ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΠ°ΠΊΡΠΎΡΠΎΠ², Π²Π»ΠΈΡΡΡΠΈΡ Π½Π° Π±ΠΈΠΎΡΠΈΠ½ΡΠ΅Π· L-Π°ΡΠΏΠ°ΡΠ°Π³ΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ Π² Pantoea ananatis ΠΈ Escherichia coli
ΠΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΡ
ΠΡΡΠ²Π»Π΅Π½Ρ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ°ΠΊΡΠΎΡΡ, Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΡΠ΅ Π΄Π»Ρ ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠΈ L-Acn ΠΊΠ»Π΅ΡΠΊΠ°ΠΌΠΈ Π . ananatis, ΠΈ ΡΠΊΠΎΠ½ΡΡΡΡΠΈΡΠΎΠ²Π°Π½ ΡΡΠ°ΠΌΠΌ, ΠΏΡΠΎΠ΄ΡΡΠΈΡΡΡΡΠΈΠΉ L-Acn. ΠΠΎΠΊΠ°Π·Π°Π½Ρ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π° ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΠΠΠΠ-Π·Π°Π²ΠΈΡΠΈΠΌΠΎΠΉ Π³Π»ΡΡΠ°ΠΌΠ°ΡΠ΄Π΅Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π½Π°Π·Ρ ΠΈΠ· Π . ananatis Π΄Π»Ρ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΡ ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠΈ L-Acn. ΠΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΠΎΠ½Π½Π°Ρ ΡΠ°Π±ΠΎΡΠ° ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π° ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠ°ΠΊΡΠΎΡΠΎΠ², Π²Π»ΠΈΡΡΡΠΈΡ Π½Π° Π±ΠΈΠΎΡΠΈΠ½ΡΠ΅Π· L-Acn ΠΊΠ»Π΅ΡΠΊΠ°ΠΌΠΈ P. ananatis ΠΈ ΠΏΠΎΠΈΡΠΊΡ Π°Π»ΡΡΠ΅ΡΠ½Π°ΡΠΈΠ²Π½ΡΡ ΠΏΡΡΠ΅ΠΉ… Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- Π‘ΠΠΠ‘ΠΠ ΠΠ‘ΠΠΠΠ¬ΠΠ£ΠΠΠ«Π₯ Π‘ΠΠΠ ΠΠ©ΠΠΠΠ
- ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ
- Π¦Π΅Π»Ρ ΠΈ Π·Π°Π΄Π°ΡΠΈ ΡΠ°Π±ΠΎΡΡ
- ΠΠ°ΡΡΠ½Π°Ρ Π½ΠΎΠ²ΠΈΠ·Π½Π° ΠΈ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΡ ΡΠ°Π±ΠΎΡΡ
- ΠΠΠΠΠ 1. ΠΠΠΠΠ ΠΠΠ’ΠΠ Π’Π£Π Π«
- 1. 1. Π¬-Π°ΡΠΏΠ°ΡΠ°Π³ΠΈΠ½ΠΎΠ²Π°Ρ ΠΊΠΈΡΠ»ΠΎΡΠ°: ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΈ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Ρ
- 1. 1. 1. ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π¬-Π°ΡΠΏΠ°ΡΠ°Π³ΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ
