ΠΠ·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΊΠΈΠ½Π΅ΡΠΎΡ ΠΎΡΠΎΠ² ΠΈ ΠΌΠΈΠΊΡΠΎΡΡΡΠ±ΠΎΡΠ΅ΠΊ: Π½ΠΎΠ²ΡΠΉ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌ Π΄Π²ΠΈΠΆΠ΅Π½ΠΈΡ Ρ ΡΠΎΠΌΠΎΡΠΎΠΌ
Π Π°Π±ΠΎΡΠ° Π±ΡΠ»Π° ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π° Π² ΡΠ΅ΡΠ½ΠΎΠΌ ΡΠΎΡΡΡΠ΄Π½ΠΈΡΠ΅ΡΡΠ²Π΅ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΈ ΡΠ΅ΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π³ΡΡΠΏΠΏ, ΡΡΠΎ Π΄Π»Ρ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΡΠ²Π»ΡΠ΅ΡΡΡ Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΡΠΌ ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎΠΌ. ΠΠ΅Π»ΠΎ Π² ΡΠΎΠΌ, ΡΡΠΎ ΠΎΠ±ΡΠ΅ΠΊΡ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ (ΠΠ€ ΠΈ ΠΠ’) ΠΈΠΌΠ΅Π΅Ρ ΡΠ°Π·ΠΌΠ΅ΡΡ Π΅Π΄ΠΈΠ½ΠΈΡ ΠΈ Π΄Π΅ΡΡΡΠΊΠΎΠ² Π½Π°Π½ΠΎΠΌΠ΅ΡΡΠΎΠ², ΠΈ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅ Π΅Π³ΠΎ Π² Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ΅ ΡΠ΅ΡΠ΅Π· ΡΠ²Π΅ΡΠΎΠ²ΠΎΠΉ ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏ ΠΎΠΊΠ°Π·ΡΠ²Π°Π΅ΡΡΡ Π½Π΅Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΡΠΌ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ ΠΠ’ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡ ΠΏΠΎΠ»ΡΡΠ°ΡΡ ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΠ΅ΡΠΊΠΈΠ΅ ΠΈ Π΄Π°ΠΆΠ΅… Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΠΠΠΠ 1. ΠΠΠΠΠ ΠΠΠ’ΠΠ ΠΠ’Π£Π Π«
- 1. 1. ΠΠ΅Π»Π΅Π½ΠΈΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ
