Анализ конформационных изменений ДНК при комплексообразовании с координационными соединениями металлов платиновой группы
Диссертация
Создание новых противоопухолевых препаратов является важной и актуальной задачей. Это связано с тем, что все существующие лекарственные средства, применяемые в химиотерапии опухолей, обладают низкой избирательностью, высокой токсичностью и, соответственно, оказывают неблагоприятное воздействие на организм. Несмотря на развитие представлений о биохимии раковой клетки и выявление новых… Читать ещё >
Содержание
- ГЛАВА 1.
- 1. 1. Структура молекулы ДНК
- 1. 2. Взаимодействие молекулы ДНК с координационными соединениями
- ГЛАВА 2. Методы исследования и материалы
- 2. 1. Вискозиметрия
- 2. 2. Спектральные методы
- 2. 3. Динамическое двойное лучепреломление
- 2. 4. Электрофорез
- 2. 5. Атомная силовая микроскопии
- 2. 6. Материалы
- ГЛАВА 3. Исследование взаимодействия ДНК с координационными соединениями палладия
- Часть 1. Взаимодействие ДНК с ацидокомплексами палладия — морфодон, эфазол
- Часть 2. Сравнительный анализ комплексообразования ДНК с цис-ДДП, транс-ДДП и их палладиевыми аналогами
- ГЛАВА 4. Исследование взаимодействия ДНК с координационными соединениями рутения
- Выводы
- Список научных трудов
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