Роль внутриклеточных Ca2+-буферов в регуляции секреции медиатора
Диссертация
Установлен ранее не известный факт, что EGTA избирательно и эффективно подавляет акты одиночного вызванного выброса медиатора АХ. Впервые показано, что Са2±зависимый процесс начального облегчения при ритмической работе синапсов избирательно чувствителен к действию быстрого буфера ВАРТА. Выявлена ранее не известная способность EGTA разобщать сопряжение между входящим по L-типу Саканалов кальцием… Читать ещё >
Содержание
- СПИСОК ИСПОЛЬЗОВАННЫХ СОКРАЩЕНИЙ
- ОБЩАЯ ХАРАКТЕРИСТИКА РАБОТЫ
- ОБЗОР ЛИТЕРАТУРЫ
- 1. Са2+ сигналы в нейронах и нервных терминалях
- 1. 1. «Са2±нанодомен» и «Са2±микродомен»
- 1. 2. Са2±домены Са2±каналов L-типа
- 1. 3. Са2±домены вокруг РиР
- 2. Мишени Са2±сигналов в терминалях синапсов
- 3. Эндогенные Са2±связывающие буферные белки и их роль в регуляции секреции медиатора
- 3. 1. Общая характеристика эндогенных Са -буферов
- 3. 2. Сопоставление эндогенных Са2±буферов с экзогенными
- 4. Экзогенные Са2±буферы и их роль в модуляции Са2±сигналов в синапсах
- 4. 1. Физико-химические свойства ВАРТА и EGTA
- 4. 2. ВАРТА и EGTA как модуляторы Са -доменов
- 4. 3. Роль ВАРТА и EGTA в оценке действующих на везикулы Са2±сигналов
- 4. 4. ВАРТА и EGTA как модуляторы Са -сигналов от Са -каналов L-типа и рианодиновых рецепторов
- 4. 4. 1. Са2±буферы и Са2±домены Са2±каналов L-типа
- 4. 4. 2. Са2±буферы и Са2±домены РиР
- 6. 1. Одиночная активность синапсов
- 6. 2. Ритмическая активность синапсов
- 6. 2. 1. Са2±зависимое облегчение передачи и роль Са2±буферов
- 6. 2. 2. Регуляция фазы депрессии и фазы плато в залпе с участием Са -буферов
- 1. 1. Влияние ВАРТА-АМ на параметры одиночной активности синапсов
- 1. 2. Влияние EGTA-AM на параметры одиночной активности синапсов
- 2. 1. Частотозависимое изменение параметров ритмической активности
- 2. 2. Частотозависимое влияние ВАРТА-АМ на параметры ритмической активности
- 2. 3. Дозозависимое влияние ВАРТА-АМ на параметры ритмической активности
- 3. 1. Влияние S (-) BAY К 8644 на параметры одиночной активности синапсов при нагрузке ВАРТА-АМ и EGTA-AM
- 3. 2. Влияние S (-) BAY К 8644 на параметры ритмической активности на фоне ВАРТА-АМ и EGTA-AM
- 4. 1. Влияние кофеина на параметры вызванной активности синапсов при нагрузке ВАРТА-АМ и EGTA-AM
- 4. 1. 1. Влияние кофеина на параметры одиночной активности синапсов при нагрузке ВАРТА-АМ и EGTA-AM
- 4. 1. 2. Влияние кофеина на параметры ритмической активности синапсов при нагрузке ВАРТА-АМ и EGTA-AM
- 4. 2. Влияние рианодина на параметры вызванной активности синапсов при нагрузке ВАРТА-АМ и EGTA-AM
- 4. 2. 1. Влияние рианодина на параметры одиночной активности синапсов при нагрузке ВАРТА-АМ и EGTA-AM
- 4. 2. 2. Влияние рианодина на параметры ритмической активности синапсов при нагрузке ВАРТА-АМ и EGTA-AM
- 6. 1. Влияние кофеина и рианодина на параметры спонтанной активности синапса
- 7. 1. Влияние везамикола и бафиломицина Al на параметры спонтанной активности
- 7. 1. 1. Влияние везамикола на параметры спонтанной активности
- 7. 1. 2. Влияние бафиломицина Al на параметры спонтанной активности
- 7. 2. Влияние везамикола и бафиломицина Al на параметры спонтанной активности синапса при действии рианодина
- 8. 1. Влияние кальмидазола (R2457) на параметры спонтанной активности синапса при действии рианодина
- 8. 2. Влияние KN-93 на параметры спонтанной активности синапса при действии рианодина
Список литературы
- Балезина О. П, Богачева П. О. Подавление секреции медиатора с участием2+
- Са -каналов Г-типа и рианодиновых рецепторов в новообразованных синапсах мыши. // Известия РАН. Серия биологическая. 2009. — №. 5. — С. 591−597.
- Балезина О.П., Букия А. Н. Ритмическая активность нервно-мышечных синапсов мыши при активации выброса депонированного кальция в присутствии кальциевого буфера // Нейрофизиология. — 2005. — Т. 37, № 4. — С. 330−338.
- Балезина О.П., Букия А. Н., Лаптева В. И. Вызванная активность нервно-мышечных синапсов мыши на фоне действия дантролена и рианодина // Российский физиологический журнал им. И. М. Сеченова. 2001. — Т. 87, № 11. — С. 1511−151
- Балезина, О. П. Роль внутриклеточных кальциевых каналов нервных терминалей в регуляции секреции медиатора // Успехи физиологических наук. -2002.-Т. 33, № 3.-С. 38−56
- Гайдуков А. Е, Балезина О. П. Потенциирующее действие аллатостатина на квантовую секрецию медиатора в нервно-мышечном синапсе мыши // Журнал эволюционной биохимии и физиологии. 2006 — Т. 42- № 6. — С. 554−558.
