Структура и функционирование 5"-регуляторной области гена NANOG восточно-европейской полёвки
Диссертация
Исследование экспрессии генов Оа4, 5ох2, КЦ4, Ба14, ЕбггЬ, Мус в культивируемых клетках предымплантационных эмбрионов, в постымплантационных эмбрионах, а также органах взрослых полёвок показало, что данные гены в основаном сохраняют паттерн органои тканеспецифичной транскрипции характерный для мыши. Таким образом, ключевые транскрипционные факторы системы плюрипотентности достаточно консервативны… Читать ещё >
Содержание
- СПИСОК СОКРАЩЕНИЙ
- ГЛАВА 1. ОБЗОР ЛИТЕРАТУРЫ
- 1. 1. Плюрипотентные клетки мыши
- 1. 1. 1. Развитие плюрипотентности в онтогенезе мыши
- 1. 1. 2. Плюрипотентные клетки мыши in vitro
- 1. 1. 3. Молекулярный контроль плюрипотентности у мыши
- 1. 2. Функция гена Nanog
- 1. 2. 1. Nanog препятствует дифференцировке ЭСК, но не является необходимым для поддержания их плюрипотентности
- 1. 2. 2. Nanog необходим для формирования «наивной» плюрипотентности
- 1. 2. 3. Nanog косвенно необходим для развития гипобласта
- 1. 2. 4. Nanog необходим для развития половой линии
- 1. 2. 5. Nanog завершает молекулярное in vitro репрограммирование соматических клеток
- 1. 2. 6. Молекулярный механизм действия Nanog
- 1. 3. Цис-элементы, регулирующие транскрипцию гена Nanog
- 1. 3. 1. Ocf4 и Sox
- 1. 3. 2. Spl/Sp
- 1. 3. 3. Klf
- 1. 3. 4. Sall4 и Salll
- 1. 3. 5. FoxD
- 1. 3. 6. GCNF
- 1. 3. 7. Nanog и Zfp281 (прямая негативная авторегуляция)
- 1. 3. 8. p
- 1. 1. Плюрипотентные клетки мыши
Список литературы
- Adewumi O., Aflatoonian B., Ahrlund-Richter L. et al. Characterization of human embryonic stem cell lines by the International Stem Cell Initiative // Nat. Biotechnol. 2007. V. 25. № 7. P. 803−816.
- Ahn S., Huang C.L., Ozkumur E. et al. TATA Binding Proteins Can Recognize Nontraditional DNA Sequences // Biophys. J. 2012. V. 103. N° 7. P. 1510−1517.
- Altschul S.F., Gish W., Miller W. et al. Basic local alignment search tool // J. Mol. Biol. 1990. V. 215. № 3. P. 403−410.
- Amati B., Alevizopoulos K. and Vlach J. Myc and the cell cycle // Front. Biosci. 1998. V. 3. № P. d250−268.
- Amit M., Carpenter M.K., Inokuma M.S. et al. Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture // Dev. Biol. 2000. V. 227. № 2. P. 271−278.
- Arman E., Haffner-Krausz R., Chen Y. et al. Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development // Proc. Nad. Acad. Sci. U. S. A. 1998. V. 95. № 9. P. 5082−5087.
- Assou S., Le Carrour T., Tondeur S. et al. A meta-analysis of human embryonic stem cells transcriptome integrated into a web-based expression atlas // Stem Cells 2007. V. 25. № 4. P. 961−973.
- Avilion AA, Nicolis S.K., Pevny L.H. et al. Multipotent cell lineages in early mouse development depend on SOX2 function // Genes Dev. 2003. V. 17. № 1. P. 126−140.
- Beddington RS. and Robertson E.J. Axis development and early asymmetry in mammals // Cell 1999. V. 96. Nq 2. P. 195−209.
- Bendall S.C., Stewart M.H., Menendez P. et al. IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro // Nature 2007. V. 448. № 7157. P. 1015−1021.
- Benezra R., Davis R.L., Lockshon D. et al. The protein Id: a negative regulator of helix-loop-helix DNA binding proteins // Cell 1990. V. 61. № 1. P. 49−59.
- Bilodeau S., Kagey M.H., Frampton G.M. et al. SetDBl contributes to repression of genes encoding developmental regulators and maintenance of ES cell state // Genes Dev. 2009. V. 23. № 21. P. 2484−2489.
