Разработка биосовместимого композиционного матриксного гидрогеля для реконструктивной терапии травм центральной нервной системы
Диссертация
Восстановление утраченных функций спинного и головного мозга существующими фармакологическими средствами не представляется возможным из-за очень низкой способности нервной ткани к регенерации. В области травмы спинного мозга формируется плотный глио-мезодермальный рубец, который вместе с биохимическими ингибирующими факторами препятствует росту регенерирующих аксонов (Брюховецкий А.С., 2010… Читать ещё >
Содержание
- СПИСОК СОКРАЩЕНИЙ
- 1. ОБЗОР ЛИТЕРАТУРЫ
- 1. 1. Структура и функции внеклеточного матрикса
- 1. 2. Взаимодействие внеклеточного матрикса и клеток
- 1. 3. Особенности внеклеточного матрикса ниш стволовых клеток
- 1. 4. Матрикс-опосредованное управление ростом и дифференцировкой клеток
- 1. 5. Внеклеточный матрикс центральной нервной системы
- 1. 6. Искусственные матриксные материалы для нейротрансплантации
- 1. 7. Реконструктивная терапия спинальных травм
- 2. МАТЕРИАЛЫ И МЕТОДЫ
- 2. 1. Выделение и очистка биополимеров — компонентов матриксных материалов
- 2. 1. 1. Получение и анализ модифицированных пектинов
- 2. 1. 2. Выделение коллагена I типа
- 2. 1. 3. Выделение и очистка димеров коллагена IV типа
- 2. 1. 4. Маркирование NCl-гексамеров коллагена IV флуоресцеина-5-изотиоцианатом
- 2. 1. 5. Определение содержания белка микробиуретовым методом
- 2. 1. 6. Анализ белковых препаратов с помощью гель-электрофореза в присутствии додецилсульфата натрия (ДСН) 40 2.1.7- Исследование морфологии молекул биополимеров методом атомно-силовой микроскопии
- 2. 2. Приготовление матриксных материалов
- 2. 2. 1. Приготовление матриц на стеклянной подложке
- 2. 2. 2. Приготовление матриксных материалов в форме гидрогелей
- 2. 2. 3. Приготовление коллагеновых мембран
- 2. 3. Исследование свойств матриксных материалов in vitro
- 2. 3. 1. Получение и культивирование нейральных стволовых клеток
- 2. 3. 2. Культивирование нейральных стволовых клеток на поверхности матриксных материалов
- 2. 4. Исследование свойств матриксных материалов in vivo
- 2. 4. 1. Подкожная имплантация матриксных материалов
- 2. 4. 2. Имплантация матриксных гидрогелей в качестве консолидирующих субстратов в модели травмы спинного мозга
- 2. 1. Выделение и очистка биополимеров — компонентов матриксных материалов
- 3. 1. Физико-химические свойства компонентов матриксных материалов
- 3. 1. 1. Анализ препаратов модифицированных пектинов
- 3. 1. 2. Анализ препарата коллагена I типа
- 3. 1. 3. Анализ препарата NCl-гексамеров коллагена IV
- 3. 2. Исследование функциональных свойств компонентов матриксных материалов
- 3. 2. 1. Анализ поведения нейральных стволовых клеток на полисахаридных и белковых субстратах
- 3. 2. 2. Анализ поведения нейральных стволовых клеток при культивировании на микроструктурированных матрицах
- 3. 3. Разработка композиционного матриксного материала
- 3. 4. Свойства матриксных гидрогелей in vitro
- 3. 5. Исследование биосовместимости биополимерных матриксов in vivo
- 3. 6. Исследование функциональных свойств матриксных гидрогелей на модели
- 4. 1. Модифицированные пектины обратимо ингибируют дифференцировку нейральных стволовых клеток в культуре
- 4. 2. Использование микроструктурированных матриксных материалов для создания имплантируемых конструкций и анализа свойств биополимеров in vitro
- 4. 3. Разработка композитного матриксного гидрогеля
- 4. 4. Гидрогели на основе пектинов и коллагенов являются биосовместимыми медленно деградируемыми матриксными композициями
- 4. 5. Имплантация композиционого гидрогеля в качестве консолидирующего субстрата в модели острой травмы спинного мозга способствует нейрорегенерации травмы спинного мозга
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