ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΈ ΠΈ ΠΏΡΠΈΡΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° Π³Π΅Π½Π° Lim3, ΡΡΠ°ΡΡΠ²ΡΡΡΠ΅Π³ΠΎ Π² ΠΊΠΎΠ½ΡΡΠΎΠ»Π΅ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΆΠΈΠ·Π½ΠΈ Drosophila melanogaster
ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Π½ΡΠ΅ Π² Π΄Π°Π½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠ°ΡΡΠΈΡΡΡΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΎ ΡΠ²ΡΠ·ΠΈ ΡΡΡΡΠΊΡΡΡΠ½ΠΎΠΉ ΠΈΠ·ΠΌΠ΅Π½ΡΠΈΠ²ΠΎΡΡΠΈ, Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ ΠΏΡΠΈΡΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ½ΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΠΈ 9 Π³Π΅Π½Π° Ρ Π΅Π³ΠΎ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠΌΠΈ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡΠΌΠΈ: ΡΡΠΎΠ²Π½Π΅ΠΌ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΠΈ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΎΠΌ Π²Π»ΠΈΡΠ½ΠΈΡ Π½Π° ΡΠ΅Π½ΠΎΡΠΈΠΏ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ°. ΠΡΠΈ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ Π΄ΠΎΠ»ΠΆΠ½Ρ Π±ΡΡΡ ΡΡΡΠ΅Π½Ρ ΠΏΡΠΈ ΡΠΎΠ·Π΄Π°Π½ΠΈΠΈ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΉ, ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΡΡ Π² ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ Π±ΠΈΠΎΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΡΠΎΠ΅ΠΊΡΠ°Ρ , Ρ ΡΠ΅Π»ΡΡ… Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- Π‘ΠΠΠ‘ΠΠ Π‘ΠΠΠ ΠΠ©ΠΠΠΠ
- 1. ΠΠΠ©ΠΠ― Π₯ΠΠ ΠΠΠ’ΠΠ ΠΠ‘Π’ΠΠΠ Π ΠΠΠΠ’Π«
- 1. 1. ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ. Π±
- 1. 2. Π¦Π΅Π»Ρ ΠΈ Π·Π°Π΄Π°ΡΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ
- 1. 3. ΠΠ°ΡΡΠ½Π°Ρ Π½ΠΎΠ²ΠΈΠ·Π½Π° ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ
- 1. 4. ΠΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠ΅Π½Π½ΠΎΡΡΡ
- 2. ΠΠΠΠΠ ΠΠΠ’ΠΠ ΠΠ’Π£Π Π«
- 2. 1. ΠΠ±ΡΠ°Ρ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° Π±Π΅Π»ΠΊΠΎΠ², ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ
LIM- ΠΈ Π³ΠΎΠΌΠ΅ΠΎΠ΄ΠΎΠΌΠ΅Π½Ρ
- 2. 1. 1. Π‘ΡΡΡΠΊΡΡΡΠ½ΠΎ-ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½Π°Ρ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΡ Π±Π΅Π»ΠΊΠΎΠ², ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ LIM- ΠΈ Π³ΠΎΠΌΠ΅ΠΎΠ΄ΠΎΠΌΠ΅Π½Ρ