- Bouwman P., Gollner H., Elsasser H.P. et al. Transcription factor Sp3 is essential for postnatal survival and late tooth development // EMBO J. 2000. V. 19. N° 4. P. 655−661.
- Boyer L. A, Lee T.I., Cole M.F. et al. Core transcriptional regulatory circuitry in human embryonic stem cells // Cell 2005. V. 122. N° 6. P. 947−956.
- Boyer LA., Plath K., Zeitlinger J. et al. Polycomb complexes repress developmental regulators in murine embryonic stem cells // Nature 2006. V. 441. N° 7091. P. 349 353.
- Brinster R.L. The effect of cells transferred into the mouse blastocyst on subsequent development // J. Exp. Med. 1974. V. 140. N° 4. P. 1049−1056.
- Brons I.G., Smithers L.E., Trotter M.W. et al. Derivation of pluripotent epiblast stem cells from mammalian embryos // Nature 2007. V. 448. N° 7150. P. 191−195.
- Bruce S.J., Gardiner B.B., Burke L.J. et al. Dynamic transcription programs during ES cell differentiation towards mesoderm in serum versus serum-freeBMP4 culture // BMC Genomics 2007. V. 8. N° P. 365.
- Cartharius K., Freeh K., Grote K. et al. Matlnspector and beyond: promoter analysis based on transcription factor binding sites // Bioinformatics 2005. V. 21. № 13. P. 29 332 942.
- Cartwright P., McLean C., Sheppard A et al. LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism // Development 2005. V. 132. № 5. P. 885−896.
- Cauffman G., Van de Velde H., Liebaers I. et al. Oct-4 mRNA and protein expression during human preimplantation development // Mol. Hum. Reprod. 2005. V. 11. N° 3. P. 173 181.
- Chambers I., Colby D., Robertson M. et al. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells // Cell 2003. V. 113. N° 5. P. 643−655.
- Chambers I., Silva J., Colby D. et al. Nanog safeguards pluripotency and mediates germline development // Nature 2007. V. 450. № 7173. P. 1230−1234.
- Chazaud C., Yamanaka Y., Pawson T. et al. Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway // Dev Cell 2006. V. 10. № 5. P. 615−624.
- Chen X., Fang F., Liou Y.C. et al. Zfpl43 regulates Nanog through modulation of Oct4 binding // Stem Cells 2008. V. 26. № 11. P. 2759−2767.
- Chen X., Xu H., Yuan P. et al. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells // Cell 2008. V. 133. № 6. P. 11 061 117.
- Cheng AM., Saxton T.M., Sakai R. et al. Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation // Cell 1998. V. 95. № 6. P. 793−803.
- Clark S.J., Harrison J., Paul C.L. et al High sensitivity mapping of methylated cytosines // Nucleic Acids Res 1994. V. 22. № 15. P. 2990−2997.
- Cole M.F., Johnstone S.E., Newman J.J. et al Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells // Genes Dev. 2008. V. 22. № 6. P. 746 755.
- Cooney A J., Hummelke G.C., Herman T. et al Germ cell nuclear factor is a response element-specific repressor of transcription // Biochem. Biophys. Res. Commun. 1998. V. 245. № 1. P. 94−100.
- Dani C., Chambers I., Johnstone S. et al Paracrine induction of stem cell renewal by LIF-deficient cells: a new ES cell regulatory pathway // Dev. Biol. 1998. V. 203. № 1. P. 149−162.
- Dejosez M., Krumenacker J.S., Zitur L.J. et al Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells // Cell 2008. V. 133. № 7. P. 1162−1174.
- Dejosez M., Levine S.S., Frampton G.M. et al Ronin/Hcf-1 binds to a hyperconserved enhancer element and regulates genes involved in the growth of embryonic stem cells // Genes Dev. 2010. V. 24. № 14. P. 1479−1484.
- Dvorak P., Dvorakova D., Koskova S. et al Expression and potential role of fibroblast growth factor 2 and its receptors in human embryonic stem cells // Stem Cells 2005. V. 23. № 8. P. 1200−1211.
- Egli D., Birkhoff G. and Eggan K. Mediators of reprogramming: transcription factors and transitions through mitosis // Nat Rev Mol Cell Biol 2008. V. 9. № 7. P. 505−516.
