Роль цитокинов в репликации ВИЧ — 1 и регуляции апоптоза лимфоцитов при ВИЧ — инфекции
Диссертация
В популяции продуктивно инфицированных С04+Т-лимфоцитов (клетках с активной репликацией вируса) наблюдается подавление программы апоптоза. Механизмы данного феномена остаются недостаточно изученными. Продемонстрировано участие в его развитии вирусных белков. В частности, белок вируса Nef инактивирует внутриклеточный белок-индуктор апоптоза Вах. Вирусный белок Tat повышает в клетке активность… Читать ещё >
Содержание
- СПИСОК СОКРАЩЕНИЙ
- ГЛАВА 1. СОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ О СВОЙСТВАХ ЦИТОКИНОВ (ИЛ-2, ИЛ-4, ИЛ-7 и ФНО-а) И ИХ РОЛИ В
- ПАТОГЕНЕЗЕ ВИЧ-ИНФЕКЦИИ (ОБЗОР ЛИТЕРАТУРЫ)
- 1. 1. Интерлейкин
- 1. 2. Интерлейкин
- 1. 3. Интерлейкин
- 1. 4. Фактор некроза опухолей-альфа
- ГЛАВА 2. МАТЕРИАЛЫ И МЕТОДЫ ИССЛЕДОВАНИЯ
- 2. 1. Характеристика объекта и предмета исследования
- 2. 2. Выделение и культивирование лимфоцитов периферической крови
- 2. 3. Культивирование лимфоцитов периферической крови, инфицированных ВИЧ
- 2. 4. Исследование активационного статуса лимфоцитов
- 2. 5. Изучение апоптоза лимфоцитов
- 2. 6. Исследование репликации ВИЧ-1 in vitro
- ГЛАВА 3. РЕЗУЛЬТАТЫ СОБСТВЕННЫХ ИССЛЕДОВАНИЙ
- 3. 1. Влияние цитокинов (ИЛ-2, ИЛ-4, ИЛ-7 и ФНО-а) на регуляцию процесса репликации ВИЧ-1 in vitro
- 3. 2. Влияние цитокинов (ИЛ-2, ИЛ-4, ИЛ-7 и ФНО-а) на активацию СБ4+Т-лимфоцитов при их инфицировании in vitro ВИЧ
- 3. 3. Взаимосвязь между процессами активации CD4+T-лимфоцитов и репликации ВИЧ
- 3. 4. Влияние цитокинов (ИЛ-2, ИЛ-4, ИЛ-7 и ФНО- а) на регуляцию процесса апоптоза лимфоцитов при их инфицировании in vitro ВИЧ
Список литературы
- Апоптоз, роль в патологии и значимость его оценки при клинико-иммунологическом обследовании больных / А. А. Ярилин и др. // Медицинская иммунология. 2000. — Т 2, № 1. — С. 59−64.
- Белозеров Е. С. ВИЧ-инфекция / Е. С. Белозеров, Е. И. Змушко. — 2-е изд., перераб. Спб.: Питер, 2003. -368 с.
- Бойчук С. В. Апоптоз : характеристика, методы изучения и его роль в патогенезе атопических заболеваний / С. В. Бойчук, И. Г. Мустафин, Р. С. Фассахов // Казанский медицинский журнал. 2000. — № 3.-С. 217−222.
- Бойчук С. В. Механизмы апоптоза лимфоцитов при атопических заболеваниях : дис.. д-ра мед. наук / С. В. Бойчук- Казан, гос. мед. унт. Казань, 2002. — 234 с.
- Бойчук С. В. Роль эндотелиальных клеток и ВИЧ-1 белка Nef в патогенезе ВИЧ-инфекции : новые механизмы репликации ВИЧ-1 / С. В. Бойчук, И. Г. Мустафин // Медицинская иммунология. — 2004. Т. 6, № 6. — С. 499−506.
- Бойчук С. В. Роль эндотелиальных клеток в регуляции апоптоза инфицированных ВИЧ-1 СБ4+Лимфоцитов / С. В. Бойчук, И. Г. Мустафин, М. В. Макарова // Медицинская иммунология. 2006. — Т. 8, № 4.-С. 523−530.
- Бойчук С. В. Роль интерлейкина-7 в регуляции апоптоза CD4 Т-лимфоцитов и репликации ВИЧ-1 / С. В. Бойчук, И. Г. Мустафин, М. В. Макарова // Нижегородский медицинский журнал. — 2006. — № 4. — С. 35−39.
- Лимфоциты. Методы: пер. с англ. / под ред. Дж. Клауса. — М.: Мир, 1990.-400 с.
- Лушников Е. Ф. Гибель клетки (апоптоз) / Е. Ф. Лушников, А. Ю. Абросимов. М.: Медицина, 2001. — 192 с.
- Медико-биологическая статистика: пер. с англ. / С. Гланц. М.: Практика, 1998. — 495с.
- Мустафин И. Г. Роль апоптоза лимфоцитов в патогенезе ВИЧ-инфекции : дис.. д-ра мед. наук / И. Г. Мустафин- Казан, гос. мед. унт. Казань, 2005. — 252с.
- Новиков В. С. Программированная клеточная гибель / В. С. Новиков. СПб.: Наука, 1996. — 276 с.
- Реброва О. Ю. Статистический анализ медицинских данных. Применение пакета прикладных программ STATISTICA / О. Ю. Реброва. М.: МедиаСфера, 2003. — 312с.
- Система FAS FASL в норме и патологии / С. Г. Аббасова и др. // Вопросы биологической, медицинской и фармацевтической химии. — 1999.-№ 3.-С. 3−17.
- Ярилин А. А. Апоптоз и его место в иммунных реакциях / А. А. Ярилин // Иммунология, 1996. № 6. — С. 10−22.
- Ярилин А. А. Апоптоз. Природа феномена и его место в целостном организме / А. А. Ярилин // Патологическая физиология и экспериментальная терапия, 1998. — № 2. — С. 38−48.
- А balanced type 1 / type 2 response is associated with longterm nonprogressive human immunodeficiency virus type 1 infection / N. Imami etal. // J. Virol.- 2002.- Vol. 76, N18.-P. 9011−9023.
- A function for interleukin 2 in Fox3-expressing regulatory T cells / J. D. Fontenot et al. // Nat. Immunol. 2005. — Vol. 6, N 11. — P. 1142−1151.
- A macrophage factor inhibits adipocyte gene expression: an in vitro model of cachexia / F. M. Torti et al. // Science. 1985. — Vol. 229, N 4716.-P. 867−869.
- A novel form of TNF / cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF / M. Kriegler et al. // Cell. 1988. — Vol. 53, N 1. — P. 45−53.
- A potential role for interleukin-7 in T cell homeostasis / T. Fry et al. //Blood. -2003. Vol. 101. N23 — P. 2294−2299.
- Activation of human polymorphonuclear neutrophil functions by interferon-y and tumor necrosis factor / M. R. Shalaby et al. // J. Immunol. 1985.-Vol. 135, N3.-P. 2069−2073.
- Alfano M. Cytokine and chemokine based control of HIV infection and replication / M. Alfano, G. Poli // Curr. Pharm. Design. 2001. — Vol. 7, N11.-P. 993−1013.
- Alfano M. Role of cytokines and chemokines in the regulation of innate immunity and HIV infection / M. Alfano, G. Poli // Mol. Immunol. — 2005. Vol. 42, N 2. — P. 161−182.
- Al-Harthi L. Human immunodeficiency virus type-1 transcription: role of the 5-untranslated leader region (review) / L. Al-Harthi, K. A. Roebuck // Int. J. Mol. Med. 1998. — Vol. 1, N 5. — P. 875−881.
- Almonti J. B. Mechanisms of CD4+T lymphocyte cell death in human immunodeficiency virus infection and AIDS / J. B. Almonti, T. Blake Ball, K. R. Fowke // J. of General Virol. 2003. — Vol. 84, N 5. — P. 1649−1661.
- Alterations in T cell phenotype and in human immunodeficiency virus type 1-specific cytotoxicity after potent antiretroviral therapy / A. Seth et al.//J. Infect. Dis. 2001.-Vol. 183, N 5.-P. 722−729.
