Исследование Р2-рецепторов и активности экто-нуклеотидаз гемопоэтических клеток человека
Диссертация
В настоящее время бурно развивающейся областью медицины и биологии являются попытки использования различных стволовых клеток для лечения и профилактики разнообразных заболеваний (De Santis М. et al., 2011; Gotts J.E., f Matthay M.A. 2011; Lai R.C. et al. 2011). Причем, выявление разнообразных стволовых клеток является отдельной трудоемкой задачей и в настоящее время в основе их идентификации… Читать ещё >
Содержание
- Список использованных сокращений
- 1. Введение
- 2. Обзор литературы
- 2. 1. Общие сведения об АТФ
- 2. 2. Классификация пуринорецепторов
- 2. 4. Р2-рецепторы
- 2. 3. Аденозиновые рецепторы
- 2. 4. 1. Р2Х-рецепторы
- 2. 4. 2. Р2У-рецепторы
- 2. 4. 3. Р2-рецепторы на клетках крови
- 2. 5. Экто-нуклеотидазы
- 2. 5. 1. Экто-нуклеотидазы в клетках крови
- 2. 6. Гемопоэтические стволовые клетки
- 2. 6. 1. Общие сведения о кроветворении
- 2. 6. 2. СБ34+ (позитивные) клетки
- 2. 6. 3. с-кк+(позитивные) клетки
- 3. 1. Аспекты биомедицинской этики
- 3. 2. Определение экспрессии Р2-рецепторов
- 3. 2. 1. Иммуномагнитная сепарация СБ34+клеток
- 3. 2. 2. Иммунофлуоресцентный анализ
- 3. 2. 3. Проточная цитофлуориметрия
- 3. 3. Определение активности экто-АТФаз
- 3. 4. Статистическая обработка результатов
- 4. 1. Определение наличия Р2-рецепторов
- 4. 1. 1. Определение наличия Р2Х- и Р2У-рецепторов на клетках пуповинной крови человека
- 4. 1. 2. Определение наличия Р2Х- и Р2У-рецепторов на клетках периферической крови человека
- 4. 1. 3. Наличие Р2Х-рецепторов на С0347с-клГ и СБ34+/с-кк+клетках пуповинной крови человека
- 4. 1. 4. Наличие Р2У-рецепторов на с-кк+/С034+клетках пуповинной крови человека
- 4. 1. 5. Сравнение наличия Р2Х-рецепторов на разных типах клеток
- 4. 1. 6. Сравнение наличия Р2У-рецепторов на разных типах клеток
- 4. 2. Определение активности экто-АТФаз в клетках крови человека
Список литературы
- Воробьев А.И. Руководство по гематологии. «Ньюдиамед», 2002. т. 1. -С. 28−45.
- Гривцова Л.Ю., Тупицын Н. Н. Ярыгин В.Н. И др. Субпопуляции мобилизованных стволовых (CD34+) клеток крови больных с последствиями тяжелой травмы спинного мозга // Иммунология гемопоэза. 2006. — Т. 3. — С. 24−42.
- Марри Р., Греннер Д., Мейес П., Родуэлл В. Биохимия человека. Москва:1. Мир", 1993. т. 1, 2.
- Михайлов В.В., Сагалович Б. М. Основы патологической физиологии:
- Руководство для врачей / Москва: Медицина, 2001. С. 704.
- Петровский Б.В. Максимов Александр Александрович. // Большая медицинская энциклопедия. «Советская энциклопедия», 1980. — т. 13 — С. 367 368.
- Козинец Г. И. Клетки крови и костного мозга. Цветной атлас-Медицинское информационное агенство Москва, 2004. С. 14−20.
- Зиганшин А.У., Зиганшина Л. Е. Фармакология рецепторов АТФ. -ГЭОТАР МЕДИЦИНА. Москва.- 1999. 9−10.
- Зиганшин А.У., Зиганшина Л. Е., Бернсток Дж. Экто-АТФазы и рецепторы
- АТФ // Экспер. клин, фармакол. 1997. — Vol. 3. — Р. 78−82.
- Зиганшин А.У., Зиганшина Л. Е. Р2-рецепторы: перспективная мишень дляf /будущих лекарств. Москва: «Геотар-медиа», 2009. — С. 133.
- Зиганшин А.У. Антагонисты Р2-рецепторов тромбоцитов: успехи, iпробелмы, перспективы // Эксперимент, и клин, фармакол. 2010. — ч. 73. -С.38.43.
- Adifolfi E., Melchiorri L., Falzoni S. et al. P2X7-receptor expression in evolutive and indolent forms of chronic B-lymphocytic leukemia // Blood. 2002. -Vol. 15.-P. 706−708.
- Alea M.P., Borroto-Escuela D.O., Romero-Fernandez W. et al. Differential expression of muscarinic acetykcholine receptor subtypes in Jurkat cells and their signalling // J'. Neuroimmunol. 2011. — Vol. 153. — P. 23−28.
- Alexander S.P.H., Mathie A., Peters J.A. Guide to Receptors and Channels (GRAC), 3rd edition // Br. J. Pharmacol. 2008. — Vol. 153. — P. 1−209.
- Anderson D.M., Lyman S.D., Baird A. et al. Molecular cloning of mast cell growth factor, a hematopoietin that is active in both memrane bound and soluble forms // Cell. 1990. — Vol. 63. — P. 235−243.