- 1. 1. 2. Π‘ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠ΅ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²ΠΎ Π¬-Π°ΡΠΏΠ°ΡΠ°Π³ΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ
- 1. 1. 3. ΠΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Ρ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΈΠ½ΡΠ΅Π·Π° Π¬-Π°ΡΠΏΠ°ΡΠ°Π³ΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ ΠΈΠ· ΡΠ³Π»Π΅Π²ΠΎΠ΄ΠΎΠ²
- 1. 2. ΠΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΠ·ΠΌ Π¬-Π°ΡΠΏΠ°ΡΠ°Π³ΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ Π² ΡΠ½ΡΠ΅ΡΠΎΠ±Π°ΠΊΡΠ΅ΡΠΈΡΡ
ΠΈ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΠ΅ ΠΌΠΈΡΠ΅Π½ΠΈ Π΄Π»Ρ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΈΠ½ΠΆΠ΅Π½Π΅ΡΠΈΠΈ ΡΡΠ°ΠΌΠΌΠ°-ΠΏΡΠΎΠ΄ΡΡΠ΅Π½ΡΠ°
- 1. 2. 1. ΠΡΠΏΠ°ΡΡΠ°ΡΠ°ΠΌΠΈΠ½ΠΎΡΡΠ°Π½ΡΡΠ΅ΡΠ°Π·Π°
- 1. 2. 2. ΠΠ·Π°ΠΈΠΌΠ½ΡΠ΅ ΠΏΡΠ΅Π²ΡΠ°ΡΠ΅Π½ΠΈΡ ΡΠΎΡΡΠΎΠ΅Π½ΠΎΠ»ΠΏΠΈΡΡΠ²Π°ΡΠ°, ΠΎΠΊΡΠ°Π»ΠΎΠ°ΡΠ΅ΡΠ°ΡΠ° ΠΈ ΠΏΠΈΡΡΠ²Π°ΡΠ°
- 1. 2. 3. Π¦ΠΈΠΊΠ» ΠΡΠ΅Π±ΡΠ°
- 1. 2. 4. ΠΡΠΏΠ°ΡΡΠ°Π·Π° ΠΈ Π΄Π΅Π³ΡΠ°Π΄Π°ΡΠΈΡ Π¬-Π°ΡΠΏΠ°ΡΠ°Π³ΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ
- 1. 2. 5. Π‘Π΅ΠΌΠ΅ΠΉΡΡΠ²ΠΎ Π°ΡΠΏΠ°ΡΠ°Π³ΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ
- 1. 3. ΠΡΡΠΈΠΌΠΈΠ»ΡΡΠΈΡ Π°Π·ΠΎΡΠ° (Π°ΠΌΠΌΠΈΠ°ΠΊΠ°) Π² ΡΠ½ΡΠ΅ΡΠΎΠ±Π°ΠΊΡΠ΅ΡΠΈΡΡ
- 1. 3. 1. ΠΡΡΠΎΡΠ½ΠΈΠΊΠΈ Π°Π·ΠΎΡΠ°
- 1. 3. 2. ΠΡΡΠΈΠΌΠΈΠ»ΡΡΠΈΡ Π°ΠΌΠΌΠΈΠ°ΠΊΠ° ΠΈ Π²Π½ΡΡΡΠΈΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠ΅ Π΄ΠΎΠ½ΠΎΡΡ Π°Π·ΠΎΡΠ°
- 1. 3. 3. ΠΠ»ΡΡΠ°ΠΌΠΈΠ½ΡΠΈΠ½ΡΠ΅ΡΠ°Π·Π° ΠΈ ΡΠ΅Π³ΡΠ»ΡΡΠΈΡ Π°ΡΡΠΈΠΌΠΈΠ»ΡΡΠΈΠΈ Π°ΠΌΠΌΠΈΠ°ΠΊΠ°
- 1. 3. 4. Π’ΡΠ°Π½ΡΠΏΠΎΡΡ Π^/Π¨Π·
- 1. 4. ΠΡΠΏΠ°ΡΡΠ°ΡΠ΄Π΅Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π½Π°Π·Ρ
- 1. 4. 1. Π’Π΅ΡΠΌΠΎΡΠΈΠ»ΡΠ½ΡΠ΅ ΠΠΠ1ΡΠ° ΠΈ ΠΠΠΠ°Ρ Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΡ Π΄Π»Ρ Π±ΠΈΠΎΡΠΈΠ½ΡΠ΅Π·Π° ΠΠΠ+
- 1. 4. 2. ΠΠ΅Π·ΠΎΡΠΈΠ»ΡΠ½ΡΠ΅ ΠΠΠΠ³Π΅ΠΈ ΠΈ ΠΠΠΡΠ°Π΅ ΠΊΠ°ΠΊ ΠΊΠ°ΡΠ°Π±ΠΎΠ»ΠΈΡΠ½ΡΠ΅ ΡΠ΅ΡΠΌΠ΅Π½ΡΡ
- 1. 4. 3. ΠΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΠ΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π°ΡΠΏΠ°ΡΡΠ°ΡΠ΄Π΅Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π½Π°Π·