- An endotoxin-induced serum factor that causes necrosis of tumors / E. A. Carswell et al. // Proc. Natl. Acad. Sei. USA. 1975. — Vol. 72, N 9. -P. 3666−3670.
- Antibody-dependent cell-mediated cytotoxicity in cervical lavage fluids of human immunodeficiency virus type 1-infected women / K. Battle-Miller et al. / J. Infect. Dis. 2002. — Vol. 185, N 4. — P. 439−447.
- Apoptosis of CD8+T cells is mediated by macrophages through interaction of HIV gpl20 with chemokine receptor CXCR4 / G. Herbein et al. //Nature. 1998. — Vol. 395, N 6698. — P. 189−194.
- Assessement of type 1 and type 2 cytokines in HIV type 1-infected individuals: impact of highly active antiretroviral therapy / N. Imami et al. // AIDS Res. and Hum. Retroviruses. 1999. — Vol. 15, N 17. — P. 149 914 508.
- Association of IL-7 with disease progression in Chinese HIV-1 seropositive individuals / Q. Wang et. al. // Chin. Med. J. 2006. — Vol. 119, N 19. — P. 288−93.
- Augmentation of cell-mediated immunotherapy against herpes simplex virus by interleukins: comparison of in vivo effects of IL-2 and IL-7 on adoptively transferred T cells / P. Wiryana et al. // Vaccine. 1997. — Vol. 15, N5.-P. 561−563.
- B cell IL-7. Human B cell lines constitutively secrete IL-7 and express IL-7 receptors / D. Benjamin et al. // J. Immunol. 1994. — Vol. 152, N 10. P. 4749−4757.
- B cell precursor growth-promoting activity: purification and characterization of a growth factor active on lymphocyte precursors /A. E. Namen et al. // J. Exp. Med. 1988. — Vol. 167, N 3. — P. 988−1002.
- Bahbouhi B. Dynamics of cytokine expression in HIV productively infected primary CD4(+)T cells / B. Bahbouhi, A. Landay, L. Al-Harthi // Blood. 2004. -Vol. 103, N 12. — P. 4581−4587.
- Baribaud F. The role of DC-SIGN and DC-SIGNR in HIV and SIV attachment, infection, and transmission / F. Baribaud, S. Pohlmann, R. W. Doms/Virology.-2001.-Vol. 286, N 1.-P. 1−6.
- Bax deficiency partially corrects interleukin-7 receptor alpha deficiency / A. R. Khaled et al. // Immunity. 2002. — Vol. 17, N 5. — P. 561−573.
- Bazzoni F. The tumor necrosis factor ligand and receptor families / F. Bazzoni, B. Beutler // N. Engl. J. Med. 1996. — Vol. 334, N 26. — P. 17 171 725.
- Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice / K. Akashi et al. // Cell. 1997. — Vol. 89, N 7. — P. 1033−1041.
- Becker Y. HIV-1 induced AIDS is an allergy and allergen is the shed pg 120 — a revies, hypothesis, and implications / Y. Becker // Virus Genes. — 2004. Vol. 28, N 4. — P. 319−331.
- Berger E. A. Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease / E. A. Berger, P. M. Murphy, J. M. Farber // Annu. Rev. Immunol. 1999. — Vol. 17, N 2. — P. 657−700.
- Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis / Y. Rafaeli et al. // Immunity. -1998.-Vol. 8, N 5. P. 615 -623.
- Beutler B. Cachectin. More than a tumor necrosis factor / B. Beutler, A. Cerami //N. Engl. J. Med. 1987. — Vol. 316, N 4. — P. 379−385.
- Bradley L. M. IL-7: maintaining T-cell memory and achieving homeostasis / L. M. Bradley, L. Haynes, S. L. Swain // Trends Immunol. -2005. Vol. 26, N 3. — P. 172−176.
- CD4 regulatory T cells prevent lethal autoimmunity in IL-2R|3-deficient mice. Implications for the nonredundant function of IL-2 / T.R. Malek et al. // Immunity. 2002. — Vol. 17, N 2. — P. 167−178.
- CD30 antigen, a marker for Hodgkins lymphoma is a receptor whose ligand defines an emerging family of cytokines with homology to TNF / C.A. Smith et al. // Cell. 1993. — Vol. 73, N 1. — P. 1349−1360.
- Cell-specific expression and lipopolysaccharide-induced regulation of tumor necrosis factor alpha (TNFalpha) and TNF receptors in rat dorsal root ganglion / Y. Li et al. // J. Neurosci. 2004. — Vol. 24, N 3. — P. 96 239 631.
- Cheingsong-Popov R. Relation between humoral responses to HIV gag and env proteins at seroconversion and clinical outcome of HIV infection / R. Cheingsong-Popov, C. Panagiotidi, C. Bowcock // Br. Med. J. 1991. — Vol. 302, N 6767. — P. 23−26.
- Chen G. TNF-R1 signaling: a beautiful pathway / G. Chen, D. V. Goeddel // Science. 2002. -Vol. 296, N 5573. — P. 1634−1635.
- Clerici M. TH1 TH2 switch is a critical step in the etiology of HIV infection / M. Clerici, G. M. Shearer // Immunol. Today. 1993. — Vol. 14, N8885.- P. 107−111.
- Clerici M. The Thl-Th2 hypothesis of HIV infection: new insights / M. Clerici, G.M. Shearer // Immunol. Today.- 1994. -Vol.l5,N3.- P.575−581.
- Cloning of the human IL-13R alphal chain and reconstitution with the IL-4Ra of a functional IL-4/IL-13 receptor complex / B. Miloux et al. // FEBS Lett. 1997. — Vol. 401, N 2−3. — P. 163−166.
- Cohen P. L. The lpr and gld genes in systemic autoimmunity: life and death in the Fas lane / P. L. Cohen, R. A. Elsenberg // Immunol. Today. -1992. Vol. 13, N 1. — P. 427−428.
- Connolly N.C. Proinflammatory cytokines in HIV disease a review and rationale for new therapeutic approaches / N. C. Connolly, S. A. Ridder, C. R. Rinaldo // AIDS Reviews. — 2005. — Vol. 7, N 2. — P. 168−180.
- Control of homeostasis of CD8+ memory T cells by opposing cytokines / C. C. Ku et al. // Science. 2000. — Vol. 288, N 5466. — P. 675 678.
- Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells / E. Brugnera et al. // Immunity. 2000. — Vol. .13, N 1. — P. 5971.
- Cossarizza A. Apoptosis and HIV infection: about molecules and genes / A. Cossarizza // Curr. Pharm. Des. 2008. — Vol. 14, N 3. — P. 237 244.
- Cross-linking Fc receptors stimulate splenic non-B, non-T cells to secrete interleukin 4 and other lymphokines / S. Ben-Sasson et al. // Proc. Natl. Acad. Sci. U.S.A. 1990. — Vol. 87, N 4. — P. 1421.
- Crosslinking CD4 by human immunodeficiency virus gpl20 primes T cells for activation-induced apoptosis / N.K. Banda et al. // J. Exp. Med. -1992.-Vol. 76, N4.-P. 1099−1106.
- Crosslinking of CD30 induces HIV expression in chronically infected T cells / P. Biswas et al. // Immunity. 1995. — Vol. 2, N 6. — P. 587 596.
- Crucial role of TNF-alpha in CD8 T cell-mediated elimination of 3LL-A9 Lewis lung carcinoma cells in vivo / A. Prevost-Blondel et al. // J. Immunol. 2000. — Vol. 164. — P. 3645−3651.
- Cumberbatch M. Langerhans cells require signals from both tumor necrosis factor-a and interleukin-1(3 for migration / M. Cumberbatch, R.J. Dearman, I. Kimber // Immunology. 1997. — Vol. 92, N 3. — P. 388 395.
- Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex / H. Asao et al. // J. Immunol. 2001. — Vol. 167, N1.-P. 1−5.
- Cytokine gene expression and T-cell proliferative responses in lymph node mononuclear cells from children with early stage human immunodeficiency virus infection / I. Airoldi et al. // Haematologica. — 2000.-Vol. 85, N1.-P. 1237−1247.
- Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes / D. Unutmaz et al. // J. Exp. Med. 1999. — Vol. 189, N 11. -P. 1735−1746.
