Роль полиаминов в защите Escherichia Coli от окислительного стресса, вызванного перекисью водорода
Диссертация
Установлена прямая корреляция между уровнями суперспирализации ДНК и экспрессии гена oxyR в клетках Е. coli в процессе адаптации к окислительному стрессу. Это позволяет говорить о том, что одной из причин возрастания промоторной активности oxyR в условиях окислительного стресса является изменение топологии ДНК. Влияние топологии ДНК на активность генов адаптации к окислительному стрессу… Читать ещё >
Содержание
- ГЛАВА 1. Обзор литературы
- 1. 1. Формирование активных форм кислорода и их токсическое действие на основные компоненты клетки
- 1. 1. 1. Формирование АФК
- 1. 1. 2. Повреждающее действие АФК на компоненты клетки
- 1. 2. Общие регуляторные механизмы адаптации микроорганизмов к стрессовым условиям
- 1. 2. 1. Двухкомпонентные сигналпроводящие системы
- 1. 2. 2. «Ощущение кворума»
- 1. 2. 3. Белки, сочетающие свойства сенсоров и транскрипционных регуляторов
- 1. 2. 4. а-факторы
- 1. 2. 5. Влияние топологического состояния ДНК на генную экспрессию
- 1. 2. 6. Регуляция адаптивного ответа на посттранскрипционном уровне
- 1. 3. Особенности адаптивного ответа микроорганизмов на окислительный стресс
- 1. 3. 1. Регулоны защиты от окислительного стресса
- 1. 3. 2. Детоксикация АФК
- 1. 3. 3. Ограничение поступления АФК в клетку
- 1. 3. 4. Активный выброс из клетки генераторов АФК
- 1. 3. 5. Биосинтез изоферментов устойчивых к АФК
- 1. 3. 6. Регуляция уровня ионов металлов
- 1. 3. 7. Регенерация и репарация повреждений
- 1. 4. Полиамины. Физиологическая роль полиаминов
- 1. 4. 1. Пути биосинтеза полиаминов
- 1. 4. 2. Физиологическая роль полиаминов
- 1. 1. Формирование активных форм кислорода и их токсическое действие на основные компоненты клетки
- 2. 1. Объекты исследования и условия культивирования
- 2. 2. Выделение плазмидной ДНК из клеток Escherichia col
- 2. 3. Трансформация Escherichia coli плазмидной ДНК
- 2. 4. Определение степени суперспирализации ДНК
- 2. 5. Определение содержания полиаминов в клетке и в среде
- 2. 6. Определение активности ферментов полиаминсинтезирующей системы
- 2. 7. Определение активности (3- галактозидазы
- 2. 8. Определение содержания белка
- 2. 9. Определение частоты мутаций
- 2. 10. Подсчет числа живых клеток
- 2. 11. Статистическая обработка данных
- 3. 1. Отклик системы синтеза полиаминов на окислительный стресс как индикатор их возможной роли в антиоксидантной защите
- 3. 2. Влияние окислительного стресса на экспрессию гена oxyR
- 3. 3. Влияние полиаминов на экспрессию генов антиоксидантной защиты
- 3. 4. Специфичность эффекта полиаминов на экспрессию генов окислительного стресса
- 4. 1. Роль полиаминов в регуляции топологии ДНК в условиях окислительного стресса
- 4. 2. Влияние путресцина на экспрессию гена oxyR через изменение топологического состояния ДНК
- 5. 1. Роль путресцина в защите ДНК от разрывов, индуцированных АФК
- 5. 2. Влияние путресцина на частоту мутаций и выживаемость Е. coli при окислительном стрессе
- 6. 1. Роль полиаминов в регуляции экспрессии генов oxyR регулона Escherichia col
- 6. 2. Влияние путресцина на экспрессию адаптивных генов через изменение топологии ДНК
- 6. 3. Полиамины как ДНК-протекторы в процессе адаптации Escherichia coli к окислительному стрессу
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