- 1. 2. Π‘ΡΡΡΠΊΡΡΡΠ° ΠΌΠΈΠΊΡΠΎΡΡΡΠ±ΠΎΡΠΊΠΈ ΠΈ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠΈΠ», ΡΠ°Π·Π²ΠΈΠ²Π°Π΅ΠΌΡΡ ΠΌΠΈΠΊΡΠΎΡΡΡΠ±ΠΎΡΠΊΠΎΠΉ
- 1. 3. ΠΠΈΠ½Π°ΠΌΠΈΠΊΠ° ΠΌΠΈΠΊΡΠΎΡΡΡΠ±ΠΎΡΠ΅ΠΊ ΠΈ Ρ ΡΠΎΠΌΠΎΡΠΎΠΌ
- 1. 4. ΠΠΈΠ½Π΅ΡΠΎΡ
ΠΎΡ: ΡΡΡΡΠΊΡΡΡΠ° ΠΈ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Ρ ΠΌΠΈΠΊΡΠΎΡΡΡΠ±ΠΎΡΠΊΠΎΠΉ
- 1. 4. 1. Π‘ΡΡΡΠΊΡΡΡΠ° ΠΈ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠΈΠ½Π΅ΡΠΎΡ ΠΎΡΠ°
- 1. 4. 2. Π‘ΠΈΠ»Π°, ΡΠ°Π·Π²ΠΈΠ²Π°Π΅ΠΌΠ°Ρ ΠΌΠΈΠΊΡΠΎΡΡΡΠ±ΠΎΡΠΊΠΎΠΉ ΠΏΡΠΈ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠΈ Ρ ΠΊΠΈΠ½Π΅ΡΠΎΡ ΠΎΡΠΎΠΌ
- 1. 4. 3. Π ΠΎΠ»Ρ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΡ ΠΌΠΎΡΠΎΡΠΎΠ² Π²ΠΎ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΠΌΠΈΠΊΡΠΎΡΡΡΠ±ΠΎΡΠΊΠΎΠΉ ΠΈ ΠΊΠΈΠ½Π΅ΡΠΎΡ ΠΎΡΠΎΠΌ
- 1. 4. 4. Dam 1-ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡ ΠΈ Π΅Π³ΠΎ ΡΠΎΠ»Ρ Π² ΠΌΠΈΡΠΎΠ·Π΅
- 1. 5. ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΠΊΡΠ»ΡΡΡΡΡ PtK
- 1. 5. 1. ΠΡΠΈΠ³ΠΎΡΠΎΠ²Π»Π΅Π½ΠΈΠ΅ ΡΡΠ΅Π·ΠΎΠ², ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠΈΡ ΠΈ ΡΡΠ΅Ρ ΠΌΠ΅ΡΠ½Π°Ρ ΡΠ΅ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΡ
- 1. 5. 2. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΈΠ·ΠΎΠ±ΡΠ°ΠΆΠ΅Π½ΠΈΠΉ ΠΊΠΎΠ½ΡΠΎΠ² ΠΌΠΈΠΊΡΠΎΡΡΡΠ±ΠΎΡΠ΅ΠΊ
- 1. 5. 3. ΠΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ΅ ΠΎΠΏΠΈΡΠ°Π½ΠΈΠ΅ ΡΡΡΡΠΊΡΡΡΡ ΠΊΠΎΠ½ΡΠΎΠ² ΠΌΠΈΠΊΡΠΎΡΡΡΠ±ΠΎΡΠ΅ΠΊ
