Кинетические закономерности связывания лигандов в системе опиатных рецепторов
24,52−56]. Поэтому использование координат Скэтчарда и Иди-Хофсти при идентификации моделей комплексообразования является более предпочтительным перед использованием других упомянутых координат. На рисунке I приведены изотермы комплексообразования и их представление в координатах Скэтчарда для различных моделей, описываемых уравнениями (4) и (5). Хорошо видно, что кривые в координатах Скэтчарда… Читать ещё >
Содержание
- ПРИНЯТЫЕ СОКРАЩЕНИЯ
- ЛИТЕРАТУРНЫЙ ОБЗОР
- 1. ИОДЫ МАТЕМАТИЧЕСКОГО АНАЛИЗА ДАННЫХ ПО КОМПЛЕКСО
- 0. БРА30ВАНИЮ ЛИГАНДОВ С ЦЕНТРАМИ СВЯЗЫВАНИЯ
- I. I. Идентификация кинетических моделей а. Графические подходы б. Методы математической статистики в. Методы имитационного моделирования г. Другие подходы
1.2. Определение физико-химических параметров комплексообразования лигандов с центрами связывания по экспериментальным данным а. Графические подходы б. Способы прямого решения системы уравнений, связывающих параметры комплексов с экспериментальными данными в. Статистические методы определения параметров
2. КОЛИЧЕСТВЕННЫЙ АНАЛИЗ СИСТЕМ С ШСКОЛЬКИМИ ТИПАМИ РЕЦЕПТОРОВ.
2.1. Концепция множественности рецепторов
2.2. Использование зависимостей типа доза-ответ для дифференциации рецепторов
2.3. Изучение связывания лигандов с биологическими препаратами как способ количественного анализа множественности рецепторов
3. ГЕТЕРОГЕННОСТЬ ОПИАТНЫХ РЕЦЕПТОРОВ .:.
— 3
3.1. Характеристики различных классов опиатных рецепторов
3.2. Модели опиатных рецепторов
4. ЭКСПЕНМЕНТАЛШАЯ ЧАСТЬ.
4.1. Исходные вещества
4.2. Составы буферных растворов
4.3. Составы сцинтилляционных смесей
4.4. Посуда и вода.
4.5. Получение препарата мембран головного мозга крыс
4.6. Получение лиофилизованных препаратов мембран головного мозга крыс
4.7. Измерение уровня равновесного связывания меченых соединений с препаратами мембран.
4.8. Изучение кинетики связывания лигандов с рецепторами
4.9. Определение концентрации мембраносвязанного белка
4.10.Математическая обработка экспериментальных данных 79 РЕЗУЛЬТАТЫ И ИХ ОБСУЖДЕНИЕ
5. ПРИМЕНЕНИЕ МЕТОДА ИМИТАЦИОННОГО МОДЕЛИРОВАНИЯ ДЛЯ АНАЛИЗА ЛИГАНД-РЕЦЕПГОРНЫХ ВЗАИМОДЕЙСТВИЙ.
6. РАЗНОСТНЫЙ МЕТОД АНАЛИЗА ЛИГАНД-РЕЦЕПТОНШХ ВЗАИМОДЕЙСТВИЙ
7. ДОКАЗАТЕЛЬСТВО СУЩЕСТВОВАНИЯ СУПЕРЗЫСОКОАФШННЫХ ЦЕНТРОВ СВЯЗЫВАНИЯ ОПИАТНЫХ ЛИГАНДОВ КИНЕТИЧЕСКИМИ МЕТОДАМИ
8. ВЛИЯНИЕ ТЕМПЕРАТУРЫ НА СВОЙСТВА ОПИАТНЫХ РЕЦЕПТОРОВ
9. ПОЛУЧЕНИЕ И СВОЙСТВА ПРЕПАРАТА ЛИОШИЗСВАННЫХ МЕМБРАН ГОЛОВНОГО МОЗГА.
ВЫВОДЫ.
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