Иммуноферментный анализ нейроспецифических антигенов в оценке проницаемости гематоэнцефалического барьера при перинатальном гипоксически-ишемическом поражении ЦНС (клинико-экспериментальное исследован
Диссертация
В связи с этим, в последние десятилетия отмечен возрастающий интерес к нейроспецифическим белкам (НСБ), как к сывороточным маркерам патологических процессов и травм головного мозга, в которых определенное место отводится нарушению резистентности гематоэнцефалического барьера (ГЭБ). Одними из наиболее изученных среди них являются глиофибриллярный кислый протеин (ОРАР), структурный белок… Читать ещё >
Содержание
- Глава 1. ОБЗОР ЛИТЕРАТУРЫ
- Гипоксически-ишемическое поражение ЦНС в перинатальном периоде и проницаемость ГЭБ для ЫБЕ и вРАР
- 1. 1. Особенности течения и исходы ГИППГМ
- 1. 2. Структурно-функциональная организация ГЭБ
- 1. 3. Содержание ЫБЕ и ОРАР в биологических жидкостях при ГИППГМ как критерий оценки проницаемости ГЭБ
- 1. 4. Экспериментальное моделирование ГИППГМ
- Глава 2. МАТЕРИАЛЫ И МЕТОДЫ
- 2. 1. Твердофазный иммуноферментный анализ ЫБЕ и ОРАР в биологических жидкостях
- 2. 2. Клинико-лабораторные методы обследования
- 2. 3. Экспериментальные исследования
- 2. 4. Статистический анализ
- Глава 3. РЕЗУЛЬТАТЫ ИССЛЕДОВАНИЙ
- Иммуноферментный анализ нейроспецифических антигенов при ГИППГМ в клинике и эксперименте
- 3. 1. Клинико-лабораторная характеристика обследованных детей
- 3. 2. Характеристика используемых иммуноферментных тест-систем
- 3. 3. Иммуноферментный анализ ЫБЕ и вРАР в сыворотке крови детей с перинатальным гипоксически-ишемическим поражением ЦНС
- 3. 4. Исследование проницаемости ГЭБ дляЕ и ОРАР у крыс с моделированием ГИППГМ
- 3. 4. 1. Динамика неврологического дефицита и нарушений высшей нервной деятельности крыс после моделирования ГИППГМ
- 3. 4. 2. Иммуноферментный анализ нейроспецифических антигенов в биологических жидкостях у крыс с ГИППГМ
- 3. 4. 3. Анализ связи показателей функционального состояния организма и содержания ЫБЕ и вРАР в биологических жидкостях крыс в динамике развития патологического процесса, вызванного ГИППГМ
Список литературы
- Антонова О.М. Нейроспецифнческая енолаза и ее роль в механизмах антительной агрессии в мозг. Дисс. к.м.н., 1997- 121с.
- Барашнев Ю.И., Перинатальная неврология. Триада-Х. 2001- 640 с.
- Белопасов В.В., Хрусталева H.A., Гроппа С. А. Иммунохимические показатели структурного повреждения мозговой ткани в различные периоды травматической болезни головного мозга. Вопр. нейрохир. 1994- № 2: с. 74−77.
- Беляева И.А. Нейроспецифические белки в крови и ликворе при клещевой нейроинфекции (клинико-диагностические и прогностические аспекты). Дисс. к.м.н., 1995- 177 с.
- Бережной Г. А., Лисяный H.H., Белик Я. В. Содержание некоторых нейроспецифических белков в крови больных с черепно-мозговой травмой. Ней-рохимия. 1991- № 10(1−2): с. 76−80.
- Березин В.А. Специфические белки нервной ткани в норме и при патологии. Дисс. д.м.н., 1985- 164 с.
- Березин В.А., Шевченко Г. М., Бунятин Г. Г. Специфические белки промежуточных филаментов в нормальной нервной ткани и в опухолях головного мозга. Нейрохимия. 1987- № 6: с. 77−81.
- Биктимиров Р.Г. Роль комплексного иммуноферментного определения нейроспецифических белков в диагностике опухолей головного мозга. Автореф. дисс. к.м.н., 1993- 133 с.
- Бредбери М. Концепция гематоэнцефалического барьера. Москва. 1983- 480 с.
- П.Вейн А. М. Вегетативные расстройства. Клиника. Диагностика. Лечение. Мед. Информ. Агентство. 2000- 164 с.
- Викторов И.В., Современные методы морфологических исследований мозга. Медицина. 1969- 156 с.
- Володин H.H., Рогаткин С. О., Кучинскас А. Диагностика и прогноз поражений ЦНС у недоношенных детей в раннем неонатальном периоде. Тез. докл. научно-пр. конф.: «Актуальные проблемы педиатрии». Тамбов. 1990- с. 25−26.
- Ганнушкина И.В. Патофизиология нарушений мозгового кровообращения. Кн. Мозг: теоретические и клинические аспекты (под ред. Покровского В.И.). Медицина. 2003- с. 463−489.
- Гроппа С.А., Чехонин В. П. Специфические антигены мозга как показатели проницаемости гематоэнцефалического барьера при болезни Альцгеймера. Ж. невропат, и психиатр. 1998- № 3: с. 50−52.
- Турина О.И., Рябухин И. А., Рогаткин С. О. Иммуноферментный анализ НСБ и антител к ним в оценке перинатальных поражений ЦНС у недоношенных детей. Педиатрия. 1995- № 3: с. 15−19.
- Турина О.И. Клинико-иммунохимическая оценка нарушений функций гематоэнцефалического барьера у новорожденных детей с перинатальными поражениями ЦНС. Дисс. к.м.н., 1996- 142 с.
- Турина О.И., Рябухин И. А., Анин А. Н. Исследование проницаемости ГЭБ у новорожденных крысят в условиях индуцированных гипертермических судорог. Бюлл. Эксп. Биол. и Мед. 1997- т. 123, № 2: с. 146−149.
- Гусев Е.И., Скворцова В. И., Ишемия головного мозга. Медицина. 2001- 328 с.
- Дегтярева М.Г. Динамический контроль функционального состояния ЦНС у детей с перинатальными постгипоксическими поражениями головного мозга на первом году жизни. Дисс. к.м.н. 2002- 254 с.
- Журба JI.Т., Мастюкова Е. М. Нарушение психомоторного развития детей первого года жизни. Медицина. 1981 — 272 с.
- Зубарева Е.А., Дворяковский И. В. Доплерография перинатальных поражений головного мозга. Видар. 1999- 358 с.
- Казьмин A.M., Дайхина Л. В., Озерова O.E. Состояние нервной системы в первые12.16 месяцев у детей, перенесших перивентрикулярную лейкомаляцию в периоде новорожденности. Ж. материнство и детство. 1992- № 37 (4−5): с. 8 13.
- Каушанская Е.Я. Значение нейроспецифических белков и протеолитических ферментов в оценке тяжести критического состояния мозга новорожденных и их нервно-психического развития в раннем возрасте. Автореф., дисс. к.м.н. 1993- 22 с.