- 1. 1. Π¬-Π°ΡΠΏΠ°ΡΠ°Π³ΠΈΠ½ΠΎΠ²Π°Ρ ΠΊΠΈΡΠ»ΠΎΡΠ°: ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΈ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Ρ
- 2. 1. ΠΠ°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΡΠ΅ ΡΡΠ°ΠΌΠΌΡ ΠΈ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Ρ
- 2. 2. Π‘ΡΠ΅Π΄Ρ ΠΈ ΡΠ΅Π°ΠΊΡΠΈΠ²Ρ
- 2. 3. ΠΠΠ-ΠΌΠ°Π½ΠΈΠΏΡΠ»ΡΡΠΈΠΈ
- 2. 4. PI ΡΡΠ°Π½ΡΠ΄ΡΠΊΡΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ Π. col
- 2. 5. ΠΠ»Π΅ΠΊΡΡΠΎΡΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ Π . ananatis ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Π½ΠΎΠΉ ΠΠΠ
- 2. 6. ΠΠ»Π΅ΠΊΡΡΠΎΡΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ Π . ananatis Π³Π΅Π½ΠΎΠΌΠ½ΠΎΠΉ ΠΠΠ
- 2. 7. ΠΠΎΠ½ΡΡΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈΠ½ΡΠ΅Π³ΡΠ°ΡΠΈΠ²Π½ΡΡ ΠΊΠ°ΡΡΠ΅Ρ Π΄Π»Ρ ΠΈΠ½Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ Π³Π΅Π½ΠΎΠ² Π² Ρ ΡΠΎΠΌΠΎΡΠΎΠΌΠ΅ Π . ananatis
- 2. 8. ΠΠΎΠ½ΡΡΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈΠ½ΡΠ΅Π³ΡΠ°ΡΠΈΠ²Π½ΠΎΠΉ ΠΊΠ°ΡΡΠ΅ΡΡ Π΄Π»Ρ Π·Π°ΠΌΠ΅Π½Ρ ΡΠΎΠ±ΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΠΌΠΎΡΠΎΡΠ° Π³Π΅Π½Π° gdhA Π . ananatis Π½Π° ΠΈΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΡΠΉ ΠΏΡΠΎΠΌΠΎΡΠΎΡ Ptac
- 2. 9. ΠΠΎΠ½ΡΡΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈΠ½ΡΠ΅Π³ΡΠ°ΡΠΈΠ²Π½ΠΎΠΉ ΠΊΠ°ΡΡΠ΅ΡΡ Π΄Π»Ρ Π΄Π΅Π»Π΅ΡΠΈΠΈ Π³Π΅Π½Π° ΡΡΡ
- 2. 10. IRed-Π·Π°Π²ΠΈΡΠΈΠΌΠ°Ρ ΠΈΠ½ΡΠ΅Π³ΡΠ°ΡΠΈΡ Π΄Π²ΡΡ ΡΠ΅ΠΏΠΎΡΠ΅ΡΠ½ΡΡ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² ΠΠΠ Π² Ρ ΡΠΎΠΌΠΎΡΠΎΠΌΡ Π . ananatis
- 2. 11. nnt/Xis-Π·Π°Π²ΠΈΡΠΈΠΌΠΎΠ΅ ΡΠ΄Π°Π»Π΅Π½ΠΈΠ΅ ΡΠ΅Π»Π΅ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΌΠ°ΡΠΊΠ΅ΡΠ° ΠΈΠ· Ρ ΡΠΎΠΌΠΎΡΠΎΠΌΡ
- 2. 12. ΠΠΎΠ½ΡΡΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Ρ pMWas/?C
- 2. 13. ΠΠΎΠ½ΡΡΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈΠ½ΡΠ΅Π³ΡΠ°ΡΠΈΠ²Π½ΠΎΠΉ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Ρ pMIVK620S