- 2. 1. 2. ΠΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ Π±Π΅Π»ΠΊΠΎΠ², ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ LIM- ΠΈ Π³ΠΎΠΌΠ΅ΠΎΠ΄ΠΎΠΌΠ΅Π½Ρ
- 2. 2. LIM-HD ΡΠ°ΠΊΡΠΎΡΡ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΈ Π² ΡΠ°Π·Π²ΠΈΡΠΈΠΈ Π½Π΅ΡΠ²Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ D. melanogaster
- 2. 2. 1. ΠΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π½Π΅ΡΠ²Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ Π΄ΡΠΎΠ·ΠΎΡΠΈΠ»Ρ
- 2. 2. 2. «Π Π°Π½Π½ΠΈΠ΅» ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΎΠ½Π½ΡΠ΅ ΡΠ°ΠΊΡΠΎΡΡ, ΡΡΠ°ΡΡΠ²ΡΡΡΠΈΠ΅ Π² ΡΠ°Π·Π²ΠΈΡΠΈΠΈ Π½Π΅ΡΠ²Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ Π΄ΡΠΎΠ·ΠΎΡΠΈΠ»Ρ
- 2. 2. 2. 1. Π‘ΠΏΠ΅ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ Π½Π΅ΠΉΡΠΎΡΠΊΡΠΎΠ΄Π΅ΡΠΌΡ. Π‘ΠΏΠΈΠ½Π½ΠΎ-Π±ΡΡΡΠ½ΠΎΠ΅ ΠΈ ΠΏΠ΅ΡΠ΅Π΄Π½Π΅-Π·Π°Π΄Π½Π΅Π΅ ΡΡΡΡΠΊΡΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π½Π΅ΠΉΡΠΎΡΠΊΡΠΎΠ΄Π΅ΡΠΌΡ Π΄ΡΠΎΠ·ΠΎΡΠΈΠ»Ρ
- 2. 2. 2. 2. ΠΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈ ΡΠΏΠ΅ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ Π½Π΅ΠΉΡΠΎΠ±Π»Π°ΡΡΠΎΠ²
- 2. 2. 2. 3. ΠΡΠΈΠΌΠΌΠ΅ΡΡΠΈΡΠ½ΡΠ΅ Π΄Π΅Π»Π΅Π½ΠΈΡ Π½Π΅ΠΉΡΠΎΠ±Π»Π°ΡΡΠΎΠ²
- 2. 2. 2. 4. ΠΡΠ΅ΠΌΠ΅Π½Π½Π°Ρ Π³Π΅Π½Π½Π°Ρ ΡΠ΅ΡΡ Π² ΡΠΏΠ΅ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ Π½Π΅ΠΉΡΠΎΠ±Π»Π°ΡΡΠ°
- 2. 2. 2. 5. ΠΡΠΈΠΌΠΌΠ΅ΡΡΠΈΡΠ½ΡΠ΅ Π΄Π΅Π»Π΅Π½ΠΈΡ Π³Π°Π½Π³Π»ΠΈΠ°Π»ΡΠ½ΡΡ ΠΌΠ°ΡΠ΅ΡΠΈΠ½ΡΠΊΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ
- 2. 2. 3. «ΠΠΎΠ·Π΄Π½ΠΈΠ΅» ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΎΠ½Π½ΡΠ΅ ΡΠ°ΠΊΡΠΎΡΡ,' ΡΡΠ°ΡΡΠ²ΡΡΡΠΈΠ΅ Π² ΡΠ΅ΡΠΌΠΈΠ½Π°Π»ΡΠ½ΠΎΠΉ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠ΅ ΠΊΠ»Π΅ΡΠΎΠΊ Π½Π΅ΡΠ²Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ Π΄ΡΠΎΠ·ΠΎΡΠΈΠ»Ρ
- 2. 3. ΠΠ΅ΠΉΡΠΎΡΠ½Π΄ΠΎΠΊΡΠΈΠ½Π½Π°Ρ ΡΠΈΡΡΠ΅ΠΌΠ° Π² ΠΊΠΎΠ½ΡΡΠΎΠ»Π΅ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΆΠΈΠ·Π½ΠΈ Drosophila melanogaster
- 2. 3. 1. ΠΠ½ΡΡΠ»ΠΈΠ½/IGF ΡΠΈΠ³Π½Π°Π»ΡΠ½ΡΠΉ ΠΏΡΡΡ ΠΈ ΡΠ½Π΄ΠΎΠΊΡΠΈΠ½Π½Π°Ρ ΡΡΠ½ΠΊΡΠΈΡ Π½Π΅ΡΠ²Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ Π² ΠΊΠΎΠ½ΡΡΠΎΠ»Π΅ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΆΠΈΠ·Π½ΠΈ Drosophila melanogaster
- 2. 3. 2. TOR ΡΠΈΠ³Π½Π°Π»ΡΠ½ΡΠΉ ΠΏΡΡΡ ΠΈ Π½Π΅ΡΠ²Π½Π°Ρ ΡΠΈΡΡΠ΅ΠΌΠ° Π² ΠΊΠΎΠ½ΡΡΠΎΠ»Π΅ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΆΠΈΠ·Π½ΠΈ Drosophila melanogaster.'