- Классификация перинатальных поражений нервной системы у новорожденных. Методические рекомендации. ВУНМЦ МЗ РФ. 2000- 40 с.
- Лиджиева Р.Ц. Специфические белки нервной ткани в оценке проницаемости гематоэнефалического барьера при коматозных состояниях у детей. Дисс. к.м.н. 1990- 218 с.
- Майзелис М.Я. Гематоэнцефалический барьер и его регуляция. Медицина. 1973- 288 с.
- Рогаткин С.О. Клинико-нейросонографические и иммунохимические критерии диагностики и прогноза перинатальных поражений ЦНС у новорожденных детей различного гестационного возраста. Автореф. дисс. к.м.н. 1993- 23 с.
- Рябухин И. А., Дмитриева Т. Б., Чехонин В. П. Гематоэнцефалический барьер (часть I). Эмбриоморфогенез, клеточная и субклеточная биология плотных контактов эндотелиоцитов. Нейрохимия 2003- 20: 12−23.
- Тимофеева JI.А. Клинико-иммунохимическая оценка нарушений проницаемости ГЭБ у плодов и новорожденных с гипербилирубинемией. Дисс. к.м.н. 1999- 132 с.
- Федоров В.П., Ушаков И. Б., Корденко А. Н. Структурно-функциональная организация гематоэнцефалического барьера. Изв. АН России, Сер. биол. 1989- 1: 24 с.
- Хохлов А.П., Фетисова И. Г., Подлесный A.M. Защитная реакция клеток мозга при изменении проницаемости гематоэнцефалического барьера. Вопросы мед. химии 1993- 39(4): 25−27.
- Чехонин В.П., Морозов Г. В., Морковкин В. М. Иммуноферментативная детекция специфических антигенов мозга как критерий проницаемости гематоэнцефалического барьера крыс при острой ишемии головного мозга. Бюлл. эксп. биол. и мед. 1988- 4: 581−583.
- Чехонин В.П., Лебедев C.B., Володин H.H., Блинов Д. В., Петров C.B., Рогаткин С. О., Экспериментальное моделирование перинатального гипоксически-ишемического поражения мозга. Вопр. гинек., акуш. и перинат. 2002- 1(2): 9−16.
- Чехонин В.П., Лиджиева Р. Ц., Коротеева Е. А. Иммунохимическое изучение механизмов аутоиммунной агрессии антител к нейроспецифическим белкам у крыс с экспериментальным прорывом ГЭБ. Нейрохимия. 1989- 9(2): 241−246.
- Чехонин В.П. Специфические белки нервной ткани человека и животных (идентификация, выделение, физико-химическая характеристика и клинико-лабора-торные исследования). Дисс. д.м.н., 1989- 379 с.
- Чехонин В.П., Асанова Л. М., Гавриленко А. Я. Иммуноферментный анализ нейроспецифических белков в сыворотке крови больных эпилепсией. ЖНИП им. С. С. Корсакова. 1995- 3:30−31.
- Чехонин В.П., Дмитриева Т. Б., Жирков Ю. А. Иммунохимический анализ нейроспецифических антигенов. Москва. 2000- 416 с.
- Штарк М.Б. Мозгоспецифические белки (антигены) нервной ткани и функции нейрона. Москва. 1985- 313 с.
- Штерн U.C. Непосредственная питательная среда органов и тканей. Москва. 1960- 224 с.
- Якунин Ю.А., Перминов B.C. Прогностические критерии гипоксических поражений ЦНС у детей. Рос. Вест, перинат. и пед. 1993- 38(2): 20−24.
- Abel H.T., Von-Rohden L., Lamme W. Intracerebral hemorrhage and neuron-specific enolase in premature and full-term infants a clinical study. Padiatr. Grenzgeb. 1993- 31(3): 133−140.
- Abraha H.D., Butterworth R.J., Bath P.M.W., Wassif W.S., Garthwaite J., Sherwood R.A. Serum S-100 protein, relationship to clinical outcome in acute stroke. Ann. Clin. Biochem. 1997- 34: 366 -370.
- Abraham C.S., Harada N., Deli M.A., Niwa M. Transient forebrain ischemia increases the blood-brain barrier permeability for albumin in stroke-prone spontaneously hypertensive rats.Cell. Mol. Neurobiol. 2002- 22(4): 455−62.
- Ahlsen G., Rosengren L., Beifrage M. Glial fibrillary acidic protein in the cerebrospinal fluid of children with autism and other neuropsychiatrie disorders. Biol. Psychiatry. 1993- 15 -33(10): 734−743.
- Albrechtsen M., Bock E. Quantification of glial fibrillary acidic protein (GFAP) in human body fluids by means of ELISA employing a monoclonal antibody. J. Neuroimmunol. 1985- 8: 301−309.
- Albrechtsen M., Massaro A., Bock E. Enzyme-linked immunosorbent assay for human glial fibrillary acidic protein using a mouse monoclonal antibody. J. Neurochem. 1985- 44: 560−565.
- Allan S., Rothwell N. Cytokines and acute neurodegeneration. Neurosci. 2001- 2: 734 744.
- Almini R., Levy T.J., Han B.H., Shan A.R., Gidday J.M., David M. Holtzman D.M., BDNF protect against spatial memory deficit following neonatal hypoxia-ischemia. Experimental neurology. 2000- 166: 99−114.
- Aquino D., Chiu F., Brosnan C., Norton W. Glial fibrillary acidic protein increases in spinal cord of Lewis rats with acute experimental autoimmune encephalomyelitis. J. Neurochem. 1988- 51: 1085−1096.
- Archelos J. J., Hartung H-P. Pathogenetic role of autoantibodies in neurological diseases. Trends in Neurosciences. 2000- 23: 317−327.
- Ashwal S., Cole D., Osborne S., Osborne T., Pearce W., A new model of neonatal stroke: reversible middle cerebral artery occlusion in the rat pup. Pediatr Neurol. 1995- 12: 191— 196.
- Aurell A., Rosengren L.E., Karlsson B., Olsson J.E., Zbornikova V., Haglid K.G. Determination of S-100 and glial fibrillary acidic protein concentrations in cerebrospinal fluid after brain infarction. Stroke. 1991- 22: 1254−1258.
- Ayata C., Ropper A.H. Ischaemic brain oedema. J. Clin. Neurosci. 2002- 9(2): 113−24.
- Babu P.P., Kumari L.R., Vemuri M.C. Differential changes in cell morphology, macromolecular composition and membrane protein profiles of neurons and astrocytes in chronic ethanol treated rats. Mol. Cell. Biochem. 1994- 12 (130 (1)): 29−40.
- Balduini W., De Angelis V., Mazzoni E., Cimino M., Long-lasting behavioral alterations following a hypoxic/ischemic brain injury in neonatal rats. Brain Research. 2000- 859: 318−325.
- Banati R.B., Gehrmann J., Czech C., Monning U., Jones L.L., Konig G., Beyreuther K., Kreutzberg G.W. Early and rapid de novo synthesis of Alzheimer beta A4-amyloid precursor protein (APP) in activated microglia. Glia. 1993- 9(3): 199−210.