- Зефиров А.Л., Мухамедьяров М. А. Механизмы кратковременных форм синаптической пластичности // Российский Физиологический Журнал им. Сеченова-2004-Т. 90, № 8. С. 1041−59.
- Каменская М.А. Современные представления о механизме квантового освобождения медиатора из моторных нервных окончаний скелетной мышцы. // Усп. Физиол. Наук 1972 — Т. З, № 3. — С. 22−63.
- Машковский М.Д. Лекарственные средства. В 2-х т. // М.: Медицина 1977 -Т. 1 — С. 127.
- Сурова Н.В. Регуляция активности нервно-мышечных синапсов мыши внутриклеточным депонированным кальцием, мобилизируемым кофеином и рианодином // Автореф. канд-та биол. Наук. 1999 — М: МГУ, С. 10−15
- Харкевич Д.А. Фармакология // М.: Медицина 1986 — С. 125.
- Adermark L., Lovinger D.M. Combined activation of L-type Ca2+ channels and synaptic transmission is sufficient to induce striatal long-term depression // J Neurosci. -2007 V. 27- № 25. — P. 6781−7.
- Adler E.M., Augustine G.F., Duffy S.N., Charlton M.P. Alien intracellular calcium chelators attenuate neurotransmitter release at the squid synapse // J. Neurosci -1991 -V.I.- P. 1496−1507.
- Alpar A., Attems J., Mulder J., Hokfelt Т., Harkany T. The renaissance of Ca (2+)-binding proteins in the nervous system: secretagogin takes center stage // Cell Signal. -2012 V.24- № 2. — P. 378−387.
- Angleson J.K., Betz W.J. Intraterminal Ca2+ and spontaneous transmitter release at the frog neuromuscular junction // J Neurophysiol. 2001 — V.85- № 1. — P. 287−94.
- Atchison W.D., O’Leary S.M. BAY К 8644 increases release of acetylcholine at the murine neuromuscular junction // Brain Res. 1987 — V. 419- № 1−2. — P. 315−319.
- Augustine G.J., Santamaria F., Tanaka K. Local calcium signaling in neurons // Neuron. 2003 — V.40- № 2. — P. 331−46.
- Baimbridge K.G., Celio M.R., Rogers J.H. Calcium-binding proteins in the nervous system // Trends Neurosci. 1992 — V. 15- № 8. — P. 303−8.
- Beaumont V., Llobet A., Lagnado L. Expansion of calcium microdomains regulates fast exocytosis at a ribbon synapse // Proc Natl Acad Sci USA.- 2005 -V.102- № 30. P. 10 700−5.
- Berridge M.J. Calcium microdomains: organization and function // Cell Calcium. -2006 V. 40- № 5−6. — P. 405−12.
- Berrout J., Isokawa M. Homeostatic and stimulus-induced coupling of the L-type Ca channel to the ryanodine receptor in the hippocampal neuron in slices // Cell Calcium. 2009 — V. 46- № 1. — P. 30−8.
- Bertram R. A simple model of transmitter release and facilitation // Neural Comput. 1997- V.9- № 3. — P. 515−23.
- Betz A., Ashery U., Rickmann M., Augustin I., Neher E., Siidhof T.C., Rettig J., Brose N. Muncl3−1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release // Neuron 1998 — V.21- № 1. — P. 123−36.
- Blatow M., Caputi A., Burnashev N., Monyer H., Rozov A. Ca buffer saturation underlies paired pulse facilitation in calbindin-D28k-containing terminals // Neuron-2003 -V.38.-P. 79−88.
- Bootman M.D., Lipp P., Berridge M.J. The organisation and functions of local Ca2+ signals // J Cell Sci 2001 — V. 114- № 12. — P. 2213−22.
- Borst J.G., Sakmann B. Effect of changes in action potential shape on calcium currents and transmitter release in a calyx-type synapse of the rat auditory brainstem // Philos Trans R Soc Lond B Biol Sci. 1999 — V. 28- № 354(1381). — P. 347−55.
- Borst J.G.G., Sakmann B. Calcium influx and transmitter release in a fast CNS synapse//Nature 1996-V. 383. — P. 431−434.
- Bortolozzi M., Lelli A., Mammano F. Calcium microdomains at presynaptic active zones of vertebrate hair cells unmasked by stochastic deconvolution // Cell Calcium. -2008 V.44- № 2. — P.158−68
- Bouchard R., Pattarini R., Geiger J.D. Presence and functional significance of presynaptic ryanodine receptors // Prog Neurobiol. 2003 — V.69- № 6. — P. 391−418.
- Brandt A., Striessnig J., Moser T. Cav1.3 channels are essential for development and presynaptic activity of cochlear inner hair cells // J Neurosci. 2003 — V.23- № 34. -P.10 832−40.
- Brans D., Riedel D., Klingauf J., Jahn R. Quantal release of serotonin // Neuron -2000-V. 28- № 1 P. 205−20.
- Budde T., Sieg F., Braunewell K.H., Gundelfmger E.D., Pape H.C. Ca2±induced Ca release supports the relay mode of activity in thalamocortical cells // Neuron. 2000 -V. 26- № 2.-P. 483−92.
- Burgoyne R.D., Weiss J.L. The neuronal calcium sensor family of Ca2±binding proteins // Biochem J. 2001 — V. 353- № 1 — P. 1−12.
- Burnashev N., Rozov A. Presynaptic Ca2+ dynamics, Ca2+ buffers and synaptic efficacy // Cell Calcium. 2005 — V. 37- № 5. — P. 489−95.
- Burrone J, Lagnado L. Synaptic depression and the kinetics of exocytosis in retinal bipolar cells // J Neurosci. 2000 — V. 20- № 2. — P. 568−78.
