ΠΠ΅Π½Ρ ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠΈ ΠΌΠΈΠΊΡΠΎΡΠΈΠ½Π° Escherichia coli S5/98, ΠΈΡ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ ΠΈ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π½Π° Π°Π½ΡΠ°Π³ΠΎΠ½ΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΡΡ ΡΡΠ°ΠΌΠΌΠΎΠ²
Π Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ ΡΡΡΠ΅ΡΡΠ²ΡΠ΅Ρ ΡΠΎΠ»ΡΠΊΠΎ ΠΎΠ΄ΠΈΠ½ ΠΊΠΎΠΌΠΌΠ΅ΡΡΠ΅ΡΠΊΠΈΠΉ ΠΏΡΠ΅ΠΏΠ°ΡΠ°Ρ, Π² ΠΊΠΎΡΠΎΡΠΎΠΌ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΎ ΡΠ²ΠΎΠΉΡΡΠ²ΠΎ ΠΌΠΈΠΊΡΠΎΡΠΈΠ½ΠΎΠ³Π΅Π½ΠΈΠΈ. ΠΡΠΎ ΠΏΡΠ΅ΠΏΠ°ΡΠ°Ρ «Π ΠΎΠΌΠ°ΠΊΠΎΠ»», ΠΎΡΠ½ΠΎΠ²Π°Π½Π½ΡΠΉ Π½Π° ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΠΎΠΌ ΡΡΠ°ΠΌΠΌΠ΅ Π coli Π17(Ρ74) — ΠΏΡΠΎΠ΄ΡΡΠ΅Π½ΡΠ΅ ΠΌΠΈΠΊΡΠΎΡΠΈΠ½Π° Π‘51 (Π‘ΠΎΠΊΠΎΠ»ΠΎΠ²Π°, Π₯ΠΌΠ΅Π»Ρ, 2001) ΠΠ½ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΡΡΡ Π΄Π»Ρ Π»Π΅ΡΠ΅Π½ΠΈΡ Π΄ΠΈΡΠ±Π°ΠΊΡΠ΅ΡΠΈΠΎΠ·ΠΎΠ² ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ ΠΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠΎΠ² ΠΏΠΎ ΠΏΠ΅ΡΠ΅ΠΊΡΠ΅ΡΡΠ½ΠΎΠΉ ΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΡΡΠΈ ΡΡΠ°ΠΌΠΌΠΎΠ²-ΠΏΡΠΎΠ΄ΡΡΠ΅Π½ΡΠΎΠ² ΠΌΠΈΠΊΡΠΎΡΠΈΠ½ΠΎΠ² ΠΈ ΠΈΠ½Π΄ΠΈΠΊΠ°ΡΠΎΡΠ½ΡΡ … Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΠ»Π°Π²Π° 1. ΠΠ±Π·ΠΎΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
- Π«.ΠΠΎΠ»ΠΈΡΠΈΠΈΡ
- 1. 1. 1. ΠΠΌΠΌΡΠ½Π½ΠΎΡΡΡ ΠΊ ΡΠΎΠ±ΡΡΠ²Π΅Π½Π½ΠΎΠΌΡ ΠΊΠΎΠ»ΠΈΡΠΈΠ½Ρ
- 1. 1 2 ΠΠ°ΡΠΈΡΠ° ΠΎΡ ΠΊΠΎΠ»ΠΈΡΠΈΠ½ΠΎΠ²
- 1. 1 3 ΠΠ²ΠΎΠ»ΡΡΠΈΡ ΠΊΠΎΠ»ΠΈΡΠΈΠ½ΠΎΠ²
- 1. 1. 4 ΠΠΎΠ»ΠΈΡΠΈΠ½ El 13 1.2. ΠΠΈΠΊΡΠΎΡΠΈΠ½Ρ
- 1. 2 1 ΠΠΈΠΊΡΠΎΡΠΈΠ½ΠΠ
- 2. ΠΠ΅Ρ Π°Π½ΠΈΠ·ΠΌ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΌΠΈΠΊΡΠΎΡΠΈΠ½Π° Π17 21 1 2.3. ΠΠΌΠΌΡΠ½ΠΈΡΠ΅Ρ ΠΊ ΠΌΠΈΠΊΡΠΎΡΠΈΠ½Ρ Π
- 4. Π Π΅Π³ΡΠ»ΡΡΠΈΡ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΠΌΠΈΠΊΡΠΎΡΠΈΠ½ΠΎΠ²ΡΡ Π³Π΅Π½ΠΎΠ² 22 1.2.5. Π£ΡΡΠΎΠΉΡΠΈΠ²ΠΎΡΡΡ ΠΊ ΠΌΠΈΠΊΡΠΎΡΠΈΠ½Ρ ΡΠΈΠΏΠ° Π
- 6. ΠΡΡΠ³ΠΈΠ΅ ΠΌΠΈΠΊΡΠΎΡΠΈΠ½Ρ ΡΠΈΠΏΠ° Π
- 3. ΠΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠΎΠ»Ρ ΠΊΠΎΠ»ΠΈΡΠΈΠ½ΠΎΠ² ΠΈ ΠΌΠΈΠΊΡΠΎΡΠΈΠ½ΠΎΠ²
- 13. 1. Π’Π΅ΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΌΠΎΠ΄Π΅Π»ΠΈ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΡΠΊΠΎΠ»ΠΎΠ³ΠΈΠΈ Π±Π°ΠΊΡΠ΅ΡΠΈΠΎΡΠΈΠ½ΠΎΠ²
- 2. ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠ΅ ΠΌΠΎΠ΄Π΅Π»ΠΈ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΡΠΊΠΎΠ»ΠΎΠ³ΠΈΠΈ Π±Π°ΠΊΡΠ΅ΡΠΈΠΎΡΠΈΠ½ΠΎΠ²
- 1. 4 ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΊΠΎΠ»ΠΈΡΠΈΠ½ΠΎΠ² ΠΈ ΠΌΠΈΠΊΡΠΎΡΠΈΠ½ΠΎΠ²
- 1. 4 1 ΠΡΠΎΠ±ΠΈΠΎΡΠΈΠΊΠΈ
- 1. 4.2. ΠΡΠΎΠ±ΠΈΠΎΡΠΈΠΊΠΈ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ Π col
- ΠΠ»Π°Π²Π° 2. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ
- 2. 1 ΠΠ°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΡΠ΅ ΡΡΠ°ΠΌΠΌΡ, ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Ρ, Π±Π°ΠΊΡΠ΅ΡΠΈΠΎΡΠ°Π³ΠΈ 43 2 2 Π‘ΡΠ΅Π΄Ρ ΠΈ ΡΡΠ»ΠΎΠ²ΠΈΡ ΠΊΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΡ 45 2 3 Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠΈ Π±Π°ΠΊΡΠ΅ΡΠΈΠΎΡΠΈΠ½Π°
- 4. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠΈΠΏΠ° Π±Π°ΠΊΡΠ΅ΡΠΈΠΎΡΠΈΠ½Π° 47 2 5 Π‘Π΅Π»Π΅ΠΊΡΠΈΡ Π½Π° Π±Π°ΠΊΡΠ΅ΡΠΈΠΎΡΠΈΠ½Π°Ρ 47 2 6 Π’ΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ Π coli 48 2 7 Π’ΡΠ°Π½ΡΠ΄ΡΠΊΡΠΈΡ Π±Π°ΠΊΡΠ΅ΡΠΈΠΉ
- 2. 7 1 ΠΡΠΈΠ³ΠΎΡΠΎΠ²Π»Π΅Π½ΠΈΠ΅ Π»ΠΈΠ·Π°ΡΠΎΠ² 49 2 7 2 Π’ΡΠ°Π½ΡΠ΄ΡΠΊΡΠΈΡ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ PI ΡΠ°Π³ΠΎΠ»ΠΈΠ·Π°ΡΠΎΠ²
- 2. 8 ΠΠ»Π΅ΠΊΡΡΠΎΡΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΡ Π±Π°ΠΊΡΠ΅ΡΠΈΠΉ
- 9. ΠΠ°Π½ΠΈΠΏΡΠ»ΡΡΠΈΠΈ Ρ ΠΠΠ