- Barber P. S., Lindsay M. Schvann cell of the olfactory nerves contain GFAP and resemble astrocytes/Neurosci. 1982- 7(12): 3077−3090.
- Barone F.C., Clerk R.K., Price W.J. Neuron-specific enolase increases in cerebral and systemic circulation followig focal ishemia. Brain Res. 1993- 1: 71−82.
- Bauer H.C., Bauer H. Neural induction of the blood-brain barrier: still an enigma. Cell Mol. Neurobiol. 2000 Feb- 20(1): 13−28.
- Benjelloun, N., Renolleau, S., Represa, A., Ben-Ari, Y. and Charriaut-Marlangue, C. Inflammatory responses in the cerebral cortex after ischemia in the P7 neonatal rat. Stroke. 1999- 30(9): 1916−1923.
- Berger R., Pierce M., Wisnievski S., Adelson P., Clark R., Ruppel R., Kochanek P. Neuron-specific enolase and slOOB in cerebrospinal fluid after severe traumatic brain injury in infants and children. Pediatrics. 2002- 109(2): 34−38.
- Berkovic S.F.- SchefFer I.E. Febrile seizures: genetics and relationship to other epilepsy syndromes. CuiT-Opin-Neurol. 1998- 11(2): 129−134.
- Blennow K., Wallin A., Ekman R. Neuron-specific enolase in cerebrospinal fluid: a biochemical marker for neuronal degeneration in dementia disorders? J. Neural. Transm. Park. Dis. Dement. Sect. 1994- 8 (3): 183−191.
- Blennow M., Hagberg H., Rosengren L. Glial fibrillary acidic protein in the cerebrospinal fluid: a possible indicator of prognosis in full-term asphyxiated newborn infants? Pediatr. Res. 1995- 37(3): 260−264.
- Blennow M., Rosengren L., Jonsson S., Forssberg H., Glial fibrillary acidic protein is increased in the cerebrospinal fluid of preterm infants with abnormal neurological findings. ActaPaediatr. 1996- 85: 485−489.
- Blennow M., Savman K., lives P., Thoresen M., Rosengren L. Brain-specific proteins in the cerebrospinal fluid of severely asphyxiated newborn infants. Acta Paediatr. 2001- 90:1171−1175.
- Bock E., Dissing J. Demonstration of enolase activity connected to the brain specific protein 14−3-2. Scand. J. Immunol. 1975- 4: 31−36.
- Bona, E., Andersson A.L., Blomgren K., Gilland E., Puka-Sundvall M., Gustafson K. Chemokine and inflammatory cell response to hypoxia-ischemia in immature rats. Pediatric Research. 1999- 45(4 Part 1): 500−508.
- Bonhomme V., Hans P., Collette I., Moonen G. Neuron-specific enolase as a marker of in vitro neuronal damage. Part III. Investigation of the astrocyte protective effect against keinate-induced neurotoxicity. J. Neurosurg. Anesthesiol. 1993- 2: 9−22.
- Bradbery M.W., Deane R. Permeability of the blood-brain barrier to lead. Neurotoxicology. 1993- 3: 1−6.
- Brown J.K., Minns R.A. Non-accidental head injury, with particular reference to whiplash shaking injury and medico-legal aspects. Dev. Med. Child. Neurol. 1993- 35(10): 849−69.
- Burtrum D., Silverstein F.S. Excitotoxic injury stimulates glial fibrillary acidic protein mRNA expression in perinatal rat brain. Exp. Neurol. 1993- 121(1): 127−132.
- Burtrum D., Silverstein F. Hypoxic-ischemic brain injury stimulated glial fibrillary acidic protein mRNA and protein expression in neonatal rats. Exp. Neurol. 1994- 126: 112 118.
- Buttner T., Weyers S., Postert T., Sprengelmeyer R., Khun W. S-100 protein: serum marker of focal brain damage after ischemic territorial MCA infarction. Stroke. 1997- 28: 1961−1965.
- Chen H., Chopp M, Schultz L, Bodzin G, Garcia JH. Sequential neuronal and astrocytic changes after transient middle cerebral artery occlusion in the rat. J. Neurol. Sci. 1993- 118: 109−116.
- Chen R., Silverstein F., Aldridge W., Johnston M. Evolution of acute cortical electroencephalogram changes in experimental perinatal hypoxic-ischemic encephalopathy. Neurology. 1986- 36: 86−90.
- Chen Y. Swanson R.A. Astrocytes and brain injury. J. Cereb. Blood. Flow. Metab. 2003- 23(2): 137−49.
- Cheng Y., Gidday J.M., Yan Q., Shah A.R., Holtzman D.M. Marked age-dependent neuroprotection by BDNF against neonatal hypoxic-ischemic brain injury. Ann. Neurol. 1997- 41:521−529.
- Chopp M., Li Y. Apoptosis in focal cerebral ischemia. Acta Neurochir. 1996- 66: 21−26.
- Chopp M., Li Y., Dereski M.O., Levine S.R., Yoshida Y., Garcia J.H. Hypothermia reduces 72-kDa heat-shock protein induction in rat brain after transient forebrain ischemia. Stroke. 1992- 23:104−107.
- Chopp M., Chan P.H., Hsu C.Y., Cheung M.E., Jacobs T.P. DNA damage and repair in central nervous system injury: National Institute of Neurological Disorders and Stroke Workshop Summary. Stroke. 1996- 27 (3): 363−369
- Clark R., Kochalek P., Adelson P. Increases in bcl-2 protein in cerebrospinal fluid and evidence for programmed cell death in infants and children after severe traumatic brain injury. J. Pediatr. 2000- 137: 197−204
- Cunningham R.T., Watt M., Winder J., McKinstry S., Lawson J.T., Johnston C.F., Hawkins S.A., Buchanan K.D. Serum neurone-specific enolase as an indicator of stroke volume. Eur. J. Clin. Invest. 1996- 26: 298−303.
- Dahl D., Bignami A. Astroglial and axonal protein in isolated brain filaments. Biochim. et Biophys. Acta. 1979- 578 (2): 305−316.
- Dahl D., Bignami A. Glial fibrillar acidic protein from normal and gliosed human brain. Demonstration of multiple related polipeptides. Biochem. Biophys. Acta. 1975- 386: 4149.
- Dauberschmidt R., Marangos P.J., Zinsmeyer J. Severe head trauma and the changes of concentration of neuron-specific enolase in plasma and cerebrospinal fluid. Clin. Chim. Acta. 1983- 131: 165−170.
- DeGiorgio C.M., Correale J.D., Gott P. S. Serum neuron-specific enolase in human status epilepticus. Neurology. 1995- 45 (6): 1134−1137.
- Dennery P.A. Predicting neonatal brain injury: are we there yet? Arch. Pediatr. Adolesc. Med. 2003- 157(12): 1151−1152.
- Dotevall L., Rosengren L.E., Hagberg L. Increased cerebrospinal fluid levels of glial fibrillary acidic protein (GFAP) in Lyme neuroborreliosis. Infection. 1996- 24: 125−129.
