Изменение свойств рибосом при рецессивной сепрессии у дрожжей Saccharomyces Cerevisiae
Диссертация
Так, был определен уровень свободных рибосомных субчастиц в клетках штамма, несущего рецессивную супрессорную мутацию по гену sup I. При центрифугировании в градиенте концентрации сахарозы пост-митохондриального экстракта из клеток супрессорного штамма был обнаружен повышенный уровень содержания свободных рибосомных субчастиц (рис. ю), который сохранялся при инги-бировании белкового синтеза как… Читать ещё >
Содержание
- I. ВВЕДЕНИЕ
- II. ОБЗОР ЛИТЕРАТУРЫ
- ГЛАВА I. СУПРЕССОРНЫЕ МУТАЦИИ
- 1. Определение супрессии. Различные виды супрессорных мутаций
- 2. Межгенная супрессия нонсенс-мутаций у дрожжей ЗассИагогаусез сегеу1э1ае, обусловленная мутациями по генам тЙ
- 3. Обнаружение и свойства рецессивных супрессоров у дрожжей
- 4. Антисупрессорные мутации у дрожжей
- Б. сегеу1з1ае.1С>
- ГЛАВА II. ПРОЦЕСС БИОСИНТЕЗА БЕЛКА
- 1. Строение рибосомы
- 2. Общая схема процесса трансляции: 22 а) Реакция аминоацилирования- б) Рибосомный этап белкового синтеза: функциональные центры рибосомы, инициация, элонгация и терминация синтеза полипептидной цепи
- 3. Генетический контроль синтеза рибосом-ных белков и рибосомной РНК у дрожжей
- ГЛАВА III. НЕОДНОЗНАЧНОСТЬ ТРАНСЛЯЦИИ И ЕЕ ФИЗИОЛО ГИЧЕСКОЕ ЗНАЧЕНИЕ
- 1. Опделение уровня ошибок при биосинтезе белка in vivo
- 2. Уровень ошибок в реакции аминоацилирования
- 3. Генетический код и проблема ложного кодирования
- 4. Факторы, влияющие на уровень рибосомной неоднозначности in vitro
- 5. Влияние мутаций по рибосомным белкам на точность считывания генетической информации
- А. Зависимость точности трансляции от присутствия в среде стрептомицина и других аминогликозидных антибиотиков
- Б. Влияние str, А и ram мутаций на неоднозначность трансляции in vivo и in vitro
- В. Мутации по рибосомным белкам у эукариот
- 6. Механизмы, лежащие в основе ошибочной трансляции
- 7. Возможное физиологическое значение неоднозначности трансляции
- Характеристика 80S рибосом, которые накапливаются в непермиссивных условиях в клетках тем-пературочувствительного супрессорного штамма
- Определение уровня свободных рибосомных субчастиц в клетках штамма, несущего рецессивную супрессорную мутацию
- III. МАТЕРИАЛЫ И МЕТОДЫ ИССЛЕДОВАНИЯ
- Материалы исследования
- Методы исследования
- ЗУ. РЕЗУЛЬТАТЫ И ИХ ОБСУЖДЕНИЕ
- Определение кодоновой специфичности рецессивных супрессоров
- Определение ошибок функционирования рибосом из штаммов, несущих рецессивные супрессорные мутации In vitro.-L^
- Анализ рибосомных белков из штаммов дрожжей, несущих рецессивные супрессорные мутации, методом электрофореза в полиакриламидном Tqo геле
- V. ЗАШНЕНИЕ
- VI. ВЫВОда
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