- Andre C., Hampe A., Lachaume P. et al. Sequence analysis of two genomic regions containing the KIT and. the FMS receptor tyrosine kinase genes // Genomics. 1997. — Vol. 39. — P. 216- 226.
- Angiolillo D.J., Suryadevara S., Capranzano P., Bass T.A. Antiplatelet drug response variability and' role of platelet function testing: a practical' guide for interventional cardiologists //Am. Heart. J. 2008. — Vol. 156 -P. 10−15.
- Ashman L.K. The biology of stem cell factor and its receptor c-Kit // Int. J. Biochem. Cell Biol. 1999. — Vol. 31.-P. 1037−1051.
- Atkinson B., Dwyer K., Enjyoki K., Robson S.C. Ecto-nucleotidases of the CD39/NTPDase family modulate platelet activation and thrombus formation: Potential as therapeutic targets // Blood Cells Mol. Dis. 2006. — Vol. 36.20. P. 217−222.
- Banerjee R.K. Ecto-ATPase // Mol. Cell. Biochem. 1981. — Vol. 37. — P. 9199.
- Baricordi O.R., Ferrari D., Melchiorri L., Chiozzi P. An ATP-activated channel is involved in mitoganic stimulation of human T-lymphocytes // Blood. 1996. -Vol. 87.-P. 682−690.
- Baricordi O.R., Melchiorri L., Adinolfi E. et al. Increased proliferation rate oflymphoid cells transfected with the P2X7ATP receptor // J. Biol. Chem. 1999. -Vol. 274.-P. 33 206−33 208.
- Beal E. Parkinson disease: protein-based stem cells generate healthy dopamine neurons // Nat. Rev. Neurol.- 2011. Vol. 134 — P. 357−367.
- Beldi G., Enjyoji K., Wu Y. et al. The role of purinergic signaling in the liver and in transplantation: effects of extracellular nucleotides on hepatic grafts vascular injury, rejection and metabolism // Front. Biosci. 2008. — Vol. 13. — P. 2588−2603.
- Ben Yebdri F., Kukulski F., Tremblay A., Sevigny J. Concomitant activation of P2Y (2) and P2Y (6) receptors on monocytes is required for TLRl/2-induced neutrophil migration by regulating IL-8 secretion // Eur. J. Immunol. 2009. — Vol. 39.-P. 2885−2894.
- Benham C.D., Tsien R.W. A novel receptor-opereted Ca2±permeable channel activated by ATP in smooth muscle //Nature. 1987. — Vol. 238. — P. 275−278.
- Beukers W.M., Pirovano I.M., Anton van Weert et al. Characterization of ecto-ATPase on human blood cells // Biochem. Pharmacol. 1993. — Vol. 46. — P. 19 591 966.
- Bissels U., Wild S., Tomiuk S., Hafher M. et al. Combined characterisation of microRNA and mRNA profiles delineates early differentation pathways of CD133+ and CD34+hemapopoietic stem and progenitor cells // Stem Cells 2011. — Vol. 29. -P. 847−957.
- Blume-Jensen P., Claesson-Welsh L., Siegbahn A. Activation of the human c-kit product by ligand-induced dimerization mediates circular acting reorganization and chemotaxis // EMBO J. 1991. — Vol. 10. — P. 4121−4128.
- Boarder M.R., Weisman G.A., Turner J.T., Wilkinson G.F. G-protein coupled purinoreceptors: from molecular biology to functional responses // Trends Pharmacol. Sci.- 1995. -Vol. 16.-P. 133−139.
- Boarder M.R., Webb T.E. P2Y receptors: Structure and Function // Handbook of Experimental Pharmacology, Vol. 151(1). Purinergic and Pyrimidinergic Signaling / Eds. M.P. Abbracchio M.P., Williams M. Berlin: Springer, 2001. — P. 66
- Boettge K., Jaeger K.H., Mettenzwei H. Das adenylsauresystem. Neuere ergebnisse und probleme //Arzneim. Forsch. 1957. — Vol. 7. — P. 24−59.
- Bouman H.J., van Werkum J.W., Rudez G. et al. The influense of variation un the P2Y12 receptor gene on in vitro platelet inhibition with the direct P2Y12 antagonist cangrelor // Thromb. Haemost. 2010. — Vol. 103. — P. 379−386.
- Bours M.J., Daqnelie P.C., Giuliani A.L. P2 receptors and extracellular ATP: a novel homeostatic pathway in inflammation // Front Biosci (Schol Ed). 2011. -Vol. 3.-P. 1443−1456.
- Boyer J.L., Downes C. P., Harden T. K. Kinetics of activation of phosphor-lipase C by P2Y-purinergic receptor agonists and guanine nucleotides // J. Bion. Chem. 1989. — Vol. 264. — P. 884 — 890.
- Boyum A. Separation of leucocytes from blood and bone marrow // Scand. S. Clin. Lob. Invest. 1968. — Vol. 1. — P. 90 — 109.
- Briddell R.A., Broudy V.C., Bruno E. et al. Further phenotypic characterization and isolation of human hematopoietic progenitor cells using a monoclonal antibody to the c-kit receptor // Blood. 1992. — Vol. 79. — P. 3159−3167.
- Bruner G., Murphy S. ATP-evoked arachidonic acid mobilization in asrtrocytes is via a P2Y-purinoergic receptor // J. Neurochem. 1990. — Vol. 55. — P. 1569−1575.