- Cytokine regulation of HIV replication induced by dendritic cell-CD4-positive T cell inrteractions / D. Weissman et al. // AIDS Res. Hum. Retrovir. 1996. — Vol. 12, N 9. — P. 759−767.
- Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes / D. Unutmaz et al. // J. Exp. Med. 1999. — Vol. 189, N 11. -P. 1735- 1746.
- Cytokines and cell surface molecules independently induce CXCR4 expression on CD4+ CCR7+ human memory T cells / P. Jourdan et al. // J. Immunol. 2000. — Vol. 165, N 5. — P. 716−724.
- Cytopathic killing of peripheral blood CD4(+) T lymphocytes by human immunodeficiency virus type 1 appears necrotic rather than apoptotic and dues not require env / M. J. Lenardo et al. // J. Virol. 2002. — Vol. 76, N 10.-P. 5082−5093.
- D’Cruz L.M. Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling / L. M. D’Cruz, L. Klein //Nat. Immunol. 2005. — Vol. 6, N 11. — P. 11 521 159.
- DC-SIGN (CD 209) expression is IL-4 dependent and is negatively regulated by IFN, TGF-beta, and anti-inflammatory agents / M. Relloso et al. // J. Immunol. 2002. — Vol. 168, N 6. — P. 2634−2643.
- De Vries J. J. Receptors and cytokines involved in allergic TH2 cell responses / J. J. de Vries, J. M. Carballido, G. Aversa // J. Allergy Clin. Immunol. 1999. -Vol. 103, N 5. — P. 492−496.
- Decreased membrane phospholipid packing and decreased cell size precede DNA cleavage in mature mouse B cell apoptosis / D. A. Mower et al. // J. Immunol. 1994. — Vol. 152, N 4. — P. 4832−4842.
- Decreased stimulation of CD4+T cell proliferation and IL-2 production by hyghly enrriched populations of HIV-infected dendritic cells / T. Kawamura et al. // J. Immunol. 2003. — Vol. 170, 10. — P. 42 604 266.
- Defective IL7R expression in T (-)B (+)NK (+) severe combined immunodeficiency / A. Puel et al. // Nat. Genet. 1998. — Vol. 20, N 4. -P. 394−397.
- Delayed expansion of V delta 2+ and V delta 1+ gamma delta T cells after acute Plasmodium falciparum and Plasmodium vivax malaria / E. Schwartz et al. // J. Allergy Clin. Immunol. 1996. — Vol. 97, N 6. — P. 1387−1392.
- Deleterious effect of HIV-1 plasma viremia on B cell costimulatory function / A. Malaspina et al. // J. Immunol. 2003. — Vol. 170, N 12. -P. 5965−5972.
- Demonstration of the Thl to Th2 cytokine shift during the course of HIV-1 infection using cytoplasmic cytokine detection on single cell level by flow cytometry / S.A. Klein et al. // AIDS. 1997. — Vol. 11, N 1. -P. 1111−1118.
- Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1 / J. T. Opferman et al. // Nature. 2003. — Vol. 426, N6967.-P. 671−676.
- Differentation of an interleukin 4-dependent precusor B-cell clone into immunoglobulin-producing cells in vitro / T. Kinashi et al. // Proc. Natl. Acad. Sci. U.S.A. 1988. — Vol. 85, N12. — P. 4473.
- Differential ability of T cell subsets to undergo activation-induced cell death / A. S. Varadhachaiy et al. // Proc. Natl. Acad. Sci. USA. 1997. -Vol. 94, N 11. — P. 5778−5783.
- Differential regulation of the antibody responses to gag and env proteins of HIV type I / J. M. Binley et al. // J. Virology. 1997. — Vol. 71, N4.-P. 2799−2809.
- Differential susceptibility to activation-induced apoptosis among peripheral Thl subsets: correlation with Bcl-2 expression and conseqquennnnces for AIDS pathogenesis / E. Ledru et al. // J. Immun. — 1998. — Vol. 160, N7.-P. 3194−3206.
- Differential susceptibility to HIV-GP 120-sensitized apoptosis in CD4+ T-cell clones with different T-helper phenotypes: role of CD95/CD95L interactions / P. Accornero et al. // Blood. 1997. — Vol. 89, N2.-P. 558−569.
- Disruption of the yc cytokine network in T cells during HIV infection / D. Sirskij et al. // Cytokine. 2008. — Vol. 43, N 8. — P. 1−14.
- Dittel B. N. The growth response to IL-7 during normal human B cell ontogeny is restricted to B-lineage cells expressing CD34 / B. N. Dittel, T. W. LeBien // J. Immunol. 1995. — Vol. 154, N 1. — P. 58−67.
- Dominant epitopes and allergic cross-reactivity: complex formation between a Fab fragment of a monoclonal murine IgG antibody and the major allergen from from brich pollen Bet v / O. Mirza et al. // J. Immunol. -2000.-Vol. 165, N 1.-P. 331−338.
- Ducrey-Rundquist O. Modalities of Interleukin-7-induced human immunodeficiency virus permissiveness in quiescent T lumphocytes / O. Ducrey-Rundquist, M. Guyader, D. Trono // J.Virol. 2002. — Vol. 76, N 18.-P. 9103−9111.
- Dynamics of cytokine expression in HIV productively infected primary CD4+T cells / B. Bahbouhi et al. // Blood. 2004. — Vol. 103, N 12.-P. 4581−4587.
- Early interleukin-4: its role in the switch towards a TH2 response and IgE-mediated allergy / H. Haas et al. // Int. Arch. Allergy Immunol. 1999. -Vol. 119, N7.-P. 86−94.
- Early lymphocyte development in bone marrow and thymus / A. G. Rolink et al. // Swiss. Med. Wkly. 2006. — Vol. 136, N 43/44. — P. 679 683.
- Early production of IL-4 and induction of Th2 responses in the lymph node originate from an MHC class I-independent CD4+NK1.1-T cell population / T. von der Weid et al. // J. Immunol. 1996. — Vol. 157, N 10. p. 4421−4427
- Ebert L.M. Up-regulation of CCR5 and CCR6 on distinct subpopulations of antigen-activated CD4+T lymphocytes / L. M. Ebert, S.R. McColl // J. Immunol. 2002. — Vol. 168, N 1. — P. 65−72.
- Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy. / T.-W. Chun et al. // Nature Med. 1999. — Vol. 5, N 6. — P. 651 655.
- Effects of B-cell stimulatory factor-l/interleukin-4 on hematopoetic progenitor cells / C. Peschel et al. // Blood. 1987. — Vol. 70, N 1. — P. 254.
- Elevated levels of circulating cachectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome / J. Lahdevirta et al. // American J. of Med. 1988. — Vol. 85, N 3. — P. 289−291.
- Elevation of IgE in HIV-infected subjects: a marker of poor prognosis / D. Isreal-Biet et al. // J. Allergy Clin. Immunol. 1994. — Vol. 89, N 1. -Pt. l.-P. 68−75.
- Endotoxin and Staphylococcus aureus enterotoxin A induce different patterns of cytokines / L. Bjork et al. // Cytokine. 1992. — Vol. 4, N 6. -P. 513−519.
- Enhanced HIV expression during Th2-oriented responses explained by the opposite regulatory effect of IL-4 and IFN-y on fusin/CXCR4 / G. Galli et al. // Eur. J. Immunol. 1998. — Vol. 28, N 10. — P. 3280−3290.
- Enhanced interleukin-1 beta, interleukin-6 and tumor necrosis factor alpha production by LPS stimulated human monocytes isolated from HIV+patients / A. Baqui et al. // Immunopharm. and immunotox. 2000. — Vol. 22, N3.-P. 401−421.
- Enterocyte expression of interleukin 7 induces development of itT cells and Peyer’s patches / K. Laky et al. // J. Exp. Med. 2000. — Vol. 191, N9.-P. 1569−1580.
- Evidence for type 2 cytokine production and lymphocyte activation in the early phases of fflV-infection /1. Meroni et al. // AIDS. 1996. — Vol. 10, Nl.-P. 23−30.
- Expression of interleukin 7 (IL-7) mRNA and protein in the normal adult human liver: implications for extrathymic T cell development / L. Golden-Mason et al. // Cytokine. -2001. Vol. 14, N3. — P. 143−151.