- 1. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Π½ΠΎΠΉ ΠΠΠ 50 2.9 2 ΠΡΠΈΡΡΠΊΠ° ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Π½ΠΎΠΉ ΠΠΠ
- 2. 9. 3. ΠΠΎΠ½ΡΠ΅Π½ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΠΠ
- 2. 9. 4. ΠΠ»Π΅ΠΊΡΡΠΎΡΠΎΡΠ΅Π· Π² Π°Π³Π°ΡΠΎΠ·Π½ΠΎΠΌ Π³Π΅Π»Π΅
- 5. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² ΠΠΠ ΠΈΠ· Π°Π³Π°ΡΠΎΠ·Ρ
- 2. 10. ΠΠ°ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΠΠ
- 2. 11. ΠΠ»ΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅
- 2. 11. 1. ΠΠ΅ΡΠΎΡΡΠΎΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΠΠ
- 2. 11. 2. ΠΠΈΠ³ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅
- 1. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Π½ΠΎΠΉ ΠΠΠ 50 2.9 2 ΠΡΠΈΡΡΠΊΠ° ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Π½ΠΎΠΉ ΠΠΠ
- 3. ΠΡΠ΅Π²ΡΠ°ΡΠ΅Π½ΠΈΠ΅ Π²ΡΡΡΡΠΏΠ°ΡΡΠΈΡ S'-kohuob Π² ΡΡΠΏΡΠ΅ 55 2.11.4. ΠΡΠ΅Π²ΡΠ°ΡΠ΅Π½ΠΈΠ΅ Π²ΡΡΡΡΠΏΠ°ΡΡΠΈΡ Π'-ΠΊΠΎΠ½ΡΠΎΠ² Π² ΡΡΠΏΡΠ΅
- 5. ΠΡΡΡΠ°ΠΈΠ²Π°Π½ΠΈΠ΅ Π»ΠΈΠ½ΠΊΠ΅ΡΠΎΠ² 56 2.11.6. ΠΠ»ΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π³Π΅Π½ΠΎΠ², ΡΠ²ΡΠ·Π°Π½Π½ΡΡ Ρ ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠ΅ΠΉ ΠΈ ΠΈΠΌΠΌΡΠ½Π½ΠΎΡΡΡΡ ΠΊ ΠΌΠΈΠΊΡΠΎΡΠΈΠ½Ρ
- 2.
- 1. ΠΡΠΈΠ³ΠΎΡΠΎΠ²Π»Π΅Π½ΠΈΠ΅ ΡΠ°Π³ΠΎΠ»ΠΈΠ·Π°ΡΠΎΠ² ΠΠΈ
- 2.
- 2. Π’ΡΠ°Π½ΡΠ΄ΡΠΊΡΠΈΡ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΠ°Π³ΠΎΠ»ΠΈΠ·Π°ΡΠΎΠ² ΠΠΈ
- 2.
- 3. ΠΠΎΠ½ΡΡΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π΄Π²ΠΎΠΉΠ½ΠΎΠ³ΠΎ Π»ΠΈΠ·ΠΎΠ³Π΅Π½Π°
- 2. 11. 6. 4 ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π±Π°Π½ΠΊΠ° Π³Π΅Π½ΠΎΠ²
- 2. 12 ΠΠΎΠ»ΠΈΠΌΠ΅ΡΠ°Π·Π½Π°Ρ ΡΠ΅ΠΏΠ½Π°Ρ ΡΠ΅Π°ΠΊΡΠΈΡ ΠΈ ΠΏΠΎΠ΄Π±ΠΎΡ ΠΏΡΠ°ΠΉΠΌΠ΅ΡΠΎΠ²
- 13. Π‘Π΅ΠΊΠ²Π΅Π½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΠΠ
- 2. 14 ΠΠ±ΡΠ΅ΠΊΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ
- 3. 1 ΠΠ½ΡΠ°Π³ΠΎΠ½ΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΡΡΠ°ΠΌΠΌΠ° Π coli S5/
- 11. ΠΠ΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΌΠ°ΡΠΊΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠ°ΠΌΠΌΠ° Π coli S5/98
2. ΠΠ΅ΡΠ΅ΠΊΡΠ΅ΡΡΠ½Π°Ρ ΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΡΡΡ ΡΡΠ°ΠΌΠΌΠ° Π coli S5 Sm ΠΈ ΠΈΠ½Π΄ΠΈΠΊΠ°ΡΠΎΡΠ½ΡΡ ΠΊΡΠ»ΡΡΡΡ 64 3.1 3 ΠΡΠΈΠ²ΡΠ΅ ΡΠΎΡΡΠ° ΡΡΠ°ΠΌΠΌΠ° Π coli S5 Sm ΠΈ ΠΈΠ½Π΄ΠΈΠΊΠ°ΡΠΎΡΠ½ΡΡ ΠΊΡΠ»ΡΡΡΡ 64 3 1 4 ΠΠΎΠ½ΠΊΡΡΠ΅Π½ΡΠ½Π°Ρ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ° ΡΡΠ°ΠΌΠΌΠΎΠ²-ΠΏΡΠΎΠ΄ΡΡΠ΅Π½ΡΠΎΠ² ΡΠ°Π·Π½ΡΡ Π±Π°ΠΊΡΠ΅ΡΠΈΠΎΡΠΈΠ½ΠΎΠ² 66 3 1 5 ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΠ°ΠΌΠΌΠ°-ΠΏΡΠΎΠ΄ΡΡΠ΅Π½ΡΠ° ΠΌΠΈΠΊΡΠΎΡΠΈΠ½Π° ΠΈ ΠΊΠΎΠ»ΠΈΡΠΈΠ½Π°
3 2 ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π³Π΅Π½ΠΎΠ² ΡΡΠ°ΠΌΠΌΠ° Π coli S5/98, ΡΠ²ΡΠ·Π°Π½Π½ΡΡ Ρ ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠ΅ΠΉ ΠΌΠΈΠΊΡΠΎΡΠΈΠ½Π° ΠΈ ΠΈΠΌΠΌΡΠ½Π½ΠΎΡΡΡΡ ΠΊ Π½Π΅ΠΌΡ
3 2 1 ΠΠ»ΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΌΠΈΠΊΡΠΎΡΠΈΠ½ΠΎΠ²ΡΡ Π³Π΅Π½ΠΎΠ²
3 2 2 Π‘ΡΡΡΠΊΡΡΡΠ° ΠΊΠ»ΠΎΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠ°
3 2 3 Π‘ΡΠ±ΠΊΠ»ΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π³Π΅Π½ΠΎΠ² ΠΈΠΌΠΌΡΠ½Π½ΠΎΡΡΠΈ ΠΊ ΠΌΠΈΠΊΡΠΎΡΠΈΠ½Ρ Π
3 3 Π£ΡΡΠΎΠΉΡΠΈΠ²ΠΎΡΡΡ ΠΊ ΠΌΠΈΠΊΡΠΎΡΠΈΠ½Ρ ΡΠΈΠΏΠ° Π
3.4 ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΈΠ·ΠΎΠ³Π΅Π½Π½ΡΡ ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΡΡ ΡΡΠ°ΠΌΠΌΠΎΠ² ΠΊΠΈΡΠ΅ΡΠ½ΠΎΠΉ ΠΏΠ°Π»ΠΎΡΠΊΠΈ -ΠΏΡΠΎΠ΄ΡΡΠ΅Π½ΡΠΎΠ² ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° Π°Π½ΡΠΈΠ±ΠΈΠΎΡΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠ°ΠΊΡΠΎΡΠΎΠ²
3.4.1. ΠΠΎΠ½ΡΡΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π²Π΅ΠΊΡΠΎΡΠΎΠ²
3.
