Синтез бис-спиросочлененных производных оксиндола с участием азометин-илидов
Диссертация
Несмотря на значительное число примеров синтеза бис-спиро методом диполярного циклоприсоединения с участием азометин-илидов, круг используемых исходных объектов как в случае диполярофилов, так и в случае аминокислот, применяемых для генерирования азометин-илидов (в основном, это саркозин и пролин) ограничен. Не изучен механизм формирования стерически перегруженных бис-спирогетерциклов… Читать ещё >
Содержание
- 1. Литературный обзор
- 1. 1. Подходы к формированию спиросоединений
- 1. 1. 1. Реакции формирования спироузла
- 1. 1. 2. Реакции одновременного формирования цикла и спироузла
- 1. 2. Существующие методы синтеза 16 спиропирролидинооксиндолов
- 1. 2. 1. Реакции формирования спироузла
- 1. 2. 1. 1. Окислительные перегруппировки тетрагидро-Р-карболинов
- 1. 2. 1. 2. Внутримолекулярные реакции Манниха
- 1. 2. 1. 3. Внутримолекулярные реакции Хека
- 1. 2. 1. 4. Реакции радикальной циклизации
- 1. 2. 1. 5. Перегруппировки [(М-азиридинометилтио)метилен]-2- 26 оксиндолов
- 1. 2. 2. Реакции одновременного формирования цикла и спироузла
- 1. 2. 2. 1. Реакции расширения цикла спироциклопропилоксиндолов
1.2.2.2 Реакции [3+2] диполярного циклоприсоединения 30 1.2.2.2.1 Синтетические подходы к построению спиропирролидинооксиндольного ядра с использованием азометин-илидов, генерируемых методом декарбоксилирования
- 1. 2. 1. Реакции формирования спироузла
- 1. 1. Подходы к формированию спиросоединений
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