- Expression of the Fas antigen in patients infected with human immunodeficiency virus / T. W. McCloskey et al. // Cytometry. 1995. -Vol. 22, N2.-P. 111−114.
- Expression patterns of the HIV type 1 coreceptors CCR5 and CXCR4 on CD4+T cells and monocytes from cord and adult blood / H. Mo et al. // AIDS Res. Hum. Retroviruses. 1998. — Vol. 14, N 7. -P. 607−617.
- Extracellular Nef protein targets CD4+T cells for apoptosis by interacting with CXCR4 surface receptors / C. O. James et al. // J. Virol. — 2004. Vol. 78, N 6. — P. 3099−3109.
- Fas ligand mediates activation-induced cell death in human T lymphocytes / M.R. Alderson et al. // J. Exp. Med. 1995. — Vol. 181, N 1.-P. 71−77.
- Fauci A.S. The human immunodeficiency virus: infectivity and mechanisms of pathogenesis / A. S. Fauci // Science. 1988. — Vol. 239, N 4840.-P. 617−622.
- Flow cytometric analysis of the Thl-Th2 balance in healthy individuals and patients infected with the human immunodeficiency virus
- HIV) receiving a plant sterol/sterol in mixture / U. Breytenbach et al. // Cell Biology International. 2001. — Vol. 25, N 1. — P. 3−9.
- Fry T. J. Interleukin-7: from bench to clinic / T. J. Fry, C. L. Mackall // Blood. 2002. — Vol. 99, N 11. — P. 3892−3904.
- Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes / M. Kondo et al. // Science. 1994. — Vol. 263, N 5152.-P. 1453−1454.
- Gaffen S. L. Overview of Interleukin-2 function, production and clinical applications / S. L. Gaffen, K. D. Liu // Cytokine. 2004. — Vol. 28, N3.-P. 109−123.
- Gannot G. Interaction between the immune system and tongue squamos cell carcinoma induced by 4-nitroquinoline N-oxide in mice / G. Gannot, A. Buchner, Y. Keisari // Oral. Oncol. 2004. — Vol. 40, N 3. — P. 287−297.
- Gibbs B. F. Human basophils as effectors and immunomodulators of allergic inflammation and innate immunity / B. F. Gibbs // Clin. Exp. Med. — 2005. Vol. 5, N 2. — P. 43−49.
- Glucocorticoids exacerbate the deleterious effects of gp 120 in hippocampal and cortical explants / A. Yusim et al. // J. Neurochem. -2000. Vol. 74, N 3. — P. 1000−1007.
- Gonzales M. E. Human immunodeficiency virus type 1 VPU protein affects Sindbis virus glycoprotein processing and enhances membrane permeabilization / M. E. Gonzales, L. Corrasco // Virology. — 2001. — Vol. 279, N 1.-P. 201−209.
- Gougeon M. L. Programmed cell death as a mechanism of CD4 and CD8 T cell deletion in AIDS. Molecular control and effect of highly active anti-retro viral therapy / M. L. Gougeon, L. Montagnier // Ann. NY Acad. Sci. 1999. — Vol. 887. -P. 199−212.
- Hack C. E. Role of cytokines in sepsis / C. E. Hack, L.A. Aarden, L. G. Thijs // Adv. Immunol. 1997.-Vol. 66.-P. 101−195.
- Herbein G. Is HIV-infection a TNF receptor signaling-driven disease? / G. Herbein, K. A. Khan // Trends Immunol. 2008. — Vol. 2, N 2. — P. 6167.
- High-level replication of human immunodeficiency virus in thymocytes requires NF-kappaB activation through interaction with thymic epithelial cells / L. Chene et al. // J. Virol. 1999. — Vol. 73, N 3. — P. 2064−2073.
- HIV infection alters the production of both type 1 and 2 cytokines but does not induce a polarized type 1 or 2 state / A. Fakoja et al. // AIDS. — 1997. — Vol. 11.-P. 1445−1452.
- HIV preferentially infects HIV-specific CD4+T cells / D. C. Douek et al. //Nature. 2002. — Vol. 417, N 6884. — P. 95−98.
- HIV-1 entry cofactor: functional cDNA cloning of a seven transmembrane, G protein-coupled receptor / Y. Feng et al. // Science. -1996. Vol. 272, 5263. — P. 872−877.
- HIV-1 gp 120-induced TNF-a production by primary human macrophages is mediated by phosphatidyllinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways / C. Lee et al. // J. Leucoc. 2005. — Vol. 78. — P. 1016−1023.
- HIV-1 induces phenotypic and functional perturbations of B cells in chronically infected individuals / S. Moir et al. / Proc. Natl. Acad. Sci. USA. 2001. — Vol. 98, N 18. — P. 10 362−10 367.
- HIV-1 Nef associated PAK and PI3 -kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals / D. Wolf et al. // Nat. Med. 2001. — Vol. 7, N 11. — P. 1217−1224.
- HIV-1 Nef inhibits ASK 1-dependent death signaling providing a potential mechanism for protecting the infected host cell / R. Geleziunas et al. // Nature. 2001. — Vol. 410, N 6830. — P. 834−838.
- HIV-1 Tat protein concomitantly downregulates apical caspase-10 and up-regulates c-FLIP in lymphoid T cells: a potential molecular mechanism to escape TRAIL cytotoxicy / D. Gibellini et al. // J. Cell. Physiol. 2005.- Vol. 203, N 3. P. 547−556.
- HIV-1 viral genes and mitochondrial apoptosis / Shedlock D. J. et al. //Apoptosis. 2008. -Vol. 13, N9.-P. 1088−1099.
- Homeostasis of naive and memory CD4+T cells: IL-2 and IL-7 differentially regulate the balance between proliferation and Fas-mediated apoptosis / S. Jaleco et al. // J. Immunol.- 2003. -Vol. 171, N 1. P. 61−68.
- Homeostasis of memory T cells / C. D. Surh et al. // Immunol. Rev.- 2006. Vol. 211. — P. 154−163.
- Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells / S. Kinoshita et al. // Cell. 1998. — Vol. 95, N 5. — P. 595−604.
- Hsu H. The TNF receptor 1-associated protein TRADD signals cell death and NF-kB activation / H. Hsu, J. Xiong, D. V. Goeddel // Cell. 1995. -Vol. 81, N4.-P. 495−504.
- Huang J. Cutting edge: histone acetylation and recombination at the TCR gamma locus follows IL-7 induction / J. Huang, S. K. Durum, K. Muegge // J. Immunol. 2001. — Vol. 167, N 11. — P. 6073−6077.
- Human dendritic cells express functional interleukin-7 / R. V. Sorg et. al. //Immunobiology. 1998. — Vol. 198, N 5. — P. 514−526.
- Human follicular dendritic cells and vascular cells produce interleukin-7: a potential role for interleukin-7 in the germinal center reaction / R. Kroncke et al. // Eur. Journal Immunol. 1996. — Vol. 26, N 10. — P. 2541−2544.
- Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells / R. G. Goodwin et al. // Proc. Natl. Acad. Sci. USA. 1989. -Vol. 86, N 1. — P. 302−306.
- Human immunodeficiency virus type 1 protease cleaves procaspase 8 in vivo / Z. Nie et al. // J. Virol. 2007. — Vol. 81, N 13. — P. 6947−6956.
- Human male genital tract secretions: both mucosal and systemic immune compartments contribute to the humoral immunity / Z. Moldoveanu / J. Immunol. 2005. — Vol. 175, N 6. — P. 4127−4136.
- Human T cells with a type-2 cytokine profile are resistant to apoptosis induced by primary activation: consequences for immunopathogenesis / M. Carbonari et al. / Clin. Exp. Immunol. 2000. — Vol. 120, N 3. — P. 454 462.
- Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin / D. Pennica et al. // Nature. 1984. — Vol. 312, N5996.-P. 724−729.
- Hussain S. P. Radical causes of cancer / S. P. Hussain, L. J. Hofseth, C. C. Harris // Nat. Rev. Cancer. 2003. — Vol. 3, N 4. — P. 276−285.
- Identification of a T-cell derived B-cell growth factor distinct from interleukin 2 / M. Howard et al. // J. Exp. Med. 1982. — Vol. 155, N 3. -P. 914.
