Индуцированная дитиотреитолом агрегация низкомолекулярных белков в присутствии ?-кристаллина
Диссертация
Фолдинг крупных мул ьтидоменных комплексов обычно протекает с образованием одного или более интермедиатов. Данный процесс связан с преодолением кинетического барьера, поэтому часто фолдинг останавливается в одном из энергетических минимумов. Это приводит к образованию частично или неправильно свернутых интермедиатов. Задерживаясь слишком долго в промежуточном состоянии, белок склонен агрегировать… Читать ещё >
Содержание
- СПИСОК СОКРАЩЕНИЙ
- 1. ОБЗОР ЛИТЕРАТУРЫ
- 1. 1. Агрегация белков
- 1. 2. Молекулярные шапероны
- 1. 3. Малые белки теплового шока
- 1. 4. а-Кристаллин
- 1. 4. 1. Особенности строения
- 1. 4. 2. Механизмы шаперонного действия
- 1. 5. Инсулин
- 1. 6. а-Лактальбумин
- 2. МАТЕРИАЛЫ И МЕТОДЫ
- 2. 1. Материалы
- 2. 2. Методы исследования
- 2. 2. 1. Выделение и очистка а-кристаллина
- 2. 2. 2. Динамическое лазерное светорассеяние (ДЛС)
- 2. 2. 3. Изучение кинетики индуцированной дитиотреитолом агрегации белков методом ДЛС
- 2. 2. 4. Флуоресцентная спектроскопия
- 2. 2. 5. Электронная микроскопия
- 2. 2. 6. Ультрафильтрация
- 2. 2. 7. Электрофоретический анализ
- 3. 1. Исследование кинетики индуцированной дитиотреитолом агрегации а-лактальбумина
- 3. 2. Действие а-кристаллина на кинетику агрегации а-лактальбумина
- 3. 3. Исследование взаимодействия а-кристаллина с а-лактальбумином методом флуоресцентной спектроскопии
- 3. 4. Исследование комплексов а-кристаллин-а-лактальбумин
- 3. 5. Механизм агрегации а-лактальбумина
- 3. 6. Кинетика индуцированной дитиотреитолом агрегации инсулина
- 3. 7. Действие а-кристаллина на кинетику агрегации инсулина
- 3. 8. Исследование взаимодействия а-кристаллина с инсулином
- 3. 8. 1. Флуоресцентная спектроскопия
- 3. 8. 2. Электронная микроскопия
- 3. 9. Модель агрегации инсулина
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