- 1. 5. 4. ΠΠΎΠ΄Ρ ΠΎΠ΄ ΠΊ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠ΄Π²ΠΈΠΆΠ½ΠΎΡΡΠΈ, Π²ΡΠ·Π²Π°Π½Π½ΠΎΠΉ Π΄Π΅ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΈΠ·Π°ΡΠΈΠ΅ΠΉ ΠΌΠΈΠΊΡΠΎΡΡΡΠ±ΠΎΡΠ΅ΠΊ in vitro
- 1. 6. ΠΠΎΡΡΠ°Π½ΠΎΠ²ΠΊΠ° Π·Π°Π΄Π°ΡΠΈ
- ΠΠΠΠΠ 2. ΠΠΠ’ΠΠΠ« ΠΠΠ ΠΠΠΠ’ΠΠ ΠΠΠΠΠ«Π₯
- 2. 1. ΠΠΏΠΈΡΠ°Π½ΠΈΠ΅ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ ΡΠ°ΡΡΠ΅ΡΠ° Π»ΠΎΠΊΠ°Π»ΡΠ½ΡΡ
ΠΊΡΠΈΠ²ΠΈΠ·Π½
- 2. 1. 1. ΠΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΈΠ½ΡΠ΅ΡΡΠ΅ΠΉΡΠ° ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ ΡΠ°ΡΡΠ΅ΡΠ° Π»ΠΎΠΊΠ°Π»ΡΠ½ΡΡ ΠΊΡΠΈΠ²ΠΈΠ·Π½ ΠΈ ΡΠΎΡΠΌΠ°Ρ ΠΈΡΡ ΠΎΠ΄Π½ΡΡ Π΄Π°Π½Π½ΡΡ
- 2. 1. 2. ΠΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΌΠ°ΡΡΡΠ°Π±ΠΎΠ² ΠΎΡΠΎΠ±ΡΠ°ΠΆΠ΅Π½ΠΈΡ’ΠΏΡΠΎΡΠΎΡΠΈΠ»Π°ΠΌΠ΅Π½ΡΠΎΠ² ΠΈ ΠΈΡ ΠΊΡΠΈΠ²ΠΈΠ·Π½ Π² ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠ΅ ΡΠ°ΡΡΠ΅ΡΠ° Π»ΠΎΠΊΠ°Π»ΡΠ½ΡΡ ΠΊΡΠΈΠ²ΠΈΠ·Π½
- 2. 1. 3. ΠΠ»Π³ΠΎΡΠΈΡΠΌΡ Π²ΡΡΠΈΡΠ»Π΅Π½ΠΈΡ ΠΊΡΠΈΠ²ΠΈΠ·Π½ ΠΎΡΠ΄Π΅Π»ΡΠ½ΡΡ ΠΏΡΠΎΡΠΎΡΠΈΠ»Π°ΠΌΠ΅Π½ΡΠΎΠ²
- 2. 1. 4. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΡΡΠ΅Π΄Π½Π΅Π½Π½ΡΡ ΠΊΡΠΈΠ²ΠΈΠ·Π½ ΠΈ ΡΠΎΡΠΌ ΠΏΡΠΎΡΠΎΡΠΈΠ»Π°ΠΌΠ΅Π½ΡΠΎΠ²
- 2. 1. 5. ΠΠ²ΡΠΎΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠ°ΡΡΠ΅Ρ Π½Π°ΠΊΠ»ΠΎΠ½Π° ΠΏΡΠΎΡΠΎΡΠΈΠ»Π°ΠΌΠ΅Π½ΡΠΎΠ² Π²Π±Π»ΠΈΠ·ΠΈ ΡΡΠ΅Π½ΠΊΠΈ ΠΌΠΈΠΊΡΠΎΡΡΡΠ±ΠΎΡΠΊΠΈ ΠΈ Π³ΡΡΠΏΠΏΠΈΡΠΎΠ²ΠΊΠ° Π²ΡΠ±ΡΠ°Π½Π½ΡΡ ΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°ΡΠ΅Π»Π΅ΠΌ ΠΏΡΠΎΡΠΎΡΠΈΠ»Π°ΠΌΠ΅Π½ΡΠΎΠ²