- Identity of tumour necrosis factor and the macrophage-secreted factor cachectin / B. Beutler et al. // Nature. 1985. — Vol. 316, N 6028. — P. 552 554.
- IL-2 activation of NK cells: involvement of MKK½/ERK but not p38 kinase pathway / T. K. Yu et al. // J. Immunol. 2000. — Vol. 164, N 12. -P. 6244−6251.
- IL-2 and related cytokines can promote T cell survival by activating AKT / E. Kelly et al. // J. Immunol. 2002. — Vol. 168, N 2. — P. 597−603.
- IL-2 rescues in vitro lymphocyte apoptosis in patients with HIV infection / Y. Adachi et al. // J. Immunol. 1996. — Vol. 157, N 9. — P. 4184−4193.
- IL-4 and IL-13 specifically increase adhesion molecule and inflammatory cytokine expression in human lung fibroblasts / C. Doucet et al.// Int. Immunol. -1998. -Vol. 10, N10.-P. 1421−1433.
- IL-4 controls the selective endothelium-driven transmigration of eosinophils from allergic individuals / R. Moser et al. // J. Immunol. — 1992. Vol. 89. — P. 6065−6069.
- IL-4 induces functional cell-surface expression of CXCR4 on human T cells / P. Jourdan et al. // J. Immunol. 1998. — Vol. 160, N 9. — P. 41 534 157.
- IL-4 induces mucin gene expression and goblet cell metaplasia in vitro and in vivo / K. Dabbagh et al. // J. immunol. 1999. -Vol. 162, N 10. — P. 6233−6237.
- IL-4 receptor {alpha} is an important modulator of IL-4 and IL-13 receptor binding: implications for the development of therapeutic targets / A.-L. Andrews et al. // J. Immunol. 2006. — Vol. 176. — 7456−7461.
- IL-4 receptor {alpha} is an important modulator of IL-4 and IL-13 receptor binding: implications for the development of therapeutic targets / P. Borger et al. //J. Immunol. 1996. — Vol. 156. — P. 1333−1338.
- IL-7 differentially regulates cell cycle progression and HIV-1-based vector infection in neonatal and adult CD4+ T cells / V. Dardalhon et al. // PNAS. -2001. Vol. 98, N 16. — P. 9277−9282.
- IL-7 enhances the survival and maintains the size of naive T cells / J. C. Rathmell et al. // J. Immunol. 2001. — Vol. 167, N 12. — P. 6869−6876.
- IL-7 increases both thymic-dependent and thymic-independent T-cell regeneration after bone marrow transplantation / C. L. Mackall et al. // Blood. 2001. — Vol. 97, N 5. — P. 1491−1497.
- IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART / F-X. Wang et al. // J. Clin. Invest. 2005. — Vol. 115. — P. 128 137.
- IL-7 promotes T cell proliferation through destabilization o f P27Kipl / W. Q. Li et al. // J. Exp. Med. 2006. — Vol. 203, N 3. — P. 573−582.
- IL-7 regulation of cytotoxic lymphocytes: pore-forming protein gene expression, interferon-gamma production, and cytotoxicity of human peripheral blood lymphocytes subsets / M. J. Smyth et al. // Cell Immunol. 1991. — Vol. 138, N 2. — P. 390−403.
- IL-7 up-regulates HIV-1 replication in naturally infected peripheral blood mononuclear cells / M. D. Smithgall et. al. // J. Immunol. 1996. -Vol. 156, N 6. — P. 2324−2330.
- IL-7-dependent extrathymic expansion of CD45RA+ T cells enables preservation of a naive repertoire / M. V. Soares et. al. // J. Immunol. -1998.-Vol. 161, N 11. -P. 5909−5917.
- IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation / R. J. Armitage et al. // J. Immunol. 1995. — Vol. 154, N2.-P. 483−490.
- Immunobiology: the immune system in liealth and disease / C. A. Janeway et al. New York: Garland Publishing, 2001. — 732 p.
- Immunologie characterization of children vertically infected with human immunodeficiency virus, with slow or rapid disease progression / A. Vigano et al. // J. Pediatr. 1995. — Vol. 126, N 3. — P. 368−374.
- Increased expression of interferon-gamma in hyperplastic lymph nodes from HIV-infected patients / M. J. Boyle et al. // Clin. Exp. Immunol. -1993. Vol. 92, N 1. — P. 100−105.
- Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implication for T-cell homeostasis / L. A. Napolitano et al. // Nat. Med. 2001. — Vol. 7, N 1. — P. 73−79.
- Individual cell analysis of the cytokine repertoire in human immunodeficiency virus-1-infected monocytes/macrophages by a combination of immunocytochemistry and in situ hybridization / R. Esser et al.// Blood. 1998. -Vol. 91, N 12. -P. 4752−4760.
- Inducible IL-2 production by dendritic cells revealed by global gene expression analysis / F. Granucci et al. // Nat. Immunol. 2001. — Vol. 2, N 9.-P. 882−888.
- Induction of HIV-1 replication in latently infected CD4+ T cells using a combination of cytokines / T.-W. Chun et al. // J. Exp. Med. 1998. -Vol. 188, N1.-P. 83−91.
- Induction of interleukin-2 receptor |3 chain expression by self-recognition in the thymus / T. Hanke et al. // J. Exp. Med. 1994. — Vol. 180, N 5. -P. 1629−1636.
- Induction of NF-kappa B during monocyte differentation is associated with activation of HIV-gene expression / G. Griffin et al. // Research in Virology. 1991. — Vol. 142. — P. 233−238.
- Induction of prolonged survival of CD4 T lymphocytes by intermittent IL-2 therapy in HIV infected patients / J. A. Kovacs et al. // J. Clin. Invest. -2005. Vol.115, N 8. — P. 2139−2148.
- Inflammatory properties of recombinant tumor necrosis factor in rabbit skin in vivo / M. Rampart et al. // J. Exp. Med. 1989. — Vol. 169, N 6. -P. 2227−2232.
- Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells / M. Cella et al. // Nature. 1997. — Vol. 388, N 6644. -P. 782−787.
- Inhibition of CD4+T cell function by the HIV envelope protein, gp 120 / D.C. Diamond et al. //J. oflmmun. 1988. — Vol. 141, N 11. — P. 37 153 717.
- Inhibition of death receptor signals by cellular FLIP / M. Irmler et al. // Nature. 1997. — Vol. 388, N 6638. — P. 190−195.
- Inhibitory effect of murine recombinant IL-4 on thymocyte development un fetal thymus organ cultures / J. Plum et al. // J. Immunol. -1990. Vol. 145, N 4. — P. 1066.
- Interferon gamma and lymphotoxin or tumor necrosis factor act synergistically to induce macrophage killing of tumor cells and shistosomula of Shistosoma mansoni / I. Esparza et al. // J. Exp. Med. 1987. — Vol. 166, N2.-P. 589−594.
- Interleukin-7 inactivates the pro-apoptotic protein Bad promoting T cell survival / W. Q. Li et al. // J. Biol. Chem. 2004. — Vol. 279, N 28. -P. 29 160−29 166.
- Interleukin7 independent development of human B cells / J. A. Prieyl et al. // Proc. Natl. Acad. Sci. USA. 1996. — Vol. 93, N 19. — P. 1 034 810 353.
- Interleukin 7 increases human immunodeficiency virus type 1 LAImediated Fas-induced T-cell death /J. D. Lelievre et al. // J. Virol. 2005. -Vol. 79, N5.-P. 3195−3199.
- Interleukin-7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes / M. Watanabe et al. // J. Clin. Invest. 1995. — Vol. 95. — P. 2945−2953.
- Interleukin 7 is produced by murine and human keratinocytes / C. Heufler etal. //J. Exp. Med. 1993.-Vol. 178. — P. 1109−1114.
- Interleukin-7: physiological roles and mechanisms of action / R. Hofmeister et al. // Cytokine Growth Factor Rev. 1999. — Vol. 10, N 1. -P. 41−60.
- Interleukin 7 receptor-deficient mice lack gammadelta T cells / K. Maki et al. // Proc. Natl. Acad. Sci. USA. 1996. — Vol. 93, N 14. — P. 7172−7177.