2. ΠΠΎΠ½ΡΡΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈΠ»Π°Π·ΠΌΠΈΠ΄ Ρ Π³Π΅Π½Π°ΠΌΠΈ Π±Π°ΠΊΡΠ΅ΡΠΈΠΎΡΠΈΠ½ΠΎΠ² Π΄Π²ΡΡ ΡΠΈΠΏΠΎΠ² 83 3 5 ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΡΡ ΡΡΠ°ΠΌΠΌΠΎΠ² ΠΊΠΈΡΠ΅ΡΠ½ΠΎΠΉ ΠΏΠ°Π»ΠΎΡΠΊΠΈ -ΠΏΡΠΎΠ΄ΡΡΠ΅Π½ΡΠΎΠ² ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° Π°Π½ΡΠΈΠ±ΠΈΠΎΡΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠ°ΠΊΡΠΎΡΠΎΠ² in vitro
3.5.1. Π‘ΡΠ°Π±ΠΈΠ»ΡΠ½ΠΎΡΡΡ ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΡΡ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄ Π² ΡΡΠ°ΠΌΠΌΠ΅ Π coli Ml7 85 3
2. ΠΠ΅ΡΠ΅ΠΊΡΠ΅ΡΡΠ½Π°Ρ ΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΡΡΡ ΡΡΠ°ΠΌΠΌΠΎΠ² ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ Π coli Π17 86 3 5.3. ΠΠΈΠ½Π°ΠΌΠΈΠΊΠ° ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΉ ΡΡΠ°ΠΌΠΌΠΎΠ² ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ Π coli Π17 Π² ΡΠΌΠ΅ΡΠ°Π½Π½ΡΡ ΠΊΡΠ»ΡΡΡΡΠ°Ρ
6. ΠΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ ΠΌΠΈΠΊΡΠΎΡΠΈΠ½ΠΎΠ³Π΅Π½Π½ΠΎΠΉ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΈ Π² Π³ΠΎΠΌΠΎΠ³Π΅Π½Π½ΠΎΠΉ ΡΡΠ΅Π΄Π΅
3 7 ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΡ Π½Π° ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
Π‘ΠΏΠΈΡΠΎΠΊ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
- ΠΠ»Π΅ΡΠΈΠ½ Π. Π, Π‘Π΅ΠΌΠ΅Π½ΠΎΠ²Π° Π Π, Π’Π°ΡΠ°ΠΊΠ°Π½ΠΎΠ² Π Π, ΠΠΈΠ²ΡΠΈΡ Π, Π Π‘Π΅ΠΌΠ΅ΠΉΡΡΠ²ΠΎ ΡΠ΅Π»Π½ΠΎΡΠ½ΡΡ Π²Π΅ΠΊΡΠΎΡΠΎΠ² Π΄Π»Ρ ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΊΠΈΡΠ»ΡΡ ΠΈ Π΄ΡΡΠ³ΠΈΡ Π³ΡΠ°ΠΌΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΡ Π±Π°ΠΊΡΠ΅ΡΠΈΠΉ, ΠΎΡΠ½ΠΎΠ²Π°Π½Π½ΡΡ Π½Π° ΡΠ΅ΠΏΠ»ΠΈΠΊΠΎΠ½Π΅ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Ρ pLF1311 ΠΠΈΠΊΡΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡ 2000 Π’. 69(1). Π‘. 75−80.
- ΠΠ°ΡΡΠΊ Π. Π, ΠΠ΅Π·ΡΡΠΊΠΎΠ² Π Π., ΠΠΈΠΏΠ°ΡΠΎΠ²Π° Π, Π, Π₯ΠΌΠ΅Π»Ρ Π, Π ΠΠ»ΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈ Π°Π½Π°Π»ΠΈΠ· Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ Π΄Π΅ΡΠ΅ΡΠΌΠΈΠ½Π°Π½ΡΠΎΠ², ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΡΡΠΈΡ ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΡ ΠΌΠΈΠΊΡΠΎΡΠΈ-Π½ΠΎΠ² Π2 ΠΈ Π27. ΠΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½Π°Ρ Π³Π΅Π½Π΅ΡΠΈΠΊΠ°. 1994. Π’. 30(6). Π‘. 731−739.
- ΠΠ°Π½ΡΡΠΎΠ² Π Π., ΠΡΠΈΠ»ΡΠΊΠΎΠ², Π Π., ΠΠ΅ΡΡΡΠΊΠΈΠ½ Π. Π‘. ΠΠΎΠΏΡΠ»ΡΡΠΈΠΎΠ½Π½Π°Ρ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ° Π±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΡΡ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄ ΠΠ°ΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ 2001. Π’ 13(1) Π‘ 77−98
- ΠΠΈΠ²ΡΠΈΡ Π Π., Π§Π΅ΡΠ½ΠΎΠΊΠΎΠ²Π° Π Π, ΠΠ»Π΅ΡΠΈΠ½ Π. Π., Π‘ΠΎΠΊΡΡΠ΅Π½ΠΊΠΎ Π Π, ΠΠ°Π»ΠΈΠ½ Π Π, ΠΡΠ°Π²ΡΠΎΠ² Π Π, ΠΡΠΊΠΎΠ² Π Π. Π¨ΡΠ°ΠΌΠΌ Π±Π°ΠΊΡΠ΅ΡΠΈΠΉ Escherichia coli M17/pColap Π΄Π»Ρ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ ΠΏΡΠΎΠ±ΠΈΠΎΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°. 2000. ΠΠΏΠΈΡΠ°Π½ΠΈΠ΅ ΠΈΠ·ΠΎΠ±ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΊ ΠΏΠ°ΡΠ΅Π½ΡΡ Π Π€. RU 2 144 954 Π‘1
- ΠΠ°Π½ΠΈΠ°ΡΠΈΡ Π’., Π€ΡΠΈΡ Π, Π‘ΡΠΌΠ±ΡΡΠΊ ΠΠΆ. ΠΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠ΅ ΠΊΠ»ΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅. Π «ΠΠΈΡ». 1984.
- ΠΠ°ΡΠ½ΡΠΊΠΈΠΉ, Π Π ΠΠΈΡΠ±Π°ΠΊΡΠ΅ΡΠΈΠΎΠ·. ΠΈΠ»Π»ΡΠ·ΠΈΠΈ ΠΈ ΡΠ΅Π°Π»ΡΠ½ΠΎΡΡΡ ΠΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡ ΠΈ Π°Π½ΡΠΈΠΌΠΈΠΊΡΠΎΠ±Π½Π°Ρ Ρ ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΡ. 2000. Π’. 2(2). Π‘ 61−64
- ΠΠΈΠ»Π»Π΅Ρ ΠΠΆ ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΡ Π² ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠΉ Π³Π΅Π½Π΅ΡΠΈΠΊΠ΅. Π. «ΠΠΈΡ». 1976.
