Терминальные районы хромосом у двух близкородственных видов бурозубок, Sorex granarius и Sorex araneus (Soricidae, eulipotyphla)
Диссертация
Мы предполагаем, что современный кариотип S. granarius образовался в результате глобальной реорганизации терминальных районов хромосом в профазе мейоза. Известно, что во время мейотической профазы на стадии «мейотического букета» теломеры прикреплены к ядерной оболочке, образуя нечто наподобие кластера (Harper et al., 2004). По-видимому, контакт теломер в мейозе может облегчать рекомбинацию между… Читать ещё >
Содержание
- СПИСОК СОКРАЩЕНИЙ
- ГЛАВА 1. ОБЗОР ЛИТЕРАТУРЫ
- 1. 1. Теломерные районы
- 1. 1. 1. Структура и состав теломер
- 1. 1. 2. Методы определения размера теломер
- 1. 1. 3. Размеры теломер у разных видов
- 1. 1. 4. Способы поддержания длины теломер
- 1. 1. 4. 1. Зависимость длины теломер от активности теломеразы
- 1. 1. 4. 2. Альтернативные способы поддержания длины теломер
- 1. 1. 5. Геномная нестабильность при дисфункции теломер
- 1. 1. 6. Теломерные повторы в интерстициальных сайтах хромосом
- 1. 2. Субтеломерные районы хромосом
- 1. 3. Структурная и функциональная связь между теломерами и ядрышком
- 1. 4. Sorex grancirius и So rex araneus — объекты для исследования терминальных районов хромосом
- 1. 1. Теломерные районы
- ГЛАВА 2. МАТЕРИАЛЫ И МЕТОДЫ
- 2. 1. Материалы
- 2. 2. Методы
- 2. 2. 1. Получение первичных клеточных культур
- 2. 2. 2. Фиксация митотических клеток
- 2. 2. 3. Приготовление цитологических препаратов
- 2. 2. 3. 1. Приготовление препаратов метафазных хромосом для FISH
- 2. 2. 3. 2. Приготовление препаратов для микродиссекции
- 2. 2. 3. 3. Приготовление препаратов фибрилл для FISH
- 2. 2. 4. Окраска хромосом нитратом серебра на ЯО районы
- 2. 2. 5. Микродиссекция метафазных хромосом
- 2. 2. 6. Получение меченых проб для FISH
- 2. 2. 7. FISH на метафазных хромосомах и фибриллах
- 2. 2. 8. 3D FISH и иммуноокрашивание
- 2. 2. 9. Q-FISH
- 2. 2. 10. Модифицированная Q-FISH
- 2. 2. 11. TRF (Telomere Restriction Fragments) анализ
- 2. 2. 12. Анализ результатов
- 3. 1. Кариотипы So rex granarius и Sorex araneus: дифференциальая окраска хромосом DAPI
- 3. 2. Локализация теломериых повторов на хромосомах Sorex granarius
- 3. 2. 1. Выявление теломериой ДНК с помощью проб разного происхождения
- 3. 3. Определение длины теломер на хромосомах Sorex granarius
- 3. 3. 1. Определение длины теломер на хромосомах Sorex granarius с помощью Q-FISH
- 3. 3. 2. Определение длины теломер на хромосомах Sorex granarius с помощью TRF (Terminal Restriction Fragments) анализа
- 3. 4. Локализация теломерных последовательностей в хромосомах Sorex araneus
- 3. 5. Определение размера теломер в хромосомах Sorex araneus с помощью модифицированной Q-FISH
- 3. 6. Теломеры и ЯО районы в хромосомах Sorex granarius и Sorex araneus
- 3. 6. 1. Локализация теломерной и 18S рДНК на хромосомах Sorex granarius
- 3. 6. 2. Локализация теломерной и 18S рДНК в интерфазных ядрах Sorex granarius
- 3. 6. 3. Выявление активных ЯО районов на хромосомах Sorex granarius
- 3. 6. 4. Локализация 18S рДНК и ЯО районов на хромосомах Sorex araneus
- 3. 7. Изучение структуры длинных теломер на хромосомах Sorex granarius
- 3. 7. 1. Изучение структуры длинных теломер Sorex granarius с помощью микродиссекционной пробы
- 3. 7. 2. Выявление рДНК в длинных теломерах Sorex granarius
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