Π₯Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΡ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠΎΠ², ΡΠ΅Π³ΡΠ»ΠΈΡΡΡΡΠΈΡ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ Π°Π»ΡΡΠ°-Π³Π»ΠΎΠ±ΠΈΠ½ΠΎΠ²ΡΡ Π³Π΅Π½ΠΎΠ² ΠΊΡΡ
ΠΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΡ
ΠΠΈΠ½ΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ, ΡΡΠ°Π½ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Π²ΠΈΡΡΡΠΎΠΌ ΡΡΠΈΡΡΠΎΠ»Π΅ΠΉΠΊΠ΅ΠΌΠΈΠΈ ΠΏΡΠΈΡ HD3 (ΠΊΠ»ΠΎΠ½ Π6 Π»ΠΈΠ½ΠΈΠΈ LSCC) ΠΊΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π»ΠΈ Π² ΡΡΠ΅Π΄Π΅ DMEM (Dulbecco's modified Eagles medium) Ρ Π΄ΠΎΠ±Π°Π²Π»Π΅Π½ΠΈΠ΅ΠΌ 8% ΡΠ΅ΡΠ°Π»ΡΠ½ΠΎΠΉ Π±ΡΡΡΠ΅ΠΉ ΡΡΠ²ΠΎΡΠΎΡΠΊΠΈ, 2% ΠΊΡΡΠΈΠ½ΠΎΠΉ ΡΡΠ²ΠΎΡΠΎΡΠΊΠΈ, 100 Π΅Π΄./ΠΌΠ» ΠΏΠ΅Π½ΠΈΡΠΈΠ»Π»ΠΈΠ½Π° ΠΈ 100 ΠΌΠΊΠ³/ΠΌΠ» ΡΡΡΠ΅ΠΏΡΠΎΠΌΠΈΡΠΈΠ½Π°. ΠΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π²Π΅Π»ΠΈ ΠΏΡΠΈ 37 Β°C Π² Π°ΡΠΌΠΎΡΡΠ΅ΡΠ΅, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠ΅ΠΉ 5,5% ΡΠ³Π»Π΅ΠΊΠΈΡΠ»ΠΎΡΡ. ΠΠ»ΠΎΡΠ½ΠΎΡΡΡ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΡΡΡΠΏΠ΅Π½Π·ΠΈΠΈ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΈΠ²Π°Π»ΠΈ Π² ΠΏΡΠ΅Π΄Π΅Π»Π°Ρ … Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΠΠΠΠ I. ΠΠΠΠΠ ΠΠΠ’ΠΠ ΠΠ’Π£Π Π«
- 1. ΠΠΎΠΌΠ΅Π½Ρ Π-Π³Π»ΠΎΠ±ΠΈΠ½ΠΎΠ²ΡΡ
Π³Π΅Π½ΠΎΠ² ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΈ ΠΊΡΡ
- 1. 1. ΠΠ±ΡΠ°Ρ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΡ Π΄ΠΎΠΌΠ΅Π½ΠΎΠ² 6-Π³Π»ΠΎΠ±ΠΈΠ½ΠΎΠ²ΡΡ Π³Π΅Π½ΠΎΠ²
- 1. 2. ΠΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΠΎΠ±Π»Π°ΡΡΠΈ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ Π»ΠΎΠΊΡΡΠ° Π΄ΠΎΠΌΠ΅Π½Π° 6-Π³Π»ΠΎΠ±ΠΈΠ½ΠΎΠ²ΡΡ Π³Π΅Π½ΠΎΠ²
- 1. 3. ΠΠ΅Ρ Π°Π½ΠΈΠ·ΠΌ ΡΠ°Π±ΠΎΡΡ ΠΎΠ±Π»Π°ΡΡΠΈ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ Π»ΠΎΠΊΡΡΠ°
- 1. 4. Π‘ΡΠ±Π΄ΠΎΠΌΠ΅Π½Ρ Π΄ΠΎΠΌΠ΅Π½Π° fi-Π³Π»ΠΎΠ±ΠΈΠ½ΠΎΠ²ΡΡ Π³Π΅Π½ΠΎΠ² ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°
- 1. 5. ΠΡΠ°Π½ΠΈΡΡ Π΄ΠΎΠΌΠ΅Π½Π°
- 2. ΠΠΎΠΌΠ΅Π½Ρ Π°-Π³Π»ΠΎΠ±ΠΈΠ½ΠΎΠ²ΡΡ