- Dell’Anna M.E., Carlozari S., Molinari M., Iuvone L., Calimici L. Neonatal anoxia induces transitory hyperactivity, permanent spatial memory deficit and CA1 cell density reduction in developing rats. Behav. Brain Res. 1991- 45: 125−134.
- Dell’Anna E., Chen Y., Engidawork E., Andersson K., Lubec G., Luthman J., Herrera-Marschitz M., Delayed neuronal death following perinatal asphyxia in rat. Exp. Brain Res. 1997- 115(1): 105−115.
- Dell’Anna E., Iuvone L., Carlozari S., Geloso M.C. Effect of acetyl-L-carnitine on hyperactivity and spatial memory deficits of rats exposed to neonatal anoxia. Neuroscience Letters. 1997- 223: 201−205.
- Delorme P., Gayet J, Grignon G. Ultrastructural study on transcapillary exchanges in the developing telencephalon of the chicken. Brain Res. 1970- 22(3): 269−83.
- Delpech B., Delpech A., Vidard M. Glial fibrillary acidic protein in tumors of the nervous system. Br. J. Cancer. 1978- 37: 33−38.
- Derugin N., Ferriero D.M., Vexler Z. Neonatal reversible focal cerebral ischemia: a news model. Neurosci Res. 1998- 32: 349−353
- Derugin N., Wendland M., Miramatsu K., Roberts T.P.L., Gregory G. Ferriero D.M., Vexler Z.S., Evolution of brain injury after transient middle cerebral artery occlusion in neonatal rats. Stroke. 2000- 31: 1752−1759.
- Du Plessis A.J., Volpe J.J. Perinatal brain injury in the preterm and term newborn. Curr. Opin. Neurol. 2002- 15(2): 151−157.
- Dziegielewska K.M., Saunders N.R. The ins and outs of brain-barrier mechanisms. Trends Neurosci. 2002- 25(2): 69−71.
- Ehlers S., Kyllerman M., Rosengren L. Analysis of glial fibrillary acidic protein in the cerebrospinal fluid of children investigated for encephalopathy. Neuropediatrics. 1994- 25: 129−133.
- Elimian A., Figueroa R., Verma U., Visintainer P., Sehgal P, Tejani N. Amniotic fluid neuron-specific enolase: a role in predicting neonatal neurologic injury? Obst. Gynecol. 1998- 92(1): 546−550.
- Endres M., Wang Z.Q., Namura S., Waeber C., Moskowitz M.A. Ischemic brain injury is mediated by the activation of poly (adp-ribose)polymerase. J. Cereb. Blood. Flow. Metab. 1997- 17(11): 1143−51.
- Eng L.F. Experimental models for astrocyte activation and fibrous gliosis. In: Althaus H.H., Seifert W. (Eds.) Glial-neuronal communication. NY: Springer. 1987- 2: 27−40.
- Eng L.F. Glial fibrillary acidic protein (GFAP): The maior protein of glial intermediate filaments in differentiated astrocytes. J. Neuroimmunol. 1981- 8: 203−214.
- Eng L.F., Vainderhaegen J.J., Bignami A. An acidic protein isolated from fibrous astrocytes. Brain Res. 1971- 28: 42−50.
- Eng L.F., Lee Y.L., Fukajama G. Isolation of glial fibrillary acidic (GFA) protein from bovine spinal cord. Trans. Amer. Soc. Neurochem. 1979- 26: 513−518.
- Eng L.F., Ghirnikar R.S. GFAP and astrogliosis. Brain. Pathol. 1994- 4(3): 229−237.
- Eng L.F., Ghirnikar R.S., Lee Y.L. Glial fibrillary acidic protein: GFAP-thirty-one years (1969−2000). Neurochem. Res. 2000- 9−10:1439−1451.
- Engidawork E., Chen Y., Dell’Anna E., Goiny M., Lubec G., Ungerstedt U., Andersson K., Herrera-Marschitz M. Effect of perinatal asphyxia on systemic and intracerebral pH and glycolysis metabolism in the rat. Exp. Neurol. 1997- 145(2 Pt 1): 390−396.
- Faivre-Sabbailh C., Rami A., Fages C., Tardy M. Effect of thyroid deficiency on GFAP and GFAP-mRNA in the cerebellum and hippocampal formation of the developing rat. Glia. 1991- 4:276−284.
- Fazzi E., Lanners J., Danova S., Ferrarri-Ginevra O., Gheza C., Luparia A., Balottin U., Lanzi G. Stereotyped behaviours in blind children. Brain Dev. 1999- 21(8): 522−528.
- Fern R. Ischemia: astrocytes show their sensitive side. Progress in Brain Res. 2001- 132: 405−411.
- Fox G., Gallacher D., Shevde S., Loftus J., Swayne G., Anatomic variation of the middle cerebral artery in the Sprague-Dawley rat. Stroke. 1993- 24: 2087−2093
- Garcia J., Liu K., Yoshida Y., Lian J., Chen S. del Zoppo G. Influx of leukocytes and platelets in an evolving brain infarct (Wistar rat). Am. J. Pathol. 1994- 144(1): 188−199.
- Garcia J.H., Yoshida Y., Chen H., Li Y., Zhang Z.G., Lian J., Chen S., Chopp M. Progression from ischemic injury to infarct following middle cerebral artery occlusion in the rat. Am. J. Pathol. 1993- 142(2): 623−635.
- Gasse H., Meyer W. Neuron-specific enolase as a marker of hypothalamo-neurohypophyseal development in postnatal Monodelphis domestica (Marsupialia). Neurosci. Lett. 1995- 189 (1): 54−56.
- Goldman I.E., Schaumburg H.H., Norton W.I. Isolation and characterisation of glial filaments and neurofilaments from human brain. Similarity of the major protein components. J. Cell Biol. 1978- 43: 964−970.
- Grasso A., Chen J.S. 14−3-2 protein in rat brain synaptosonees: An immunochemical study. Febs. Let. 1974- 40: 154−157.
- Grasso A., Roda G., Hoque-Angeletti R.A. Preparation and properties of the brain specific protein 14−3-2. Brain Res. 1977- 124: 497−507.
- Grasso A., Haglid K.J., Hanson H.A. Localization of 14−3-2 protein in the rat brain by immunoelectron microscopy. Brain Res. 1977- 122: 582−585.
- Greishen G., Ischaemia of the preterm brain. Biol. Neonate. 1992- 62: 243−247.
- Grogaard, B., Schurer, L., Gerdin, B. and Arfors, K.E. Delayed hypoperfusion after incomplete forebrain ischemia in the rat. The role of polymorphonuclear leukocytes. J. Cereb. Blood Flow & Metab. 1989- 9(4): 500−505.
- Grogaard B., Schurer L., Gerdin B., Arfors K.-E. Q. The role of polymorphonuclear leukocytes in postischemic delayed hypoperfusion. In Oxygen Free Radicals in Shock, ed. U. Novelli, Karger, Basel, Florence. 1985- 74−78.