- Eilers M. and Eisenman R.N. Myc’s broad reach // Genes Dev. 2008. V. 22. № 20. P. 27 552 766.
- Eiselleova L., Matulka K., Kriz V. et al. A complex role for FGF-2 in self-renewal, survival, and adhesion of human embryonic stem cells // Stem Cells 2009. V. 27. N° 8. P. 18 471 857.
- Elling 17., Klasen C., Eisenberger T. et al. Murine inner cell mass-derived lineages depend on Sall4 function // Proc. Nad. Acad. Sei. U. S. A. 2006. V. 103. № 44. P. 1 631 916 324.
- Evans M.J. and Kaufman M.H. Establishment in culture of pluripotential cells from mouse embryos // Nature 1981. V. 292. № 5819. P. 154−156.
- Falkner F.G. and Zachau H.G. Correct transcription of an immunoglobulin kappa gene requires an upstream fragment containing conserved sequence elements // Nature 1984. V. 310. № 5972. P. 71−74.
- Feldman B., Poueymirou W., Papaioannou V.E. et al. Requirement of FGF-4 for postimplantation mouse development // Science 1995. V. 267. № 5195. P. 246−249.
- Fidalgo M., Faiola F., Pereira C.F. et al Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming // Proc. Nad. Acad. Sei. U. S. A. 2012. V. № P.
- Frankenberg S., Gerbe F., Bessonnard S. et al Primitive endoderm differentiates via a three-step mechanism involving Nanog and RTK signaling // Dev Cell 2011. V. 21. № 6. P. 1005−1013.
- Frazer K. A, Pachter L., Poliakov A et al. VISTA: computational tools for comparative genomics // Nucleic Acids Res 2004. V. 32. № Web Server issue. P. W273−279.
- Fuchs E. and Segre J. A Stem cells: a new lease on life // Cell 2000. V. 100. № 1. P. 143 155.
- Fuhrmann G., Chung AC., Jackson K.J. et al. Mouse germline restriction of Oct4 expression by germ cell nuclear factor // Dev Cell 2001. V. 1. N° 3. P. 377−387.
- Fujikura J., Yamato E., Yonemura S. et al Differentiation of embryonic stem cells is induced by GATA factors // Genes Dev. 2002. V. 16. № 7. P. 784−789.
- Gardner R.L. and Beddington R.S. Multi-lineage 'stem' cells in the mammalian embryo // J. Cell Sei. Suppl. 1988. V. 10. № P. 11−27.
- Goldin S.N. and Papaioannou V.E. Paracrine action of FGF4 during periimplantation development maintains trophectoderm and primitive endoderm // Genesis 2003. V. 36. № 1. P. 40−47.
- Greber B., Wu G., Bernemann C. et ah Conserved and divergent roles of FGF signaling in mouse epiblast stem cells and human embryonic stem cells // Cell Stem Cell 2010. V. 6. № 3. P. 215−226.
- Grigor’eva E.V., Shevchenko AI., Mazurok NA. et ah FGF4 independent derivation of trophoblast stem cells from the common vole // PLoS One 2009. V. 4. № 9. P. e7161.
- Gu P., LeMenuet D., Chung A.C. et ah Orphan nuclear receptor GCNF is required for the repression of pluripotency genes during retinoic acid-induced embryonic stem cell differentiation // Mol. Cell. Biol. 2005. V. 25. № 19. P. 8507−8519.
- Guenther M.G., Frampton G.M., Soldner F. et ah Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells // Cell Stem Cell 2010. V. 7. № 2. P. 249−257.
- Guo G., Huss M., Tong G.Q. et ah Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst // Dev Cell 2010. V. 18. № 4. P. 675−685.
- Guo G., Yang J., Nichols J. et ah Klf4 reverts developmental^ programmed restriction of ground state pluripotency // Development 2009. V. 136. № 7. P. 1063−1069.
- Hahnel AC., Rappolee DA., Millan J.L. et ah Two alkaline phosphatase genes are expressed during early development in the mouse embryo // Development 1990. V. 110. № 2. P. 555−564.
- Han J., Yuan P., Yang H. et ah Tbx3 improves the germ-line competency of induced pluripotent stem cells // Nature 2010. V. 463. N° 7284. P. 1096−1100.