- Burrone J., Neves G., Gomis A., Cooke A., Lagnado L. Endogenous calcium buffers regulate fast exocytosis in the synaptic terminal of retinal bipolar cells // Neuron. 2002 — V. 33- № 1. -P. 101−12.
- Bykhovskaya M., Polagaeva E., Hackett J.T. Mechanisms underlying different facilitation forms at the lobster neuromuscular synapse // Brain Res.- 2004 V. 1019. — P. 10−21.
- Caillard O., Moreno H., Schwaller B., Llano I., Celio M.R., Marty A. Role of the calcium-binding protein parvalbumin in short-term synaptic plasticity // Proc Natl Acad Sci USA.- 2000 V. 21- № 97(24). — P. 13 372−7.
- Carter A.G., Vogt K.E., Foster K.A., Regehr W.G.Assessing the role of calcium-induced calcium release in short-term presynaptic plasticity at excitatory central synapses //J Neurosci. 2002 — V. 1- № 22(1).-P.21−8.
- Castonguay A., Robitaille R. Xestospongin C is a potent inhibitor of SERCA at a vertebrate synapse // Cell Calcium. 2002 — V. 32- № 1. — P. 39−47.
- Catterall W.A., Few A.P. Calcium channel regulation and presynaptic plasticity // Neuron. 2008 — V. 59- № 6. — P. 882−901.
- Celenza K.M., Shugert E., Velez S.J.Depressing effect of caffeine at crayfish neuromuscular synapses II. Initial search for possible sites of action // Cell Mol Neurobiol. 2007 — V. 27- № 3. — P. 381−93.
- Chen C., Regehr W.G. Contributions of residual calcium to fast synaptic transmission // J Neurosci. 1999 -V. 1- № 19(15). — P. 6257−66.
- Cheng H., Lederer W.J., Cannell M.B., Calcium sparks—elementary events underlying excitation-contraction coupling in heart-muscle // Science 1993 — V. 262 -P.740−744.
- Cheung W.Y. Calmodulin plays a pivotal role in cellular regulation // Science. -1980 V. 4- № 207(4426). — P. 19−27.
- Church P.J., Stanley E.F. Single L-type calcium channel conductance with physiological levels of calcium in chick ciliary ganglion neurons // J Physiol. 1996 — V. 496- № 1.-P. 59−68.
- Collin T, Chat M., Lucas M.G., Moreno H., Racay P., Schwaller B., Marty A., Llano I. Developmental changes in parvalbumin regulate presynaptic Ca2+ signaling // J Neurosci 2005 — V. 25. — P. 96−107.
- Cummings D.D., Wilcox K. S, Dichter M.A. Calcium-dependent paired-pulse facilitation of miniature EPSC frequency accompanies depression of EPSCs at hippocampal synapses in culture // J. Neurosci 1996 — V. 1- № 16(17). — P.5312−23.
- Dan P., Lin E., Huang J., Biln P., Tibbits G.F. Three-dimensional distribution of cardiac Na±Ca2+ exchanger and ryanodine receptor during development // Biophys J. -2007 V. 1- № 93(7). — P. 2504−18.
- D’Angelo E., Rossi P., Gall D., Prestori F., Nieus T, Maffei A., Sola E. Long-term potentiation of synaptic transmission at the mossy fiber-granule cell relay of cerebellum // Prog Brain Res. 2005 — V. 148. — P. 69−80.
- Dargan S.L., Parker I. Buffer kinetics shape the spatiotemporal patterns of IP3-evoked Ca2+ signals // J Physiol. 2003 — V. 553- № 3. — P. 775−88.
- Dargan S.L., Schwaller B., Parker I. Spatiotemporal patterning of IP3-mediated Ca2+ signals in Xenopus oocytes by Ca2±binding proteins // J Physiol. 2004 — V. 556- № 2.-P. 447−61.
- Day N.C., Wood S. J, Ince P. G, Volsen S. G, Smith W, Slater C. R, Shaw P.J. Differential localization of voltage-dependent calcium channel al subunits at the human and rat neuromuscular junction // J Neurosci 1997 — V. 17. — P. 6226−6235
- Del Castillo J, Katz B. Quantal components of the end-plate potential // J. Physiol. -1954-V. 124.-P. 560−573.
- Dolphin A.C. Facilitation of Ca2+ current in excitable cells // Trends Neurosci. -1996 V.19- № 1. -P. 35−43.
- Dunlap K. Calcium channels are models of self-control // J Gen Physiol. 2007 -V.129- № 5. — P.379−83.
- Egger V, Stroh O. Calcium buffering in rodent olfactory bulb granule cells and mitral cells // J Physiol. 2009 — V. 587- № 18. — P. 4467−79
- Eggermann E., Bucurenciu I., Goswami S.P., Jonas P. Nanodomain coupling between Ca2+ channels and sensors of exocytosis at fast mammalian synapses // Nat Rev Neurosci. 2012 — V. 13- № 1. — P. 7−21.
- Eggermann E., Jonas P. How the 'slow' Ca buffer parvalbumin affects transmitter release in nanodomain-coupling regimes // Nat Neurosci. 2011 — V. 15- № 1. — P. 20−2.
- Ehrlich B.E., Kaftan E., Bezprozvannaya S., Bezprozvanny I. The pharmacology of intracellular Ca -release channels // Trends Pharmacol Sci. 1994 — V. 15- № 5. — P. 145−9.
- Emptage N.J., Reid C.A., Fine A. Calcium stores in hippocampal synaptic boutons mediate short-term plasticity, store-operated Ca2+ entry, and spontaneous transmitter release // Neuron. 2001 — V. 29- № 1. — P. 197−208.
- Engel A.G. Review of evidence for loss of motor nerve terminal calcium channels in Lambert-Eaton myasthenic syndrome // Ann N Y Acad Sci. 1991 — V. 635. — P. 24 658.