- Π‘ΠΎΠΊΠΎΠ»ΠΎΠ²Π° Π Π., Π₯ΠΌΠ΅Π»Ρ Π Π. ΠΡΠΎΠ±ΠΈΠΎΡΠΈΠΊ ΡΠΎΠΌΠ°ΠΊΠΎΠ» ΠΈ Π΅Π³ΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ Π² Π²Π΅ΡΠ΅ΡΠΈΠ½Π°ΡΠΈΠΈ. ΠΠ΅ΡΠ΅ΡΠΈΠ½Π°ΡΠΈΡ 2001. № 11. Π‘. 46−49.
- Π’Π°ΡΠ°ΠΊΠ°Π½ΠΎΠ² Π Π. ΠΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΎΠ±ΠΈΠΎΡΠΈΠΊΠΎΠ² Π² ΠΆΠΈΠ²ΠΎΡΠ½ΠΎΠ²ΠΎΠ΄ΡΡΠ²Π΅ ΠΠ°Π»ΡΠ³Π° 1998
- Π’Π°ΡΠ°ΠΊΠ°Π½ΠΎΠ² Π Π. ΠΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΡ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΏΡΠΎΠ±ΠΈΠΎΡΠΈΠΊΠΎΠ² Π½Π° ΠΌΠΈΠΊΡΠΎΡΠ»ΠΎΡΡ ΠΏΠΈΡΠ΅Π²Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°ΠΊΡΠ° ΠΈ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ ΠΠ΅ΡΠ΅ΡΠΈΠ½Π°ΡΠΈΡ. 2000. № 1 Π‘. 47−54.
- Π’Π°ΡΠ°ΠΊΠ°Π½ΠΎΠ² ΠΠ, ΠΠΈΠΊΠΎΠ»ΠΈΡΠ΅Π²Π° Π’. Π, ΠΠ»Π΅ΡΠΈΠ½ Π. Π, ΠΠΎΠΌΠΊΠΎΠ²Π° ΠΠ ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΠΏΡΠΎΠ΄ΡΡΠ΅Π½ΡΠ° ΠΌΠΈΠΊΡΠΎΡΠΈΠ½Π° ΡΠΈΠΏΠ° Π Π½Π° ΡΠ΅Π»ΡΡ. ΠΠ΅ΡΠ΅ΡΠΈΠ½Π°ΡΠΈΡ. 2005.
- Π’Π°ΡΠ°ΠΊΠ°Π½ΠΎΠ² Π. Π, ΠΠΈΠΊΠΎΠ»ΠΈΡΠ΅Π²Π° Π’. Π., ΠΠ»Π΅ΡΠΈΠ½ Π Π, ΠΠΎΠΌΠΊΠΎΠ²Π° Π Π ΠΠΈΠΊΡΠΎΡΠ»ΠΎΡΠ° ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ° ΠΈ Π·Π΄ΠΎΡΠΎΠ²ΡΠ΅ ΡΠ΅Π»ΡΡ ΠΏΡΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠΈ ΠΏΡΠΎΠ΄ΡΡΠ΅Π½ΡΠ° ΠΌΠΈΠΊΡΠΎΡΠΈΠ½Π° ΡΠΈΠΏΠ° Π. ΠΠ΅ΡΠ΅ΡΠΈΠ½Π°ΡΠΈΡ (Π² ΠΏΠ΅ΡΠ°ΡΠΈ)
- Π’Π°ΡΠ°ΠΊΠ°Π½ΠΎΠ² Π Π., ΠΠΈΠΊΠΎΠ»ΠΈΡΠ΅Π²Π° Π’. Π, ΠΠ»Π΅ΡΠΈΠ½ Π Π, ΠΠΎΠΌΠΊΠΎΠ²Π° Π Π ΠΠΈΠΊΡΠΎΡΠΈΠ½Ρ ΠΈ ΠΈΡ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Π½Π° ΡΠΊΠΎΠ»ΠΎΠ³ΠΈΡ Π±Π°ΠΊΡΠ΅ΡΠΈΠΉ Π² ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ΅ ΠΌΡΡΠ΅ΠΉ. ΠΠΎΠΊΠ»Π°Π΄Ρ Π ΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ Π°ΠΊΠ°Π΄Π΅ΠΌΠΈΠΈ ΡΠ΅Π»ΡΡΠΊΠΎΡ ΠΎΠ·ΡΠΉΡΡΠ²Π΅Π½Π½ΡΡ Π½Π°ΡΠΊ (Π² ΠΏΠ΅ΡΠ°ΡΠΈ)
- Π’Π°ΡΠ°ΠΊΠ°Π½ΠΎΠ² Π Π, Π―ΠΊΠΎΠ²Π»Π΅Π²Π°, Π Π., ΠΠ»Π΅ΡΠΈΠ½ Π Π Π₯Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° ΡΠ½ΡΠ΅ΡΠΎΠ±Π°ΠΊΡΠ΅-ΡΠΈΠΉ, ΠΏΡΠΎΠ΄ΡΡΠΈΡΡΡΡΠΈΡ ΠΌΠΈΠΊΡΠΎΡΠΈΠ½Ρ Π½ΠΈΠ·ΠΊΠΎΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠ΅ Π°Π½ΡΠΈΠ±ΠΈΠΎΡΠΈΠΊΠΈ ΠΠΈΠΊΡΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡ 2004 Π’ 73(2) Π‘. 150−155.
- Π’Π°ΡΠ°ΠΊΠ°Π½ΠΎΠ² Π.Π., Π―ΠΊΠΎΠ²Π»Π΅Π²Π° Π. Π., ΠΠΈΠΊΠΎΠ»ΠΈΡΠ΅Π²Π° Π’. Π., ΠΠΎΠΌΠΊΠΎΠ²Π° Π Π., ΠΠ°Π½ΡΡ ΠΈ-Π½Π° Π.Π., ΠΠ»Π΅ΡΠΈΠ½ Π Π ΠΠ΅ΠΊΡΠΎΡ pLF22 Π΄Π»Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π³Π΅Π½ΠΎΠ² Π² ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΊΠΈΡΠ»ΡΡ Π±Π°ΠΊΡΠ΅ΡΠΈΡΡ ΠΠΈΠΊΡΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡ. 2004 Π’73(2) Π‘ 170−175.
- Π₯ΠΌΠ΅Π»Ρ Π, Π ΠΠΈΠΊΡΠΎΡΠΈΠ½Ρ ΠΏΠ΅ΠΏΡΠΈΠ΄Π½ΡΠ΅ Π°Π½ΡΠΈΠ±ΠΈΠΎΡΠΈΠΊΠΈ ΡΠ½ΡΠ΅ΡΠΎΠ±Π°ΠΊΠ³Π΅ΡΠΈΠΉ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ ΡΠΈΠ½ΡΠ΅Π·Π°, ΡΡΡΡΠΊΡΡΡΠ°, ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΠ΅Π½Π΅ΡΠΈΠΊΠ° 1999. Π’. 35(1) Π‘. 5−16
- Π₯ΠΌΠ΅Π»Ρ Π, Π, ΠΠ΅ΡΠ»ΠΈΡΠΊΠ°Ρ, Π 3, Π€ΠΎΠΌΠ΅Π½ΠΊΠΎ Π Π, ΠΠ°ΡΡΡΡ Π° Π Π‘., ΠΠ°ΡΡΠΊ Π Π, ΠΡ-ΡΠ΅ΠΏΠΈΠ½Π° Π Π, ΠΠΈΠΏΠ°ΡΠΎΠ²Π° Π, Π, ΠΠ΅Π·ΡΡΠΊΠΎΠ² Π. Π. ΠΠΈΠΊΡΠΎΡΠΈΠ½Ρ Π½ΠΎΠ²ΡΠ΅ ΠΏΠ΅ΠΏΡΠΈΠ΄Π½ΡΠ΅ Π°Π½ΡΠΈΠ±ΠΈΠΎΡΠΈΠΊΠΈ ΡΠ½ΡΠ΅ΡΠΎΠ±Π°ΠΊΡΠ΅ΡΠΈΠΉ ΠΈ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ ΠΈΡ ΡΠΈΠ½ΡΠ΅Π·Π°. ΠΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½Π°Ρ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡ 1999 Π’. 33(1) Π‘.113−119.