- 2. 2. Π‘ΠΎΡ ΡΠ°Π½Π΅Π½ΠΈΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΡΠ°ΡΡΠ΅ΡΠΎΠ², ΠΏΡΠΎΠΈΠ·Π²Π΅Π΄Π΅Π½Π½ΡΡ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ ΡΠ°ΡΡΠ΅ΡΠ° Π»ΠΎΠΊΠ°Π»ΡΠ½ΡΡ ΠΊΡΠΈΠ²ΠΈΠ·Π½
- 2. 3. ΠΠ°ΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠΈΠ½Π΅ΡΠΎΡ
ΠΎΡΠ½ΡΡ
ΡΡΡΡΠΊΡΡΡ, Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΡΡΡΠΈΡ
Ρ ΠΌΠΈΠΊΡΠΎΡΡΡΠ±ΠΎΡΠΊΠ°ΠΌΠΈ
- 2. 3. 1. ΠΠΏΠΈΡΠ°Π½ΠΈΠ΅ ΠΌΠΎΠ΄Π΅Π»ΠΈ
- 2. 3. 2. ΠΠ½Π΅ΡΠ³Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ
- 2. 3. 3. ΠΡΠ±ΠΎΡ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ² ΠΌΠΎΠ΄Π΅Π»ΠΈ
- 2. 3. 4. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΌΠΎΠ΄Π΅Π»ΠΈ
- 2. 1. ΠΠΏΠΈΡΠ°Π½ΠΈΠ΅ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ ΡΠ°ΡΡΠ΅ΡΠ° Π»ΠΎΠΊΠ°Π»ΡΠ½ΡΡ
ΠΊΡΠΈΠ²ΠΈΠ·Π½
- 3. 1. ΠΠ΅ΡΠ°Π»ΡΠ½ΠΎΠ΅ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½ΠΈΠ΅ ΡΠΎΡΠΌ ΠΏΡΠΎΡΠΎΡΠΈΠ»Π°ΠΌΠ΅Π½ΡΠΎΠ² ΠΈΠ· ΠΊΠΈΠ½Π΅ΡΠΎΡ
ΠΎΡΠ½ΡΡ
ΠΌΠΈΠΊΡΠΎΡΡΡΠ±ΠΎΡΠ΅ΠΊ
- 3. 1. 1. Π Π°Π·Π½ΠΎΠΎΠ±ΡΠ°Π·ΠΈΠ΅ ΡΠΎΡΠΌ ΠΏΡΠΎΡΠΎΡΠΈΠ»Π°ΠΌΠ΅Π½ΡΠΎΠ² Π½Π° ΠΏΠ»ΡΡ-ΠΊΠΎΠ½ΡΠ°Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΠΌΠΈΠΊΡΠΎΡΡΡΠ±ΠΎΡΠ΅ΠΊ
- 3. 1. 2. ΠΡΠ»ΠΈΡΠΈΠ΅ ΡΠΎΡΠΌ ΠΏΡΠΎΡΠΎΡΠΈΠ»Π°ΠΌΠ΅Π½ΡΠΎΠ² ΠΈΠ· ΠΌΠΈΠΊΡΠΎΡΡΡΠ±ΠΎΡΠ΅ΠΊ in vivo ΠΈ in vitro
- 3. 1. 3. ΠΠ΅ΡΠ°Π»ΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· ΡΠΎΡΠΌΡ ΠΏΡΠΎΡΠΎΡΠΈΠ»Π°ΠΌΠ΅Π½ΡΠΎΠ² ΠΊΠ°ΠΊ ΡΠΏΠΎΡΠΎΠ± ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ Π΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΠΌΠΈΠΊΡΠΎΡΡΡΠ±ΠΎΡΠ΅ΠΊ
