Биофизические основы создания новых ферментных препаратов пролонгированного действия
Диссертация
Данная работа посвящена разработке биофизической стратегии конструирования высокоактивных ферментных препаратов пролонгированного действия, используя принципы и подходы, открытые природой и отобранные ею в результате эволюции. Стратегия основана на выявлении фундаментальных закономерностей взаимодействия лекарственных препаратов с транспортным белком плазмы крови человека (САЧ) и получению… Читать ещё >
Содержание
- СПИСОК ИСПОЛЬЗУЕМЫХ СОКРАЩЕНИЙ
- ГЛАВА 1. ОБЗОР ЛИТЕРАТУРЫ
- 1. 1. Применение ферментов в медицине
- 1. 2. Модификация ферментов
- 1. 2. 1. Функциональные группы белков
- 1. 2. 2. Модификация белков природными и модифицированными природными полимерами
- 1. 2. 3. Модификация синтетическими полимерами
- 1. 2. 3. 1. Системы депонирования белковых лекарств в организме
- 1. 2. 3. 2. Модификация белков монофункциональными полимерами
- 1. 2. 3. 3. Синтетические полифункциональные полимеры
- 1. 2. 4. Фермент-белковые конъюгаты
- 1. 2. 5. Проблемы биоконъюгации
- 1. 3. Механизмы биологического действия РНКаз
- 1. 4. Факторы, необходимые для проявления РНКазами биологического действия
- 1. 5. Сывороточный альбумин человека (САЧ)
- 1. 5. 1. Метаболизм и распределение альбумина
- 1. 5. 2. 1. Аминокислотная последовательность альбумина
- 1. 5. 2. 2. Вторичная структура и доменная организация
- 1. 5. 2. 3. Пространственная структура молекулы альбумина в растворе
- 1. 5. 2. 4. Распределение аминокислотных остатков и зарядов
- 1. 5. 3. Физико-химические свойства молекулы САЧ
- 1. 5. 4. Влияние физико-химических факторов на структуру и свойства альбумина
- 1. 5. 4. 1. Влияние значения рН среды
- 1. 5. 4. 2. Денатурация макромолекулы САЧ
- 1. 5. 4. 2. 1. Температурная денатурация
- 1. 5. 4. 2. 2. Влияние мочевины на структуру САЧ
- 1. 5. 5. Функции альбумина в организме
- 1. 5. 5. 1. Связывающие центры альбумина
- 1. 5. 5. 1. 1. Главные центры неспецифического связывания («лекарственные»)
- 1. 5. 5. 1. 2. Центр связывания двухвалентных катионов
- 1. 5. 5. 1. 3. Тиоловая группа остатка Cys
- 1. 5. 5. 1. 4. Центры связывания неэтерифицированных жирных кислот
- 1. 5. 5. 1. 5. «Минорные» центры
- 1. 5. 5. 1. 6. Билирубин связывающие центры
- 1. 5. 6. Группы молекулы САЧ, доступные для химической модификации
- 1. 5. 1. Метаболизм и распределение альбумина
- 1. 6. Получение конъюгатов ферментов с белками при помощи глутарового альдегида
- 1. 6. 1. Химическое поведение глутарового альдегида в растворе
- 1. 6. 2. Взаимодействие ГА с белками
- 1. 6. 3. Факторы, определяющие успешную иммобилизацию ферментов
- 2. 1. Материалы н методы
- 2. 2. Характеристика химических реактивов
- 2. 3. Характеристика используемых белков
- 2. 3. 1. Рибонуклеаза из Bacillus Intermedins 7р
- 2. 3. 2. Бычья панкреатическая рнбопуклеаза
- 3. 1. Конъюгаты ферментов с сывороточным альбумином человека, их получение и характеристики
- 3. 1. 1. Получение и исследование физико-химических свойств безлигандного сывороточного альбумина человека
- 3. 1. 2. Способ получения конъюгатов ферментов с БЛСАЧ
- 3. 1. 3. Исследование физико-химических характеристик конъюгатов и их биологической активности in vitro
- 3. 1. 3. 1. Ферментативная активность конъюгатов
- 3. 1. 3. 2. Определение «молекулярной массы» конъюгатов
- 3. 1. 3. 3. Активность конъюгатов БЛСАЧ и панкреатической РНКазы в отношении двунитевой РНК
- 3. 1. 4. Способ очистки конъюгатов от примесных агрегатов САЧ
- 3. 1. 5. Изучение биологической активности конъюгатов in vivo
- 3. 1. 5. 1. Пролонгация действия модифицированного фермента в организме
- 3. 1. 5. 2. Исследование проникновения панкреатической рибонуклеазы через гематоэнцефалический барьер
- 3. 2. 1. Молекулярный докинг обезжиренного альбумина и РНКазы А
- 3. 2. 2. Анализ поверхности контактов предполагаемых комплексов
- 3. 2. 3. Анализ влияния взаимодействия РНКазы, А и обезжиренного САЧ на активность фермента
- 3. 2. 4. Анализ структуры центров связывания РНКазы, А макромолекулы албьумина
- 3. 2. 5. Анализ возможных взаимодействий макромолекул в составе полимерного комплекса
- 3. 2. 6. Гидрофобные взаимодействия
- 3. 2. 7. Конформационный анализ
- 3. 2. 8. Предсказание биологической активности БЛСАЧ-модифицированных ферментов (РНКаз)
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