- 2. 3. 3. JNK ΡΠΈΠ³Π½Π°Π»ΡΠ½ΡΠΉ ΠΏΡΡΡ ΠΈ Π½Π΅ΡΠ²Π½Π°Ρ ΡΠΈΡΡΠ΅ΠΌΠ° Π² ΠΊΠΎΠ½ΡΡΠΎΠ»Π΅ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΆΠΈΠ·Π½ΠΈ Drosophila melanogaster
- 2. 3. 4. ΠΠ΅Π°ΡΠ΅ΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈ Π½Π΅ΡΠ²Π½Π°Ρ ΡΠΈΡΡΠ΅ΠΌΠ° Π² ΠΊΠΎΡ ΡΠΎΠ»Π΅ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΆΠΈΠ·Π½ΠΈ Drosophila melanogaster
- 2. 3. 5. ΠΠΊΠΈΡΠ»ΠΈΡΠ΅Π»ΡΠ½ΡΠΉ ΡΡΡΠ΅ΡΡ ΠΈ Π½Π΅ΡΠ²Π½Π°Ρ ΡΠΈΡΡΠ΅ΠΌΠ° Π² ΠΊΠΎΠ½ΡΡΠΎΠ»Π΅ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΆΠΈΠ·Π½ΠΈ
- 2. 1. ΠΠ±ΡΠ°Ρ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° Π±Π΅Π»ΠΊΠΎΠ², ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ
LIM- ΠΈ Π³ΠΎΠΌΠ΅ΠΎΠ΄ΠΎΠΌΠ΅Π½Ρ
- 2. 3. 6. ΠΠΎΠΈΡΠΊ Π½ΠΎΠ²ΡΡ Π½Π΅ΠΉΡΠΎΠ½Π°Π»ΡΠ½ΡΡ Π³Π΅Π½ΠΎΠ², ΡΡΠ°ΡΡΠ²ΡΡΡΠΈΡ Π² ΠΊΠΎΠ½ΡΡΠΎΠ»Π΅ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΆΠΈΠ·Π½ΠΈ Π΄ΡΠΎΠ·ΠΎΡΠΈΠ»Ρ
- 3. 1. ΠΠΈΠ½ΠΈΠΈ Π΄ΡΠΎΠ·ΠΎΡΠΈΠ»Ρ
- 3. 2. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ Π³Π΅Π½ΠΎΠΌΠ½ΠΎΠΉ ΠΠΠ ΠΠ³ΠΎΠΠΎΡΠ¨Π°
- 3. 3. ΠΠΎΠ»ΠΈΠΌΠ΅ΡΠ°Π·Π½Π°Ρ ΡΠ΅ΠΏΠ½Π°Ρ ΡΠ΅Π°ΠΊΡΠΈΡ
- 3. 4. Π‘Π΅ΠΊΠ²Π΅ΡΡΡΠΎΠ²Π°Π½ΠΈΠ΅
- 3. 5. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠΎΡΠ°Π»ΡΠ½ΠΎΠΉ Π ΠΠ ΠΠ³ΠΎΡΠΎΡΠ¬ΠΠ°
- 3. 6. ΠΠ±ΡΠ°ΡΠ½Π°Ρ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΡ
- 3. 7. ΠΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π΅Π½Π½Π°Ρ ΠΠ¦Π Π² ΡΠ΅Π°Π»ΡΠ½ΠΎΠΌ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ
- 3. 8. ΠΠΎΠ·Π΅ΡΠ½-Π±Π»ΠΎΡ Π³ΠΈΠ±ΡΠΈΠ΄ΠΈΠ·Π°ΡΠΈΡ
- 3. 9. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΡΠ°ΡΡΠΎΠ² ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΈ Ρ ΠΏΠΎΠΌΠΎΡΡΡ 5'-ΠΠΠ‘Π
- 3. 9. 1. 5'-ΠΠΠ‘Π
- 3. 9. 2. ΠΡΠΈΡΡΠΊΠ° ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ² ΠΠ¦Π , ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ Π² ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ 5'-11ΠΠ‘Π
- 3. 9. 3. ΠΠΎΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² ΠΊΠΠΠ, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ Π² ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ 5Π§1ΠΠ‘Π
