Π ΠΎΠ»Ρ ΠΌΠ΅Ρ Π°Π½ΠΎΡΠ΅Π½ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΊΠ°Π½Π°Π»Π° MscL Π² Π²ΠΎΡΠΏΡΠΈΡΡΠΈΠΈ ΡΡΡΠ΅ΡΡΠΎΠ²ΡΡ ΡΠΈΠ³Π½Π°Π»ΠΎΠ² ΠΊΠ»Π΅ΡΠΊΠ°ΠΌΠΈ Synechocystis
ΠΡ ΠΏΡΠ΅Π΄ΠΏΡΠΈΠ½ΡΠ»ΠΈ ΠΏΠΎΠΏΡΡΠΊΡ Π²ΡΡΡΠ½Π΅Π½ΠΈΡ Π΄Π°Π½Π½ΡΡ Π²ΠΎΠΏΡΠΎΡΠΎΠ² Π²ΠΏΠ΅ΡΠ²ΡΠ΅ ΠΈ ΠΎΠ±Π½Π°ΡΡΠΆΠΈΠ»ΠΈ, ΡΡΠΎ ΠΠ²ΡΠ¬ ΡΠ²Π»ΡΠ΅ΡΡΡ Π²Π°ΠΆΠ½ΡΠΌ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠΌ ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ½ΡΡ ΡΠ΅ΠΏΠ΅ΠΉ Π² ΠΊΠ»Π΅ΡΠΊΠ°Ρ ΠΡΠΏΠ΅ΡΠΊΠΎΡΡΠ½ΠΉΡ ΠΏΡΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΡΡΡΠ΅ΡΡΠΎΠ²ΡΡ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡΡ . ΠΠΎ Π²ΡΠ΅ΠΉ Π²ΠΈΠ΄ΠΈΠΌΠΎΡΡΠΈ, ΠΈΠΌ ΠΏΡΠΈΡΡΡΠ° Π½Π΅ ΡΠΎΠ»ΡΠΊΠΎ ΡΡΠ½ΠΊΡΠΈΡ Π·Π°ΡΠΈΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΎΡ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡ ΡΠΈΡΠΎΠΏΠ»Π°Π·ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Ρ ΠΏΡΠΈ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΌ Π²ΠΎΠ·ΡΠ°ΡΡΠ°Π½ΠΈΠΈ ΡΡΡΠ³ΠΎΡΠ½ΠΎΠ³ΠΎ Π΄Π°Π²Π»Π΅Π½ΠΈΡ, Π½ΠΎ ΡΠ°ΠΊΠΆΠ΅ ΠΈ ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ½Π°Ρ ΡΡΠ½ΠΊΡΠΈΡ. ΠΡΡΠ°Π½ΡΠ½ΡΠΉ ΡΡΠ°ΠΌΠΌ… Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΠ»Π°Π²Π° 1. ΠΠ±Π·ΠΎΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
- 1. 1. Π‘ΡΡΡΠΊΡΡΡΠ° ΠΈ Π»ΠΎΠΊΠ°Π»ΠΈΠ·Π°ΡΠΈΡ ΠΌΠ΅Ρ
Π°Π½ΠΎΡΠ΅Π½ΡΠΎΡΠ½ΡΡ
ΠΊΠ°Π½Π°Π»ΠΎΠ²
- 1. 1. 1. ΠΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΠΈ Π²ΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ MscL
- 1. 1. 2. ΠΠ°Π½Π½ΡΠ΅ ΠΊΡΠΈΡΡΠ°Π»Π»ΠΎΠ³ΡΠ°ΡΠΈΠΈ ΠΎ ΡΡΡΡΠΊΡΡΡΠ΅ MscL
- 1. 2. ΠΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌ ΡΠ°Π±ΠΎΡΡ ΠΌΠ΅Ρ
Π°Π½ΠΎΡΠ΅Π½ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΊΠ°Π½Π°Π»Π°
- 1. 2. 1. ΠΠΎΠ΄Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ ΠΊΠ°Π½Π°Π»Π°
- 1. 2. 2. Π€ΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠ°Π½Π°Π»Π° ΠΊΠ°ΠΊ Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΠ»Π°ΠΏΠ°Π½Π° Π΄Π»Ρ ΡΠ±ΡΠΎΡΠ° ΡΡΡΠ³ΠΎΡΠ½ΠΎΠ³ΠΎ Π΄Π°Π²Π»Π΅Π½ΠΈΡ Π² ΡΡΡΠ΅ΡΡΠΎΠ²ΡΡ ΡΡΠ»ΠΎΠ²ΠΈΡΡ
- 1. 3. ΠΠ΅Ρ Π°Π½ΠΎΡΠ΅Π½ΡΠΎΡΠ½ΡΠ΅ ΠΊΠ°Π½Π°Π»Ρ MscL Π΄ΡΡΠ³ΠΈΡ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠ²
- 1. 4. ΠΠ½Π°Π»ΠΈΠ· ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π³Π΅Π½ΠΎΠ² Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΠΠ-ΠΌΠΈΠΊΡΠΎΡΡΡΠ΅ΠΉ (DNA microarray)
- 1. 4. 1. ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅
- 1. 4. 2. ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΌΠΈΠΊΡΠΎΡΠΈΠΏΠΎΠ² Π² ΠΈΠ·ΡΡΠ΅Π½ΠΈΠΈ ΠΌΠΈΠΊΡΠΎΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠ²
- 1. 4. 3. ΠΠ΅ΡΠΎΠ΄ ΠΠΠ-ΠΌΠΈΠΊΡΠΎΡΡΡΠ΅ΠΉ
