ΠΡΠΎΡΡΡΠ°Π½ΡΡΠ²Π΅Π½Π½Π°Ρ ΡΡΡΡΠΊΡΡΡΠ° ΡΠ΅Π½ΠΈΠ»Π°Π»Π°Π½ΠΈΠ»-ΡΠ ΠΠ-ΡΠΈΠ½ΡΠ΅ΡΠ°Π·Ρ ΠΈΠ· Thermus thermophilus Π² ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ΅ Ρ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠΌ Π»ΠΈΠ³Π°Π½Π΄ΠΎΠΌ
ΠΠ΅Ρ Π°Π½ΠΈΠ·ΠΌ Π°ΠΌΠΈΠ½ΠΎΠ°ΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΡΠΎΠ»Ρ ΡΠ»ΠΎΠΆΠ½ΡΠΌ, ΠΏΠΎΡΠΊΠΎΠ»ΡΠΊΡ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΠ΅ ΡΠ·Π½Π°Π²Π°Π½ΠΈΠ΅ ΡΠΎΠ΄ΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΡΠ ΠΠ, ΠΏΠΎ-Π²ΠΈΠ΄ΠΈΠΌΠΎΠΌΡ, Π²ΠΊΠ»ΡΡΠ°Π΅Ρ Π² ΡΠ΅Π±Ρ ΠΊΠΎΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΎΠ½Π½ΡΠ΅ ΠΏΠ΅ΡΠ΅ΡΡΡΠΎΠΉΠΊΠΈ ΠΊΠ°ΠΊ ΡΠ°ΠΌΠΎΠΉ ΡΠΈΠ½ΡΠ΅ΡΠ°Π·Ρ, ΡΠ°ΠΊ ΠΈ ΡΠ ΠΠ, ΠΏΡΠΎΠΈΡΡ ΠΎΠ΄ΡΡΠΈΠ΅ Π² Ρ ΠΎΠ΄Π΅ ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ ΠΈ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΠ° Π°ΠΌΠΈΠ½ΠΎΠ°ΡΠΈΠ»-Π°Π΄Π΅Π½ΠΈΠ»Π°ΡΠ°. Π₯ΠΎΡΡ Π±ΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²ΠΎ ΠΈΠ· ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΡΡ Π½Π° Π½Π°ΡΡΠΎΡΡΠΈΠΉ Π΄Π΅Π½Ρ ΡΡΡΡΠΊΡΡΡ ΠΏΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡ Π²Π°ΠΆΠ½ΠΎΡΡΡ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ Ρ Π°Π½ΡΠΈΠΊΠΎΠ΄ΠΎΠ½ΠΎΠ²ΡΠΌ ΡΡΠΈΠΏΠ»Π΅ΡΠΎΠΌ ΡΠ ΠΠ Π΄Π»Ρ ΡΠΎΡΠ½ΠΎΠ³ΠΎ… Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- 1. ΠΠΠΠΠ ΠΠΠ’ΠΠ ΠΠ’Π£Π Π«
- 1. 1. ΠΠΌΠΈΠ½ΠΎΠ°ΡΠΈΠ»-ΡΠ ΠΠ-ΡΠΈΠ½ΡΠ΅ΡΠ°Π·Ρ: ΠΊΡΠ°ΡΠΊΠΈΠΉ ΠΎΠ±Π·ΠΎΡ ΡΡΠ½ΠΊΡΠΈΠΉ
- 1. 2. ΠΠΌΠΈΠ½ΠΎΠ°ΡΠΈΠ»-ΡΠ ΠΠ-ΡΠΈΠ½ΡΠ΅ΡΠ°Π·Ρ: Π΄Π²Π° ΠΊΠ»Π°ΡΡΠ°, ΡΠ΅ΠΌΡ ΠΏΠΎΠ΄ΠΊΠ»Π°ΡΡΠΎΠ²
- 1. 3. ΠΠΌΠΈΠ½ΠΎΠ°ΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅: Π°ΠΊΡΠΈΠ²Π°ΡΠΈΡ ΡΠ ΠΠ
- 1. 4. ΠΠ·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Π°ΠΌΠΈΠ½ΠΎΠ°ΡΠΈΠ»-ΡΠ ΠΠ-ΡΠΈΠ½ΡΠ΅ΡΠ°Π· Ρ ΡΠ ΠΠ
- 1. 5. ΠΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΡ Π°ΠΌΠΈΠ½ΠΎΠ°ΡΠΈΠ»-ΡΠ ΠΠ-ΡΠΈΠ½ΡΠ΅ΡΠ°Π·: ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΠ΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠ΅ Π°Π½ΡΠΈΠ±ΠΈΠΎΡΠΈΠΊΠΈ
- 1. 6. ΠΠΌΠΈΠ½ΠΎΠ°ΡΠΈΠ»-ΡΠ ΠΠ-ΡΠΈΠ½ΡΠ΅ΡΠ°Π·Ρ: ΠΏΡΠΎΠΈΡΡ ΠΎΠΆΠ΄Π΅Π½ΠΈΠ΅ ΠΈ ΡΠ²ΠΎΠ»ΡΡΠΈΡ