- Π§Π΅ΠΌΠ΅ΡΠΈΡ, Π Π, ΠΡ ΡΠ½ΠΎΠ² Π Π, ΠΠ°Ρ ΠΈΡΠΎΠ² Π, Π Π‘Π΅ΠΊΠ²Π΅Π½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΠΠ Π «ΠΠ°ΡΠΊΠ°» 1999 144−133.
- Π¨Π΅ΠΌΡΡΠΊ Π Π€ Π‘ΡΠ°Π½Π΄Π°ΡΡΠΈΠ·Π°ΡΠΈΡ ΠΊΠΎΠ»ΠΈΠ±Π°ΠΊΡΠ΅ΡΠΈΠ½Π° ΠΠ²ΡΠΎΡΠ΅ΡΠ΅ΡΠ°Ρ Π½Π° ΡΠΎΠΈΡΠΊΠ°Π½ΠΈΠ΅ ΡΡΠ΅Π½ΠΎΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΠΊΠ°Π½Π΄ΠΈΠ΄Π°ΡΠ° Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ Π½Π°ΡΠΊ Π 1983 Π‘ 16
- Π―ΠΊΠΎΠ²Π»Π΅Π²Π°, Π Π, ΠΠ»Π΅ΡΠΈΠ½ Π Π, Π’Π°ΡΠ°ΠΊΠ°Π½ΠΎΠ² Π. Π Π‘ΡΡΡΠΊΡΡΡΠ½Π°Ρ Π½Π΅ΡΡΠ°Π±ΠΈΠ»ΡΠ½ΠΎΡΡΡ Π½Π΅ΠΊΠΎΡΠΎΡΡΡ ΠΈΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΡΡ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄ ΠΈ Π³Π΅ΡΠ΅ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ½Π°Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ Ρ ΠΈΡ ΠΏΡΠΎΠΌΠΎΡΠΎΡΠ° ΠΠΎΠΊΠ». Π ΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ ΠΠΊΠ°Π΄Π΅ΠΌΠΈΠΈ ΡΠ΅Π»ΡΡΠΊΠΎΡ ΠΎΠ·ΡΠΉΡΡΠ²Π΅Π½Π½ΡΡ Π½Π°ΡΠΊ 2001 № 2. Π‘. 33−36
- Aguilar A., Perez-Diaz J.Π‘., Baquero F, Asensio Π‘ Microcin 15m from Escherichia coll. mechanism of antibiotic action Antimicrob. Agents Chemother 1982. V. 21(3) P 381−386.
- Allah N., Afif H, Couturier M, Van Melderen L. The highly conserved TldD and TldE proteins of Escherichia coh are involved in microcin B17 processing and in CcdA degradation J Bactenol 2002. V. 184(12) P 3224−3231
- Appel K., Haken W Every planar map is four colorable. A M.S. Contemporary Math. 1989. V. 98.
- Asensio Π‘, Perez-Diaz J C. A new family of low molecular weight antibiotics from Enterobacteria. Biochemical and biophysical research communications 1976 V. 69(1) P. 7−14
- Bachvarov D R, Ivanov I G Large scale purification of plasmid DNA Prep Biochem 1983. V. 13(2). P. 161−166
- Baquero F, Moreno F The microcins FEMS Microbiol. Lett 1984 V. 23. P 117−124
- Baquero F., Bouanchaud D, Martinez-Perez MC, Fernandez C. Microcin plasmids: a group of extrachromosomal elements coding for low-molecular-weight antibiotics in Escherichia coh J. Bacteriol. 1978. V. 135. P. 342−347.
- Baquero M.R., Bouzon M, Varea J., Moreno F. sbmC, a stationary-phase induced SOS Escherichia coh gene, whose product protects cells from the DNA replication inhibitor microcin Π17. Mol Microbiol. 1995. V 18(2) P 301−311.
- Benedetti H, Frenette M, Baty D, Kmbiehler M, Pattus F, Lazdunski J.C. Individual domains of colicins confer specificity in colicin uptake, in poreproperties and in immunity requirements J Mol Biol 1991. V. 217. P 429−439
- Birnboim H Π‘, Doly J A rapid alkaline extraction procedure for screening recombinant plasmid DNA Nucleic Acids Res. 1979 V 7(6) P. 1513−1523
- Bishop L J, Bjes E S, Davidson V. L, Cramer W A. Localization of the immunity protein-reactive domain in unmodified and chemically modified COOH-terminal peptides of colicin El J Bacteriol 1985 V 164 P. 237−244.
- Blum G, Marre R, Hacker J. Properties of Escherichia coll strains of serotype 06. Infection 1995 V. 23(4). P. 234−236.
- Braun V, Pilsl H, Gross P. Colicins* structures, modes of action, transfer through membranes, and evolution Arch Microbiol. 1994 V. 161(3) P. 199−206 Review.
- Braun V., Patzer S I, Hantke K Ton-dependent colicins and microcins modular design and evolution. Biochimie. 2002. V. 84(5−6) P 365−380.
- Brendel V., Perelson A S. Quantitative model of ColEl plasmid copy number control J.Mol.Biol. 1993. V 229(4) P. 860−872.
- Bruand C., Le Chatelier E, Ehrlich S.D., Janniere L. A fourth class of theta-replicating plasmids: the pAM beta 1 family from gram-positive bacteria Proc. Natl. Acad Sci USA. 1993. V 90(24) P 11 668−11 672
- Chan P T, Ohmori H., Tomizava J., Lebowitz J. Nucleotide sequence and gene organization of ColEl DNA The Journal of Biological Chemistry. 1985 V 260(15) P. 8925−8935
- Chao L, Levin B R Structured habitats and the evolution of anticompetitor toxins in bacteria Proc. Natl Acad Sci. U S A. 1981. V 78(10) P. 6324−6328
- Chumchalova J., Smarda J Human tumor cells are selectively inhibited by colicins. Folia Microbiol (Praha) 2003 V. 48(1). P. 111−115.
- Cocconcelli P S, Elli M, Riboli B, Morelli L Genetic analysis of the replication region of the Lactobacillus plasmid vector pPSC22 Res Microbiol 1996 V 147(8) P 619−624
- Collins M D, Gibson G R Probiotics, prebiotics, and synbiotics approaches for modulating the microbial ecology of the gut. Am. J. Clin Nutr 1999 V. 69(5) P 1052−1057 Review
- Connell N., Han Z, Moreno F, Kolter R An E coli promoter induced by the cessation of growth Mol Microbiol 1987. V. 1(2) P. 195−201
- Cursino L, Smajs D., Smarda J, Nardi R M, Nicoli J R, Chartone-Souza E, Nascimento A M. Exoproducts of the Escherichia coll strain H22 inhibiting some enteric pathogens both in vitro and in vivo. J. Appl Microbiol 2006 V 100(4). P. 821−829.