- Fakler B., Adelman J.P. Control of K (Ca) channels by calcium nano/microdomains // Neuron. 2008 — V. 59- № 6. — P. 873−81.
- Falke J.J., Drake S.K., Hazard A.L., Peersen O.B. Molecular tuning of ion binding to calcium signaling proteins // Q Rev Biophys. 1994 — V. 27- № 3. — P. 219−90.
- Fedchyshyn M.J., Wang L.Y. Developmental transformation of the release modality at the calyx of Held synapse // J Neurosci. 2005 — V. 25- № 16. — P. 4131−40.
- Felmy F., Neher E., Schneggenburger R. Probing the intracellular calcium sensitivity of transmitter release during synaptic facilitation // Neuron. 2003 — V. 37- № 5.-P. 801−11.
- Fierro L., Llano I. High endogenous calcium buffering in Purkinje cells from rat cerebellar slices // J. Physiol. 1996 — V. 496. — P. 617—625.
- Fisher S. A., Fischer T.M., Carew T.J. Multiple overlapping processes underlying short-term synaptic enhancement // Trends Neurosci. 1997 — V. 20 — P. 170−177.
- Flink M.T., Atchison W.D. Iberiotoxin-induced block of Ca2±activated K+ channels induces dihydropyridine sensitivity of ACh release from mammalian motor nerve terminals//J Pharmacol Exp Ther. 2003 — V.305- № 2. — P. 646−52.
- Fong S.W., McLennan I.S., Mclntyre A., Reid J., Shennan K.I., Bewick G.S. TGF-beta2 alters the characteristics of the neuromuscular junction by regulatingpresynaptic quantal size // Proc Natl Acad Sci USA.- 2010 V. 107- № 30 — P. 135 159.
- Forsythe I. D, Tsujimoto T, Barnes-Davies M, Cuttle M. F, Takahashi T. Inactivation of presynaptic calcium current contributes to synaptic depression at a fast central synapse// Neuron. 1998 — V. 20-№ 4. — P. 797−807.
- Fredholm B.B. Adenosine, adenosine receptors and the action of caffeine // Pharmacol. Toxicol. 1995 — V. 76. — P. 93−101.
- Fredholm B. B, Battig K, Holmen J, Nehlig A, Zvartau E.E.Actions of caffeine in the brain with special reference to factors that contribute to its widespread use // Pharmacol Rev. 1999 — V. 51- № 1.-P. 83−133.
- Gall D, Roussel C, Susa I, D’Angelo E, Rossi P, Bearzatto B, Galas M. C, Blum D, Schurmans S, Schiffmann S.N. Altered neuronal excitability in cerebellar granule cells of mice lacking calretinin // J Neurosci 2003 — V.23 — P. 9320−9327.
- Gentile L, Stanley E.F. A unified model of presynaptic release site gating by calcium channel domains // Eur J Neurosci. 2005 — V. 21- № 1. — P. 278−82.
- Gilmanov I. R, Samigullin D. V, Vyskocil F, Nikolsky E. E, Bukharaeva E.A. Modeling of quantal neurotransmitter release kinetics in the presence of fixed and mobile calcium buffers // J Comput Neurosci. 2008 — V. 25- № 2. — P. 296−307.
- Gordon G. R, Bains J.S. Noradrenaline triggers multivesicular release at glutamatergic synapses in the hypothalamus // J Neurosci. 2005 — V. 25- № 49. -P. 11 385−95.
- Gulley R. L, Landis D. M, Reese T.S. Internal organization of membranes at end bulbs of Held in the anteroventral cochlear nucleus // J Comp Neurol. 1978 — V. 180- № 4.-P. 707−41.
- Gurden H, Schiffmann S. N, Lemaire M, Bohme G. A, Parmentier M, Schurmans S. Calretinin expression as a critical component in the control of dentate gyrus long-term potentiation induction in mice // Eur J Neurosci 1998 — V. 10. — P. 3029−3033.
- Hachisuka J, Soga-Sakakibara S, Kubota M, Narita K, Kuba K. Enhancement of24″ 9+
- Ca -induced Ca release by cyclic ADP-ribose in frog motor nerve terminals // Neuroscience. 2007 — V. 146- № 1. — P. 123−34.
- He T, Lnenicka G.A. Ca2+ buffering at a drosophila larval synaptic terminal // Synapse. 2011 — V. 65- № 7. — P. 687−93.
- He X., Yang F., Xie Z., Lu B. Intracellular Ca (2+) and Ca (2+)/calmodulin-dependent kinase II mediate acute potentiation of neurotransmitter release by neurotrophin-3 // J Cell Biol. 2000 — V. 149- № 4. — P. 783−92.
- Helmchen F., Borst G.G., Sakmann B. Calcium dynamics associated with a single action potential in a CNS presynaptic terminal // Biophys. J. 1997 — V. 72. — P. 1458— 1471.9486. Helmchen F., Imoto K., Sakmann B. Ca buffering and action potential-evoked
- Ca signaling in dendrites of pyramidal neurons // Biophys. J. 1996 — V. 70. — P.1069—1081.
- Heuser J.E., Reese T.S., Dennis M.J., Jan Y., Jan L., Evans L. Synaptic vesicle exocytosis captured by quick freezing and correlated with quantal transmitter release // J Cell Biol. 1979-V. 81- № 2. — P. 275−300.
- Hinrichsen R.D., Burgess-Cassler A., Soltvedt B.C., Hennessey T., Kung C.2+
- Restoration by calmodulin of a Ca -dependent K current missing in a mutant of Paramecium // Science. 1986 — V. 232- № 4749. — P. 503−6.
- Holtzman S.G. CGS 15 943, a nonxanthine adenosine receptor antagonist: effects on locomotor activity of nontolerant and caffeine-tolerant rats // Life Sci. 1991 — V. 49- № 21.-P. 1563−70.