- 1. 4. 4. ΠΠ°ΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ· Π΄Π°Π½Π½ΡΡ
- 1. 4. 5. ΠΡΠΎΠ±Π»Π΅ΠΌΡ, Π²ΠΎΠ·Π½ΠΈΠΊΠ°ΡΡΠΈΠ΅ ΠΏΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠΈ ΠΌΠΈΠΊΡΠΎΡΠΈΠΏΠΎΠ² (ΡΠΈΠ°Π½ΠΎΡΠΈΠΏΠΎΠ²)
- 1. 1. Π‘ΡΡΡΠΊΡΡΡΠ° ΠΈ Π»ΠΎΠΊΠ°Π»ΠΈΠ·Π°ΡΠΈΡ ΠΌΠ΅Ρ
Π°Π½ΠΎΡΠ΅Π½ΡΠΎΡΠ½ΡΡ
ΠΊΠ°Π½Π°Π»ΠΎΠ²
- 2. 1. Π¨ΡΠ°ΠΌΠΌΡ ΡΠΈΠ°Π½ΠΎΠ±Π°ΠΊΡΠ΅ΡΠΈΠΉ
- 2. 2. Π£ΡΠ»ΠΎΠ²ΠΈΡ ΠΊΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΡ
- 2. 3. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠΎΡΡΠ° ΠΊΡΠ»ΡΡΡΡ
- 2. 4. ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠ΅ ΡΡΠ»ΠΎΠ²ΠΈΡ ΠΊΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΡ
- 2. 5. ΠΠ½Π°Π»ΠΈΠ· ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π³Π΅Π½ΠΎΠ² Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΠΠ-ΠΌΠΈΠΊΡΠΎΡΡΡΠ΅ΠΉ
- 2. 6. ΠΠ½Π°Π»ΠΈΠ· ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π³Π΅Π½ΠΎΠ² Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΠΎΠ·Π΅ΡΠ½-Π±Π»ΠΎΡΡΠΈΠ½Π³Π°
- 2. 7. ΠΡΠΎΠ±Ρ Π΄Π»Ρ ΠΠΎΠ·Π΅ΡΠ½-Π³ΠΈΠ±ΡΠΈΠ΄ΠΈΠ·Π°ΡΠΈΠΈ
- 2. 8. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠΎΡΡΠ°Π²Π° ΠΆΠΈΡΠ½ΡΡ ΠΊΠΈΡΠ»ΠΎΡ
- 3. 1. ΠΠ΅Ρ Π°Π½ΠΎΡΠ΅Π½ΡΠΎΡΠ½ΡΠΉ ΠΊΠ°Π½Π°Π» ΠΠ²Ρ!- ΠΡΠΏΠ΅ΡΠΠΎΡΡΡΠΠ·
- 3. 2. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΌΡΡΠ°Π½ΡΠ° ΠΡΡΡ
- 3. 3. ΠΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° ΠΌΡΡΠ°Π½ΡΠ° ΠΡΠ²Ρ
- 3. 4. Π ΠΎΡΡΠΎΠ²ΡΠ΅ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ ΠΊΡΠ»ΡΡΡΡ
- 3. 5. ΠΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΡΠΎΡΡΠ°Π²Π° ΠΆΠΈΡΠ½ΡΡ ΠΊΠΈΡΠ»ΠΎΡ ΠΏΡΠΈ Π°Π΄Π°ΠΏΡΠ°ΡΠΈΠΈ ΠΊ ΠΏΠΎΠ½ΠΈΠΆΠ΅Π½Π½ΡΠΌ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΠ°ΠΌ
- 3. 6. ΠΠ½Π°Π»ΠΈΠ· ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π³Π΅Π½ΠΎΠ² ΠΈ ΠΡΡΡ!- Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΡΡΡΠ΅ΡΡΠ° Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΠΠ-ΠΌΠΈΠΊΡΠΎΡΡΡΠ΅ΠΉ
- 3. 6. 1. ΠΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΠ΅ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΡ
- 3. 6. 2. Π‘ΡΠ°Π²Π½Π΅Π½ΠΈΠ΅ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π³Π΅Π½ΠΎΠ² Ρ ΠΌΡΡΠ°Π½ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°ΠΌΠΌΠ° ΠΈ Π΄ΠΈΠΊΠΎΠ³ΠΎ ΡΠΈΠΏΠ° ΠΏΡΠΈ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΡΡ (ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΡ ) ΡΡΠ»ΠΎΠ²ΠΈΡΡ ΡΠΎΡΡΠ°
- 3. 6. 3. Π₯ΠΎΠ»ΠΎΠ΄ΠΎΠ²ΠΎΠΉ ΡΡΡΠ΅ΡΡ
- 3. 6. 4. Π’Π΅ΠΏΠ»ΠΎΠ²ΠΎΠΉ ΡΡΡΠ΅ΡΡ
- 3. 6. 5. ΠΠΈΠΏΠ΅ΡΠΎΡΠΌΠΎΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΡΡΠ΅ΡΡ 0,5 Π ΠΈ 1 Π ΡΠΎΡΠ±ΠΈΡΠΎΠΌ
- 3. 6. 6. Π‘ΠΎΠ»Π΅Π²ΠΎΠΉ ΡΡΡΠ΅ΡΡ (0,5 Π ΠΠ°Π‘1)
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