- 1. 7. Π€Π΅Π½ΠΈΠ»Π°Π»Π°Π½ΠΈΠ»-ΡΠ ΠΠ-ΡΠΈΠ½ΡΠ΅ΡΠ°Π·Π°
- 1. 7. 1. Π‘ΡΡΡΠΊΡΡΡΠ° ΠΈ ΡΠ²ΠΎΠΉΡΡΠ²Π°
- 1. 7. 2. ΠΠ΅ΠΊΠ°Π½ΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΡΠ½ΠΊΡΠΈΠΈ
- 1. 7. 3. ΠΠΎΠΌΠΏΠ»Π΅ΠΊΡ Ρ ΡΠ ΠΠΠ Π¬Π΅
- 1. 7. 4. ΠΠΎΠΌΠΏΠ»Π΅ΠΊΡΡ Ρ Phe ΠΈ PheOH-AMP
- 2. 1. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ
- 2. 1. 1. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΈ ΠΎΡΠΈΡΡΠΊΠ° ΡΠ΅Π½ΠΈΠ»Π°Π»Π°Π½ΠΈΠ»-ΡΠ ΠΠ-ΡΠΈΠ½ΡΠ΅ΡΠ°Π·Ρ
- 2. 1. 2. ΠΡΠΈΡΡΠ°Π»Π»ΠΈΠ·Π°ΡΠΈΡ ΡΠ΅Π½ΠΈΠ»Π°Π»Π°Π½ΠΈΠ»-ΡΠ ΠΠ-ΡΠΈΠ½ΡΠ΅ΡΠ°Π·Ρ
- 2. 1. 3. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° PheRS-Phe-AMP
- 2. 1. 4. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π΄Π°Π½Π½ΡΡ ΡΠ΅Π½ΡΠ³Π΅Π½ΠΎΠ²ΡΠΊΠΎΠΉ Π΄ΠΈΡΡΠ°ΠΊΡΠΈΠΈ
- 2. 2. ΠΠ±ΡΠ°Π±ΠΎΡΠΊΠ° ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ²
- 2. 2. 1. ΠΠ΅ΡΠ²ΠΈΡΠ½Π°Ρ ΠΎΠ±ΡΠ°Π±ΠΎΡΠΊΠ° Π΄Π°Π½Π½ΡΡ ΡΠ΅Π½ΡΠ³Π΅Π½ΠΎΠ²ΡΠΊΠΎΠΉ Π΄ΠΈΡΡΠ°ΠΊΡΠΈΠΈ
- 2. 2. 2. ΠΠΎΡΡΡΠΎΠ΅Π½ΠΈΠ΅ ΠΈ ΡΡΠΎΡΠ½Π΅Π½ΠΈΠ΅ ΠΏΡΠΎΡΡΡΠ°Π½ΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΠΌΠΎΠ΄Π΅Π»ΠΈ
- 3. 1. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅, ΠΎΡΠΈΡΡΠΊΠ° ΠΈ ΠΊΡΠΈΡΡΠ°Π»Π»ΠΈΠ·Π°ΡΠΈΡ Π³ΠΎΠΌΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ ΡΠ΅ΡΠΌΠ΅Π½ΡΠ°
- 3. 2. Π Π΅Π°ΠΊΡΠΈΡ Π°ΠΌΠΈΠ½ΠΎΠ°ΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π² ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠΈ Π΄ΠΈΠ²Π°Π»Π΅Π½ΡΠ½ΡΡ ΠΈΠΎΠ½ΠΎΠ²
- 3. 3. ΠΠ±Π·ΠΎΡ ΡΡΡΡΠΊΡΡΡΡ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ°
- 3. 4. Π‘Π²ΡΠ·ΡΠ²Π°Π½ΠΈΠ΅ ΠΈ ΡΠ°ΡΠΏΠΎΠ·Π½Π°Π²Π°Π½ΠΈΠ΅ ΡΠ΅Π½ΠΈΠ»Π°Π»Π°Π½ΠΈΠ½-Π°Π΄Π΅Π½ΠΈΠ»Π°ΡΠ°
- 3. 5. Π Π°ΡΠΏΠΎΠ·Π½Π°Π²Π°Π½ΠΈΠ΅ ΡΠ΅Π½ΠΈΠ»Π°Π»Π°Π½ΠΈΠ½Π° Π² ΡΡΠ΄Ρ Π°ΡΠΎΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ Π°ΠΌΠΈΠ½ΠΎΠΊΠΈΡΠ»ΠΎΡ
- 3. 6. ΠΠΎΠ½ ΠΌΠ΅ΡΠ°Π»Π»Π° Π² ΠΎΠ±Π»Π°ΡΡΠΈ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ Π°- ΠΈ Π -ΡΡΠ±ΡΠ΅Π΄ΠΈΠ½ΠΈΡ Π³Π΅ΡΠ΅ΡΠΎΠ΄ΠΈΠΌΠ΅ΡΠ°
- 3. 7. ΠΠΎΠ½ ΡΡΠ»ΡΡΠ°ΡΠ° Π½Π° ΠΏΠΎΠ²Π΅ΡΡ Π½ΠΎΡΡΠΈ ΠΠΠ-ΡΠ²ΡΠ·ΡΠ²Π°ΡΡΠ΅Π³ΠΎ Π΄ΠΎΠΌΠ΅Π½Π°
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