- 2. 14. ΠΠ½ΡΠ΅Π³ΡΠ°ΡΠΈΡ mini-Mu-ΠΊΠ°ΡΡΠ΅ΡΡ Π² Ρ ΡΠΎΠΌΠΎΡΠΎΠΌΡ Π . ananatis
- 2. 15. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠ΅ΡΠΌΠ΅Π½ΡΠ°ΡΠΈΠ²Π½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠ΅ΠΉ Π² ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ ΡΠΊΡΡΡΠ°ΠΊΡΠ°Ρ
- 2. 16. ΠΠ½ΡΠ΅Π³ΡΠ°ΡΠΈΡ Π³Π΅Π½Π° Π’Π1643 Π’. maritima Π² Ρ ΡΠΎΠΌΠΎΡΠΎΠΌΡ Π . ananatis
- 2. 17. ΠΠΎΠ½ΡΡΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Ρ pET-ADH-P
- 2. 18. ΠΠΎΠ½ΡΡΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄ pET15-ADH-Rp ΠΈ pET15-ADH-Bj
- 2. 19. ΠΡΠΈΡΡΠΊΠ° Π°ΡΠΏΠ°ΡΡΠ°ΡΠ΄Π΅Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π½Π°Π·
- 2. 20. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π°ΡΠΏΠ°ΡΡΠ°ΡΠ΄Π΅Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π½Π°Π·Ρ
- 2. 21. ΠΠ½ΡΠ΅Π³ΡΠ°ΡΠΈΡ Π³Π΅Π½Π°, ΠΊΠΎΠ΄ΠΈΡΡΡΡΠ΅Π³ΠΎ Π°ΡΠΏΠ°ΡΡΠ°ΡΠ΄Π΅Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π½Π°Π·Ρ ΠΈΠ·
- 2. 22. ΠΠ½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ
- 2. 23. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΎΠΊΡΠ°Π»ΠΎΠ°ΡΠ΅ΡΠ°ΡΠ°, ΠΈΠΎΠ½ΠΎΠ² Π°ΠΌΠΌΠΎΠ½ΠΈΡ, L-Π°ΡΠΏΠ°ΡΠ°Π³ΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΈ L-Π³Π»ΡΡΠ°ΠΌΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡ
- 2. 24. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ L-Π°ΡΠ³ΠΈΠ½ΠΈΠ½Π°
- 2. 25. ΠΠ»ΠΈΠ³ΠΎΠ½ΡΠΊΠ»Π΅ΠΎΡΠΈΠ΄Ρ
- 3. 1. Π‘ΡΠ°Π²Π½Π΅Π½ΠΈΠ΅ ΠΏΡΡΠ΅ΠΉ Π±ΠΈΠΎΡΠΈΠ½ΡΠ΅Π·Π° ΠΈ ΠΊΠ°ΡΠ°Π±ΠΎΠ»ΠΈΠ·ΠΌΠ° L-Π°ΡΠΏΠ°ΡΠ°Π³ΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ Π² Π. coli ΠΈ Π . ananatis
- 3. 1. 1. Π Π΅ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΡ ΠΏΡΡΠ΅ΠΉ Π±ΠΈΠΎΡΠΈΠ½ΡΠ΅Π·Π° ΠΈ ΠΊΠ°ΡΠ°Π±ΠΎΠ»ΠΈΠ·ΠΌΠ° L-Π°ΡΠΏΠ°ΡΠ°Π³ΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ Π² Π . Π°ΠΏΠ°ΠΏΠ°ΠΠ Π½Π° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΠΏΠΎΠ»Π½ΠΎΠΉ Π½ΡΠΊΠ»Π΅ΠΎΡΠΈΠ΄Π½ΠΎΠΉ ΠΏΠΎΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ Π³Π΅Π½ΠΎΠΌΠ°