- 3. 2. Π Π°Π·Π»ΠΈΡΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρ ΡΠΎΡΠΌΠ°ΠΌΠΈ ΠΏΡΠΎΡΠΎΡΠΈΠ»Π°ΠΌΠ΅Π½ΡΠΎΠ² in vivo ΠΈ in vitro
- 3. 2. 1. Π ΠΎΠ»Ρ Π°Π΄Π³Π΅Π·ΠΈΠΈ ΠΏΡΠΎΡΠΎΡΠΈΠ»Π°ΠΌΠ΅Π½ΡΠΎΠ²
- 3. 2. 2. Π€Π°ΠΊΡΠΎΡΡ, Π²Π»ΠΈΡΡΡΠΈΠ΅ Π½Π° ΡΠΎΡΠΌΡ ΠΏΡΠΎΡΠΎΡΠΈΠ»Π°ΠΌΠ΅Π½ΡΠΎΠ² ΠΈΠ· ΠΊΠΈΠ½Π΅ΡΠΎΡ ΠΎΡΠ½ΡΡ ΠΌΠΈΠΊΡΠΎΡΡΡΠ±ΠΎΡΠ΅ΠΊ
- 3. 2. 3. ΠΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΡΠΎΡΠΌΡ ΠΏΡΠΎΡΠΎΡΠΈΠ»Π°ΠΌΠ΅Π½ΡΠΎΠ² Π² ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΡΠ°Π·Π°Ρ ΠΌΠΈΡΠΎΠ·Π°
- 3. 3. ΠΠ°ΠΊΡΠ΅ΠΏΠ»Π΅Π½ΠΈΠ΅ ΡΠΈΠ±ΡΠΈΠ»Π» Π½Π° ΠΏΡΠΎΡΠΎΡΠΈΠ»Π°ΠΌΠ΅Π½ΡΠ°Ρ ΠΊΠΈΠ½Π΅ΡΠΎΡ ΠΎΡΠ½ΡΡ ΠΌΠΈΠΊΡΠΎΡΡΡΠ±ΠΎΡΠ΅ΠΊ
- 4. 1. ΠΠΎΠ²ΡΠΉ ΡΠΏΠΎΡΠΎΠ± Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΌΠΈΠΊΡΠΎΡΡΡΠ±ΠΎΡΠ΅ΠΊ Ρ Ρ
ΡΠΎΠΌΠΎΡΠΎΠΌΠΎΠΉ
- 4. 1. 1. Π‘Π²ΡΠ·ΡΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΎΡΠΎΡΠΈΠ»Π°ΠΌΠ΅Π½ΡΠΎΠ² Ρ ΠΊΠΈΠ½Π΅ΡΠΎΡ ΠΎΡΠ½ΡΠΌΠΈ ΡΠΈΠ±ΡΠΈΠ»Π»Π°ΠΌΠΈ ΠΈ Π°ΡΠΏΠ΅ΠΊΡΡ ΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΌΠΈΡΠΎΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π²Π΅ΡΠ΅ΡΠ΅Π½Π°
- 4. 1. 2. Π₯ΠΈΠΌΠΈΡ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΊΠΈΠ½Π΅ΡΠΎΡ ΠΎΡΠ½ΡΡ ΡΠΈΠ±ΡΠΈΠ»Π» ΠΈ ΠΏΡΠΎΡΠΎΡΠΈΠ»Π°ΠΌΠ΅Π½ΡΠΎΠ²
- 4. 1. 3. Π‘ΡΠ°Π²Π½Π΅Π½ΠΈΠ΅ Ρ ΠΎΠΏΡΠ±Π»ΠΈΠΊΠΎΠ²Π°Π½Π½ΡΠΌΠΈ ΡΠ²Π΅Π΄Π΅Π½ΠΈΡΠΌΠΈ ΠΎ ΡΡΡΡΠΊΡΡΡΠ΅ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΊΠΈΠ½Π΅ΡΠΎΡ ΠΎΡΠΎΠ² Ρ ΠΌΠΈΠΊΡΠΎΡΡΡΠ±ΠΎΡΠΊΠ°ΠΌΠΈ