- Ikeda K., Bekkers J.M. Counting the number of releasable synaptic vesicles in a presynaptic terminal // Proc Natl Acad Sci USA.- 2009 V. 106- № 8. — P. 2945−50.
- John L.M., Mosquera-Caro M., Camacho P., Lechleiter J.D. Control of IPs-mediated Ca2+ puffs in Xenopus laevis oocytes by the Ca2±binding protein parvalbumin // J Physiol. 2001 — V. 535- № 1. — P. 3−16.
- Jones S.W. Overview of voltage-dependent calcium channels // J Bioenerg Biomembr. 1998 — V.30- № 4. — P. 299−312.
- Josephson I.R., Guia A., Sobie E.A., Lederer W.J., Lakatta E.G., Stern M.D. Physiologic gating properties of unitary cardiac L-type Ca channels // Biochem Biophys Res Commun. 2010 — V. 396- № 3. — P. 763−6.
- Judd K., Shugert E., Velez S.J. Depressing effects of caffeine at crayfish neuromuscular synapses I. Dosage response and Ca++ gradient effects. // Cell Mol Neurobiol. 2007 — V. 27- № 3. — P. 367−80.
- Karadsheh N, Kussie P, Linthicum D.S. Inhibition of acetylcholinesterase by caffeine, anabasine, methyl pyrrolidine and their derivatives // Toxicol. Lett. 1991 — V. 55- № 3,-P. 335−42.
- Karunanithi S, Marin L, Wong K, Atwood H.L. Quantal size and variation determined by vesicle size in normal and mutant Drosophila glutamatergic synapses // J Neurosci. 2002 — V. 22- № 23 — P. 10 267−76.
- Kasai H, Petersen O.H. Spatial dynamics of second messengers: IP3 and cAMP as long-range and associative messengers // Trends Neurosci. 1994 — V. 17- № 3. — P. 95 101.
- Katz B, Miledi R. The effect of calcium on acetylcholine release from motor nerve terminals // Proc. R. Soc. 1965 — V. 161 — P. 495−503.
- Kijima H, Tanabe N. Calcium-independent increase of transmitter release at frog end-plate by trinitrobenzene sulphonic acid // J. Physiol. 1988 — V. 403, P. 135−49.
- Klingauf J, Neher E. Modeling buffered Ca diffusion near the membrane: implications for secretion in neuroendocrine cells // Biophys. J. 1997 — V. 72 — P.674−690.
- Koenig J. H, Yamaoka K, Ikeda K. Calcium-induced translocation of synaptic vesicles to the active site // J Neurosci. 1993 — V. 13- № 6. — P. 2313−22.
- Koster H. P, Hartog A, Van Os C. H, Bindels R.J. Calbindin-D28K facilitates cytosolic calcium diffusion without interfering with calcium signaling // Cell Calcium.1995-V. 18- № 3.-P. 187−96.2+
- Kremer L, Lee A. Endogenous and exogenous Ca buffers differentially7+ 74modulate Ca -dependent inactivation of Ca (v)2.1 Ca channels// J Biol Chem. 2006. -V. 281- № 8. — P.4691−8.
- Leao R.M., von Gersdorff H. Synaptic vesicle pool size, release probability and94synaptic depression are sensitive to Ca buffering capacity in the developing rat calyx of Held //Braz J Med Biol Res. 2009 — V. 42- № 1. — P.94−104.
- Lee S.H., Rosenmund C., Schwaller B., Neher E. Differences in Ca buffering properties between excitatory and inhibitory hippocampal neurons fromthe rat // J Physiol 2000 — V. 525. — P. 405−418.
- Lips M.B., Keller B.U. Endogenous calcium buffering in motoneurones of the nucleus hypoglossus from mouse//J. Physiol. 1998-V. 511-№ 1.-P. 105−17.
- Lipscombe D., Helton T.D., Xu W. L-type calcium channels: the low down// J Neurophysiol. 2004. — V.92- № 5. — P. 2633−41.
- Liu Q., Chen B., Yankova M., Morest D.K., Maryon E., Hand A.R., Nonet M.L., Wang Z.W. Presynaptic ryanodine receptors are required for normal quantal size at the Caenorhabditis elegans neuromuscular junction // J Neurosci. 2005 — V. 29. -P. 674 554.
- Llano I., Gonzalez J., Caputo C., Lai F.A., Blayney L.M., Tan Y.P., Marty A. Presynaptic calcium stores underlie large-amplitude miniature IPSCs and spontaneous calcium transients // Nat. Neurosci. 2000 — V. 3- № 12. — P. 1256−65.
- Losavio A., Muchnik S. Spontaneous acetylcholine release in mammalian neuromuscular junctions // Amer. Physiol. Soc. 1997 — V.273- № 6/1. — P.1835−1841.
- Maeda H., Ellis-Davies G.C., Ito K., Miyashita Y., Kasai H. Supralinear Ca2+ signaling by cooperative and mobile Ca2+ buffering in Purkinje neurons // Neuron 1999 -V.24.-P. 989−1002.94. 9+
- Matveev V., Bertram R., Sherman A. Ca current versus Ca channel cooperativity of exocytosis // J Neurosci. 2009 — V. 29- № 39. — P. 12 196−209.
- Matveev V., Bertram R., Sherman A. Calcium cooperativity of exocytosis as a measure of Ca channel domain overlap // Brain Res. 2011 — V. 1398. — P. 126−38.
- Matveev V., Zucker R.S., Sherman A. Facilitation through buffer saturation: constraints on endogenous buffering properties // Biophys J. 2004 — V. 86- № 5. — P. 2691−709.
- Meinrenken C.J., Borst J.G., Sakmann B. Calcium secretion coupling at Calyx of held governed by nonuniform channel-vesicle topography // J Neurosci. 2002 — V. 22- № 5.-P. 1648−67.