Π³Π΅Π½ΠΎΠ² ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΈ ΠΊΡΡ
- 2. 1. ΠΠ±ΡΠ°Ρ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΡ Π΄ΠΎΠΌΠ΅Π½ΠΎΠ²
- 2. 2. Π Π°ΡΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠ΅ Π΄ΠΎΠΌΠ΅Π½ΠΎΠ² Π°-Π³Π»ΠΎΠ±ΠΈΠ½ΠΎΠ²ΡΡ Π³Π΅Π½ΠΎΠ² Π² ΠΏΠ΅ΡΠΌΠ°Π½Π΅Π½ΡΠ½ΠΎ ΠΎΡΠΊΡΡΡΠΎΠΉ Ρ ΡΠΎΠΌΠ°ΡΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΠΈ
- 2. 3. ΠΠ΅ΡΠ΅ΠΊΡΡΠ²Π°Π½ΠΈΠ΅ Π΄ΠΎΠΌΠ΅Π½ΠΎΠ² Π°-Π³Π»ΠΎΠ±ΠΈΠ½ΠΎΠ²ΡΡ Π³Π΅Π½ΠΎΠ² ΠΈ Π³Π΅Π½Π° «-14»
- 2. 4. ΠΡΠΎΡΡΡΠ°Π½ΡΡΠ²Π΅Π½Π½Π°Ρ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΡ Π΄ΠΎΠΌΠ΅Π½Π° Π°-Π³Π»ΠΎΠ±ΠΈΠ½ΠΎΠ²ΡΡ Π³Π΅Π½ΠΎΠ²
- 2. 5. ΠΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠ° Π°ΡΠ΅ΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π³ΠΈΡΡΠΎΠ½ΠΎΠ² Π² Π΄ΠΎΠΌΠ΅Π½Π΅ Π°-Π³Π»ΠΎΠ±ΠΈΠ½ΠΎΠ²ΡΡ Π³Π΅Π½ΠΎΠ²
- 1. ΠΠΎΠΌΠ΅Π½Ρ Π-Π³Π»ΠΎΠ±ΠΈΠ½ΠΎΠ²ΡΡ
Π³Π΅Π½ΠΎΠ² ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΈ ΠΊΡΡ
Π‘ΠΏΠΈΡΠΎΠΊ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
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- Π’Π°ΠΊΠΆΠ΅ Π±Π»Π°Π³ΠΎΠ΄Π°ΡΡ Π²ΡΠ΅Ρ ΡΠΎΡΡΡΠ΄Π½ΠΈΠΊΠΎΠ² Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠΈΠΈ «ΡΡΡΡΠΊΡΡΡΠ½ΠΎ-ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΠΈ Ρ ΡΠΎΠΌΠΎΡΠΎΠΌ» Π·Π° ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΊΡ ΠΈ ΠΏΠΎΠΌΠΎΡΡ ΠΏΡΠΈ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΠΈ ΡΠ°Π±ΠΎΡΡ. ΠΡΠΎΠ±ΡΡ ΠΏΡΠΈΠ·Π½Π°ΡΠ΅Π»ΡΠ½ΠΎΡΡΡ Ρ ΠΎΡΡ Π²ΡΡΠ°Π·ΠΈΡΡ ΠΠ΅ΡΡΠΎΠ²ΠΎΠΉ ΠΠ°ΡΠ°Π»ΡΠ΅ Π·Π° Π»ΠΈΡΠ½ΠΎΠ΅ ΡΡΠ°ΡΡΠΈΠ΅ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ ΠΈ ΠΎΡΠΎΡΠΌΠ»Π΅Π½ΠΈΠΈ Π΄ΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΠΈ.
- ΠΠ»Π°Π³ΠΎΠ΄Π°ΡΡ ΠΌΠΎΠΈΡ ΠΎΠΏΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² Π΄.Π±.Π½., ΠΏΡΠΎΡΠ΅ΡΡΠΎΡΠ°, ΡΠ».-ΠΊΠΎΡΡ. ΠΠ»Π΅ΠΊΡΠ΅Ρ ΠΠ΅ΡΡΠΎΠ²ΠΈΡΠ° Π ΡΡΠΊΠΎΠ²Π° ΠΈ Π΄.Π±.Π½., ΠΏΡΠΎΡΠ΅ΡΡΠΎΡΠ° ΠΠ°ΡΠΏΠΎΠ²Π° ΠΠ°Π΄ΠΈΠΌΠ° ΠΡΠ²ΠΎΠ²ΠΈΡΠ° Π·Π° ΠΏΡΠΎΡΠ²Π»Π΅Π½Π½ΡΠΉ ΠΈΠ½ΡΠ΅ΡΠ΅Ρ, ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅ ΠΈ ΡΠ΅Π½Π½ΡΠ΅ Π·Π°ΠΌΠ΅ΡΠ°Π½ΠΈΡ.