- 3. 9. 4. Π’ΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ Π. ΡΠΎΠ
- 3. 9. 5. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Π½ΠΎΠΉ ΠΠΠ Π΄Π»Ρ ΡΠ΅ΠΊΠ²Π΅Π½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ
- 3. 11. Π‘ΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ·
- 4. 1. ΠΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΠΈ ΠΏΡΠΎΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΠΌΠΎΡΠΎΡΠ° ΠΈ ΠΈΠ½ΠΈΡΠΈΠ°ΡΠΈΠΈ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΈ Π«ΡΠΠ Π³Π΅Π½Π° Π«ΡΠ
- 4. 2. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΈΡΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° Π² Π«ΡΠ Π»ΠΎΠΊΡΡΠ΅
- 4. 3. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π°ΡΡΠΎΡΠΈΠ°ΡΠΈΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΠΏΡΠΈΡΠΎΠ΄Π½ΡΠΌ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠΌ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠΎΠΌ Π² Π«ΡΠ Π»ΠΎΠΊΡΡΠ΅ ΠΈ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡΡ ΠΆΠΈΠ·Π½ΠΈ
- 4. 4. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π°ΡΡΠΎΡΠΈΠ°ΡΠΈΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠΌ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠΎΠΌ Π² Π«ΡΠ Π»ΠΎΠΊΡΡΠ΅ ΠΈ Π΅Π³ΠΎ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠ΅ΠΉ
- 5. 1. ΠΠΎΠ΄Π΅Π»Ρ ΠΈΠ½ΠΈΡΠΈΠ°ΡΠΈΠΈ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΈ ΠΌΠ ΠΠ Π«ΡΠΠ, Π«ΡΠΠ‘ Π³Π΅Π½Π° Π«ΡΠ
- 5. 2. ΠΡΠ΅Π½ΠΊΠ° Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΎΡΠ±ΠΎΡΠ° Π½Π° ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΡΡ ΠΎΠ±Π»Π°ΡΡΡ Π«ΡΠΠ, Π«ΡΠΠ‘
- 5. 3. ΠΠ΅Π»ΠΊΠΈ Π Π΅Π² ΠΈ ΠΉΡ Π² Π² ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΈ Π¬ΡΠ³ΠΠ ΠΈ ΠΊΠΎΠ½ΡΡΠΎΠ»Π΅ ΠΠ Π΄ΡΠΎΠ·ΠΎΡΠΈΠ»Ρ
- 5. 4. ΠΡΠ½ΠΎΠ²Π½ΡΠ΅ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΡ ΡΡΠ°ΡΡΠΈΡ Π«ΡΠ Π² ΠΊΠΎΠ½ΡΡΠΎΠ»Π΅ ΠΠ Π΄ΡΠΎΠ·ΠΎΡΠΈΠ»Ρ
Π‘ΠΏΠΈΡΠΎΠΊ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
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