- Burnstock G. Evolution of the autonomic innervation of visceral and cardiovascular systems in vertebrates // Pharmacol. Rev. 1969. — Vol. 21. — P. 247- 324.
- Burnstock G. Purinergic nerves // Pharmacol. Rev. 1972. — Vol. 24. — P. 509 581.
- Burnstock G. A unifing purinrgic hypothesis for the initiation of pain // Lancet. 1996a. — Vol. 347. — P. 1604−1605.
- Burnstock G. Purinoreceptros: ontogeny and phylogeny // Drug. Dev. Res. -1996b. Vol. 39. — P. 204−242.
- Burnstock G., King B.F. Nombering of cloned P2 purinoreceptors // Drug Rev. Res. 1996c. — Vol. 38. — P. 67−71.
- Burnstock G. Purine-mediated signaling in pain and visceral perception I I Trends in Pharmacological Science. 2001. — Vol. 22. — P. 182−188.
- Burnstock G. Cotransmission // Curren opinion in pharmacology. 2004. -Vol. 4.-P. 47−52.
- Burnstock G. Pathophysiology and therapeutic potential of purinergic signaling // Pharmacol. Rev. 2006a. — Vol. 58. — P. 58−86.
- Burnstock G. Purinergic signaling an overview // Novartis Found Symp. — 2006b. — Vol*. 276. — P. 26−48.
- Burnstock G. Purine and pyrimidine receptors // Cell. Mol. Life Sci. 2007. -Vol. 64.-P. 1471−1483.
- Burnstock G. Purines, purinoreceptors molecular biology, overview // Encyclopedia of Neuroscience. — 4td ed. / Ed.L.R. Squire. — Oxford: Academic Press, 2009.-P. 1253−1262.
- Chiozzi P., Sans J.M., Ferrari D. et al. Sponaneous cell fusion in macrophage cultures expressing high levels of the P2Z/P2X7 receptors // J. Cell Biol. 1997. -Vol. 138.-P. 697−706.
- Clemens M. J. PKR a protein kinase regulated by double — stranded RNA // Int. J. Biochem. Cell Biol. — 1997. — Vol. 29. — P. 945−949.
- Clifford E.E., Martin K.A., Dalai P. et al. Stage-specific expression of P2Y receptors, ecto-apyrase, and ecto-5-nucleotidase in myeloid leukocytes // Am. J. Physiol. 1997. — Vol. 273. — P. 973−987.
- Cohn Z.A., Parks E. The regulation of pinocytosis in mouse macrophages. 3. The induction of vesicle formation by nucleoside and nucleotides // J. Exp. Med. -1967. Vol. 125 (3). — P. 457−466.
- Communi D., Janssens R., Robaye B. et al. Rapid up-regulation of P2Y messenger during granulocytic differentiation of HL-60 cells // FEBS Lett. 2000. -Vol. 475.-P.39−42.
- Conigrave A.D., Lee J.Y., van der Weyden L. et al. Pharmacological profile of a novel cyclic AMP-linked P2 receptor on undifferentiated HL-60 leukemia cells //
- Br. J. Pharmacol. 1998. — Vol. 124. — P. 1580−1585.
- Conigrave A. D., Fernando K. C., Gu B. et al. P2Y (11) receptor expression by human lymphocytes: evidence for two cAMP-linked purinoceptors // Eur. J. Pharmacol. -2001. Vol. 426.-P. 157−163.
- Cotrina M.L., Jane H.-C. Lin., Alexandre A.-R. et al. Connexins regulate calcium signaling by controlling ATP release // Proc. Natl. Acad, Sci. USA 1998. -Vol. 95.-P. 15 735−15 740.
- Coutinho-Silva R., Persechini P.M., Bisaggio R.D., Perfettini J.L. P2Z/P2X7 receptor-depended apoptosis of dendritic cells //Am. J. Physiol. 1999. — Vol. 276. -P. 1139−1147.
- Cowen D.S., Lazarus H.M., Shurin S.B. et al. Extracellular adenosine triphosphate activates calcium mobilization in human phagocytic leykocytes and neutrophil/monocyte progenitor cells // J. Clin. Invest. 1989. — Vol. 83. — P. 16 511 660.
- Cronstein B.N., Rosenstein E.D., Ktamer S.B. et al. Adenosine: a physiologic modulator of superoxide anion generation by human neutrophils. Adenosine acts via an A2 receptor on human neutrophils // J. Immunol. 1985. — Vol. 135. — P. 13 661 371.
- Cronstein B.N., Levin R.I., Philips M: R. et al. Neutrophil adherence to endothelium is enchanced via adenosine Al receptors and inhibited via adenosine A2 receptors // J. Immunol. 1992. — Vol. 148. — P. 2201−2206.
- Cronstein B.N., Van de Stouwe M., Druska L. et al. Nonsteroidal antiinflammatory agents inhibit stimulated neutrophil adhesion to endothelium: adenosine depended and independed mechanisms // Inflam. — 1994. Vol. 18. — P. 323−355.
- Cronstein B.N., Maarten G.B., Becker B.F. Purinergic mechanisms in inflammation // Drug. Developer. Res. 1996. — Vol. 39. — P. 426−435.
- Dantuma E., Merchant S., Suqaya K. Stem cells for the treatment of neurodegenerative diseases // Stem cell Res. Ther. -2011. Vol. 10. -P. 37−42.