- Mercer A. J, Chen M, Thoreson W.B. Lateral mobility of presynaptic L-type calcium channels at photoreceptor ribbon synapses // J Neurosci. 2011 — V. 31- № 12. -P. 4397−406.
- Missler M, Zhang W, Rohlmann A, Kattenstroth G, Hammer R. E, Gottmann K, Siidhof T.C. Alpha-neurexins couple Ca channels to synaptic vesicle exocytosis // Nature. 2003 — V. 423- № 6943. — P. 939−48.
- Mukhamedyarov M. A, Grishin S. N, Zefirov A. L, Palotas A. The mechanisms of multi-component paired-pulse facilitation of neurotransmitter release at the frog neuromuscular junction // Pflugers Arch. 2009 — V. 458- № 3. — P. 563−70.
- Miiller A, Kukley M, Uebachs M, Beck H, Dietrich D. Nanodomains of single Ca2+ channels contribute to action potential repolarization in cortical neurons // J Neurosci. 2007a — V. 27- № 3. — P. 483−95.
- Muller M, Felmy F, Schwaller B, Schneggenburger R. Parvalbumin is a mobile presynaptic1. Ca bufferin the Calyx of held that accelerates the decay of Ca and shortterm facilitation // J Neurosci 2007 — V. 27. — P. 2261−2271.
- Nagerl U. V, Novo D, Mody I, Vergara J.L. Binding kinetics of calbindin-D (28k) determined by flash photolysis of caged Ca2+ // Biophys J. 2000 — V. 79- № 6. -P. 300 918.
- Narita K, Akita T. Hachisuka J, Huang S, Ochi K, Kuba K. Functional coupling of Ca channels to ryanodine receptors at presynaptic terminals. Amplification of exocytosis and plasticity // J.Gen. Physiol. 2000 — V. l 15- № 4. — P. 519−32.
- Narita K., Akita T., Osanai M., Shirasaki T., Kijima H., Kuba K. A Ca2±induced Ca2+ release mechanism involved in asynchronous exocytosis at frog motor nerve terminals // J Gen Physiol. 1998 — V.112- № 5. — P. 593−609.
- Naves L.A., Van der Kloot W., Repetitive nerve stimulation decreases the acetylcholine content of quanta at the from neuromuscular junction // J. Physiol. (Lond.) 2001 — V. 532. — P. 637−647.
- Neher E. Details of Ca2+ dynamics matter // J Physiol. 2008 — V.586- № 8. — P. 2031.
- Neher E. Vesicle pools and Ca microdomains: new tools for understanding their roles in neurotransmitter release // Neuron 1998a — V.20. — P. 389−399.
- Neher E., Augustine G. J. Calcium gradients and buffers in bovine chromaffin cells // J. Physiol. 1992 -V. 450. — P. 273—301.
- Neher E., Sakaba T. Multiple roles of calcium ions in the regulation of neurotransmitter release // Neuron. 2008 — V. 59- № 6. -P. 861−72.
- Neher E., Usefulness and limitations of linear approximations to the understanding of Ca2+ signals // Cell Calcium. 1998b — V. 24. — P. 345−357.
- Niggli E., Shirokova N. A guide to sparkology: the taxonomy of elementary cellular Ca2+ signaling events // Cell Calcium. 2007 — V. 42- № 4−5. — P. 379−87.
- Nishimura M., Tsubaki K., Yagasaki O., Ito K. Ryanodine facilitates calcium-dependent release of transmitter at mouse neuromuscular junctions // Br J Pharmacol. -1990-V. 100- № 1.-P. 114−8.
- Oheim M., Kirchhoff F., Stiihmer W. Calcium microdomains in regulated exocytosis // Cell Calcium. 2006 — V. 40- № 5−6. — P. 423−39.
- Ousley A.H., Froehner S.C. An anti-peptide antibody spe- cific for the class A calcium channel alpha 1 subunit labels mammalian neuromuscular junction // Proc Natl Acad Sci USA 1994-V. 91.-P. 12 263−12 267.
- Palecek J., Lips M.B., Keller B.U. Calcium dynamics and buffering in motoneurones of the mouse spinal cord // J. Physiol. 1999 — V. 520.2. — P. 485—502.
- Parekh A.B. Ca2+ microdomains near plasma membrane Ca2+ channels: impact on cell function // J Physiol. 2008 — V. 586- № 13. — P. 3043−54.
- Parekh A.B. Decoding cytosolic Ca2+ oscillations // Trends Biochem Sci. 2011 — V. 36- № 2.-P. 78−87.
- Patel J. C, Witkovsky P, Avshalumov M. V, Rice M.E. Mobilization of calcium from intracellular stores facilitates somatodendritic dopamine release // J Neurosci. -2009 V. 29- № 20. — P. 6568−79.
- Paulsen O, Heggelund P. The quantal size at retinogeniculate synapses determined from spontaneous and evoked EPSCs in guinea-pig thalamic slices // J. Physiol. 1994-V. 480- № 3.-P. 505−11.
- Peng Y. Ryanodine-sensitive component of calcium transients evoked by nerve firing at presynaptic nerve terminals // J. Neurosci. 1996 — V. 16- № 21. — P. 6703−12.
- Perissinotti P.P., Giugovaz Tropper B, Uchitel O.D. L-type calcium channels are involved in fast endocytosis at the mouse neuromuscular junction// Eur J Neurosci. 2008 V.27-№ 6.-P.1333−44.
- Pethig, R, Kuhn M, Payne R, Adler E, Chen T.-H, Jaffe L. F. On the dissociation constants of BAPTA-type Ca2+ buffers // Cell Calcium. 1989 — V. 10. — P. 491−498.
