Синтез катионных амфифилов липидной природы и создание на их основе липосомальных систем доставки нуклеиновых кислот
Диссертация
Основной целью работы является создание эффективных и безопасных липосомальных систем доставки, способных переносить терапевтические НК в клетки млекопитающих, для лечения наследственных и приобретенных заболеваний. Для достижения поставленной цели, в первую очередь, было необходимо предложить дизайн и разработать современные подходы к синтезу малотоксичных положительно заряженных амфифильных… Читать ещё >
Содержание
- СПИСОК СОКРАЩЕНИЙ
- ВВЕДЕНИЕ
- 1. ЛИТЕРАТУРНЫЙ ОБЗОР
- 1. 1. Основные стадии транспорта нуклеиновых кислот с участием катионных липосом
- 1. 2. Внеклеточные и внутриклеточные барьеры
- 1. 3. Модульные системы доставки НК
- 1. 4. Катионные амфифилы — основные компоненты модульной системы доставки НК
- 1. 4. 1. Моно- и дикатионные амфифилы с длинноцепными алкильными или ацильными заместителями
- 1. 4. 2. Катионные производные фосфатидилхолина
- 1. 4. 3. Амфифильные производные имидазола и пиридина
- 1. 4. 4. Монокатионные липиды холестеринового ряда
- 1. 4. 5. Поликатионные амфифилы
- 1. 4. 6. Катионные амфифилы на основе аминокислот
- 1. 4. 7. Гемини-амфифилы
- 1. 5. Стратегии по увеличению эффективности доставки
- 1. 5. 1. Клеточное нацеливание катионных липосом с использованием различных лигандов
- 1. 5. 1. 1. Углеводные лиганды для нацеливания на гепатоциты
- 1. 5. 1. 2. Фолиевая кислота для нацеливания на опухолевые клетки
- 1. 5. 1. 3. Другие лиганды
- 1. 5. 2. Улучшение интернализации систем доставки
- 1. 5. 3. Увеличение высвобождения НК
- 1. 5. 3. 1. рН-чувствительные линкеры
- 1. 5. 3. 2. Линкеры, чувствительные к действию внутриклеточных восстановителей
- 1. 5. 3. 3. Другие подходы к увеличению высвобождения НК
- 1. 5. 1. Клеточное нацеливание катионных липосом с использованием различных лигандов
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