- Davey H. Flow cytometry for clinical microbiology / CLI. 2004. — Vol. 2. -P. 12−15.
- De Santis M., De Luca C., Mappa I. et al. In-utero stem cell transplantation: clinical use and therapeutic potential // Minerva Ginecol. 2011. — Vol. 63. — P. 387 398.
- Di Virgilio F., Pizzo P., Zanovello P., Gollavo D. Exracellular ATP as a possible mediator of cell-mediated cutoxocoty // Immunol. Today. 1990. — Vol. 11'. — P. 274 277.
- Di Virgilio F., Chiozzi P., Ferrari D. et al. Nucleotide receptors: an emerging' family of regulatory molecules in blood cells // Blood. 2001. — Vol. 97. — P. 587 600.
- Di Virgilio F., Wiley J.S. The P2X7-receptor of CLL lymphocytes a molecule with a split personality // Lancet. — 2002. — Vol. 360. — P. 1898−1899.
- Dolci S., Williams D.E., Ernst M.K. Requirement for mast cell growth factor for primordial germ cell survival in culture // Nature. 1991. — Vol. 352. — P. 809 811.
- Droin N., Guery L., Benikhlef N., Solary E. Targeting apoptosis protein in hematological malignancies // Cancer Lett. 2011. — Vol.87.- 23−34.
- Drury A.N., Szent-Guorgy A. The physiological activity of adenine compounds with special reference to their effects upon the mammalian heart // J. Physiol. 1929. -Vol. 68.-P. 213−237.
- Dubyak G.R., Cowen D.S. Activation of inositol phospholipidspecific phospholipase C by P2-purinergic receptors in human phagocytic leukocytes // Ann. N. Y. Acad. Sci. 1990. — Vol. 603. — P. 227−245.
- Dubyak G.R., El-Moatassim C. Signal transduction via P2-purinoreceptors for external ATP and other nucleotides // Am. J. Physiol. 1993. — Vol. 265. — P. 577 606.
- Dubyak G.R., Clifford E.E., Humpheys B.D. et al. Expression of multiple ATP receptor subtypes during the differentiation and inflammatory activation of myeloidleukocytes // Drug. Dev. Res. 1996. — Vol. 39 — P. 269−278.
- Dubyak G.R., Abbraccho M.P., Williams M. Role of P2 receptors in the Immune system // Handbook of experimental pharmacology. Purinergic and pyrimidinergic signaling. -2001. Vol. 151. — P. 323−354.
- Edwards F.A., Gibb A J. ATP- a fast neurotransmitter // fEBS Lett. 1993. -Vol. 325.-P. 86−89.
- Elliott M.R., Chekeni F.B., Trampont P.C. et al. Nucleosides released by apoptotic cells ast as a find-me signal to promota phagocytic clearance // Nature. -2009.-Vol. 461.-P. 282−286.
- Engelhardt W.A. Enzymes as structural element of physiological mechanisms // Proc. Int. Symp. Enzyme Chem.- 1957. Vol. 2. — P. 163−166.
- Escribano L., Ocqueteau M., Almeida J. Expression of the c-kit (CD 117) molecule in normal amd malignant hematopoiesis // Leuk. Lymphoma. — 1998. Vol. 30.-P. 459−466.
- Falzoni S., Munerati M., Ferrari D., Spisani S. The purinergic P2z receptor of human macrophage cells. Characterisation and possible physiological role // J. Clin. Invest. 1995. — Vol. 95. — P. 1207−1216.
- Ferrari D., Munerati M., Melchiorri L. et al. Responses to extracellular ATP of lymphoblastoid cell lines from Duchenne muscular dystrophy patients // Mol. Pharmacol. 1994. — Vol. 267. — P. 886−892.
- Ferrari D., Cgiozzi P., Falzoni S., Dal Susino M. Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages // J. Immunol.-1997a.-Vol. 159.-P. 1451−1458.
- Ferrari D., Chiozzi P., Falzoni S., Hanau S. Purinergic modulation of interleukin-1P release from microglial cells stimulated with bacterial endotoxin // J. Exp. Med. 1997. — Vol. 185. — P. 579−582.
- Forrester T. Release ATP from the heart. Presentation of release model using human erythrocyte //Ann. N. Y. Acad. Sci. 1990. -Vol. 603. — P. 335−352.
- Fredholm B.B., Ijzerman A.P., Jacobson K.A. et al. Intrenationa union ofpharmacology. XXV. Nomenclature and classification of adenosine receptors // Pharmacol. Rev. 2001. -Vol. 53. — P. 527−552.
- Fu N., Drinnenberg I., Kelso J., Wu J.-R. et al. Comparison of protein and mRNA expression evolution in human and chimpanzees // Plosone. 2007. -Vol. 2. — P. 216−221.
- Furness J.B., Morris J.L., Gibbins I.L., Costa M. Chemical cording of neurons and plurichemical transmission // Annu. Rev. Pharmacol. Toxicol. 1989. — Vol. 29. — P. 289−306.
- Gachet C. The platelet P2 receptors as molecular targets for old and. new antiplatelet drugs // Pharmacol. Ther. -2005. Vol. 108. -P. 180−192.
- Gacher C. P2 receptors, platelet function and pharmacological implications // Thromb. Haemost.- 2008. -Vol. 99. P. 466−472.