- Giulian D., Reactive microglia and ischemic injury. In: Primer on cerebrovascular diseases (Welsh M., Caplan L., Siesjo B., Weir B., Reis D., eds.). San Diego, CA, Academic. 1997- 117−124.
- Gunn A.J., Gunn T.R., Dehaan H.H., Williams C.E., Gluckman, P.D. Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs. Journal of Clinical Investigation. 1997- 99(2): 248−256.
- Janesco K., SatchellM., Kochalek P., et al. IL-1 converting enzyme (ICE), IL-1, and cytochrome C in CSF after head injury in infants and children. J. Neurotrauma. 2000- 17: 956.
- HO.Jankovic B.D., Jakulic S., Howat J. Delayed skin hypersensitivity reactions to human brain S-100 protein in psychiatric patiens. Biol. Psychiatry. 1982- 17: 687−692.
- Janzer R.C. The blood-brain barrier: cellular basis. J. Inherit. Metab. Dis. 1993- 12: 639 647.
- Johnsson H., Johnsson P., Ailing C., Westaby S., Blomquist S. Significance of SI00 release after coronary artery bypass grafting. Ann. Thorac. Surg. 1998- 65: 1639−1644.
- Joo F. Minireview: regulation messendger molecules of the permiability in the cerebral microvessels. Neurobiology. 1993- 1:3−10.
- Joo F. Insigt into the regulation messenger molecules of the permiability of the blood-brain barrier. Micr. Res. Tech. 1994- 27: 507−515.
- Farrell C.Z., Risan W. Normal and abnormal development of the blood-brain barrier. Micrisc. Res. Tech. 1994- 27(6): 495 506.
- Haataja L., Mercuri E., Regev R., Cowan F., Rutherford M., Dubowitz V., Dubowitz L. Optimality score for the neurologic examination of the infant at 12 and 18 months of age. J. Pediatr. 1999- 135(2 Pt 1): 153−161.
- Hagberg H., Gilland E., Bona E., Hanson L.A., Hahn-Zoric M., Blennow M. Enhanced expression of interleukin (IL)-1 and IL-6 messenger RNA and bioactive protein after hypoxia-ischemia in neonatal rats. Pediatric Research. 1996- 40(4): 603−609.
- Hallenbeck J.M., Mechanisms of secondary brain damage in cerebral ischemia and trauma. New York. 1996- p. 231
- Hans P., Bonhomme V., Collette J. Neuron-specific enolase as a marker of in vitro neuronal damage. Part I: Assessment of neuron-specific enolase as a quantitative and specific marker of neuronal damage. J. Neurosurg. Anesth. 1993- 5(2): 111−116.
- Hardemark H., Ericsson N., Kotwica Z., Rundstrom G., Mendel-Hartvig I., Olsson Y., Pahlmann S., Persson L. S-100 protein and neuron-specific enolase on CSF after experimental traumatic or focal ischemic brain damage. J. Neurosurg. 1989- 71: 727 731.
- Hardemark H., Persson L., Bolander H., Hillered L., Olsson Y., Pahlman S. Neuron-specific enolase is a marker of cerebral ischemia and infarct size in rat cerebrospinal fluid. Stroke. 1988- 19:1140−1444.
- Harris N.G., Gauden V., Fraser P.A., Williams S.R., Parker G.J. MRI measurement of blood-brain barrier permeability following spontaneous reperfusion in the starch microsphere model of ischemia. Magn. Reson. Imaging. 2002- 20(3): 221−230.
- Hartfield R.H., Mckernan R.M. CSF neuron-specific enolase as a quantitative marker of neuronal damage in a rat sroke model. Brain Res. 1992- 2: 249−252.
- Hatfield J.S., Scoff R.R., Maisel H. The lens epithelium contains glial fibrillary acidic protein (GFAP). J. Neuroimmunol. 1985- 8(4−6): 347−357.
- Hattori H., Morin A., Schwartz P., Fujikawa D., Wasterlain C. Posthypoxic treatment with MK-801 reduces hypoxic-ischemic damage in the neonatal rat. Neurology. 1989- 39:713−718.
- Hay E., Royds J., Davies-Jones G., Lewtas N., Timperley W., Taulor C. Cerebrospinal fluid enolase in stroke. J. Neurol. Neurosurg. Psychiatry. 1984- 47: 724−729.
- Herrmann M., Curio N., Jost S., Wunderlich M.T., Synowitz H., Wallesch C.W. Protein S-100B and neuron specific enolase as early neurobio-chemical markers of the severity of traumatic brain injury. Restor. Neurol. Neurosci. 1999- 14: 109−114.
- Hewicker-Trautwein M., Trautwein G. An immunohistochemical study of the fetal sheep neocortex and cerebellum with antibodies against nervous system-specific proteins. J. Comp. Pathol. 1993- 109(4): 409−421.
- Hoeger H., Englemann M., Bernert G., Seidl R., Bubna-Littitz H., Mosgoeller W., Lubec B., Lubec G., Long term neurological and behavioral effects of graded perinatal asphyxia in the rat. Life sciences. 2000- 66(10): 947−962.
- Hossmann K.A. Reperfusion of the brain after global ischemia hemodynamic disturbances. Shock. 1997- 8(2): 95−101.
- Hudome S., Palmer C., Roberts R.L., Mauger D., Housman C. and Towfighi J. The role of neutrophils in the production of hypoxic-ischemic brain injury in the neonatal rat. Pediatric Research. 1997- 41(5): 607−616.
- Hunt R.W., Loughnan P., Fink A.M., Volpe J.J., Inder T.E. Magnetic resonance demonstration in the newborn of generalized cerebral venous dilation with spontaneous resolution. Eur. J. Paediatr. Neurol. 2002- 6(5): 289−92.
- Huppi P. S., Warfield S., Kikinis R., Barnes P.D., Zientara G.P., Jolesz F.A., Tsuji M.K., Volpe J.J. Quantitative magnetic resonance imaging of brain development in premature and mature newborns. Ann. Neurol. 1998- 43(2): 224−35.
- Ishiguro Y., Kato K. Enolase isoenzymes as markers for differential diagnosis of neuroblastoma, rhabdomyosarcoma and Wilms' tumor. Gann. 1984- 75: 53−60.
- Ito U., Go K.G., Walker J.T. Experimental cerebral ischemia in mongolian gerbils. Behavior of the blood-brain barrier. Acta Neuropath. 1976- 34: 1−6.
- Iuvone L., Geloso M.C., Dell’Anna M.E., Changes in open field behavior, spatial memory, and hippocampal parvalbumin immunoreactivity folloving enrichment in rats exposed to neonatal anoxia. Exp. Neurol.1996- 139: 25−33.
- Kalman M. GFAP expression withdraws a trend of glial evolution? Brain Res. Bulletin. 2002- 57: 509−511.
- Kato K., Kimura S. SlOOao (oca) protein is mainly located in the heart and striated muscles. Biochim. Biophys. Acta. 1985- 842: 146−150.
- Kermer P., Klocker N., Bahr M. Neuronal death after brain injury (models, mechanisms, and therapeutic strategies in vivo). Cell Tissue Res. 1999- 298: 383−395.