- Hanna J., Saha K., Pando B. et ah Direct cell reprogramming is a stochastic process amenable to acceleration // Nature 2009. V. 462. № 7273. P. 595−601.
- Hanna J.H., Saha K. and Jaenisch R. Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues // Cell 2010. V. 143. Na 4. P. 508−525.
- Hanna L. A, Foreman R.K., Tarasenko I. A et ah Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo // Genes Dev. 2002. V. 16. № 20. P. 2650−2661.
- Hart AH., Hartley L., Ibrahim M. et ah Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human // Dev. Dyn. 2004. V. 230. № 1. P. 187−198.
- Hatano S.Y., Tada M., Kimura H. et al. Pluripotential competence of cells associated with Nanog activity // Mech. Dev. 2005. V. 122. № 1. P. 67−79.
- Hattori N., Imao Y., Nishino K. et al. Epigenetic regulation of Nanog gene in embryonic stem and trophoblast stem cells // Genes Cells 2007. V. 12. N° 3. P. 387−396.
- Hayashi K., Lopes S.M., Tang F. et al. Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states // Cell Stem Cell 2008. V. 3. № 4. P. 391−401.
- Herr W. and Cleary MA. The POU domain: versatility in transcriptional regulation by a flexible two-in-one DNA-binding domain // Genes Dev. 1995. V. 9. N° 14. P. 16 791 693.
- Hikasa H., Ezan J., Itoh K. et al. Regulation of TCF3 by Wnt-dependent phosphorylation during vertebrate axis specification // Dev Cell 2010. V. 19. № 4. P. 521−532.
- Hikasa H. and Sokol S.Y. Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2 // J. Biol. Chem. 2011. V. 286. N° 14. P. 12 093−12 100.
- Hoffman W.H., Biade S., Zilfou J.T. et al. Transcriptional repression of the anti-apoptotic survivin gene by wild type p53 // J. Biol. Chem. 2002. V. 277. N° 5. P. 3247−3257.
- Jiang J., Chan Y.S., Loh Y.H. et al. A core Klf circuitry regulates self-renewal of embryonic stem cells // Nat Cell Biol 2008. V. 10. № 3. P. 353−360.
- Johnson M.H. and Ziomek CA. The foundation of two distinct cell lineages within the mouse morula // Cell 1981. V. 24. № 1. P. 71−80.
- Jurka J., Klonowski P., Dagman V. et al. CENSOR—a program for identification and elimination of repetitive elements from DNA sequences // Comput. Chem. 1996. V. 20. № 1. P. 119−121.
- Kaczynski J., Cook T. and Urrutia R. Spl- and Kruppel-like transcription factors // Genome Biol 2003. V. 4. № 2. P. 206.
- Karantzali E., Lekakis V., Ioannou M. et al. Salll regulates embryonic stem cell differentiation in association with nanog // J. Biol. Chem. 2011. V. 286. № 2. P. 10 371 045.
- Karantzali E., Schulz H., Hummel О. et al. Histone deacetylase inhibition accelerates the early events of stem cell differentiation: transcriptomic and epigenetic analysis // Genome Biol 2008. V. 9. № 4. P. R65.
- Kelly K. E, Ng D.Y., Jayakumaran G. et al. beta-catenin enhances Oct-4 activity and reinforces pluripotency through a TCF-independent mechanism // Cell Stem Cell 2011. V. 8. № 2. P. 214−227.
- Kelly S.J. Studies of the developmental potential of 4- and 8-cell stage mouse blastomeres // J. Exp. Zool. 1977. V. 200. № 3. P. 365−376.
- Kidder B.L., Yang J. and Palmer S. Stat3 and c-Myc genome-wide promoter occupancy in embryonic stem cells // PLoS One 2008. V. 3. № 12. P. e3932.
- Kiefer S.M., McDill B.W., Yang J. et al. Murine Salll represses transcription by recruiting a histone deacetylase complex // J. Biol. Chem. 2002. V. 277. № 17. P. 14 869−14 876.
- Kim J., Chu J., Shen X. et al. An extended transcriptional network for pluripotency of embryonic stem cells // Cell 2008. V. 132. № 6. P. 1049−1061.
- Kim J., Woo A.J., Chu J. et al. А Мус network accounts for similarities between embryonic stem and cancer cell transcription programs // Cell 2010. V. 143. № 2. P. 313−324.