- Gaddum J.H., Holtz P. The localization of the action of drugs on the pulmonary vessels of dogs and cats // J. Pharmacol. 1933. — Vol. 77. — P. 139−158.
- Galli S.J. Allergy // Curr. Biol.- 2000. Vol. 10. — P. 93−95.
- Gargett C.E., Cornish J.E., Wiley J.S. ATP, a partial agonist for the P2Z receptor of human lymphocytes // Br. J. Pharmacol. 1997. — Vol. 122: -P. 911−917.
- Gever J.R., Cockayne D.A., Dillon M.P. et al. Pharmacology of P2X-channels // Pflugers Arch. 2006. — Vol. 452. — P. 513−537.
- Gillespie J.H. The biological significance ot the linkages in adenosine triphophoric acid // J. Phisiol. 1993. — Vol. 80. — P. 345−349.
- Gilman A.G. G protein: transducers of receptor-generated signals // Annu. Rev. Biochem. 1987. — Vol. 56. — P. 615−649.
- Godin I., Deed R., Cooke J. Effects of the steel gene product on mouse primordial germ cell survival in culture // Nature. -1991. -V. 352. P. 807−809.
- Gordon J.L. Extracellular ATP: effects, sources and fate // Biochem. J. 1986. -Vol. 233.-P. 309−319.
- Gotts J.E., Matthay M.A. Mesenchymal stem cells and acute lung injury // Crit. Care Clin.-2011.-Vol. 27.-P. 719−733.
- Grassi E Purinergic control of neutrophil activation // J. Mol. Cell. Biol.— 2010.-Vol. 2.-P. 176−177.
- Gu B.J., Zhang W., Worthington R.A. et al. A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptor // J. Biol. Chem. 2001. — Vol. 276.-P. 11 135−11 142.
- Gudmundsson K.O., Thorsteinsson L., Siqurjonsson O.E. Gene expression analysis of hemapopoietic progenitor cells identifies Dlg7 as a potential stem cell gene // Stem Cells. 1997. — Vol. 25. — P. 1498−1506.
- Gunetti M., Noqhero A., Molla F. et al. Ex vivo-expanded bone marrow CD34(+) for acute myocardial infarction treatment: in vitro and in vivo studies // Cytotherapy.- 2011. Vol. 15. — P. 18−25.
- Gutmann H.R., Chow Y.M., Vessella R.L. et al. The kinetic Properties of the ecto-ATPase of human peripheral^ blood lympocytes and of chronic lymphatic leukemia cells //Blood. 1983. — Vol. 62. — P. 1041−1046.
- Hechler B., Cattaneo M., Gachet C. The P2-receptors in platelet function // Semin. Thromb. Hemost. 2005. -Vol. 31.-P. 150−161.
- Hoffbrand A.V., Moss P.A.H., Pettit J.E. Essenttial Haematology. / Wiley-Blackwell, 2006.-P. 1−3.
- Huang E., Nocka K., Beier D.R. et al. The hematopoietic growth factor KL is encoded at the SI locus and is the ligand of the c-kit receptors, the gene product ot the W locus // Cell. 1990. — Vol. 63. — P. 225−233.
- Humphreys B.D., Rice J., Kertesy S.B., Dubyak G.R. Stress-activated protein kinase/JNK activation and apoptotic induction by the macrophage P2X7 nucleotide receptor// J. Biol. Chem. 2000. — Vol. 275. — P. 26 792−26 798.
- Jin J., Dasari V.R., Sistare F.D., Kunapuli S.P. Distribution of P2Y-receptorssubtypes on hematopoietic cells // Br. J. Pharmacol. 1998. — Vol. 123. — P. 789−794.
- Jiang Q., Mak D., Devidas S. et al. Cystic fibrosis transmembrane conductance regulator-associated ATP release is controllled by a chloride sensor // The J. of Cell Biol. 1998. — Vol. 143. — P. 645−657.
- Jin K., Mao X.O., Sun Y. et al. A Stem cell factor stimulates neurogenesis in vitro and in vivo // J. Clin. Invest. 2002. — V. 110. — P. 311−319.
- Kapur R., Majumdar M., Xiao X. et al. Signaling through the interaction of membrane-restricted stem> cell factor and c-Kit receptor tyrosine kinase: Genetic evidence for a differential role in erythropoiesis // J. Blood.-1998.-V. 91.-P. 879−889.
- Katsuragi T., Tokunaga T., Ogba M. et al. Implication of ATP release from atrial but not papillary muscle segments of quinea pig by- isoproterenol and forskolin. //Life Sei. 1993. — Vol. 53. — P. 961−967.
- Keller J.R., Ortiz M., Ruscetti F.W. Steel factor (c-kit ligand) promotes the survival of hematopoietic stem/progenitor cells in the absence of cell division // Blood.- 1995-Vol. 86-P. 1757−1764.
- Kennerdell J. R., Carthew R. W. Use of dsRNA-mediated genetic inter-ference to demonstrate that frizzled and frizzled 2 act in the wingless pathway // Cell. 1998 -Vol. 95-P. 1017−1026.
- Keshet E., Lyman S. D, Williams D. E. Steel Factor and c-kit Regulate CellMatrix Adhesion // J. Blood. 1994. — Vol. 183. — P. 1033−1038.
- Klein C., Grahnert A., Abdelrahman A. et al. Extracellular NAD (+) induces a rise in Ca 2+ (I) in activated human monocytes via of P2Y (1) and P2Y (11) receptors // Cell Calcium 2009. — Vol. 46 (4). — P. 263−272.