- 3. 1. 2. ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½Π°Ρ ΠΏΡΠΎΠ²Π΅ΡΠΊΠ° ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π½ΠΎΠΉ ΡΡ
Π΅ΠΌΡ ΠΏΡΡΠ΅ΠΉ Π±ΠΈΠΎΡΠΈΠ½ΡΠ΅Π·Π° ΠΈ ΠΊΠ°ΡΠ°Π±ΠΎΠ»ΠΈΠ·ΠΌΠ° Π¬-Π°ΡΠΏΠ°ΡΠ°Π³ΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ Π² Π . Π°ΠΏΠ°ΠΏΠ°Π¨
- 3. 1. 2. 1. ΠΡΠΏΠ°ΡΡΠ°ΡΠ°ΠΌΠΈΠ½ΠΎΡΡΠ°Π½ΡΡΠ΅ΡΠ°Π·Π½Π°Ρ ΡΠ΅Π°ΠΊΡΠΈΡ
- 3. 1. 2. 2. Π€ΠΎΡΡΠΎΠ΅Π½ΠΎΠ»ΠΏΠΈΡΡΠ²Π°Ρ-ΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°Π·Π½Π°Ρ ΡΠ΅Π°ΠΊΡΠΈΡ
- 3. 1. 2. 3. Π‘ΠΈΠ½ΡΠ΅Π· Π³Π»ΡΡΠ°ΠΌΠ°ΡΠ°
- 3. 1. 2. 4. ΠΠ Π‘ gdhA ΠΊΠΎΠ΄ΠΈΡΡΠ΅Ρ ΠΠΠΠ-Π·Π°Π²ΠΈΡΠΈΠΌΡΡ Π³Π»ΡΡΠ°ΠΌΠ°ΡΠ΄Π΅Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π½Π°Π·Ρ
- 3. 1. 2. 5. Π£ΡΠΈΠ»ΠΈΠ·Π°ΡΠΈΡ Π°ΡΠΏΠ°ΡΡΠ°ΡΠ° Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠ° ΡΠ³Π»Π΅ΡΠΎΠ΄Π°
- 3. 1. 2. 6. Π£ΡΠΈΠ»ΠΈΠ·Π°ΡΠΈΡ Π³Π»ΡΡΠ°ΠΌΠ°ΡΠ° Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠ° ΡΠ³Π»Π΅ΡΠΎΠ΄Π°
- 3. 1. 2. 7. Π£ΡΠΈΠ»ΠΈΠ·Π°ΡΠΈΡ ΡΡΠΌΠ°ΡΠ°ΡΠ°
- 3. 2. 1. Π ΠΎΠ»Ρ Π΄Π΅Π»Π΅ΡΠΈΠΉ ΠΠ°ΡΡΠ,Π¬Π ΠΈ Π¬Π·ΠΈΡΠ, Π° ΡΠ°ΠΊΠΆΠ΅ Π°ΠΌΠΏΠ»ΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ Π³Π΅Π½ΠΎΠ² Π€ΠΠ-ΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈΠ»Π°Π·Ρ, Π³Π»ΡΡΠ°ΠΌΠ°ΡΠ΄Π΅Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π½Π°Π·Ρ ΠΈ Π°ΡΠΏΠ°ΡΡΠ°ΡΠ°ΠΌΠΈΠ½ΠΎΡΡΠ°Π½ΡΡΠ΅ΡΠ°Π·Ρ Π² ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠΈ Π¬-Π°ΡΠΏΠ°ΡΡΠ°ΡΠ°
- 3. 2. 2. ΠΠ½Π°ΠΊΡΠΈΠ²Π°ΡΠΈΡ ΠΏΠΈΡΡΠ²Π°ΡΠΊΠΈΠ½Π°Π· Π ΡΠΊΠ ΠΈ Π ΡΠΊΠ
- 3. 2. 3. ΠΠ½ΡΠ΅Π³ΡΠ°ΡΠΈΡ Π°Π»Π»Π΅Π»ΡΡΡΡ ΠΈ ΠΎΡΠ±ΠΎΡ ΡΡΠ°ΠΌΠΌΠ°, ΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΠ³ΠΎ ΠΊ Π¬-Π°ΡΠΏΠ°ΡΡΠ°ΡΡ
- 3. 2. 4. ΠΠ½Π°ΠΊΡΠΈΠ²Π°ΡΠΈΡ ΠΌΠ°Π»Π°ΡΠ΄Π΅Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π½Π°Π·Ρ ΠΈ Π³Π»ΡΠΊΠΎΠ·ΠΎΠ΄Π΅Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π½Π°Π·Ρ