- 4. 2. Π‘Π²ΡΠ·Ρ ΡΠΎΡΠΌ ΠΏΡΠΎΡΠΎΡΠΈΠ»Π°ΠΌΠ΅Π½ΡΠΎΠ² ΡΡΠ΅Π΄Π½Π΅ΠΉ ΠΊΡΠΈΠ²ΠΈΠ·Π½Ρ Ρ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ΠΌ ΠΊΠΈΠ½Π΅ΡΠΎΡ ΠΎΡΠ½ΡΠΌΠΈ ΡΠΈΠ±ΡΠΈΠ»Π»Π°ΠΌΠΈ
- 4. 3. Π‘ΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ ΠΈΠ·ΠΎΠ³Π½ΡΡΡΡ ΠΏΡΠΎΡΠΎΡΠΈΠ»Π°ΠΌΠ΅Π½ΡΠΎΠ² ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΈΠ²Π°ΡΡ ΠΏΡΠΎΡΠ΅ΡΡΠΈΠ²Π½ΠΎΠ΅ Π΄Π²ΠΈΠΆΠ΅Π½ΠΈΠ΅ Ρ ΡΠΎΠΌΠΎΡΠΎΠΌΡ
- 4. 4. Π ΠΎΠ»Ρ ΡΠΈΠ±ΡΠΈΠ»Π»ΡΡΠ½ΠΎΠ³ΠΎ ΠΊΠΈΠ½Π΅ΡΠΎΡ ΠΎΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° Ndc
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- Birl/Slil5 ΠΊΠΈΠ½Π΅ΡΠΎΡ ΠΎΡΠ½ΡΠ΅ Π±Π΅Π»ΠΊΠΈ, ΡΡΠ°ΡΡΠ²ΡΡΡΠΈΠ΅ Ρ ΡΠ΅Π³ΡΠ΅Π³Π°ΡΠΈΠΈ Ρ ΡΠΎΠΌΠΎΡΠΎΠΌ CBF3 (c-repeat-binding factor) ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡ Π±Π΅Π»ΠΊΠΎΠ², ΡΠΎΡΠΌΠΈΡΡΡΡΠΈΡ ΠΊΠΈΠ½Π΅ΡΠΎΡ ΠΎΡ
- DASH ΠΊΠΈΠ½Π΅ΡΠΎΡ ΠΎΡΠ½ΡΠΉ Π±Π΅Π»ΠΊΠΎΠ²ΡΠΉ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡ, Π²ΠΊΠ»ΡΡΠ°ΡΡΠΈΠΉ Π² ΡΠ΅Π±Ρ Daml Dsnl ΠΊΠΈΠ½Π΅ΡΠΎΡ ΠΎΡΠ½ΡΠΉ Π±Π΅Π»ΠΊΠΎΠ²ΡΠΉ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡ, ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΈΠ²Π°ΡΡΠΈΠΉ ΡΡΡΡΠΊΡΡΡΡ ΠΊΠΈΠ½Π΅ΡΠΎΡ ΠΎΡΠ°1. ΠΡΠΎΠΏ
- Araldite ΡΠ°Π·Π½ΠΎΠ²ΠΈΠ΄Π½ΠΎΡΡΡ ΡΠΏΠΎΠΊΡΠΈΠ΄Π½ΠΎΠΉ ΡΠΌΠΎΠ»Ρ. Π³ΡΠ°Π½ΠΈΠ»ΠΈΠ»-(Π°Π»ΡΡΠ°, Π±Π΅ΡΠ°)-ΠΌΠ΅ΡΠΈΠ»Π΅Π½-Π΄ΠΈΡΠΎΡΡΠΎΠ½Π°Ρ) Π½Π΅Π³ΠΈΠ΄ΡΠΎΠ»ΠΈΠ·ΡΠ΅ΠΌΡΠΉ Π°Π½Π°Π»ΠΎΠ³ GMPCPP ΡΡΠ±ΡΠ»ΠΈΠ½Π°, ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΡΠΉ Π΄Π»Ρ ΡΠ±ΠΎΡΠΊΠΈ ΡΡΠ°Π±ΠΈΠ»ΡΠ½ΡΡ ΠΠ’.
