Экспериментальное исследование взаимодействий кроветворных клеток с элементами стромы
Диссертация
В эмбриогенезе кроветворение впервые возникает в желточном мешке, а затем последовательно перемещается в печень, селезенку и костный мозг. При этом стволовые и родоначапьные клетки претерпевают определенные изменения, касающиеся их дифференцировочных потенций и поверхностного фенотипа. По-видимому, наиболее примитивными являются СКК желточного мешка. Хотя в желточном мешке происходит только… Читать ещё >
Содержание
- СПИСОК СОКРАЩЕНИЙ
- ОБЗОР ЛИТЕРАТУРЫ
- I. СОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ О СТВОЛОВЫХ И ЮДОНАЧАЛЬНЫХ КРОВЕТВОРНЫХ КЛЕТКАХ
- II. КРОВЕТВОРНОЕ МИКРООКРУЖЕНИЕ. И
- 1. Клеточный состав кроветворного микроокружения
- 2. Морфологическая и функциональная неоднородность кроветворного микроокружения
- 3. стромальные клетки- предшественники
- 4. Кроветворное микроокружение в эмбриогенезе
- III. РОЛЬ КРОВЕТВОРНОГО МИКРООКРУЖЕНИЯ В РЕГУЛЯЦИИ КРОВЕТВОРЕНИЯ
- 1. Цитокины, участвующие в регуляции кроветворения
- 1. 1. Фактор стволовых клеток
- 1. 2. Интерлейкин
- 1. 3. Колониестимулирующие факторы
- 1. 4. Эритропоэтин
- 1. 5. Тромеопоэтин
- 1. 6. Особенности регуляции ранних кроветворных клеток с помощью цитокинов
- 2. Продукция цитокинов клетками кроветворной стромы
- 3. Значение межклеточных взаимодействий для регуляции кроветворения
- 4. Механизмы межклеточных взаимодействий: роль внеклеточного матрикса и поверхностных молекул стромальных клеток
- 5. Адгезия кроветворных клеток к строме и ее роль в регуляции кроветворения
- IV. ЭКСПЕРИМЕНТАЛЬНЫЕ ПОДХОДЫ К ИССЛЕДОВАНИЮ МЕЖКЛЕТОЧНЫХ ВЗАИМОДЕЙСТВИЙ В КРОВЕТВОРЕНИИ
- 1. Длительные культуры кроветворных тканей
- 2. Получение колоний на АЦ-мембранах
- 3. Кроветворная дифференцировка эмбриональных стволовых клеток
- 4. Применение методов генетической инженерии в изучении регуляции кроветворения
- МАТЕРИАЛЫ И МЕТОДЫ ИССЛЕДОВАНИЯ
- I. ЭКСПЕРИМЕНТАЛЬНЫЕ ЖИВОТНЫЕ
- II. ОСНОВНАЯ ЭКСПЕРИМЕНТАЛЬНАЯ МОДЕЛ
- 1. Условия облучения
- 2. Получение очагов кроветворения на подслое, образованном in vrvo
- 2. 1. Имплантация АЦ-мембран для формирования подслоя
- 2. 2. Введение суспензии костного мозга
- 2. 3. Предварительная фиксация подслоя
- 2. 4. Методика экспериментов с кровопусканием
- 2. 5. Использование кополимера этиленвинилацетата для доставки эритропоэтина к подслою
- 2. 5. 1. Приготовление ЭВА
- 2. 5. 2. Имплантация ЭВА под подслой на АЦ-мембране
- 3. 1. Получение эмбрионов мыши с датированным сроком развития
- 3. 2. Культивирование клеток
- 3. 2. 1. Получение эмбриональных фибробластов мыши
- 3. 2. 2. Получение фибробластов го кожи, печени, конечностей (с костным мозгом), почки и селезенки
- 3. 2. 3. Получение монослойных культур костного мозга
- 3. 2. 4. Постоянные линии фибробластов
- 3. 2. 5. Получение подслоев фибробластов на АЦ-мембранах
- 3. 2. 6. Получение первичных монослойных культур гепатоцитов, почечного эпителия и клеток селезенки
- 3. 3. Имплантация подслоев мышам и введение суспензии костного мозга
- 2. 1. Образование кроветворных колоний на подслоях, содержащих фибробласты костного мозга
- 2. 1. 1. Кроветворные колонии на подслое фибробластов из конечностей 17-суточных эмбрионов и новорожденных мышей
- 2. 1. 2. Кроветворные колонии на подслое фибробластов монослойной культуры костного мозга взрослых мышей
- 2. 2. Образование кроветворных колоний на подслое фибробластов кожи 17 — суточных эмбрионов и новорожденных мышей
- 2. 3. Образование кроветворных колоний на подслое фибробластов печени 17 -суточных эмбрионов
- 2. 4. Образование кроветворных колоний на подслое фибробластов почки взрослых мышей
- 2. 5. Образование кроветворных колоний на подслое фибробластов селезенки взрослых мышей
- 3. 1. Кроветворение на подслоях, содержащих гепатоциты эмбрионов и новорожденных мышей
- 3. 2. Кроветворение на подслое клеток почки новорожденных и взрослых мышей
- 3. 3. Кроветворение на подслое клеток селезенки взрослых мышей
- 1. 1. Подслой клеток СЗН 10Т½ clone
- 1. 2. Подслой клеток ДФК
- 1. 3. Подслой клеток ЗТЗ
- 1. 4. Подслой клеток NIH/3T
- 1. 5. Подслой клеток NCTC clone L
- 1. 1. Исследование днфференцировки сингенных кроветворных клеток на подслое мыши после кровопускания
- 1. 2. Исследование днфференцировки кроветворных клеток морской свинки на подслое мыши после кровопускания
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