Сравнительная характеристика мезенхимальных клеток пульпы молочного зуба и костного мозга: фенотип и первичная оценка возможности применения в тканевой инженерии кости
Диссертация
В настоящее время наиболее распространёнными высокотехнологичными хирургическими подходами к восстановлению повреждённых органов являются реконструктивная хирургия и трансплантация органов. С их помощью спасены миллионы жизней, но они имеют принципиальные ограничения. Во-первых, биомедицинские конструкции, как правило, не могут полностью заменить живую ткань. Во-вторых, главной проблемой… Читать ещё >
Содержание
- СПИСОК СОКРАЩЕНИЙ!
- ВВЕДЕНИЕ
- Глава 1. ОБЗОР ЛИТЕРАТУРЫ
- 1. '. 1. Тканевая инженерия костной ткани: основные принципы и область применения.'.:".-.л
- 1. 2. Источники клеточного материала для остеорегенеративной .".,' терапии-.-.1 1Ш
- 1. 2. Г. Эмбриональные стволовые-клетки
- 1. 2. 1. 1. История изучения эмбриональных стволовых-клеток
- 1. 2. 1. 2. О возможности клинического применения эмбриональных стволовых! клеток--.,
- 1. 2. '-2- Мезенхимальныестволовыеклетки
- 1. 2. 2. 1. История изучения мезенхимальных стволовых клеток
- 1. 2. 212. Источники мезенхимальных стволовых клеток
- 1. 2. 2. 3. Характеристика мезенхимальных стволовыхклеток.'."
- 1. 2. 2. 4. Мультипотенгность мезенхимальных стволовых клеток
- 1. 2. 2. 5. Попытки применения мезенхимальных стволовых клеток в терапии костных дефектов
- 1. 2. 2. 6. Основания для поиска альтернативных источников мезенхимальных, стволовых клеток
- 1. 2. 3. — Мезенхимальные клетки пульпы зуба
- 1. 23. 1. История изучения. мезенхимальных- клеток пульпы зуба
- 1. '. 1. Тканевая инженерия костной ткани: основные принципы и область применения.'.:".-.л
- 1. 23−2. Свойства-мезенхимальных клеток пульпы зуба
- 1. 2. 3. 3. Мультипотентность мезенхимальных, клеток пульпы зуба
- 1. 2. 4. Мезенхимальные клетки пульпы молочного зуба
- 1. 2. 4. 1. Мультипотентность мезенхимальных клеток пульпы молочного зуба
- 1. 2. 4. 2. Остеоиндуктивный потенциал мезенхимальных клеток пульпы молочного зуба
- 1. 2. 5. Клиническое применение мезенхимальных клеток пульпы зуба
- 1. 3. Скэффолды, применяемые в тканевой инженерии кости
- 1. 3. 1. История создания скэффолдов для тканевой инженерии кости
- 1. 3. 2. Биодеградируемые полимеры
- 1. 3. 2. 1. Полиэстеры
- 1. 3. 2. 2. Прочие биодеградируемые полимеры
- 2. 1. Культуры клеток
- 2. 2. Изготовление полилактидных скэффолдов
- 2. 3. Заселение скэффолдов клетками.44*
- 2. Л. Проточнаящитофлуориметрия
- 2. 5. Остеогенная дифференцировка
- 2. 6. Адипогенная дифференцировка
- 2. 7. Исследование активности щелочной фосфатазы
- 2. 8. Иммуноцитохимическое окрашивание
- 2. 9. Получение и обработка цифровых изображений
- 3. 1. Морфология полученных культур клеток
- 3. 2. Цитофенотипические профили МСК костного мозга и МК пульпы молочного зуба.503.3. Оценка способности клеток к дифференцировке в адипоциты
- 3. 4. Оценка способности клеток к дифференцировке в остеобласты
- 3. 5. Изменение уровня экспрессии остеонектина клетками в процессе остеогенной дифференцировки
- 3. 6. Изменение уровня активности щелочной фосфатазы в клетках в процессе остеогенной дифференцировки
- 3. 7. Культивирование МСК костного мозга и МК пульпы молочного зуба на полилактидных скэффолдах
- 3. 8. Изменение уровня экспрессии остеокальцина МК пульпы молочного зуба в процессе остеогенной дифференцировки на полилактидных скэффолдах
- 4. 1. МК пульпы молочного зуба и МСК костного мозга обладают сходной морфологией и фенотипом, соответствующим мультипотентным мезенхимальным стромальным клеткам
- 4. 2. Культура МК пульпы молочного зуба содержит прогениторные клетки, обладающие остеогенным потенциалом
- 4. 3. МК пульпы молочного зуба сохраняют остеогенный потенциал при культивировании на полилактидном скэффолде в составе тканеинженерного комплекса
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