- Interleukin-7 reduces the levels of spontaneous apoptosis in CD4+ and CD8+ T cells from HIV-1-infected individuals / L. Vassena et al. // PNAS. -2007.-Vol. 104, N7.-P. 2355−2360.
- Interleukin-7 upregulates the interleukin-2-gene expression in activated human T lymphocytes at the transcriptional level by enhancing the DNA binding activities of both nuclear factor of activated
- T cells and activator protein-1 / S. I. Gringhuis et al. // Blood. 1997. -Vol. 90, N 7. — P. 2690−2700.
- Interleukin-7-treated naive T cells can be productively infected by T-cell-adapted and primary isolates of human immunodeficiency virus 1 / C. M. Steffens et al. // Blood. 2002. — Vol. 99, N 9. — P. 33 103 318.
- Interleukin (IL)-15 Ra-deficient natural killer cells survive in normal but not IL-15 Ra-deficient mice / R. Koka et al. // J. Exp. Med. 2003. -Vol. 197. — P. 977−984.
- Isolation and characterization of multiple variants of recombinant human interleukin 4 expressed in mammalian cells / H. V. Le et al. // J. Biol. Chem. 1988. — Vol. 263, N 22. — P. 10 817.
- Keane M.P. The importance of balanced pro-inflammatory and antiinflammatory mechanisms in diffuse lung disease / M. P. Keane, R. M. Strieter // Respir. Res. 2002. — Vol. 3, N 5. — P. 5.
- Kedzierska K. Cytokines and HTV-1: interactions and clinical implications / K. Kedzierska, S. M. Crowe // Antivir. Chem. Chemother. -2001.-Vol. 12, N3.-P. 133−150.
- Kidd P. Thl/Th2 balance: The hypothesis, its limitations, and implications for health and disease / P. Kidd // Altern. Med. Rev. 2003. — Vol.8, N3.-P. 223−246.
- Kile B. T. The role of the intrinsic apoptosis pathway in platelet life and death / B. T. Kile // J. Thromb. Haemost. 2009. — Vol.7, N 1. — P. 214 217.
- Kinter A. Interleukin-2 and Human immunodeficiency virus infection: pathogenic mechanisms and potential for immunologic enhancement / A. Kinter, A. Fauci // Immunological Research. 1996. — Vol. 15, N 1. -P. 1−15.
- Korin Y. D. Progression to the Gib phase of the cell cycle is required for completion of induced human immunodeficiency virus type 1 reverse transcription in T cells / Y. D. Korin, J. A. Zack // J. Virol. 1998. — Vol. 72, N4.-P. 3161−3168.
- Krammer P.H. CD95's deadly mission in the immune system / P.H. Krammer // Nature. 2000. — Vol. 407, N 6805. — P. 789−795.
- Kryworuchko M. Interleukin-2: from T cell growth and homeostasis to immune reconstitution of HIV patients / M. Kryworuchko, J. Theze // Vitam. Horm. 2006. — Vol. 74. — P. 531−547.
- Lack of evidance for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals / C. Graziosi et al. // Science. 1994. — Vol. 265, N5169.-P. 248−252.
- Lefrancois L. Extrathymic intestinal T-cell development: virtual reality? / L. Lefrancois, L. Puddington // J. Immunol. Today. 1995. — Vol. 16, N 1. -P. 16−21.
- Levy J. A. HIV pathogenesis and long-term survival / J. A. Levy // AIDS.- 1993.-Vol. 7, N11.-P. 1401−1410.
- Levy J. A. Pathogenesis of human immunodeficiency virus infection / J. A. Levy // Microbiol. Rev. 1993. — Vol. 57, N 12. — P. 183−189.
- Lin W. J. Implication of Toll-like receptor and tumor necrosis factor alpha signaling in septoc shock / W. J. Lin, W. C. Yeh // Shock. 2005. -Vol. 24, N2/-P. 206−209.
- Lin W.-W. A cytokine-mediated link between innate immunity, inflammation, and cencer / W.-W. Lin, M. Karin // J. Clin. Invest. 2007. -Vol. 117, N 5. -P. 1175−1183.
- Locksley R. M. The TNF and TNF receptor superfamilies: integrating mammalian biology / R. M. Locksley, N. Killeen, M. J. Lenardo // Cell. -2001.-Vol. 104, N4.-P. 487−501.
- Long-term culture system for selective growth of human B-cell progenitors / D. J. Rawlings et al. // Proc. Natl. Acad. Sci. USA. 1995. -Vol. 92, N5.-P. 1570−1574.
- Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice / M. Pellegrini et al. // J. Exp. Med. 2004. — Vol. 200, N9.-P. 1189−1195.
- Ma A. Diverse function of IL-2, IL-15, and IL-7 in lymphoid homeostasis / A. Ma, R. Koka, P. Burkett // Annu. Rev. Immunol. 2006. -Vol. 24, N 1. — P. 657−679.
- Macrophage-dependent apoptosis of CD4+T lymphocytes from HIV-infected individuals is mediated dy FasL and tumor necrosisfactor / A. D. Badley et al. // J. Exp. Med. 1997. — Vol. 185, N 1. — P. 5564.
- Malek T. R. Tolerance, not immunity, crucially depends on IL-2 / T. R. Malek, A. L. Bayer // Rev. Immunol. 2004. — Vol. 4, N 9. — P. 665 674.
- Massive infection and loss of memory CD4+T cells in multiple tissues during acute SIV infection / J. J. Mattapallil et al. // Nature. 2005. — Vol. 434, N 7037. — P. 1093 — 1097.
- Mazzucchelli R. Interleukin-7 receptor expression: intelligent design / R. Mazzucchelli, S. K. Durum // Nat. Rev. Immunol. 2007. — Vol. 7. — P. 144−154.
- McCune J. M. The dynamics of CD4+T-cell depletion in HIV disease / J. M. McCune //Nature. 2001. — Vol. 410, N 6831. — P. 974−979.
- McDermott M.F. TNF and TNFR biology in health and disease / M. F. McDermott // Cell. Mol. Biol. 2001. — Vol. 47, N 4. — P. 619−635.
- Means R. T., Jr. Inhibition of human eiythroid colony-forming units by tumor necrosis factor requires beta interferon / R. T. Means Jr., S. B. Krantz // J. Clin. Invest. 1993. — Vol. 91, N 2. — P. 416−419.
- Mechanism of HIV-associated lymphocyte apoptosis / A. D. Badley et al. // Blood. 2000. — Vol. 96, N 6. — P. 2951−2964.
- Mechanisms of IgE elevation in HIV-1 infection / G. Marone et al. / Crit. Rev. Immunol. 2000. — Vol. 20, N 6. — P. 477−496.
- Mehrotra P. T. Synergistic effects of IL-7 and IL-12 on human T cell activation / P. T. Mehrotra, A. J. Grant, J. P. Siegel // J. Immunol. 1995. -Vol. 154, N8.-P. 5093−5102.
- Membrane and soluble forms of Fas (CD95) and Fas ligand in peripheral blood mononuclear cells and in plasma from human immunodeficiency virus-infected persons / N. Hosaka et al. // Infect. Dis. -1998.-Vol. 178, N 11. P. 1030−1039.
- Microbial isooprenoid biosynthesis and human gammadelta T cell activation / M. Eberl et al. //FEBS Lett. 2003. — Vol. 544, N 17.- P. 4−10.
- Ming W. J. Tumor necrosis factor is chemotactic for monocytes and polymorphonuclear leukocytes / W. J. Ming, L. Bersani, A. Mantovani // J. Immunol.-1987.-Vol. 138, N5.-P. 1469−1474.
- Molecular characterization of the acute inflammatory response to infections with gram-negative versus gram-positive bacteria / R. J. Feezor et al. // Infect Immun. 2003. — Vol. 71, N 10. — P. 58 035 813.
- Molecular mechanisms of IL-4 effect on HIV expression in promonocytic cell lines and primary human monocytes / H. M. Naif et al. // J. of leucocyte biology. 1994. — Vol. 56, N 3. — P. 335−339.
- Morgan D. A. Selective in vitro growth of T lymphocytes from normal human bone marrows / D. A. Morgan, F. W. Ruscetti, R. Gallo // Science. -1976.-Vol. 193, N4257.-P. 1007−1008.
