΡΠ°ΡΡΠΈΡ . Π¦ΠΈΡΠΎΠ»ΠΎΠ³ΠΈΡ, 1011−1022.
- Albano, F., Anelli, L., Zagaria, A., Lonoce, A., La Starza, R., Liso, V., Rocchi, M., and Specchia, G. (2008). Extramedullar molecular evidence of the 5'KIAAl 509/3'PDGFRB fusion gene in chronic eosinophilic leukemia. Leuk Res 32,347−351.
- Alexiadis, V., Ballestas, M. E., Sanchez, C., Winokur, S., Vedanarayanan, V., Warren, M., and Ehrlich, M. (2007). RNAPol-ChIP analysis of transcription from FSHD-linked tandem repeats and satellite DNA. Biochim Biophys Acta 1769,29−40.
- Alves, G., Tatro, A., and Fanning, T. (1996). Differential methylation of human LINE-1 retrotransposons in malignant cells. Gene 176,39−44.
- Armbruester, V., Sauter, M., Krautkraemer, E., Meese, E., Kleiman, A., Best, Π., Roemer, K., and Mueller-Lantzsch, N. (2002). A novel gene from the human endogenous retrovirus Π expressed in transformed cells. Clin Cancer Res 8,1800−1807.
- Armbruester, V., Sauter, M., Roemer, K., Best, Π., Hahn, S., Nty, A., Schmid, A., Philipp, S., Mueller, A., and Mueller-Lantzsch, N. (2004). Np9 protein of human endogenous retrovirus Π interacts with ligand of numb protein X. J Virol 78,10 310−10 319.
- Athanasiadis, A., Rich, A., and Maas, S. (2004). Widespread A-to-I RNA editing of Alu-containing mRNAs in the human transcriptome. PLoS Biol 2, e391.
- Babushok, D. V., and Kazazian, H. H., Jr. (2007). Progress in understanding the biology of the human mutagen LINE-1. Hum Mutat 28, 527−539.
- Beckers, M., Gabriels, J., van der Maarel, S., De Vriese, A., Frants, R. R., Collen, D., and Belayew, A. (2001). Active genes in junk DNA? Characterization of DUX genes embedded within 3.3 kb repeated elements. Gene 264, 51−57.
- Belancio, V. P., Hedges, D. J., and Deininger, P. (2006). LINE-1 RNA splicing and influences on mammalian gene expression. Nucleic Acids Res 34,1512−1521.
- Bosnakovski, D., Lamb, S., Simsek, Π’., Xu, Z., Belayew, A., Perlingeiro, R., and Kyba, M. (2008a). DUX4c, an FSHD candidate gene, interferes with myogenic regulators and abolishes myoblast differentiation. Exp Neurol.
- Bourc’his, D., and Bestor, Π’. H. (2004). Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L. Nature 431,96−99.
- Brannan, Π‘. I., and Bartolomei, M. S. (1999). Mechanisms of genomic imprinting. Curr Opin Genet Dev 9, 164−170.
- Burgers, W. A., Blanchon, L., Pradhan, S., de Launoit, Y., Kouzarides, Π’., and Fuks, F. (2007). Viral oncoproteins target the DNA methyltransferases. Oncogene 26,1650−1655.
- Buscher, K., Trefzer, U., Hofinann, M., Sterry, W., Kurth, R., and Denner, J. (2005). Expression of human endogenous retrovirus Π in melanomas and melanoma cell lines. Cancer Res 65, 4172−4180.
- Chen, E. S., Zhang, K., Nicolas, E., Cam, H. P., Zofall, M., and Grewal, S. I. (2008a). Cell cycle control of centromeric repeat transcription and heterochromatin assembly. Nature 451, 734−737.
- Chen, L. L., DeCerbo, J. N., and Carmichael, G. G. (2008b). Alu element-mediated gene silencing. Embo J 27,1694−1705.
- Depil, S., Roche, C., Dussart, P., and Prin, L. (2002). Expression of a human endogenous retrovirus, HERV-K, in the blood cells of leukemia patients. Leukemia 16, 254−259.
- Dewannieux, M., Esnault, C., and Heidmann, T. (2003). LINE-mediated retrotransposition of marked Alu sequences. Nat Genet 35,41−48.
- Ding, H., Beckers, M. C., Plaisance, S., Marynen, P., Collen, D., and Belayew, A. (1998). Characterization of a double homeodomain protein (DUX1) encoded by a cDNA homologous to 3.3 kb dispersed repeated elements. HumMol Genet 7,1681−1694.