- Kim J.S., Yoon S.S., Kim Y.H., Ryu J.S. Serial measurement of interleukin-6, transforming growth factor- b, and S-100 protein in patients with acute stroke. Stroke. 1996- 27: 1553−1557.
- Kleinschnitz C., Bendszus M., Frank M., Solymosi L., Toyka K.V., Stoll G. In vivo monitoring of macrophage infiltration in experimental ischemic brain lesions by magnetic resonance imaging. J. Cereb. Blood Flow Metab. 2003- 23(11): 1356−61.
- Kohlhauser C., Kaehler S., Mosgoeller W., Singewald N., Kouvelas D., Prast H., Hoeger H., Lubec B. Histological changes and neurotransmitters levels three month following perinatal asphyxia in the rat. Life Sci. 1999- 64(23): 2109−2124.
- Kohlhauser C., Mosgoeller W., Hoeger H., Lubec B. Myelination deficits in brain of rats following perinatal asphyxia. Life Sci. 2000- 67: 2355−2368.
- Kragh J., Bolwig T.G., Woldbye D.P. Electroconvulsive shock and lidocaine-induced seizures in the rat activate astrocytes as measured by glial fibrillary acidic protein. Biol. Psychiatry. 1993- 33(11−12): 794−800.
- Krause D., Kurz I., Dermictzel R. Cerebral pericytes a second line of deference in controlling blood-brain barrier peptide metabolism. Adv. Exp. Med. Biol. 1993- 331: 149−152.
- Kretzschmar D., Pflugfelder G. Glia in development, function, and neurodegeneration of the adult incest brain. Brain Res. Bulletin. 2002- 57: 121−131.
- Krupinski J., Kaluza J., Kumar P., Wang M, Kumar S. Prognostic value of blood vessel density in ischaemic stroke. Lancet. 1993- 342(8873): 742−746.
- Krupinski J, Kaluza J., Kumar P., Kumar S., Wang J.M. Role of angiogenesis in patients with cerebral ischemic stroke. Stroke. 1994- 25: 1794−1798.
- Lee J.C., Olszewski J. Increased cerebrovascular permeability after repeated electroshocks. Neurology. 1996- 11: 515−519.
- Levene M., Role of excitatory amino acid antagonists in the management of birth asphyxia. Biol Neonate. 1992- 62:248−251.
- Leviton A., Fenton T., Kuban K. C., Pagano M. Labor and delivery characteristics and the risk of germinal matrix hemorrhage in low birth weight infants. J. Child-Neurol. 1991- 6(1): 35−40.
- Litt L., Hirai K., Basus V.J., James T.L. NTP and PCr responses to hypoxia by hypothermic and normothermic respiring, superfiised, neonatal rat cerebrocortical slices: an NMR spectroscopy study at 14.1 Tesla. Acta Neurochir Suppl. 2003- 86: 71−4.
- Lubec B., Kozlov A., Krapfenbauer K., Berger A., Hoeger H., Herrera-Marschitz M., Nohl H., Koeck T., Lubec G. Nitric oxide and nitric oxide syntase in the early phase of perinatal asphyxia of the rat Neurosci. 1999- 93(3): 1017−1023.
- Marangos P.J., Paul S.M. Brain levels of neuron-specific and nonneuronal enolase in Hantingrons disease. J. Neurochem. 1981- 35(5): 1338−1340.
- Marangos P.J., Cambell I.C., Schmechel D.E. Blood platelets contain a neuron-specific antigen. J. Neurochem. 1980- 34(5): 1254−1258.
- Marangos P.J., Cambell I.C., Cohen R.M. Neuronal and glial proteins: Structure, function and clinical application. San Diego etc.: Acad. Press. 1998- p. 398.
- Marks K.A., Mallard E.C., Roberts I., Williams C.E., Sirimanne E.S., Johnston B. Delayed vasodilation and altered oxygenation after cerebral ischemia in fetal sheep. Pediatric Research. 1996- 39(1): 48−54.
- Martens P., Raabe A., Johnsson P. Serum S-100 and neuron-specific enolase for prediction of regaining consciousness after global cerebral ischemia. Stroke. 1998- 29: 2363−2366.
- Martin L.J. Neuronal cell death in nervous system development, disease, and injury (Review). Int. J. Mol .Med. 2001- 7(5): 455−478.
- McDonald J., Silverstein F., Johnston M. MK-801 protect the neonatal brain from hypoxic-ischemic damage. Eur. J. Pharmacol. 1987- 140: 359−361.
- McGeer P., Itagaki S., Togo H., Mcgeer E. Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR. Neurosci. Lett. 1987- 79(1−2): 195−200.
- McGeer P.L., Kawamata T., Walker D.G., Akiyama H., Tooyama I., McGeer E.G. Microglia in degenerative neurological disease. Glia. 1993- 7: 84−92.
- Meisenberg G., Simmons W.H. Peptides and blood-brain barrier. Life Sci. 1993- 32: 2611−2623.
- Miller D.B., Blekman C.F., O’Callagan J.P. An increase glial fibrillary acidic protein follows brain hypertyermia in rats. Brain Res. 1987- 415: 371−374.
- Missler U, Wiesmann M., Friedrich C., Kaps M. S-100 protein and neuron-specific enolase concentrations in blood as indicators of infarction volume and prognosis in acute ischemic stroke. Stroke. 1997- 28: 1956−1960.
- Mitsufuji N., Yoshioka H., Okano S., Nishiki T., Sawada T., A new model of transient cerebral ischemia in neonatal rats. J. Cereb. Blood Flow Metab. 1996- 16: 237−243.
- Miyake K., Yamamoto W., Tadokoro M., Takagi N., Sasakava K., Nitta A., Furukawa S., Takeo S. Alteration in hippocampal GAP-43, BDNF, and LI following sustained cerebral ischemia. Brain Res. 2002- 935: 24−31.
- Mokuno K., Kato K., Kavai K., Matsuoka Y., Yanagi T., Sobue I. Neuron-specific enolase and s-100 protein levels in cerebrospinal fluid of patient with various neurological diseases. J. Neurol. Sci. 1983- 60: 443−451.
- Moller M., Ingild A., Bock E. Immunohistochemical demonstration of S-100 protein and GFA protein in intersticial cells of rat pineal gland. Brain. Res. 1978- 140(1): 1−13.
- Moore B.W. A soluble protein characteristic of the nervous system. Biochem. biophys. Res. Commun. 1965- 19: 739 744.
- Mori T., Morimoto K., Hayakawa T. Radioimmunoassay of astroprotein (an astrocyte specific cerebroprotein) in cerebrospinal fluid and its clinical significance. Neurol. Med.-Chir. (Tokyo). 1978- 18: 25−31.
- Nagdyman N., Kornen W., Ko H., Muller C., Obladen M. Early Biochemical Indicators of Hypoxic-Ischemic Encephalopathy after Birth Asphyxia. Pediatric Research. 2001- 49(4): 133−139.