- Cursino L, Smarda J., Chartone-Souza E., Nascimento A. Recent updated aspects of colicins of Enterobacteriaceae. Brasil J. Microbiol 2002 V 33. P. 185−195.
- Czaran T.L., Hoekstra R.F. Killer-sensitive coexistence in metapopulations of micro-organisms Proc. Biol Sci. 2003 V. 270(1522) P 1373−1378.
- Czaran T.L., Hoekstra R F., Pagie L. Chemical warfare between microbes promotes biodiversity. Proc. Natl Acad. Sci USA. 2002. V. 99(2) P. 786−790
- Davies J.K., Reeves P. Genetics of resistance to colicins in Escherichia coll K-12: cross-resistance among colicins of group A. J. Bacteriol 1975. V. 123(1) P 102−117
- Delgado M A, Rintoul M R, Farias R N., Salomon R A Escherichia coll RNA polymerase is the target of the cyclopeptide antibiotic microcin J25. J Bacteriol V 183(15) P. 4543−4550
- Destoumieux-Garzon D, Peduzzi J., Rebuffat S Focus on modified microcins structural features and mechanisms of action Biochimie. 2002 V 84(5−6) P. 511−519 Review
- Djordjevic G. M, Klaenhammer T. R Positive selection, cloning vectors for gram-positive bacteria based on a restriction endonuclease cassette Plasmid 1996.V. 35(1) P.37−45.
- Durrett R, Levin S. Allelopathy in Spatially Distributed Populations J Theor Biol. 1997. V 185(2). P. 165−171
- Dykes G A, Hastings J.W. Selection and fitness in bacteriocin-producing bacteria. Proc. Biol. Sci. 1997. V 264(1382) P 683−687.
- Ebina Y., Takahara Y., Kishi F., Nakazawa A., Brent R. LexA protein is a repressor of the colicin El gene J. Biol. Chem. 1983. V. 258(21). P. 13 258−13 261.
- Elmer G.W. Probiotics: «living drugs». Am. J. Health Syst. Pharm. 2001 V 58(12). P. 1101−1109. Review.
- Fang A., Demain A L Influence of aeration and carbon source on production of microcin B17 by Escherichia coh ZK650. Appl. Microbiol Biotechnol. 1997. V. 47(5). P. 547−553.
- Farid-Sabet S. Interaction of I-labeled colicin El with Escherichia coll J Bacterid. 1982 V. 150(3) P. 1383−1390
- Feldgarden M, Golden S, Wilson H., Riley M.A. Can phage defence maintain colicin plasmids in Escherichia colli Microbiology. 1995 V. 141(11) P. 29 772 984.
- Feldgarden M, Riley M A. High levels of colicin resistance in Escherichia coh. Evolution 1998. V. 52. P. 1270−1276
- Feldgarden M, Riley M A The phenotypic and fitness effects of colicin resistance in Escherichia coh K-12 Evolution 1998 V. 53 P. 1019−1027
- Finlay B B, Frost L S, Paranchych W Localization, cloning, and sequence determination of the conjugative plasmid ColB2 pilin gene. J. Bactenol 1984 V. 160(1) P 402−407
- Finnegan J, Sherratt D Plasmid ColEl conjugal mobility: the nature of bom, a region required in cis for transfer. Mol Gen Genet. 1982. V 185(2) P. 344 351
- Frank S Spatial polymorphism of bactenocins and other allelopathic traits Evol Ecol 1994 V 8 P 369−386
- Franz C M, Holzapfel W H, Stiles M E Enterococci at the crossroads of food safety7 Int J Food Microbiol 1999. V. 47(1−2) P. 1−24. Review.
- Fredericq F. Colicins. Annu. Rev Microbiol 1957. V. 11 P 7−22
- Fuller R Probiotics in man and animals J. Appl. Bacteriol 1989 V. 66(5) P 365−378. Review.
- Fuqua C., Parsek M R., Greenberg E P. Regulation of gene expression by cell-to-cell communication: acyl-homoserine lactone quorum sensing Annu Rev Genet 2001. V. 35. P. 439−468 Review.
- Garcia-Bustos J.F., Pezzi N., Mendez E. Structure and mode of action of micro-cin 7, an antibacterial peptide produced by Escherichia coh Antimicrob Agents Chemother. 1985. V. 27(5). P. 791−797.
- Garrido M.C., Herrero M, Kolter R, Moreno F. The export of the DNA replication inhibitor Microcin B17 provides immunity for the host cell. EMBO J. 1988. V. 7(6) P. 1853−1862.
- Genilloud 0., Moreno F, Kolter R. DNA sequence, products, and transcriptional pattern of the genes involved in production of the DNA replication inhibitor microcin B17. J. Bacteriol. 1989. V. 171(2) P.1126−1135.
- Gonzalez-Pastor J.E., San Millan J L, Castilla M A, Moreno F. Structure and organization of plasmid genes required to produce the translation inhibitor microcin C7. J. Bacteriol. 1995. V. 177(24) P.7131−7140.
- Gorbach S L. Probiotics and gastrointestinal health. Am J. Gastroenterol 2000. V 95(1) P. 2−4
- Gordon D. M, O’Brien C L Bacteriocin diversity and the frequency of multiple bacteriocin production in Escherichia coli Microbiology. 2006. V 152(11) P 3239−3244.
- Gordon D. M, Riley M A, Pinou T. Temporal changes in the frequency of colicinogeny in Escherichia coli from house mice Microbiology. 1998 V. 144(8) P. 2233−2240
- Gordon D M, Riley M A. A theoretical and empirical investigation of the invasion dynamics of colicinogeny Microbiology. 1999 V 145(3) P. 655−661
- Groisman E A, Casadaban M J Mini-mu bacteriophage with plasmid replicons for in vivo cloning and lac gene fusing J Bacteriol. 1986 V 168(1) P 357 364
- Grompone G, Bidnenko V, Ehrlich S.D., Michel B PriA is essential for viability of the Escherichia coli topoisomerase IV parE10(Ts) mutant J. Bacteriol 2004 V 186(4) P 1197−1199
- Grozdanov L., Raasch C., Schulze J., Sonnenborn U., Gottschalk G, Hacker J., Dobrindt U. Analysis of the genome structure of the nonpathogenic probiotic Escherichia coli strain Nissle 1917. J. Bacteriol 2004 V. 186(16) P 54 325 441.
- Hardy KG. Cohcinogeny and related phenomena Bacteriol Rev 1975 V 39(4) P. 464−515. Review
- Harkness R E., Braun V. Colicin M inhibits peptidoglycan biosynthesis by interfering with lipid carrier recycling J Biol. Chem 1989. V 264(11). P. 61 776 182.
- Hernandez-Chico C, San Millan J. L, Kolter R, Moreno F Growth phase and ompR regulation of transcription of microcin B17 genes J Bacteriol 1986 V. 167(3). P. 1058−1065.
- Herrero M., Moreno F Microcin B17 blocks DNA replication and induces the SOS system in Escherichia coli J Gen Microbiol. 1986. V. 132(2) P. 393−402.
- Housden N G., Loftus S.R., Moore G R., James R., Kleanthous C Cell entry mechanism of enzymatic bacterial colicins: porin recruitment and the thermodynamics of receptor binding. Proc. Natl Acad Sci. U S A. 2005 V. 102(39) P 13 849−13 854.
- Itoh T., Tomizawa J. Formation of an RNA primer for initiation of replication of ColEl DNA by ribonuclease H Proc. Natl. Acad. Sci USA. 1980 V. 77(5). P. 2450−2454.
- James R, Kleanthous C, Moore G R The biology of E colicins paradigms and paradoxes Microbiology 1996 V 142. P 1569−1580.