- Kim K., Doi A, Wen B. et al. Epigenetic memory in induced pluripotent stem cells // Nature 2010. V. 467. № 7313. P. 285−290.
- Knoepfler P. S., Zhang X.Y., Cheng P.F. et al. Мус influences global chromatin structure // EMBO J. 2006. V. 25. № 12. P. 2723−2734.
- Ко L.J. and Prives C. p53: puzzle and paradigm // Genes Dev. 1996. V. 10. № 9. P. 10 541 072.
- Kunath Т., Saba-El-Leil M.K., Almousailleakh M. et al. FGF stimulation of the Erkl/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment // Development 2007. V. 134. № 16. P. 2895−2902.
- Kurimoto K, Yabuta Y., Ohinata Y. et al. An improved single-cell cDNA amplification method for efficient high-density oligonucleotide microarray analysis // Nucleic Acids Res 2006. V. 34. № 5. P. e42.
- Marson A, Levine S.S., Cole M.F. et al. Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells // Cell 2008. V. 134. № 3. P. 521−533.
- Medvedev S.P., Shevchenko A I., Elisaphenko E. A et al. Structure and expression pattern of Oct4 gene are conserved in vole Microtus rossiaemeridionalis // BMC Genomics2008. V. 9. No P. 162.
- Meilhac S.M., Adams R.J., Morris SA et al. Active cell movements coupled to positional induction are involved in lineage segregation in the mouse blastocyst // Dev. Biol.2009. V. 331. № 2. P. 210−221.
- Meissner A, Wernig M. and Jaenisch R. Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells // Nat. Biotechnol. 2007. V. 25. № 10. P. 11 771 181.
- Merrill B.J., Pasolli H. A, Polak L. et al. Tcf3: a transcriptional regulator of axis induction in the early embryo // Development 2004. V. 131. N° 2. P. 263−274.
- Messerschmidt D.M. and Kemler R. Nanog is required for primitive endoderm formation through a non-cell autonomous mechanism // Dev. Biol. 2010. V. 344. № 1. P. 129 137.
- Mitsui K, Tokuzawa Y., Itoh H. et al. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells // Cell 2003. V. 113. N° 5. P. 631−642.
- Miyanari Y. and Torres-Padilla M.E. Control of ground-state pluripotency by allelic regulation of Nanog // Nature 2012. V. 483. N° 7390. P. 470−473.
- Monk M., Boubelik M. and Lehnert S. Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development // Development 1987. V. 99. N° 3. P. 371−382.
- Monk M. and McLaren A X-chromosome activity in foetal germ cells of the mouse // J. Embryol. Exp. Morphol. 1981. V. 63. N° P. 75−84.
- Navarro P. and Avner P. When X-inactivation meets pluripotency: an intimate rendezvous // FEBS Lett. 2009. V. 583. N° 11. P. 1721−1727.
- Navarro P., Chambers I., Karwacki-Neisius V. et al. Molecular coupling of Xist regulation and pluripotency // Science 2008. V. 321. N° 5896. P. 1693−1695.
- Newman AM. and Cooper J.B. Lab-specific gene expression signatures in pluripotent stem cells // Cell Stem Cell 2010. V. 7. № 2. P. 258−262.
- Nguyen H., Rendi M. and Fuchs E. Tcf3 governs stem cell features and represses cell fate determination in skin // Cell 2006. V. 127. № 1. P. 171−183.
- Niakan K.K., Ji H., Maehr R. et al. Soxl7 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal // Genes Dev. 2010. V. 24. № 3. P. 312−326.
- Nichols J., Chambers I., Taga T. et al. Physiological rationale for responsiveness of mouse embryonic stem cells to gpl30 cytokines // Development 2001. V. 128. № 12. P. 2333−2339.
- Nichols J., Silva J., Roode M. et al. Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo // Development 2009. V. 136. № 19. P. 3215−3222.
- Nichols J. and Smith A Naive and primed pluripotent states // Cell Stem Cell 2009. V. 4. № 6. P. 487−492.
- Nichols J., Zevnik B., Anastassiadis K. et al. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4 // Cell 1998. V. 95. № 3. P. 379−391.
- Niwa H., Burdon T., Chambers I. et al. Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3 // Genes Dev. 1998. V. 12. № 13. P. 2048−2060.