- Nakajima W., Ishida, A., Lange M.S., Gabrielson K.L., Wilson M.A., Martin, L.J. Apoptosis has a prolonged role in the neurodegeneration after hypoxic ischemia in the newborn rat. The Journal of Neuroscience. 2000- 20(21): 7994−8004.
- Nakane P.K., Kawaoi A. Peroxidase-labeled antibody. A new method of conjugation. H. Histochem. Cytochem. 1974- 22: 1084−1091.
- Nedelcu J., Klein M.A., Aguzzi A., Boesiger P., Martin E. Biphasic edema after hypoxic-ischemic brain injury in neonatal rats reflects early neuronal and late glial damage. Pediatric Research. 1999- 46(3): 297−304.
- Niebroj-Dobosz I., Rafalowska J., Lukasiuk M. Immunochemical analysis of some proteins in cerebrospinal fluid and serum of patients with ischemic strokes. Folia Neuropathol. 1994- 32(3): 129−137.
- Northington F.J., Ferriero D.M., Graham E.M., Traystman R.J., Martin L.J. Early neurodegeneration after hypoxia-ischemia in neonatal rat is necrosis while delayed neuronal death is apoptosis. Neurobiol. Dis. 2001- 8(2): 207−219.
- Padget D.N. The development of the cranial arteries in the human embrio. Carnegie Inst. Publ. 575, Contribution to Embriology. 1948- 32:205−261.
- Pardridge W.M. Transport of nutrients and hormones through the blood-brain barrier. Fed.Proc. 1984- 43: 201−204.
- Pardridge W.M. Neurotrophins, neuroprotection and the blood-brain barrier. Curr. Opin. Investig. Drugs. 2002- 3(12): 1753−1757.
- Palmer C. Hypoxic-ischemic encephalopathy: Therapeutic approaches against microvascular injury, and role of neutrophils, PAF, and free radicals. Clinics in Perinatology. 1995- 22(2): 481−517.
- Palmer C. Neurobiology of perinatal asphyxia. Penn. State Coll. Med. 2001- 1:1−18.
- Palmer C., Menzies S., Roberts R.L., Connor J.R. Iron containing «plaques» develop in the brains of rats months after neonatal hypoxic-ischemic brain injury. Pediatric Research. 1998−43:322−328.
- Pantoni L. Pathophysiology of age-related cerebral white matter changes. Cerebrovasc. Dis. 2002- 13 Suppl 2: 7−10.
- Parati E., Bez A., Ponti D., Grazia U., Corsini E., Cova L., Sala S., Colombo A., Allessandri G., Pagano S. Human stem cells express extra-neural markers. Brain Res. 2002- 925:213−221.
- Petito C.K., Halaby I.A. Relationship between ischemia and ischemic neuronal necrosis to astrocyte expression of glial fibrillary acidic protein. Int. J. Dev. Neurosci. 1993- 11(2): 239−247.
- Petty M., Wettstein J. Elements of cerebral microvascular ischaemia. Brain Res. Reviews. 2001- 36: 23−34.
- Pluta R. Blood-brain barrier dysfunction and amyloid precursor protein accumulation in microvascular compartment following ischemia-reperfusion brain injury with 1-year survival. Acta Neurochir. Suppl. 2003- 86: 117−122.
- Prinz R.A., Marangos P.J. Use of neuron-specific enolase as a serum marker for neuroendocrine neoplasms. Surgery. 1982- 92(5): 887−889.
- Pulera M. R., Adams L.M., Liu H., Santos D.G., Nishimura R.N., Yang F., Cole G.M., Wasterlain C.G., Apoptosis in a neonatal rat model of cerebral hypoxia-ischemia. Stroke 1998- 29: 2622−2630.
- Raabe A., Grolms C., Sorge O., Zimmermann M., Seifert V. Serum S-100B protein in severe head injury. Neurosurgery. 1999- 45:477- 483.
- Raju T.N.K. Some animal models for the study of perinatal asphyxia. Biol. Neonate. 1992- 1:202−214.
- Reiber H. Dynamics of brain-derived proteins in cerebrospinal fluid. Clinica Chimica Acta. 2001- 310:173−186.
- Renolleau S., Aggoun-Zouaoui D., Ben-Ari Y., Charriaut-Marlangue C., A model of transient unilateral focal ischemia with reperfusion in the P7 neonatal rats. Stroke. 1998- 29: 1454−1461.
- Rice J., Vannucci R., Brierley J. The influence of immaturity on hypoxia-ischemic brain damage in the rat. Ann Neurol. 1981- 9: 131−141.
- Risau W., Hallmann R, Albrecht U. Differentiation-dependent expression of proteins in brain endothelium during development of the blood-brain barrier. Dev Biol. 1986- 117(2): 537−545.
- Rodriguez M., Ursy G., Bernal F., Cusi V., Mahy N. Perinatal human hypoxia-ischemia vulnerability correlates with brain calcification. Neurobiology of Diseases. 2001- 8: 5968.
- Roher A., Wolff. D. Purification, ultrastructure and chemical analysis of Alzheimer’s disease amyloid plaque core protein. Proc. Natl. Acad. Sci. USA. 1986- 83: 2662— 2666.
- Roncali L., Nico B., Ribatti D., Bertossi M., Mancini L. Microscopical and ultrastructural investigations on the development of the blood-brain barrier in the chick embryo optic tectum. Acta Neuropathol (Berl). 1986- 70(3−4): 193−20.
- Rosen H., Rosengren L., Herlitz J., Blomstrand C. Increased serum levels of the S-100 protein are associated with hypoxic brain damage after cardiac arrest. Stroke. 1998- 29: 473−477.
- Rosengren L.E., Haglid K.G. Long term neurotoxicity of styrene. A quantitative study of glil fibrillary acidic protein (GFAP) and S-100. Brit. J. Industr. Med. 1989- 46:. 316 320.
- Rosengren L.E., Wikkeiso C., Hagberg L. A sensitive ELISA for glial fibrillary acidic protein: application in CSF of adults. J. Neurosci. Methods. 1994- 51: 197−204.
- Roth S.C., Edwards A.D., Cady E.B., Delpy D.T., Wyatt J.S., Azzopardi D. Relation between cerebral oxidative metabolism following birth asphyxia and neurodevelopmental outcome and brain growth at one year. Dev. Med. Child. Neurol. 1992- 34: 285−95.
- Ruppel R., Kochalek P., Adelson P. Excitotoxicy after severe traumatic brain injury in infants and children: the role of chield abuse. J. Pediatr. 2001- 138: 18−25.
- Ruutianen J., Newcombe J., Malmi A. Measurement of glial fibrillary acidic protein (GFAP) and anti-GFAP-antibodies by solid-phase radioimmunoasseys. J. Acta Neurol. Scandinav. 1981- 63:297−305.
- Sameshima H., Ikenoue T., Long-term magnesium sulfate treatments as protection against hypoxic-ischemic brain injury in seven-day-old rats. Am. J. Obstet Gynecol. 2001- 184:185−190.
- Saunders N.R. Handbook of Experimental Pharmacology. 1992. V.103: 328−369.