- Kerr B., Riley M A, Feldman M.W., Bohannan B J Local dispersal promotes biodiversity in a real-life game of rock-paper-scissors. Nature 2002 V 418(6894) P.171−174
- Klaenhammer T R Bacteriocins of lactic acid bacteria. Biochimie. 1988. V. 70. P 337−349
- Klaenhammer T R Probiotic bacteria today and tomorrow J Nutr. 2000 V 130(2) P 415−416 Review
- Kleerebezem M Quorum sensing control of lantibiotic production, nisin and subtilin autoregulate their own biosynthesis. Peptides. 2004. V 25(9) P. 14 051 414 Review
- Kolter R, Moreno F Genetics of ribosomally synthesized peptide antibiotics Annu Rev Microbiol 1992 V 46 P. 141−163
- Lakey JH, Slatin S.L. Pore-forming colicins and their relatives Curr Top Microbiol Immunol. 2001. V. 257 P. 131−161
- Lavina M., Gaggero C, Moreno F. Microcin H47, a chromosome-encoded microcin antibiotic of Escherichia coh J. Bacteriol. 1990. V 172(11) P. 65 856 588.
- Lavina M., Pugsley AP., Moreno F. Identification, mapping, cloning and characterization of a gene (sbmA) required for microcin B17 action on Escherichia coh K12 J. Gen. Microbiol 1986. V. 132(6) P. 1685−1693.
- Lazdunski C, Bouveret E., Rigal A, Journet L., Lloubes R, Benedetti II Colicin import into Escherichia coh cells requires the proximity of the inner membranes and others factors. Int. J. Med. Microbiol. 2000 V 290. P. 337−344
- Lenski R.E., Riley M. A Chemical warfare from an ecological perspective Proc Natl. Acad. Sci USA 2002. V. 99(2) P 556−558.
- Lindeberg M, Cramer W A Identification of specific residues in colicin El involved in immunity protein recognition. J. Bacteriol 2001 V. 183(6) P 21 322 136
- Liu J Microcin B17* posttranslational modifications and their biological implications Proc. Natl Acad. Sci USA. 1994. V. 91(11) P. 4618−4620. Review
- Lomovskaya O, Kawai F, Matin A. Differential regulation of the mcb and emr operons of Escherichia coll role of mcb in multidrug resistance. Antimicrob Agents Chemother 1996 V.40(4) P. 1050−1052
- Lomovskaya O, Lewis K, Matin A EmrR is a negative regulator of the Escherichia coli multidrug resistance pump EmrAB J. Bacteriol. 1995. V. 177(9) P 2328−2334
- Lotz W Effect of guanosine tetraphosphate on in vitro protein synthesis directed by El and E3 colicinogenic factors J Bacteriol. 1978 V. 135. P 707−712
- Lu F M, Chak K F Two overlapping SOS boxes in ColEl operon are responsible for the viability of cells harboring the Col plasmid Mol Gen Genet 1996. V 251 P 407−411
- Luoma S., Peltoniemi K, Joutsjoki V, Rantanen T, Tamminen M, Heikkinen I., Palva A. Expression of six peptidases from Lactobacillus helveticus in Lacto-coccus lactis. Appl Environ Microbiol. 2001. V 67(3). P. 1232−1238
- Madison L L, Vivas E.I., Li Y M., Walsh C.T., Kolter R. The leader peptide is essential for the post-translational modification of the DNA-gyrase inhibitor mi-crocinBl 7. Mol. Microbiol 1997. V. 23(1). P 161−168
- Majamaa H., Isolauri E Probiotics- a novel approach in the management of food allergy. J. Allergy Clin Immunol 1997. V. 99(2) P 179−185.
- Mao W., Siegele D.A. Genetic analysis of the stationary phase-induced mcb op-eron promoter in Escherichia coli. Mol Microbiol. 1998. V. 27(2) P. 415−424.
- Martinez J.L., Perez-Diaz J.C. Isolation, characterization, and mode of action on Escherichia coli strains of microcin D93. Antimicrob. Agents Chemother. 1986. V. 29(3). P 456−460.
- McCracken A., Turner MS, Giffard P., Hafner L.M., Timms P Analysis of promoter sequences from Lactobacillus and Lactococcus and their activity in several Lactobacillus species. Arch Microbiol. 2000 V. 173(5−6) P 383−389.
- Metchnikoff E The Prolongation of Life: Optimistic Studies Mitchell C. edited London: W Heinemann 1907 P. 161−183.
- Michiels J, Dirix G, Vanderleyden J, Xi C. Processing and export of peptide pheromones and bactenocins in Gram-negative bacteria Trends Microbiol. 2001 V. 9(4) P. 164−168. Review
- Montalto M., Arancio F., Izzi D., Cuoco L, Curigliano V., Manna R, Gasbarrini G. Probiotics: history, definition, requirements and possible therapeutic applications. Ann. Ital Med. Int 2002. V. 17(3) P. 157−165 Review.
- Moreno F., Gonzalez-Pastor J.E., Baquero M.R., Bravo D 1 he regulation of mi-crocin B, C and J operons Biochimie. 2002. V. 84(5−6). P. 521−529 Review
- Mrda Z., Zivanovic M, Rasic J., Gajin S., Somer L., Trbojevic S, Majoros J., Petrovic Z. Therapy of Helicobacter pylori infection using Lactobacillus acidophilus. Med Pregl. 1998 V. 51(7−8) P 343−345.
- Neu HC The crisis in antibiotic resistance. Science 1992. V 257(5073) P 1064−1073. Review
- O’Brien G.J., Chambers S. T, Peddie B., Mahanty H K. The association between colicinogenicity and pathogenesis among uropathogenic isolates of Escherichia coli. Microb. Pathog. 1996 V. 20(3). P. 185−190.
- Ozeki E.T., Stocker H., De Margerie H. Production of colicin by single bacteria Nature. 1959. V. 184. P. 337−339.
- Pagie L., Hogeweg P. Colicin diversity: a result of eco-evolutionary dynamics J. Theor. Biol. 1999. V. 196(2). P. 251−261
- Pavlova S I., Kilic A O, Topisirovic L, Miladinov N., Hatzos C., Tao L. Characterization of a cryptic plasmid from Lactobacillus fermentum KC5b and its use for constructing a stable Lactobacillus cloning vector. Plasmid. 2002 V 47(3) P. 182−192
- Petering D H, Byrnes R W, Antholine W E. The role of redox-active metals in the mechanism of action of bleomycin. Chem Biol. Interact 1990. V. 73(2−3) P 133−182. Review.
- Pierrat OA, Maxwell A Evidence for the role of DNA strand passage in the mechanism of action of microcin B17 on DNA gyrase Biochemistry. 2005 V. 44(11) P. 4204−4215.
- Pinou T, Riley MA Nucleotide polymorphism in microcin V plasmids Plasmid 2001 V 46(1) P 1−9
- Poey ME, Azpiroz MF, Lavma M Comparative analysis of chromosome-encoded microcins Antimicrob Agents Chemother. 2006. V. 50(4) P. 14 111 418
- Pons A M, Lanneluc I, Cottenceau G, Sable S. New developments in non-post translationally modified microcins Biochimie 2002 V 84 P. 531−537
- Pouwels P.H., Leer R.J., Boersma W.J. The potential of Lactobacillus as a carrier for oral immunization' development and preliminary characterization of vector systems for targeted delivery of antigens J. Biotechnol. 1996 V 44(1−3) P 183−192.