- Niwa H., Miyazaki J. and Smith AG. Quantitative expression of Oct-¾ defines differentiation, dedifferentiation or self-renewal of ES cells // Nat. Genet. 2000. V. 24. № 4. P. 372−376.
- Niwa H., Ogawa K., Shimosato D. et al. A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells // Nature 2009. V. 460. № 7251. P. 118 122.
- Niwa H., Toyooka Y., Shimosato D. et al. Interaction between Oct¾ and Cdx2 determines trophectoderm differentiation // Cell 2005. V. 123. Nq 5. P. 917−929.
- Okita K, Ichisaka T. and Yamanaka S. Generation of germline-competent induced pluripotent stem cells // Nature 2007. V. 448. № 7151. P. 313−317.
- Orkin S.H., Wang J., Kim J. et al. The transcriptional network controlling pluripotency in ES cells // Cold Spring Harb. Symp. Quant. Biol. 2008. V. 73. № P. 195−202.
- Ovitt C.E. and Scholer H.R. The molecular biology of Oct-4 in the early mouse embryo // Mol. Hum. Reprod. 1998. V. 4. № 11. P. 1021−1031.
- Paling N.R., Wheadon H., Bone H.K. et al. Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling // J. Biol. Chem. 2004. V. 279. № 46. P. 48 063−48 070.
- Pan G., Li J., Zhou Y. et al. A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal // FASEB J. 2006. V. 20. № 10. P. 17 301 732.
- Parslow T.G., Blair D.L., Murphy W.J. et al. Structure of the 5' ends of immunoglobulin genes: a novel conserved sequence // Proc. Natl. Acad. Sei. U. S. A. 1984. V. 81. № 9. P. 2650−2654.
- Pasini D., Bracken AP., Jensen M.R. et al. Suzl2 is essential for mouse development and for EZH2 histone methyltransferase activity // EMBO J. 2004. V. 23. N° 20. P. 40 614 071.
- Pearson W.R. and Lipman D.J. Improved tools for biological sequence comparison // Proc. Natl. Acad. Sci. U. S. A. 1988. V. 85. № 8. P. 2444−2448.
- Pebay A, Wong R.C., Pitson S.M. et al. Essential roles of sphingosine-l-phosphate and platelet-derived growth factor in the maintenance of human embryonic stem cells // Stem Cells 2005. V. 23. N° 10. P. 1541−1548.
- Pereira L., Yi F. and Merrill B.J. Repression of Nanog gene transcription by Tcf3 limits embryonic stem cell self-renewal // Mol. Cell. Biol. 2006. V. 26. N° 20. P. 7479−7491.
- Plusa B., Piliszek A, Frankenberg S. et al. Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst // Development 2008. V. 135. N° 18. P. 3081−3091.
- Pratt H.P., Bolton V.N. and Gudgeon K. A The legacy from the oocyte and its role in controlling early development of the mouse embryo // Ciba Found. Symp. 1983. V. 98. N° P. 197−227.
- Qi X., Li T.G., Hao J. et al. BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways // Proc. Natl. Acad. Sci. U. S. A. 2004. V. 101. N° 16. P. 6027−6032.
- Rao S., Zhen S., Roumiantsev S. et al. Differential roles of Sall4 isoforms in embryonic stem cell pluripotency // Mol. Cell. Biol. 2010. V. 30. N° 22. P. 5364−5380.
- Rastan S. and Robertson E.J. X-chromosome deletions in embryo-derived (EK) cell lines associated with lack of X-chromosome inactivation // J. Embryol. Exp. Morphol. 1985. V. 90. N° P. 379−388.
- Reik W., Dean W. and Walter J. Epigenetic reprogramming in mammalian development // Science 2001. V. 293. № 5532. P. 1089−1093.
- Resnick J.L.y Bixler L.S., Cheng L. et al. Long-term proliferation of mouse primordial germ cells in culture // Nature 1992. V. 359. N° 6395. P. 550−551.
- Rodda D.J., Chew J.L., Lim L.H. et al. Transcriptional regulation of nanog by OCT4 and SOX2 // J. Biol. Chem. 2005. V. 280. N° 26. P. 24 731−24 737.
- Roussigne M., Kossida S., Lavigne AC. et al. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase // Trends Biochem. Sei. 2003. V. 28. № 2. P. 66−69.