- Porta M, Zima A. V, Nani A, Diaz-Sylvester P. L, Copello J. A, Ramos-Franco J, Blatter L. A, Fill M. Single ryanodine receptor channel basis of caffeine’s action on Ca2+ sparks // Biophys J. 2011 — V. 100- № 4. P. 931−8.
- Pozzo-Miller L. D, Pivovarova N. B, Connor J. A, Reese T. S, Andrews S.B. Correlated measurements of free and total intracellular calcium concentration in central nervous system neurons // Microsc Res Tech. 1999 — V. 46- № 6. — P. 370−9.
- Robitaille R, Charlton M.P. Presynaptic calcium signals and transmitter release are modulated by calcium-activated potassium channels // J. Neurosci. 1992 — V. 12- № 1. — P. 297−305.
- Roed A. Caffeine-induced blockade of neuromuscular transmission and its reversal by dantrolene sodium // Eur. J. Pharmacol. 1982 — V. 83- № 1−2. — P. 83−90.
- Rosato-Siri M. D, Piriz J, Tropper B. A, Uchitel O.D. Differential Ca2±dependence of transmitter release mediated by P/Q- and N-type calcium channels at neonatal rat neuromuscular junctions // Eur J Neurosci. 2002 — V.15- № 12. — P. 187 480.
- Ruiz R., Cano R., Casanas J.J., Gaffield M.A., Betz W.J., Tabares L. Active zones and the readily releasable pool of synaptic vesicles at the neuromuscular junction of the mouse // J Neurosci. 2011 — V. 31- № 6. — P. 2000−8.
- Sajikumar S., Li Q., Abraham W.C., Xiao Z.C. Priming of short-term potentiation and synaptic tagging/capture mechanisms by ryanodine receptor activation in rat hippocampal CA1 // Learn Mem. 2009 — V. 16- -№ 3. — P. 178−86.
- Sakaba T., Neher E. Quantitative relationship between transmitter release and calcium current at the Calyx of held synapse // J Neurosci. 2001 — V. 21- № 2. — P. 46 276.
- Santafe M.M., Lanuza M.A., Garcia N., Tomas J. Calcium inflow-dependent protein kinase C activity is involved in the modulation of transmitter release in the neuromuscular junction of the adult rat // Synapse. 2005 — V. 57- № 2. — P. 76−84.
- Schmidt H., Arendt O., Brown E.B., Schwaller B., Eilers J. Parvalbumin is freely mobile in axons, somata and nuclei of cerebellar Purkinje neurons // J Neurochem 2007 -V. 100.-P. 727−735.
- Schmidt H., Eilers J. Spine neck geometry determines spino-dendritic cross-talk in the presence of mobile endogenous calcium binding proteins // JComputNeurosci 2009 -V.27.-P. 229−243.
- Schmidt H., Kunerth S., Wilms C., Strotmann R., Eilers J. Spino-dendritic crosstalk in rodent Purkinje neurons mediated by endogenous Ca2±binding proteins // J Physiol 2007b — V. 581. — P. 619−629.
- Schneggenburger R., Forsythe I.D. The Calyx of Held // Cell Tissue Res. 2006 -V. 326- № 2.-P. 311−37.
- Schneggenburger R., Neher E. Presynaptic calcium and control of vesicle fusion // Curr Opin Neurobiol. 2005 — V. 15- № 3. — P. 266−74.
- Schwaller B. Cytosolic Ca2+ buffers // Cold Spring Harb Perspect Biol. 2010 — V. 2- № 11.-P. a004051.
- Schwaller B. The continuing disappearance of «pure «Ca2+ buffers // Cell Mol Life Sci. 2009 — V. 66. — P. 275−300.
- Schwartz A. D, Whitacre C. L, Wilson D.F. Do ryanodine receptors regulate transmitter release at the neuromuscular junction of rat? // Neurosci. Lett. 1999 — V. 274.-P. 163−166.
- Scott R. Use-dependent control of presynaptic calcium signalling at central synapses // J Anat. 2007 — V. 210- № 6. — P. 642−50.
- Searl T, Prior C, Marshall I. G, Acetylcholine recycling and release at rat motor nerve terminals studied using (-)-vesamicol and troxpyrrolium // J. Physiol. (Lond.) -1991-V. 444.-P. 99−116.
- Shahrezaei V, Cao A,. Delaney K.R. Ca2+ from one or two channels controls fusion of a single vesicle at the frog neuromuscular junction // J Neurosci. 2006 — V. 26- № 51.-P. 13 240−9.
- Simkus C. R, Strieker C. The contribution of intracellular calcium stores to mEPSCs recorded in layer II neurones of rat barrel cortex // J Physiol. 2002 — V. 545- № 2.-P. 521−35.
- Sitsapesan R, Montgomery R. A, Williams A.J. New insights into the gating mechanisms of cardiac ryanodine receptors revealed by rapid changes in ligand concentration // Circ Res. 1995 — V. 77- № 4. — P. 765−72.
- Smellie F. W, Davis C. W, Daly J. W, Wells J.N. Alkylxanthines: inhibition of adenosine-elicited accumulation of cyclic AMP in brain slices and of brain phosphodiesterase activity // Life Sci. 1979 — V. 24- № 26. — P. 2475−82.
- Stanley E.F. The calcium channel and the organization of the presynaptic transmitter release face // Trends Neurosci. 1997 — V. 20- № 9. — P. 404−9.
- Stanley EF. Presynaptic calcium channels and the transmitter release mechanism. AnnN Y Acad Sci. 1993 Jun 21−681:368−72.
- Stern M.D. Buffering of calcium in the vicinity of a channel pore // Cell Calcium. 1992 — V.13- № 3. — P. 183−92.