- Koles L., Furst S., Illes P. Pyrine ionotropic (P2X) receptors // Cur. Pharm. Des. 2007. — Vol. 13. — P. 2368−2384.
- Kraj M., Poglod R., Kopec-Szlezak J. et al. C-ki receptor (CD117) expression on plasma cells in monoclonal gammopathies // Leuk. Lymphoma — 2004. Vol. 45. -P. 2281−2289.
- Kunapuli S.P., Dorsam R.T., Murugappan S., Ding Z. Clopidogrel: Interactionswith the P2Y12 Receptor and Clinical Relevance // Cur. Pharm. Des. 2003. — Vol. 9.-P. 2303−2316.
- Kukulski R, Ben Yebdri R, Lecka J., Kauffenstein G. Extracellular ATP and P2-receptors are required for IL-8 to induce neutrophil migration // Cytolkine. -2009.-Vol. 46 (2)-P. 166- 170.
- Lai R.C., Chen T.S., Lim S.K. Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease // Regen Med. — 2001. Vol. 6. — P. 481−492.
- Leal D.B., Streher C.A., Neu T.N. et al. Characterization of NTPDase (NTPDasel- ecto-apyrase- ecto-diphosphohydrolase- CD39- EC 3.6.1.5) activity in human lymphocytes //Biochim. Biophys. Acta. 2005. — Vol. 1721 — P. 9−15.
- Lee D.H., Park K. S., Kong I. D. et al. Expression of P2-receptors in human B cells and Epstein-Barr virus-transformed lymphoblastoid cell lines // BMC Immunol. -2006.-Vol. 7.-P. 22−34.
- Lemoli R.M., Ferrari D., Fogli M. et al. Extracellular nucleotides are potent stimulators of human hematopoietic stem cells in vitro and in vivo // Blood. 2004. -Vol. 104.-P. 1662−1670.
- Li Z., Liang D., Chen L. Potential therapeutic target for ATP-gated P2X-receptor ion channels //Assay Drug Dev. Technol. 2008. — Vol. 6. — P. 277−284.
- Limdvall O., Kokaia Z. Stem cell research in stroke: how far from the clinic? // Stroke.-2011. Vol. 42-P. 2369−2375.
- Lipmann F. Metabolic generation and utilization of phosphate bond energy // Adv. Enzymol. 1941. — Vol. 1 — P. 99−162.
- Lohmann J.U., Endl I., Bosch T. C. Silencing of Developmental Genes in Hydra //Dev. Biol. 1999. — Vol. 214. — P. 211−214.
- Lorenze A., Schwabe U. Pl-receptor // Handbook of pharmacology: purinergic and pyrimidinergic signaling / Eds. Abbracchio M.P., Williams M. Berlin- Heidelberg: Springer-Verlag, 2001. — Vol. 151 (1). -P. 19−45.
- Mallardo M., Poltroieri P., D’Urso O.F. Non-protein coding RNA biomarkersand differential expression in cancers: a review // J. Exp. Clin. Cancer Res. 2008. — Vol. 27.-P. 19−31.
- Mancino G., Placido R., Di Virgilio R P2X7 receptors and apoptosis in tuberculosis infection // J. Biol. Requl. Homeost. Agents 2001. — Vol. 15. — P. 286 293.
- Marcus A. J., Broekman M.J., Drosopoulos J.H. et al. Metabolic control of excessive extracellular nucleotide accumulation by CD39/ecto-nucleotidase-l: implication for ischemic vascular diseases // J. Pharmacol. Exp. Ther. 2003. — Vol. 305.-P. 9−16.
- Marcus A.J., Broekman M.J., Drosopoulos J.H. et al. Role of CD39 (NTPase-1) in thromboregulation, cerebroprotection, and cardioprotection // Semin. Thromb. Hemost. 2005. — Vol. 31. — P. 234−246.
- Marquardt D.L., Gruber H.E., Wasserman S.I. Adenosine release from stimulated cells // Proc. Natl. Acad. Sci. USA.- 1984. Vol. 81. — P. 6192−6196.
- Markwardy F., Lohn M., Bohm T., Klapperstuck M. Purinoreceptor-operated cationic channels in human B lymphocytes // BMC Immunol. 1997. — Vol. 498. — P. 143−151.
- Matsui Y., Toksoz D., Nishikawa S. Effect of Steel factor and leukaemia inhibitory factor on murine primordial germ cells in culture // Nature. 1991. — Vol. 353.-P. 750−752.
- Matsumoto T. Propress and perspective in bone research // Nichon Rinsho.— 2011.-Vol. 69- P. 1175−1180.
- Meghji P. Storage, release, uptake, and inactivation of purines // Drug Dev. Res. 1993 — Vol. 28 — P. 214−219.
- Miller J.S., Cervenka T., Lund J., Okazaki IJ. et al. Purine metabolites suppress proliferation of human NK cells through a lineage-specific purine receptor // The J. of Immunology. 1999. — Vol. 162. — P. 7376−7382.
- Mimeault M., Hauke R., Batra S.K. Stem cells: a revolution in therapeutics — recent advances in stem cell biology and their therapeutic applications in regenerativemedicine and cancer therapies // Nature. 2007. — Vol. 82. — P. 252−260.
