Определение органических ксенобиотиков в волосах человека методом высокоэффективной тонкослойной хроматографии
Диссертация
Практическая значимость работы. Доказано, что полиароматические углеводороды аккумулируются в волосах курильщиков. Предложены способы приготовления стандартных образцов волос с известным эндогенным содержанием органических ксенобиотиков на основе двух подходов: сорбции из газовой фазы и из водного раствора. Для группового определения соединений класса ПАУ предложена новая хроматографическая… Читать ещё >
Содержание
- СПИСОК СОКРАЩЕНИЙ ОБЗОР ЛИТЕРАТУРЫ
- 1. Волос как объект анализа
- 1. 1. Отбор пробы
- 1. 2. Очистка и измельчение
- 1. 3. Извлечение органических ксенобиотиков из волос
- 2. Методы определения ксенобиотиков в волосах человека
- 3. Классы определяемых соединений
- 3. 1. Наркотические вещества
- 3. 2. Лекарственные препараты
- 3. 3. Полиароматические углеводороды
- ЭКСПЕРИМЕНТАЛЬНАЯ ЧАСТЬ И ОБСУЖДЕНИЕ РЕЗУЛЬТАТОВ
- 1. Исходные вещества, аппаратура и техника эксперимента
- 1. 1. Выбор модельных соединений
- 1. 2. Реактивы и материалы
- 1. 3. Выбор оптимальных параметров сканирования тонкослойных пластин на денситометре «Сатад»
- 1. 4. Выбор метода предварительного концентрирования
- 2. Определение ПАУ в волосах человека
- 2. 1. Оптимизация условий хроматографического определения ПАУ в тонком слое
- 2. 2. Изучение сорбции ПАУ из сигаретного дыма на волосы человека
- 2. 3. Выбор условий извлечения ПАУ из матрицы волос
- 2. 4. Практическое
- приложение: изучение защитного влияния полиэтиленгликолевых эфиров хитозана на волосы человека
- 3. Определение лекарственных препаратов в волосах человека
- 3. 1. Определение параметров экстракции лекарственных препаратов в системе вода — гексан
- 3. 2. Оптимизация условий хроматографического определения лекарственных препаратов в тонком слое
- 3. 3. Изучение сорбции лекарственных препаратов из водных растворов на волосы человека
- 3. 4. Выбор условий извлечения лекарственных препаратов из матрицы волос
- 4. Определение изученных ксенобиотиков в реальных образцах волос
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