- Striessnig J., Koschak A., Sinnegger-Brauns M.J., Hetzenauer A., Nguyen N.K., Busquet P., Role of voltage-gated L-type Ca2+ channel isoforms for brain function // Biochem Soc Trans. 2006- V. 34. — P. 903−909.
- Sugita S., Shin O.H., Han W., Lao Y., Sudhof T.C. Synaptotagmins form a hierarchy of exocytotic Ca sensors with distinct Ca2+ affinities // EMBO J. 2002 — V. 21- № 3,-P. 270−80.j i
- Sutko J.L., Airey J.A. Ryanodine receptor Ca release channels: does diversity in form equal diversity in function? // Physiol. Rew. 1996 — V. 76. — P. 1027−1071.
- Suzuki S., Osanai M., Murase M., Suzuki N., Ito K., Shirasaki T., Narita K., Ohnuma K., Kuba K., Kijima H. Ca dynamics at the frog motor nerve terminal // Pflugers Arch. 2000 — V.440- № 3. — P. 351−365.
- Tanabe N., Kijima H. Ca2±dependent and -independent components of transmitter release at the frog neuromuscular junction // J. Physiol. 1992 — V. 455. — P. 271−89.
- Tsien R.Y. New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis and properties of prototype structure // Biochem. 1980-V. 19. — P.2396−2404.
- Tuckwell H.C. Quantitative aspects of L-type Ca currents // Prog Neurobiol. -2011 -V. 96- № 1.-P. 1−91.
- Ulrich D., Liischer H.R. Miniature excitatory synaptic currents corrected for dendritic cable properties reveal quantal size and variance // J. Neurophysiol. 1993 — V. 69- № 5. — P. 1769−73.
- Urbano F.J., Depetris R.S., Uchitel O.D. Coupling of L-type calcium channels to neurotransmitter release at mouse motor nerve terminals // Pflugers Arch. 2001 — V. 441- № 6.-P. 824−31.
- Urbano F.J., Uchitel O.D. L-type calcium channels unmasked by cell-permeant Ca2±buffer at mouse motor nerve terminals // Pflugers Arch. 1999 — V. 437- № 4. — P. 523−8.
- Van der Kloot W. 2-(4-Phenylpiperidino) cyclohexanol (AH5183) decreases quantal size at the frog neuromuscular junction // Pfliigers Arch. 1986 — V. 406. -P. 83−85.
- Van der Kloot W. Loading and recycling of synaptic vesicles in the Torpedo electric organ and the vertebrate neuromuscular junction // Prog Neurobiol. 2003 — V. 71- № 4.-P. 269−303.
- Van der Kloot W, Benjamin W. B, Balezina O.P. Calcitonin gene-related peptide acts presynaptically to increase quantal size and output at frog neuromuscular junctions // J Physiol. 1998 — V. 507- № 3. — P. 689−95.
- Van der Kloot W, Molgo J. Quantal acetylcholine release at the vertebrate neuromuscular junction // J. Physiol. Rev 1994 — V. 34 — P. 1−105.
- Verkhratsky A. Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons // Physiol Rev. 2005 — V. 85- № 1. — P. 201−79.
- Ward S. M, Kenyon J.L. The spatial relationship between Ca2+ channels and Ca2+7+activated channels and the function of Ca -buffering in avian sensory neurons // Cell Calcium. 2000 — V. 28- № 4. — P. 233−46.
- Wayman G. A, Tokumitsu H, Davare M. A, Soderling T.R. Analysis of CaM-kinase signaling in cells // Cell Calcium. 2011 — V. 50- № 1. — P. 1−8.
- Whitton P. S, Marshall I. G, Parsons S.M. Reduction of quantal size by vesamicol (AH5183), an inhibitor of vesicular acetylcholine storage // Brain Res. 1986 — V. 385. -P.189−192.7+
- Xu J, He L, Wu L.G. Role of Ca"T channels in short-term synaptic plasticity// Curr Opin Neurobiol. 2007 — V.17- № 3. — P. 352−9.
- Yamada W. M, Zucker R.S. Time course of transmitter release calculated from simulations of a calcium diffusion model // Biophys J. 1992 — V. 61- № 3. — P. 671−82.
- Yang P. S, Alseikhan B. A, Hiel H, Grant L, Mori M. X, Yang W. Switching of Ca -dependent inactivation of Cav1.3 channels by calcium binding proteins of auditory hair cells // J Neurosci. 2006 — V. 26. — P. 10 677−10 689.
- Yuchi Z, Van Petegem F. Common allosteric mechanisms between ryanodine and inositol-1,4,5-trisphosphate receptors // Channels (Austin). 2011 — V. 5- № 2. — P. 120−3.
- Yue D. T, Backx P. H, Imredy J.P. Calcium-sensitive inactivation in the gating of single calcium channels // Science. 1990 — V. 250- № 4988. — P. 1735−8.
- Zhao M., Hollingworth S., Baylor S.M. AM-Loading of fluorescent Ca2+ indicators into intact single fibers of frog muscle // Biophys. J. 1997 -V. 72. — P. 27 362 747.
- Zhou Z., Neher E. Mobile and immobile calcium buffers in bovine adrenal cells //
- J. Physiol. 1993 — V. 469. — P. 245—273.2+ 2+
- Zucker R.S. Increased Ca buffering enhances Ca -dependent process // J
- Physiol. 2001 V. 531- № 3. — P. 583.
- Zucker R.S., Regehr W.G. Short-term synaptic plasticity // Annu. Rev. Physiol. -2002-V.64.-P. 355−405.
- Zucker, R. S. Calcium- and activity-dependent synaptic plasticity // Curr. Opin. Neurobiol. 1999 — V. 9. — P. 305−313.
- Zweifach A., Lewis R.S. Calcium-dependent potentiation of store-operated calcium channels in T lymphocytes // J Gen Physiol. 1996 — V.107- № 5. — P. 597−610.