- Mitchell C.H., Carre D.A., McGlinn A.M., Stone R.A. A release mechanisms for stored ATP in ocular ciliary epithelial cells // Proc. Natl. Acad. Sci. USA. 1999. -Vol. 95.-P. 7174−7178.
- Moreschi I., Bruzzone S., Nicholas R.A. et al. Extracellular NAD= is an agonist ot the human P2Y11 purinergic receptor in human granulocytes // J. Biol. Chem.- 2006. -Vol. 281.-P. 31 319−31 429.
- Ngo H., Tschudi C., Gull K., Ullu E. Double-stranded RNA induces mRNA degradation-in Trypanosoma brucei // Proc. Natl. Acad. Sci. U S A 95. 1998. — Vol. 95.-P. 14 687−14 692.
- Nocka K., Buck J., Levi E., Besmer P. Candidate Uganda for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid’progenitors // J. EMBO. 1990. — Vol. 10. — P. 3287−3294.
- Oshimi Y., Miyazaki S., Oda S. ATP-induced Ca2 response mediated by P2U and P2Y purinoceptors in human macrophages: signalling from dying cells to macrophages // Immunology. 1999. — Vol. 98. — P. 220−227.
- Palmer T.M., Trevethick M.A. Supression of inflammatory and immune responses by the A2A-adenosine receptor: an introduction // Br. J. Pharmacol'. 2008. -Vol. 153.-P. 27−34.
- Pearson J.D., Gordon J.L. P2-purinoreceptors in the blood vessel wall // Biochem. Pharmacol. 1989. — Vol. 38. — P. 4157−4163.
- Pearson J.D., Coade S. B., Cusack N. J. Characterisation of ecto-nucleotidases on vascular smooth-muscle cells // Biochem. J. 1985. — Vol. 230. — P. 503−507.
- Podesta M., Zocchi E., Pitto A. et al. Extracellular cyclic ADP-ribose increases intracellular free calcium concentration and stimulates proliferation of human hemopoietic progenitors // Faseb. J. 2000. — Vol. 14. — P. 680−690.
- Ramamurthi A., Robson S.C., Lewis R.S. Effects of nitric oxide and soluble nucleoside triphosphate diphosphohydrolasw (NTPDase) on inhibition of platelet deposition in vitro // Thromb. Res. 2001. — Vol. 102. — P. 331−341.
- Richards F.A. The effect of adenylic acid and adenosine on the human heart and blood vessels//J. Physiol. 1934.-Vol. 81.-P. 10.
- Rossi L., Manfredini R., Bertollini F. et al. The extracellular nucleotide UTP is a potent inducer of hematopoietic stem cell migration // Blood. 2007. — Vol. 109. -P. 533−542.
- Sak K., Boeynaems J-M., Everaus H. Involvement of P2Y-receptors in the differentiation of haematopoietic cells // J. of Leukocyte Biology. 2003. -Vol. 73. -p- 442−447.
- Sanchez Alvarado A., Newmark P.A. Double-stranded RNA specifi-cally disrupts gene expression during planarian regeneration // Proc. Natl. Acad. Sci. USA. 1999. -Vol. 96. — P. 5049−5054.
- Segel G.B., Ryan D. H, Lichtman M.A. Ecto-nucleotide triphosphatese activity oh human lymphocyres: studies of normal and CLL lymphocytes // Journal of cellular physiol. 1985. — Vol. 124. — P. 424−432.
- Shinozuka K., Kitagawa S., Kunitomo M. et al. Release of endogenous AYP from caudal artery from rats with arteriosclerosis // Eur. J. Pharmacol. 1994. — Vol. 292.-P. 115−118.
- Simmons D.L., Satterthwaite A.B., Tenen D.G. et al. Molecular cloning of cDNA encoding CD34, a sialomucin of human hematopoietic stem cells // The J. of Immunol. 1992. — Vol. 148. — P. 267−271.
- Simmons P.J., Aylett G.W., Niutta S. et al. c-kit is expressed by primitivehuman hematopoietic cells that give rise to colony-forming cells in stroma-dejuendent or cytokine-supplemented culture // Exp. Hematol- 1994. Vol. 22. — P. 157−165.
- Sluyter R., Barden J.A., Wiley J.S. Detection of P2X purinergic receptors on human B lymphocytes // Cell Tissue Res. 2001. — Vol. 304. — P. 231−236.
- Sogo S., Inaba M., Ogata H. et al. Induction of c-kit molecules on human 0034^/0-^
- Solet D.J., Zacharski L.R., Plehn J.F. The role of adenosine 5'-diphosphate receptor blockade in patients with cardiovascular disease // Am. J. Med. 2,001. -Vol. 111.-P. 45−53.
- Somers G.R., Hammet F.M., Trute L. et al. Expression of the P2Y6-purinergic receptors in human T cells infiltraing inflammatory bowel disease // Lab. Incvest. -1998.-Vol. 78.-P. 1375−1383.
- Susumu I. Pluripotent hemopoietic stem cells in mice and humans // P. S.E.B.M. -2000. -Vol. 223. P. 149−155.
- Suzuki H., Takei M., Nakahata T., Fukamachi H. Inhibitory effect of adenosine on degranulation of human cultered mast cells upon cross-linking of Fc epsilon RI // Biochem. Biophys. Res. Commun. 1998. -Vol. 242. — P. 697−702.
