Липидный спектр сыворотки крови и полиморфизм генов-кандидатов дислипидемии в пожилом и старческом возрасте
Диссертация
Практическая значимость работы обусловлена гериатрическими аспектами исследования факторов риска нарушений липидного гомеостаза. Полученные в настоящем исследовании данные могут быть использованы как исходные для формирования региональных референтных показателей липидного спектра сыворотки крови в пожилом и старческом возрасте. Возможно использование полученных результатов для прогнозирования… Читать ещё >
Содержание
- Список сокращений и обозначений
- Введение
- Глава 1. Обзор литературы
- 1. 1. Фенотипические проявления старения
- 1. 2. Причины и механизмы старения: основные гипотезы
- 1. 3. Метаболические основы возрастных изменений липидного спектра крови и старение
- 1. 4. Дислипидемии: ассоциации с сердечно-сосудистыми заболеваниями и смертностью в пожилом и старческом возрасте
- 1. 5. Молекулярно-генетические основы старения
- Глава 2. Материалы и методы исследования
- 2. 1. Материалы исследования
- 2. 2. Методы исследования
- 2. 2. 1. Методы определения концентраций липидов в сыворотке крови.47^
- 2. 2. 2. Фенотипирование дислипидемий
- 2. 2. 3. Выделение ДНК из венозной крови человека
- 2. 2. 4. Амплификация полиморфных ДНК-локусов
- 2. 2. 5. Электрофорез амплифицированных фрагментов ДНК
- 2. 3. Статистическая обработка результатов исследования
- Глава 3. Результаты исследования
- 3. 1. Анализ липидного спектра сыворотки крови в разных возрастных группах
- 3. 2. Полиморфизм в экзоне 4 гена АРОЕ в популяции татар: ассоциации с возрастом и концентрацией липидов
- 3. 3. Полиморфизм Q192R генаР (97У7 в популяции татар: ассоциации с возрастом и концентрацией липидов
- 3. 4. Полиморфизм 1405Vгена СЕТР в популяции татар: ассоциации с возрастом и концентрацией липидов
- Глава 4. Обсуждение результатов исследования
- Выводы
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