- Moser M. Dendritic cell regulation of Thl-Th2 development / M. Moser, K. M. Murphy / Nat. Immunol. 2000. — Vol. 1, N 2. — P. 199−205.
- Mucosal and systemic HIV-1-specific immunity in HIV-1-exposed but uninfected heterosexual men / S. Lo Caputo et al. // AIDS. 2003. — Vol. 17, N4.-P. 531−539.
- Nasal mast cells in perennial allergic rhinitics exhibit increased expression of the FceRI, CD40L, IL-4, and IL-13, and can induce IgEsynthesis in B cells / R. M. Pawankar et al. // J. Clin. Invest. 1997. -Vol. 99, N7.-P. 1492−1499.
- Napolitano L. A. Approaches to immune reconstitution in HIV infection / L. A. Napolitano // Top. HIV Med. 2003. — Vol. 11, N 2. — P. 160−163.
- O’Garra A. Cytokines induce the development of functionally heterogeneous T helper cell subsets / A. O’Garra // Immunity. 1998. — Vol. 8, N 3. — P. 275−283.
- Old L.J. Tumor necrosis factor (TNF) / L.J. Old // Science. 1985. -Vol. 230, N 4726. — P. 630−632.
- Oppsite role for interleukin-4 and interferon-y on CD30 and lymphocyte activation gene-3 (LAG-3) expression by activated naive T cells / F. Annuziato et al. // Eur. J. Immunol. 1997. — Vol. 27, N8. — P. 22 392 244.
- Orlinick J. R. TNF-related legands and their receptors / J. R. Orlinick, M.V. Chao // Cell. Signal. 1998.-Vol. 10, N2.-P. 543−551.
- Paul W. Interleukin-4: a prototypic immunoregulatory lymphokine / W. Paul // Blood. 1991. — Vol. 77, N 5. — P. 1859−1870.
- Paul W. E. Lymphocyte responses and cytokines / W. E. Paul, R. A. Seder // Cell. 1994. — Vol. 76, N 12. — P. 241−251.
- Paul W. E. Interleukin-4: signaling mechanisms and control of T cell differentation / W. E. Paul // Ciba Found. Symp. 1997. — Vol. 204, N 6. -P. 208−216.
- Perchel C. Preferential proliferation of immature B lineage cells in long-term stromal cell-dependent cultures with IL-4 / C. Perchel, I. Green, W.E.Paul// J. Immunol.-1989.-Vol. 142, N17.-P. 1558.
- Potential role for IL-7 in Fas-mediated T cell apoptosis during HIV infection / C. Fluur et al. // J. Immunol. 2007. — Vol. 178, N 8. -P. 5340−5350.
- Predictive value of CD4 lymphocyte numbers for the development of opportunistic infections and malignancies in HIV-infected persons / S. M. Crowe et al. // J. Acquir. Immune Defic. Syndr. 1991. — Vol. 4, N 8. -P. 770−776.
- Primary HIV-1 infection is associated with preferential depletion of CD4+T lymphocytes from effector sites in the gestrointestinak tract / S. Menandru et al. // J. Exp. Med. 2004. — Vol. 200, N 16. — P. 749−759.
- Programmed death of T cells in HIV-1 infection / L. Meyaard et al. // Science. 1992. — Vol. 257, N 6. — P. 217−219.
- Progressive B cell apoptosis and expression of Fas ligand during human immunodeficiency virus type 1 infection / A. Samuelsson et al. / AIDS Res. Hum. Retroviruses. 1997. — Vol. 13, N 8. — P. 10 311 038.
- Prussin C. IgE, mast cells, basophils, and eosinophils / C. Prussin, D. D. Metcalfe // J. Allergy Clin. Immunol. 2003. — Vol. 111, N 2. — P. 486 494.
- Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection / D. D. Ho et al. // Nature. 1995. — Vol. 373, 6510. — P. 123 126.
- Reciprocal regulation of CD30 expression on CD4+T cells by IL-4 and IFN-gamma / T. Nakamura et al. // J. Immunol. 1997. — Vol. 158, N 7. -P. 2090−2098.
- Recombinant interleukin 4 stimulates human immunodeficiency virus production by infected monocytes and macrophages / F. Kazazi et al. // J. Gen. Virol. 1992. -Vol. 73, Pt. 4. — P. 941−949.
- Recruitment of TNF receptor 1 to lipid rafts is essential for TNFa-mediated NF-kB activation / D. F. Legier et al. // Immunity. 2003. — Vol. 18, N7.-P. 655−664.
- Regulation of human cytotoxic T lymphocyte development by IL-7 / C. J. Hickman et al. // J. Immunol. 1990. — Vol. 145, N 8. — P. 24 152 420.
- Regulation of human T cell proliferation by IL-7 / R. J. Armitage et al. // J. Immunol. 1990. — Vol. 144, N 4. — P. 938−941.
- Regulation of the mRNA expression for tumor necrosis factor-a in rat liver macrophages / M. Grewe et al. // J. Hepatol. 1994. — Vol. 20, N 1. -P. 811−818.
- Relationship between serum IL-7 concentrations and lymphopenia upon different levels of HIV immune control / C. Fluur et al. // AIDS. — 2007. Vol. 21, N 8. — P. 1048−1050.
- Robb R. J. Heterogeneity of human T-cell growth factor (s) due to variable glycosylation / R. J. Robb, K. A. Smith // Mol. Immunol. 1981. — Vol. 18, N5.-P. 1087−1094.
- Romagnani S. Regulation of T cell response / S. Romagnani // Clin. Exp. Allergy. 2006. — Vol. 36, N 11. — P. 1357−1366.
- Sacaguchi S. Regulatory T cells: key controllers of immunologic self-tolerance/S. Sacaguchi//Cell.-2000.-Vol. 101, N 15.-P. 455−458.
- Sakai K. The Vif and Vpr zccessory proteins independently cause HIV-1-induced T cell cytopathicity and cell cycle arrest / K. Sakai, J. Dimas, M. J. Lenardo // Proc. Natl. Acad. Sci. USA. 2006. — Vol. 103, N 9. -P. 3369−3374.
- Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp 120 / M. O. Westendorp et al. // Nature. 1995. — Vol. 375, N 6531. -P. 497−500.
- Serum levels of TNF-a and soluble TNF receptors in HIV type 1 infection — correlations to clinical, immunologic, and virologicparameters / P. Aukrust et al. // J. Infect. Dis. 1994. — Vol. 169, N 2. — P. 420−424.
- Sequential acquisition of mitochondrial and plasma membrane alterations duing early lymphocyte apoptosis / M. Castedo et al. // J. Immunol.-1996.-Vol. 157, N2.-P. 512−521.
- Sex differences in HIV-1 viral load and TNF-a plasmatic level? / M. Saves et al. // AIDS. -1999. -Vol. 13, N1.-P. 1414−1415.
- Shattock R. J. Inhibiting sexual transmission of HIV-1 infection / R. J. Shattock, J.P. Moore // Nat. Rev. Microbiol. 2003. — Vol. 1, N 1. -P. 25−34.
- Sheikh M. S. Death receptors as targets of cancer therapeutics / M. S. Sheikh, Y. Huang // Curr. Cancer Drug Targets. 2004. — Vol. 4, N 1. — P. 97−104.
- Shluns K. S. Cytokine control of memory T-cell development and survival / K. S. Shluns, L. Lefrancois // Nat. Rev. Immunol. 2003. — Vol. 3, N 2. — P. 269−279.
- Singh V. K. The paradigm of Thl and Th2 cytokines: its relevance to autoimmunity and allergy / V. K. Singh, S. Mehrotra, S. S. Agaval // Immunol. Res. 1999. — Vol. 20, N 5. — P. 147−161.
- Soluble receptors for TNF as predictors of progression to AIDS in asymptomaatic HIV type 1 infection / M. Godfriend et al. // J. Infect. Dis. -1994. Vol. 169, N 8. — P. 739−745.
- Spriggs D. R. Genomic structure, induction, and production of TNF-alpha / D. R. Spriggs, S. Deutsch, D. W. Kufe // Immunol. Ser. 1992. -Vol. 56.-P. 3−34.