- Tahrani A.A., Bailey C.J., Del Prato S., Barnett A.H. Management of «type 2 diabetes: new and future developments in treatment // Lancet 2011. — Vol. 378. — P. 182−197.
- Trams E.G. On the evolution of neurochemical transmission // Differenta."ti on.1981.-Vol. 19.-P. 123−133.
- Tsukimoto M., Maehata M., Harada H. et al. Involvement of chloride in apoptotic cell death induced by activation of Atp-sensitive P2X7 purinoreceptors // J.Biol.Chem. 2005. — Vol. 280. — P. 2653−2658.
- Vial C., Hecher B., Leon C. et al. Presence of P2X1 purinoreceptors in human platelets and megakarioblastic cell lines patients // Thromb. Haemost. -1997. Vol. 78.-P. 1500−1504.
- Virgilio C., Robertson G., Surprenant A., North R.A. Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3 and heteromeric P2X2/3 receptors // Mol. Pharmacol. 1998. — Vol. 53. — P. 969−973.
- Volarevic V., Arsenijevic N., Lukic M.L., Stojkovic M. Concise review: mesenchymal stem cell treatment of the complications of diabetes mellitus // Stem Cell.-2011.-Vol. 29.-P. 5−10.
- Wang L., Ostberq O., Wihborq A.K., Broqren H. Quantification of ADP and ATP receptor exoression in human platelet // Mol. Pharmacol. 2003. — Vol. 1. — P. 330−336.
- Wang L., Jacobsen S.E., Bentsson A., Erlinge D. P2-receptor mRNA expression profiles in human lymphocytes, monocytes and CD34+cells // BMC Immunology. 2004. — Vol. 5. — P. 16−23.
- Wang L., Olivecrona G., Goberg M. et al. ADP acting on P2Y13 receptors is anegative feedback pathway for ATP release from human red blood cells // Circ. Res. -2005.-Vol. 96.-P. 189−196.
- White T.D. Characteristics of neuronal release of ATP // Biol. Psychiatry. -1984.-Vol. 8.-P. 487−493.
- Wiley J.S., Dubyak G.R. Extracellular adenosine triphosphate increases cation permeability of chronic lymphocytic leukemic lymphocytes // Blood. 1989. -Vol. 73.-P. 1316−1323.
- Wiley J.S., Gargett C.E., Zhang W. Parial agonists and antagonists reveal a second permeability state of human phicyte P2Z/P2X7 channel // Am. J. Physiol. 1998.-Vol. 275.-P. 1224−1231.
- Yamada M., Hamamori Y., Akita H. Yokoyama M. P2-Purinoreceptoers activation stimulates phosphoinositide hydrolysis and inhibits accumulation of cAMP in cultured ventricular myocytes // Circ. Res. 1992. — Vol. 70. — P. 477−485.
- Ye Z.J., Gulcicek E., Stone K. et al. Complex interactionin EML cell stimulation by stem cell factor and IL-3 // Proc. Natl. Acad. Sci U.S.A. 2011. -Vol. 108.-P. 4882−4887.
- Yee N.S., Paek I., Besmer P. Role of kit-ligand in proliferation and suppression of apoptosis in mast cells: basis for radiosensitivity of white spotting and steel mutant mice // J. Exp. Med. 1994. -Vol. 179. — P. 1777−1787.
- Yip L., Woehrle T., Corriden R. et al. Autocrine regulation ot T-cell activation by ATP release and P2X7 receptors // FASEB J. 2009. -Vol. 23. — P. 1685−1693.
- Zanovello P., Bronte V., Rosato A. et al. Responses of mouse lymphocytes to extracellular ATP. II. Extracellular ATP causes cell type-dependent lysis and DNA fragmentation // J. Immunol. 1990. -Vol. 145. — P. 1545−1550.
- Zezula J., Freissmuth M. The A2A-adenozine receptor: a GPCR with unique features // Br. J. Pharmacol. 2008. — Vol. 152. — P. 184−190.
- Zheng L.M., Zychlinsky A., Liu C.C., Ojcius D.M. et al. Extracellular ATP as a trigger for apoptosis or programmed cell death // J. Cell. Biol. 1991. — Vol. 112. — P. 279−288.
- Zimmermann H. Signaling via ATP in the nervous system // Trends Neurosci. -1994. Vol. 17. — P. 420−426.
- Zimmermann H. Ecto-nucleotidases // Handbook of pharmacology: purinergic and pyrimidinergic signaling / Eds. Abbracchio M.P., Williams M. Berlin- Heidelberg: springer-Verlag, 2001. — Vol. 151 (I). — P. 209−250.
- Ziganshin A.U., Hoyle C.H.V., Burnstock G. Ecto-enzymes and metabolism of extracellular ATP//Drug. Dev. Res. 1994. — Vol. 32. — P. 134−146.
- Ziganshina L.E., Ziganshin A.U., Hoyle C.H.V., Burnstock G. Acute oedema formation induced by ATP: Re-evaluation of the mechanisms involved // Inflamm. Res. 1996. — Vol. 45. — P. 96−102.
- Zsebo K.M., Wypych J., McNiece I.K. Identification, purification, and biological characterization of haematopoietic stem cell factor from buffalo rat liver-conditioned medium // J. Cell. 1990. -Vol. 63. — P. 195−201.
- Zulewski H. Hypothyroidism // Ther Umsch. 2011. -Vol. 68. — P. 315−320.