- 3. 2. 5. ΠΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΠΠΠ-Π·Π°Π²ΠΈΡΠΈΠΌΠΎΠΉ Π³Π»ΡΡΠ°ΠΌΠ°ΡΠ΄Π΅Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π½Π°Π·Ρ ΠΈΠ·
- 3. 3. ΠΠΎΠ²ΡΠ΅ Π¬-Π°ΡΠΏΠ°ΡΡΠ°ΡΠ΄Π΅Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π½Π°Π·Ρ ΠΈΠ· ΠΌΠ΅Π·ΠΎΡΠΈΠ»ΡΠ½ΡΡ Π±Π°ΠΊΡΠ΅ΡΠΈΠΉ
- 3. 3. 1. ΠΠΎΠΈΡΠΊ Π°Π½Π°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈΡ Π°ΡΠΏΠ°ΡΡΠ°ΡΠ΄Π΅Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π½Π°Π· Π² Π³Π΅Π½ΠΎΠΌΠ°Ρ Π±Π°ΠΊΡΠ΅ΡΠΈΠΉ
- 3. 3. 2. ΠΠΊΡΠΏΡΠ΅ΡΡΠΈΡ Π²ΡΠ±ΡΠ°Π½Π½ΡΡ Π³Π΅Π½ΠΎΠ² ΠΏΡΠ΅Π΄ΠΏΠΎΠ»Π°Π³Π°Π΅ΠΌΡΡ Π°ΡΠΏΠ°ΡΡΠ°ΡΠ΄Π΅Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π½Π°Π· Π² Π. col
- 3. 3. 3. ΠΡΠΈΡΡΠΊΠ° ΠΈ Π±ΠΈΠΎΡ ΠΈΠΌΠΈΡΠ΅ΡΠΊΠ°Ρ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° Π½ΠΎΠ²ΡΡ Π΄Π΅Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π½Π°Π·
- 3. 3. 4. Π‘ΡΠ±ΡΡΡΠ°ΡΠ½Π°Ρ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΡΡΡ ΠΈ ΠΊΠΈΠ½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΡ Π½ΠΎΠ²ΡΡ ΠΠΠΡΠΎΡ ΠΠΈΠ‘Π±-ΠΠΠΠ³ΡΠ° ΠΈ ΠΠΈΡ6-ΠΠΠΠ¬]Π°
- 3. 3. 5. Π Π°Π·Π»ΠΈΡΠΈΡ Π°ΡΠΏΠ°ΡΡΠ°ΡΠ΄Π΅Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π½Π°Π· ΠΈΠ· Π΄Π²ΡΡ ΠΏΠΎΠ΄Π³ΡΡΠΏΠΏ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΡΠ΅ΡΠΌΠ΅Π½ΡΠ°ΡΠΈΠ²Π½ΠΎΠΉ ΠΊΠΈΠ½Π΅ΡΠΈΠΊΠΈ
- 3. 3. 6. Π Π°Π·Π»ΠΈΡΠΈΡ Π² ΠΊΠΎΡΠ°ΠΊΡΠΎΡΠ½ΠΎΠΉ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΡΡΠΈ Π°ΡΠΏΠ°ΡΡΠ°ΡΠ΄Π΅Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π½Π°Π· ΠΈΠ· Polaromonas sp. ΠΈ Π. japonicum Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ Π³ΠΎΠΌΠΎΠ»ΠΎΠ³ΠΈΡΠ½ΠΎΠ³ΠΎ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΎΡΡΡΠ°Π½ΡΡΠ²Π΅Π½Π½ΡΡ ΡΡΡΡΠΊΡΡΡ
- 3. 3. 7. ΠΠΊΡΠΏΡΠ΅ΡΡΠΈΡ Π°ΡΠΏΠ°ΡΡΠ°ΡΠ΄Π΅Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π½Π°Π·Ρ ΠΈΠ· Π. japonicum ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΡ ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠΈ L-Π°ΡΠ³ΠΈΠ½ΠΈΠ½Π° ΡΡΠ°ΠΌΠΌΠΎΠΌ-ΠΏΡΠΎΠ΄ΡΡΠ΅Π½ΡΠΎΠΌ Π. col
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