- Reeves P. The bacteriocins. Bacterid. Rev. 1965. V. 29. P 24−45 Review
- Rembacken BJ., Snelling AM., Hawkey PM, Chalmers DM, Axon AT Non-pathogenic Escherichia coll versus mesalazine for the treatment of ulcerative colitis: a randomised trial. Lancet. 1999 V 354(9179) P. 635−639
- Riley M.A., Gordon D. M The ecological role of bacteriocins in bacterial competition Trends Microbiol. 1999 V 7(3). P. 129−133 Review.
- Riley M A. Molecular mechanisms of bacteriocin evolution Ann Rev Microbiol. 1998.V. 32 P. 255−278.4
- Riley M. A, Gordon DMA survey of Col plasmids in natural isolates of Escherichia coli and an investigation into the stability of Col-plasmid lineages J. Gen. Microbiol. 1992. V. 138(7) P. 1345−1352.
- Riley M. A, Wertz J.E. Bacteriocins: evolution, ecology, and application. Annu Rev. Microbiol. 2002. V. 56 P. 117−137 Review.
- Riley M A, Pinou T, Wertz J. E, Tan Y, Valletta C M Molecular characterization of the klebicin B plasmid of Klebsiella pneumoniae. Plasmid 2001. V. 45(3) P 209−221
- Riley MA, Tan Y, Wang J Nucleotide polymorphism in colicin El and la plasmids from natural isolates of Escherichia coli. Proc Natl Acad Sci. USA. 1994 V. 91(23) P. 11 276−11 280
- Riley M A Molecular mechanisms of colicin evolution. Mol Biol. Evol. 1993 V 10(6) P 1380−1395
- Riley M A Positive selection for colicin diversity in bacteria. Mol Biol Lvol 1993 V 10(5) P 1048−1059
- Riley, M A, Gordon, D M The ecology and evolution of bacteriocins J Ind Microbiol 1996 V 17 P 151−158
- Rodriguez-Sainz MC., Hernandez-Chico C., Moreno F A his Tn5 mutation affects production of microcins B17, C7, and H47 and colicin V J Bactenol 1991. V. 173(21). P. 7018−7020.
- Rodriguez-Sainz M. C, Hernandez-Chico C., Moreno F Molecular characterization of pmhA, an Escherichia coli chromosomal gene required for the production of the antibiotic peptide MccBl 7. Mol Microbiol. 1990. V. 4(11) P 1921−1932
- Sabik J.F., Suit J L., Luria S E. cea-kil operon of the ColEl plasmid J Bacteriol. 1983 V. 153(3). P. 1479−1485
- Salles B., Weisemann J.M., Weinstock G.M. Temporal control of colicin El induction J. Bacteriol 1987. V 169. P. 5028−5034.
- San Millan J. L, Hernandez-Chico C, Pereda P, Moreno F Cloning and mapping of the genetic determinants for microcin B17 production and immunity J Bacteriol. 1985. V. 163(1) P. 275−281.
- San Millan J.L., Kolter R, Moreno F. Evidence that colicin X is microcin B17 J. Bacteriol. 1987. V 169(6) P. 2899−2901.
- San Millan J. L, Kolter R, Moreno F. Plasmid genes required for microcin B17 production J. Bacteriol 1985. V 163(3). P 1016−1020.
- Sano Y, Matsui H, Kobayashi M, Kageyama M Molecular structures and functions of pyocins SI and S2 in Pseudomonas aeruginosa. J. Bacteriol 1993. V 175(10). P. 2907−2916
- Saunders SE, Burke J F. Rapid isolation of miniprep DNA for strand se-quensing Nucl. Aci Research 1990. V. 18(16). P. 4948
- Smajs D., Pilsl H, Braun V Colicin U, a novel colicin produced by Shigella boydu J Bactenol 1997. V 179(15). P 4919−4928.
- Smarda J, Smajs D Colicins exocellular lethal proteins of Escherichia coli Fol Microbiol 1998 V 43 P 563−582.
- Smarda J, Smajs D Colicins exocellular lethal proteins of Escherichia coli. Fol Microbiol 1998 V 43 P 563−582.
- Strobel M, Nomura M Restriction of the growth of bacteriophage BF23 by a colicine I (col I-P9) factor Virology. 1966 V. 28(4). P. 763−765.
- Sullivan A, Edlund C, Nord C E Effect of antimicrobial agents on the ecological balance of human microflora Lancet Infect. Dis 2001. V. 1(2). P 101−114 Review
- Sullivan A, Nord C E Probiotics in human infections J Antimicrob. Chemother 2002 V 50(5) P 625−627 Review164165166167.168 169,170.171.172 173 174 175 176 192
- Szajewska H., Kotowska M, Mrukowicz J Z., Armanska M, Mikolajczyk W Efficacy of Lactobacillus GG in prevention of nosocomial diarrhea in infants J Pediatr 2001. V 138(3). P. 361−365
- Vaughan E E, Mollet B. Probiotics in the new millennium Nahrung 1999. V 43(3) P. 148−153 Review
- Vieira J., Messing J The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers Gene 19 821. V 19(3) P 259−268
- Vizan J L, Hernandez-Chico C, del Castillo I, Moreno F. The peptide antibiotic microcin B17 induces double-strand cleavage of DNA mediated by E coll DNA gyrase EMBO J 1991 V 10(2) P. 467−476
- Vollaard E J, Clasener H A Colonization resistance. Antimicrob Agents Chemother 1994 V 38(3) P 409−414 Review.
- Waters V.L., Crosa J.H. Colicin V virulence plasmids Microbiol Rev 1991 V 55(3). P. 437−450 Review.
- Womble D D, Rownd R H Genetic and physical map of plasmid NR1 comparison with other IncFII antibiotic resistance plasmids Microbiol Rev 1988 V 52(4). P. 433−451. Review.
- Xiong A., Gottman A., Park C, Baetens M., Pandza S, Matin A The EmrR protein represses the Escherichia coli emrRAB multidrug resistance operon by directly binding to its promoter region Antimicrob. Agents Chemother. 2000 V 44(10) P. 2905−2907
- Yamada M., Ebina Y., Miyata T, Nakazawa T., Nakazawa A Nucleotide sequence of the structural gene for colicin El and predicted structure of the protein. Proc. Natl. Acad. Sei USA 1982. V. 79(9) P. 2827−2831.
- Yorgey P., Davagnino J, Kolter R. The maturation pathway of microcin B17, a peptide inhibitor of DNA gyrase Mol Microbiol. 1993. V. 9(4). P. 897−905
- Yorgey P., Lee J., Kordel J., Vivas E., Warner P., Jebaratnam D., Kolter R Post-translational modifications in microcin B17 define an additional class of DNA gyrase inhibitor. Proc Natl. Acad. Sei USA. 1994. V 91(10) P. 4519−4523
- Zhang SP., Yan LF, Zubay G. Regulation of gene expression in plasmid ColEl: delayed expression of the hi gene. J. Bacteriol. 1988. V. 170(12) P. 5460−5467.
- Zmder N D Resistance to colicins E3 and K induced by infection with bacteriophage fl Proc Natl Acad Sei. U S A 1973 V. 70(11) P 3160−31 641*Π΅Ρ Π ΡΠ°ΠΉΡ I1. V12411. Π‘ΠΎ1Π1 6646 ΠΏ.Π½. «Π³ΡΡΡΠΎ Π1. ΠΡ1ΠΠ111. Π*ΡΠ 18 411. ΠΠ·ΡΠ!1. Π¬Π΅Ρ Π ΡΠ°ΠΉΡ1. Π―Π« 33 761. Π1ΠΈ| 2491