Нейрофизиологический анализ механизмов слухового восприятия в норме и при патологии центральной нервной системы
В отдельных работах при исследовании компактного белого вещества (мозолистое тело, внутренняя капсула и ножки мозга), авторы пришли к выводу, что миелинизация компактного белого вещества изначально больше по сравнению с некомпактным белым веществом. По-видимому, сохранность морфо-функциональной целостности правой лобной области является важным как для перехода от автоматических к контролируемым… Читать ещё >
Содержание
- Список сокращений
- Раздел I. Обзор литературы
- Раздел II. Методика
- Раздел III. Результаты собственных исследований и их обсуждение
- Глава 1. Компоненты N100, N200 и Р300 СВП у здоровых испытуемых
1.1. Амплитудно-временные параметры компонентов N100, N200 и Р300 СВП у испытуемых молодого и зрелого возраста при прослушивании звуков без инструкции и с инструкцией считать тоны, в задачах с использованием двухстимульной методики необычности стимула.
1.2. Амплитудно-временные параметры компонентов N100, N200 и Р300 СВП при прослушивании звуков без инструкции и при инструкции считать тоны у испытуемых молодого и зрелого возраста, зарегистрированные с использованием трехстимульной методики необычности стимула.
1.3. Сравнение компонентов N100, N200 и Р300 СВП, зарегистрированных в задачах с использованием двух- и трехстимульной звуковой методик необычности стимула
1.4. Топографические особенности компонентов N100, N200 И Р300 СВП в ситуациях счета и прослушивания звуков в задачах с использованием двух- и трехстимульной слуховой последовательности.
1.5. Локализация эквивалентных дипольных источников компонента
РЗОО СВП при прослушивании звуков без инструкции и с инструкцией считать тоны в задачах с использованием двух- и трехстимульной звуковой последовательности.
1.6. Сравнение компонентов N100, N200 и Р300 СВП, зарегистрированных в ответ на целевой тон при прослушивании звуков в задаче с двухстимульной последовательностью и на отличный, но нецелевой тон в задаче с трехстимульной звуковой последовательностью у здоровых испытуемых.
Глава 2. Компоненты MMN и ND слухового вызванного потенциала у здоровых испытуемых и компонент MMN у пациентов с шизофренией.
2.1. Негативность рассогласования, или MMN, у здоровых испытуемых и пациентов с шизофренией.
2.2. Компонент ND СВП у здоровых испытуемых.
Глава 3. Компоненты N100, N200 и Р300 СВП у пациентов на ранних стадиях восстановления сознания после длительной травматической комы.
3.1. Динамика компонента Р300 СВП при посттравматическом бессознательном остоянии.
3.2. Длиннолатентные компоненты СВП (N100, N200 и Р300) в прогнозе восстановления сознания у больных с тяжелой черепномозговой травмой.
Глава 4. Особенности восприятия сложных слуховых стимулов у здоровых испытуемых и пациентов на ранних стадиях восстановления сознания после черепно-мозговой травмы.
4.1. Сравнительный анализ вызванной синхронизации и десинхронизации и вейвлет-синхронности коротких отрезков ЭЭГ при эмоциональном и логическом восприятии музыки у здоровых испытуемых.
4.2. Анализ вейвлет-синхронности коротких отрезков ЭЭГ при восприятии музыки у пациентов с угнетением сознания вследствие тяжелой черепно-мозговой травмы.
4.3. Анализ вейвлет-синхронности коротких отрезков ЭЭГ при восприятии имен у здоровых испытуемых пациентов с угнетением сознания вследствие тяжелой черепно-мозговой травмы (данные отдельных наблюдений).
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- Основные работы, опубликованные по теме диссертации:
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- Шарова E.B., Щекутьев Г. А., Окнина Л. Б., Трошина Е. М. Прогностическая значимость электрической активности мозга (ЭЭГиВП) при затяжных посттравматических бессознательных состояниях // Научно-практический журнал «Доктор.ру». 2008. N.4. С.30−37.
- Шарова Е.В., Зайцев О. С., Щекутьев Г. А., Окнина Л. Б., Трошина Е. М. ЭЭГ и ВП в прогнозировании развития посттравматических бессознательных состояний после тяжелой травмы мозга // Нейронауки: теоретичш та юпшчш аспекта. Т.4. N.2. 2008. С. 83−90.
- Окнина Л. Б., Кузнецова О. А., Ениколопова Е. В. Временные особенности включения дипольных источников РЗОО акустического вызванного потенциала в задачах разной степени сложности у здоровых испытуемых // Ж. Физиология человека. 2009. Т. 35.N.3.C. 1−8.
- Шарова Е.В., Болдырева Г. Н., Куликов М. А., Волынский П. Е., Котенев А. В., Окнина Л. Б. ЭЭГ-корреляты состояний зрительного и слухового внимания у здоровых испытуемых // Ж. Физиология человека. 2009. Т.35. N.1. С.5−13.
- Всероссийской Конференции «Современные направления в исследовании функциональной межполушарной асимметрии и пластичности мозга». 2010, Москва. С.283−286.