Роль рекомбинации в эволюции неполиомиелитных энтеровирусов
Диссертация
Цель работы: Изучить естественную рекомбинацию у неполиомиелитных энтеровирусов на основании анализа нуклеотидной последовательности штаммов, циркулирующих в России и в СНГ. Изучить предполагаемую роль рекомбинации в возникновении новых форм энтеровирусной инфекции на примере штаммов, вызвавших вспышки энтеровирусного увеита в Сибири в 1980;1989 гг. На основании филогенетических взаимоотношений… Читать ещё >
Содержание
- Список сокращений
- Глава 1. Обзор литературы
- 1. 1. Общая характеристика энтеровирусов
- 1. 1. 1. Классификация
- 1. 1. 2. Физико-химические свойства и структура вириона
- 1. 1. 3. Структура генома
- 1. 1. 4. Репликация энтеровирусов
- 1. 1. 5. Клинические проявления неполиомиелитной энтеровирусной инфекции
- 1. 1. 6. Молекулярные основы вирулентности энтеровирусов
- 1. 2. Молекулярная эпидемиология энтеровирусов
- 1. 2. 1. Филогенетические взаимоотношения прототипных энтеровирусов
- 1. 2. 2. Вариабельность различных участков энтеровирусного генома
- 1. 2. 3. Примеры изучения молекулярной эпидемиологии энтеровирусов
- 1. 2. 4. Классическое и молекулярное типирование энтеровирусов
- 1. 3. Рекомбинация у энтеровирусов
- 1. 3. 1. Рекомбинация у вируса полиомиелита
- 1. 3. 2. Рекомбинация у вируса полиомиелита у реципиентов ОПВ
- 1. 3. 3. Рекомбинация у неполиомиелитных энтеровирусов
- 1. 3. 4. Рекомбинация у циркулирующих неполиомиелитных энтеровирусов
- 1. 3. 5. Рекомбинация и независимая эволюция фрагментов генома у других пикорнавирусов и вирусов пикорна-надгруппы
- 1. 4. Энтеровирусный увеит
- 1. 4. 1. Эпидемиология энтеровирусного увеита, выделение и идентефикация вируса-возбудителя
- 1. 4. 2. Клинические проявления энтеровирусной инфекции, осложненной увеитом
- 1. 4. 3. Серологическое изучение эпидемиологии энтеровирусного увеита
- 1. 4. 4. Молекулярная эпидемиология энтеровирусного увеита
- 1. 4. 5. Моделирование энтеровирусного увеита на приматах
- 1. 4. 6. Вероятная внутриглазная персистенция энтеровирусов после острого энтеровирусного увеита
- 1. 4. 7. Системная энтеровирусная инфекция, вызываемая «увеитными» штаммами энтеровирусов
- 1. 4. 8. Резюме
- 1. 5. Предпосылки для данного исследования
- 1. 1. Общая характеристика энтеровирусов
- Глава 2. Материалы и методы
- 2. 1. Использованные штаммы
- 2. 2. Использованные олигонуклеотиды
- 2. 3. Определение нуклеотидной последовательности
- 2. 3. 1. Выделение РНК и синтез кДНК
- 2. 3. 2. Амплификация фрагментов ДНК в ПЦР
- 2. 3. 3. Тактика определения нуклеотидной последовательности
- 2. 3. 4. Клонирование фрагментов ДНК в плазмиды Е. Col
- 2. 3. 5. Определение нуклеотидной последовательности ДНК
- 2. 4. Анализ нуклеотидных последовательностей
- Глава 3. Результаты
- 3. 1. Филогенетический анализ частичных геномных последовательностей штаммов EV11 и EV19 — возбудителей ЭУ
- 3. 1. 1. Филогенетический анализ штаммов — возбудителей ЭУ в области генома VP 1−2А
- 3. 1. 2. Филогенетический анализ штаммов — возбудителей ЭУ в области генома 3D
- 3. 1. 3. Филогенетический анализ штаммов — возбудителей ЭУ в 5' НТО
- 3. 2. Филогенетический анализ полных геномных последовательностей штаммов EV11 и EV19 — возбудителей ЭУ
- 3. 2. 1. Анализ сходства полных нуклеотидных последовательностей штаммов — возбудителей ЭУ в различных участках генома с использованием программы Simplot
- 3. 2. 2. Анализ полных нуклеотидных последовательностей штаммов — возбудителей ЭУ с использованием программы Geneconv
- 3. 3. Филогенетический анализ циркулирующих штаммов Enterovirus В разных серотипов в четырех участках генома
- 3. 3. 1. Филогенетический анализ в области генома VP
- 3. 3. 2. Филогенетический анализ в области генома 3D
- 3. 3. 3. Филогенетический анализ в 5'НТО
- 3. 3. 4. Филогенетический анализ в области генома 2А
- 3. 3. 5. Примеры рекомбинации у циркулирующих штаммов Enterovirus В
- 3. 4. Анализ полных геномных последовательностей современных штаммов Enterovirus В разных серотипов
- 3. 4. 1. Анализ в сравнении с прототипными штаммами Enterovirus В
- 3. 4. 2. Сравнение изученных штаммов Enterovirus В с другими современными штаммами Enterovirus В
- 3. 4. 3. Оценка возможности использования других методов для анализа рекомбинации у энтеровирусов
- 3. 5. Молекулярная эпидемиология EV30 на территории СНГ
- 3. 1. Филогенетический анализ частичных геномных последовательностей штаммов EV11 и EV19 — возбудителей ЭУ
- Глава 4. Обсуяедение
- 4. 1. Роль рекомбинации в возникновении штаммов -возбудителей ЭУ и СПЗ
- 4. 2. Широкое распространение рекомбинации у энтеровирусов
- 4. 3. Молекулярная эпидемиология EV30 на территории СНГ и в мире — «единое эпидемиологическое пространство» и последовательная смена вариантов
- 4. 4. Независимая эволюция фрагментов генома энтеровирусов
- 4. 5. Новая модель генетики энтеровирусов
- 4. 6. Влияние рекомбинации на классификацию энтеровирусов и подходы к полногеномному типированию энтеровирусов
- 4. 7. Параллели между микро- и макроэволюцией энтеровирусов
- 4. 8. Возможные механизмы возникновения новых форм энтеровирусной инфекции
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