- Ned ΠΌΠΎΡΠΎΡΠ½ΡΠΉ Π±Π΅Π»ΠΎΠΊ, ΠΈΠΌΠ΅ΡΡΠΈΠΉ ΠΌΠΈΠ½ΡΡ-Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ
- Ndc80 ΡΠ΅ΡΡΠ°ΠΌΠ΅ΡΠ½ΡΠΉ ΡΠΈΠ±ΡΠΈΠ»Π»ΡΡΠ½ΡΠΉ Π±Π΅Π»ΠΎΠΊ, Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΡΡΡΠΈΠΉ Ρ ΠΠ’ Ndc80p Π±Π΅Π»ΠΎΠΊ, Π²Ρ ΠΎΠ΄ΡΡΠΈΠΉ Π² ΡΠΎΡΡΠ°Π² Ncd80
- NK350 Ρ ΠΈΠΌΠ΅ΡΠ½ΡΠΉ ΠΊΠΈΠ½Π΅Π·ΠΈΠ½, Π½Π΅ ΠΏΡΠΎΡΠ²Π»ΡΡΡΠΈΠΉ ΠΌΠΎΡΠΎΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Nuf2p ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° Ncd80 pentaHIS ΠΏΠ΅Π½ΡΠ°Π³ΠΈΡΡΠΈΠ΄ΠΈΠ½
- PET (polyethylene terephthalate) ΡΠ°Π·Π½ΠΎΠ²ΠΈΠ΄Π½ΠΎΡΡΡ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½pkllp ΠΌΠΈΠ½ΡΡ-Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΡΠΉ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠΉ ΠΌΠΎΡΠΎΡ
- PRAXIS (principal axis) ΠΌΠ΅ΡΠΎΠ΄ ΠΌΠΈΠ½ΠΈΠΌΠΈΠ·Π°ΡΠΈΠΈ, ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π½ΡΠΉ Π . ΠΡΠ΅Π½ΡΠΎΠΌ
- PtKi ΡΠΏΠΈΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ ΠΏΠΎΡΠΊΠΈ ΠΊΠ΅Π½Π³ΡΡΠΎΠ²ΠΎΠΉ ΠΊΡΡΡΡ
- Spc24p Π±Π΅Π»ΠΎΠΊ, Π²Ρ ΠΎΠ΄ΡΡΠΈΠΉ Π² ΡΠΎΡΡΠ°Π² Ncd80
- Spc25p Π±Π΅Π»ΠΎΠΊ, Π²Ρ ΠΎΠ΄ΡΡΠΈΠΉ Π² ΡΠΎΡΡΠ°Π² Ncd801. ΠΠ’Π€ Π°Π΄Π΅Π½ΠΎΠ·ΠΈΠ½ ΡΡΠΈΡΠΎΡΡΠ°Ρ1. ΠΠΠ€ Π³ΡΠ°Π½ΠΎΠ·ΠΈΠ½ Π΄ΠΈΡΠΎΡΡΠ°Ρ1. ΠΠ’Π€ Π³ΡΠ°Π½ΠΎΠ·ΠΈΠ½ ΡΡΠΈΡΠΎΡΡΠ°Ρ
- Π-ΠΠ’ Π΄Π΅ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΈΠ·ΡΡΡΠ°ΡΡΡ ΠΠ’1. Π-ΡΡΠ±ΡΠ»ΠΈΠ½ ΡΡΠ±ΡΠ»ΠΈΠ½, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΠΉ Π³ΠΈΠ΄ΡΠΎΠ»ΠΈΠ·ΠΎΠ²Π°Π½Π½ΡΡ ΠΠ’Π€
- ΠΠΠ’ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΡΡΡΠ°Ρ Ρ ΠΊΠΈΠ½Π΅ΡΠΎΡ ΠΎΡΠΎΠΌ ΠΠ’ΠΊΡΠΈΠΎΠΠ’ ΠΊΡΠΈΠΎΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½Π°Ρ ΡΠΎΠΌΠΎΠ³ΡΠ°ΡΠΈΡ1. ΠΠ€ ΠΊΠΈΠ½Π΅ΡΠΎΡ ΠΎΡΠ½Π°Ρ ΡΠΈΠ±ΡΠΈΠ»Π»Π°1. ΠΠ’ ΠΌΠΈΠΊΡΠΎΡΡΡΠ±ΠΎΡΠΊΠ°Π½Π΅ΠΠΠ’ Π½Π΅ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΡΡΡΠΈΠ΅ Ρ ΠΊΠΈΠ½Π΅ΡΠΎΡ ΠΎΡΠΎΠΌ ΠΠ’1. Π-ΠΠ’ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠΈΠ·ΡΡΡΠ°ΡΡΡ ΠΠ’1. ΠΠ€ ΠΏΡΠΎΡΠΎΡΠΈΠ»Π°ΠΌΠ΅Π½Ρ1. ΠΠ’ ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½Π°Ρ ΡΠΎΠΌΠΎΠ³ΡΠ°ΡΠΈΡ