- Steel factor (c-kit ligand) stimulates the in vitro growth of immature CD3-/CD4-/CD8-thymocytes: synergy with IL-7 /P. J. Morrissey et al. // Cell. Immunol.-1994.-Vol. 157, N 1.-P. 118−131.
- Takahashi K. Dendritic cells generated from human blood in granulocyte macrophage-colony stimulating factor and interleukin-7 / K. Takahashi, M. C. Honeyman, L. C. Harrison // Hum. Immunol. 1997. -Vol. 55, 2.-P. 103−116.
- TH1 and TH2 cytokine production by peripheral blood mononuclear cells from HIV-infected patients / W. Barcellini et al. // AIDS. 1994. -Vol. 8, N 1. — P. 757−762.
- Thl and Th2 responses? HIV-1 coreceptors and HIV-1 infection / G. Galli et al. // J. Biol. Regul. Homeost. Agents. 2001. — Vol. 15, N 4. -P. 308−313.
- The C-terminal moiety of HIV-1 Vpr induces cell death via a caspase-independent mitochondrial pathway / T. Roumier et al. // Cell Death Differ. -2002.-Vol. 9, N 1. P. 1212−1219.
- The IL-4 receptor: signaling mechanisms and biologic functions / K. Nelms et al. // Annu. Rev. Immunol. 1999. — Vol. 17, N 7. — P. 701−738.
- The influence of cytokines, chemokines and their receptors on HIV-1 replication in monocytes and macrophages / K. Kedzierska et al. // Rev. Med. Virol. 2003. — Vol. 13, N 2. — P. 39−56.
- The trophic action of IL-7 on pro-T cells: inhibition of apoptosis of pro-Tl, -T2, and -T3 cells correlates with Bcl-2 and Bax levels and is independent of Fas and p53 pathways / K. Kim et al. // J. Immunol. 1998. -Vol. 160, N4.-P. 5735−5741.
- The state of maturation of monocytes into macrophages determines the effects of IL-4 and IL-13 on HIV replication / H. M. Naif, et al. // J. Immunol. 1997. — Vol. 158, N 9. — P. 501−511.
- Theze J. Interleukin-2 and its receptors: recent advances and new immunological functions / J. Theze, P. M. Alzari, J. Bertoglio // Immunol. Today.-1996.-Vol. 17, N 10.-P. 481−486.
- TNF-a drives HIV-1 replication in U937 cell clones and upregulates CXCR4 / P. Biswas et al. // Cytokine. 2001. — Vol. 13, N 6. -P. 55−59.
- TNF-related apoptosis-inducing ligand (TRAIL) in HIV-l-infected patients and its in vitro production by antigen-presenting cells / J.-P. Herbeuval et al. // Blood. 2005. — Vol. 105, N 6. — P. 2458−2464.
- Trushin S. A. CD4 T cells treated with gpl20 acquire a CD45R0+/CD45RA+ phenotype / S. A. Trushin, G. D. Bren, A. D. Badley // Open Virol J. 2009. — Vol.3. — P. 21−25.
- Tsitsikow E. N. CD30 induction of human immunodeficiency virus gene transkcription is mediated by TRAF2 / E. N. Tsitsikow, D. A. Wright, R. S. Geha // Proc. Natl. Acad. Sci. 1997. — Vol. 94, N 8. -P. 1390−1395.
- Tumor necrosis factor: a master-regulator of leukocyte movement / J. D. Sedgwick et al. // Immunol. Today. 2000. — Vol. 21, N 3. — P. 110 113.
- Tumor necrosis factor alpha induces angiogenic factor up-regulation in malignant glioma cells: a role for RNA stabilization and HuR / I. B. Nabors et al. // Cancer Res. 2003. — Vol. 63, 14. — P. 4181−4187.
- Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell clone / T. Folks et al. // Proc. Nat. Acad. Sci. USA. 1989, 15. — Vol. 86. — P. 2365−2368.
- Tumor necrosis factor, cancer and anticancer therapy / S. Mocellin et al. // Cytokine Growth Factor Rev. 2005. — Vol. 16, N 1. -P. 35−53.
- Tumour necrosis factor (TNF) and TNF-related molecules in HIV-1+ individuals: relationship with in vitro Thl/Th2-type response / G. Rizzardi et al. // Clin, and Exp. Immunol. 1998. — Vol. 114, N 1. — P. 61−65.
- Tumor necrosis factor type alpha stimulates human endothelial cells to produce granulocyte/macrophage colony-stimulating factor / V. C. Broudy et al. //Proc. Natl. Acad. Sci. USA. 1986. — Vol. 83, N 19.-P. 7467−7471.
- Tumor necrosis factor-a levels in patients with HIV with wasting in South Asia / N. Wig et al. // AIDS Patient Care STDS. 2005. — Vol. 19, N 4.-P. 212−215.
- Tumour necrosis factors (alfa, beta) induced by HIV-1 in peripheral biood mononuclear cells potentiate virus replication / A. Vyakarnam et al. //AIDS.-1990.-Vol. 4, N 1.-P. 21−27.
- Two CD95 (APO-l/Fas) signaling pathways / C. Scaffidi et al. II EMBO J. 1998. — Vol. 17, N6.-P. 1675−1687.
- Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death / L. Van Parijs et al. // Immunity. 1999. — Vol. 11, N 3. — P. 281−288.
- Unequal death in T helper cell (Th)l and TH2 effectors: Thl, but not TH2, effectors undrgo rapid Fas/FasL-mediated apoptosis / X. Zhang et al. //J.Exp. Med. 1997.-Vol. 185, N 10.-P. 1837−1849.
- Unutmaz D. Antigen-independent activation of naive and memory resting T cells by a cytokine combination / D. Unutmaz, P. Pileri, S. Abrignani // J. Exp. Med. 1994. — Vol. 180, N 3. — P. 1159−1164.
- Unutmaz D. Human naive T cells activated by cytokines differentiate into a split phenotype with functional features intermediate between naive and memory T cells / D. Unutmaz, F. Baldoni, S. Abrignani // Int. Immunol. -1995.-Vol. 7, N4.-P. 1417−1424.
- Valdez H. Cytokines and cytokine therapies in HIV infection / H. Valdez, M. Lederman // AIDS Clin. Rev. 1997. — Vol. 6. — P. 187 228.
- Van Parijs L. Homeostasis and self-tolerance in the immune system: turning lymphocytes off / L. Van Parijs, A.K. Abbas // Science. 1998, N 5361. — Vol. 280. — P. 243−248.
- Veazey R. S. Getting to the guts of HIV pathogenesis / R. S. Veazey, A.A. Lackner // J. Exp. Med. 2004. — Vol. 200, N 5. — P. 697−700.
- Walddmann T. A. T-cell receptors for cytokines: targets for immunotherapy of leukemia/lymphoma / T. A. Walddmann // Ann. Oncol. 2000.-Vol. 11, N2.-P. 101−106.
- Walddmann T. A. The biology of Interleukin-2 and Interleukin-15: implications for cancer therapy and vaccine design / T. A. Walddmann // Nat. Rev. Immunol. 2006. — Vol. 6. — P. 595−601.
- Wajant H. Tumor necrosis factor signaling/H. Wajant, K. Pfizenmaier, P. Scheuurich //Cell death differ.-2003. -Vol. 10, N 1.-P.45−65.
- Wesselborg S. Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells / S. Wesselborg, O. Jassen, D. Kabelitz // J. Immunol. 1993. — Vol. 150, N 10. — P. 43 384 345.
- Women with cervicovaginal antibody-dependent cell-mediated cytotoxicity have lower genital HIV-1 RNA / P. Nag et al. / J. Infect. Dis. -2004.-Vol. 190, N 11. P. 1970−1978.
- Xing Z. The hunt for new tuberculosis vaccines: anti-TB immunity and rational design of vaccine / Z. Xing // Curr. Pharm. Des. 2001. — Vol. 7, N 11. — P. 1015−1037.1. ПРИМЕЧАНИЯ
- Изучение процессов активации и апоптоза лимфоцитов, репликации ВИЧ-1 проводились совместно с аспирантом кафедры патофизиологии Казанского государственного медицинского университета А. В. Иванковой.* *