- Schaarschmidt H., Prange H.W., Reiber H. Neuron-specific enolase and S-100 protein levels in cerebrospinal fluid of patients with various neurological diseases. J. Neurolog. Sciences. 1983- 60:443−451.
- Schmechel D.E., Marangos P.J., Brightman M. Neuron specific enolase is a marker for peripheral and central neuroendocrine cells. Nature (London). 1979- 276: 834−836.
- Schwartz P.H., Massarweh W.F., Vinters H.V., Wasterlain C.G., A rat model of severe neonatal hypoxic-ischemic brain injury. Stroke. 1992- 23: 539−546.
- Steinberg R., Gueniau C., Scarna H., Keller A., Worcel M., Pujol J. Experimental brain ischemia: neuron-specific enolase level in cerebrospinal fluid as an index of neuronal damage. J. Neurochem. 1984- 43(1): 19−23.
- Stewart P.A., Hayakawa K Early ultrastructural changes in blood-brain barrier vessels of the rat embryo. Brain Res. Dev. Brain Res. 1994- 78(1): 25−34.
- Steward O., Torre E.R., Tomasulo R., Lothman E. Neuronal activity up-regulates astroglial gene expression. Proc. Natl. Acad. Sci. USA. 1991- 88: 6819−6823.
- Steward O., Torre E.R., Tomasulo R. Seizures and the regulation of astroglial gene expression. Epilepsy Res. Suppl. 1992- 7:197−209.
- Tan S., Parks D.A. Preserving brain function during neonatal asphyxia. Clinics in Perinatology. 1999- 26(3): 733−735.
- Thomberg E., Thiringer K., Hagberg H., Kjellmer I. Neuron specific enolase in asphyxiated newborns: association with encephalopathy and cerebral function monitor trace. Arch. Dis. Child. Fetal. Neonatal. 1995- 72: 392.
- Thompson C.M., Puterman A.S., Linley L.L., Hann F.M., Vanderelst C.W., Molteno C.D. The value of a scoring system for hypoxic ischaemic encephalopathy in predicting neurodevelopmental outcome. Acta Paediatr. 1997- 86(7): 757−761.
- Thoresen M., Penrice J., Lorek A., Cady E.B., Wylezinska M., Kirkbride V. Mild hypothermia after severe transient hypoxia-ischemia ameliorates delayed cerebral energy failure in the newborn piglet. Pediatric Research. 1995- 37(5): 667−670.
- Verdu Perez A., Falero M.P., Arroyos A., Estevez F., Felix V., Lopez Y., Pantoja A., Ureta A. Blood neuronal specific enolase in newborns with perinatal asphyxia. Rev. Neurol. 2001- 32(8): 714−717.
- Vinores S.A., Marangos P.J. Immunoradiometric and immunohistochemical demonstration of neuron-specific enolase in experimental rat gliomas. Cancer Res. 1984- 44: 2595−2601.
- Volbrodt A.W., Dobrogowska D.H. Immunocytochemical evaluation of blood-brain barrier to endogenous albumin in adult, newborn and aged mice. Folia Histochem. Cytobiol. 1994- 32(2): 63−70.
- Volpe J.J. Brain injury in the premature infant: overview of clinical aspects, neuropathology, and pathogenesis. Semin Pediatr Neurol. 1998- 5(3): 135−151.
- Volpe J.J. Neonatal seizures: current concepts and revised classification. Pediatrics. 1989- 84(3): 422−428.
- Volpe J.J. Neurobiology of periventricular leukomalacia in the premature infant. Pediatr. Res. 2001- 50 (5): 553−562.
- VoIpe J.J. Neurology of the Newborn. Saunders, Philadelfia. 1995- p. 422.
- Volpe J.J. Overview: normal and abnormal human brain development. Ment. Retard. Dev. Disabil. Res. Rev. 2000- 6(1): 1−5.
- Volpe J.J. Perinatal brain injury: from pathogenesis to neuroprotection. Ment. Retard. Dev. Disabil. Res. Rev. 2001- 7(1): 56−64.
- Vorgias C.E., Traub P. Isolation of glial fibrillary acidic protein from bovine brain white matter and its purification by affinity chromatography on single-stranded DNA-cellulose. Biochem. and Biophys. Res. Communs. 1983- 115(1): 68−75.
- Warlow C.P., Dennis M.S., van Gijn J. Stroke. A practical guide to manadgement. Oxford, Blackwell Science Ltd, 1996- p.430.
- Wen T.C., Rogido M., Genetta T., Sola A. Permanent focal cerebral ischemia activates erythropoietin receptor in the neonatal rat brain. Neurosci. Lett. 2004- 355(3): 165−168.
- Westaby S., Johnsson P., Parry A.J., Blomqvist S., Solem J.O., Ailing C., Pillai R., Taggart D.P., Grebenik C., Stahl E. Serum SI00 protein: a potential marker for cerebral events during cardiopulmonary bypass. Ann. Thorac. Surg. 1996- 61: 88−92.
- Williams C.E., Gunn A., Gluckman P.D. Time course of intracellular edema and epileptiform activity following prenatal cerebral ischemia in sheep. Stroke. 1991- 22(4): 516−521.
- Wilsniewski H., Wegiel J., Wang K.C., Kujawa M., Lach B. Ultrastructural studies of the cells forming amyloid fibers in classical plaques. Can. J. Neurol. Sci. 1989- 16: 535 542.
- Winfree A. SFI studies in the sciences of complexity. Addison Wesley, MA, Reading 1993- 207−298.
- Whitaker J., Lisak R., Bashir R. Immunoreactive myelin basic protein in the cerebrospinal fluid in neurological disorders. Ann. Neurol. 1980- 7: 58−64.
- Woertgen C., Rothoerl R.D., Brawanski A. Time profile of neuron specific enolase serum levels after experimental brain injuiy in rat. Acta Neurochir. Suppl. 2000- 76: 371−373.
- Wunderlich M.T., Ebert A.D., Kratz T., Gortler M., Jost St., Herrmann M. The early neurobehavioral outcome after stroke is related to the release of neurobiochemical markers of brain damage. Stroke. 1999- 30: 1190 -1195.
- Xiang J., Ennis S.R., Abdelkarim G.E., Fujisawa M., Kawai N., Keep R.F. Glutamine transport at the blood-brain and blood-cerebrospinal fluid barriers. Neurochem. Int. 2003- 43(4−5): 279−288.
- Zandbergen E.G., de Haan R.J., Hijdra A. Systematic review of prediction of poor outcome in anoxic-ischaemic coma with biochemical markers of brain damage. Intensive Care Med. 2001- 27(10): 1661−1667.
- Zhang F., White J., Iadecola C. Nitric oxide donors increase blood flow and reduce brain damage in focal ischemia: evidence that nitric oxide is beneficial in the early stages of cerebral ischemia. J. Cereb. Blood Flow. Metab. 1994- 14: 217−226.
- Zhang R.L., Chopp M., Chen H., Garcia J.H. Temporal profile of ischemic tissue damage, neutrophil response, and vascular plugging following permanent and transient (2H) middle cerebral artery occlusion in the rat. J. Neural. Sci. 1994- 125: 3−10.