- Rowland B.D., Bernards R. and Peeper D.S. The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene // Nat Cell Biol 2005. V. 7. № 11. P. 1074−1082.
- Rowland B.D. and Peeper D.S. KLF4, p21 and context-dependent opposing forces in cancer // Nat Rev Cancer 2006. V. 6. N° 1. P. 11−23.
- Schwartz S., Zhang Z., Frazer K. A et al. PipMaker—a web server for aligning two genomic DNA sequences // Genome Res. 2000. V. 10. № 4. P. 577−586.
- Seiwood L. and Johnson M.H. Trophoblast and hypoblast in the monotreme, marsupial and eutherian mammal: evolution and origins // Bioessays 2006. V. 28. № 2. P. 128−145.
- Shamblott M.J., Axelman J., Wang S. et al. Derivation of pluripotent stem cells from cultured human primordial germ cells // Proc. Natl. Acad. Sei. U. S. A. 1998. V. 95. № 23. P. 13 726−13 731.
- Shevchenko A.I., Pavlova S.V., Dementyeva E.V. et al. Mosaic heterochromatin of the inactive X chromosome in vole Microtus rossiaemeridionalis // Mamm. Genome 2009. V. 20. № 9−10. P. 644−653.
- Shi J.J., Cai D.H., Chen X.J. et al. Cloning and characterization of the rabbit POU5F1 gene // DNA Seq. 2008. V. 19. N° 1. P. 56−61.
- Shields J.M., Christy R.J. and Yang V.W. Identification and characterization of a gene encoding a gut-enriched Kruppel-like factor expressed during growth arrest // J. Biol. Chem. 1996. V. 271. № 33. P. 20 009−20 017.
- Silva J., Barrandon O., Nichols J. et al. Promotion of reprogramming to ground state pluripotency by signal inhibition // PLoS Biol 2008. V. 6. № 10. P. e253.
- Silva J., Chambers I., Pollard S. et al. Nanog promotes transfer of pluripotency after cell fusion // Nature 2006. V. 441. N° 7096. P. 997−1001.
- Silva J., Nichols J., Theunissen T.W. et al. Nanog is the gateway to the pluripotent ground state // Cell 2009. V. 138. N° 4. P. 722−737.
- Silva S.S., Rowntree R.K., Mekhoubad S. et al. X-chromosome inactivation and epigenetic fluidity in human embryonic stem cells // Proc. Nad. Acad. Sci. U. S. A. 2008. V. 105. N° 12. P. 4820−4825.
- Sineva G.S. and Pospelov V. A Inhibition of GSK3beta enhances both adhesive and signalling activities of beta-catenin in mouse embryonic stem cells // Biol. Cell. 2010. V. 102. N° 10. P. 549−560.
- Smith K.N., Lim J.M., Wells L. et al. Myc orchestrates a regulatory network required for the establishment and maintenance of pluripotency // Cell Cycle 2011. V. 10. N° 4. P. 592−597.
- Smith K.N., Singh AM. and Dalton S. Myc represses primitive endoderm differentiation in pluripotent stem cells // Cell Stem Cell 2010. V. 7. № 3. P. 343−354.
- Sridharan R., Tchieu J., Mason M.J. et al. Role of the murine reprogramming factors in the induction of pluripotency // Cell 2009. V. 136. N° 2. P. 364−377.
- Strizzi L., Bianco C., Normanno N. et al. Cripto-1: a multifunctional modulator during embiyogenesis and oncogenesis // Oncogene 2005. V. 24. N° 37. P. 5731−5741.
- Surani M. A Reprogramming a somatic nucleus by trans-modification activity in germ cells // Semin. Cell Dev. Biol. 1999. V. 10. N° 3. P. 273−277.
- Surani MA., Hayashi K. and Hajkova P. Genetic and epigenetic regulators of pluripotency // Cell 2007. V. 128. N° 4. P. 747−762.
- Suzuki A, Raya A, Kawakami Y. et al. Nanog binds to Smadl and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells // Proc. Natl. Acad. Sci. U. S. A. 2006. V. 103. N° 27. P. 10 294−10 299.
- Takahashi K. and Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors // Cell 2006. V. 126. N° 4. P. 663−676.
- Takeda J., Seino S. and Bell G.I. Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues // Nucleic Acids Res 1992. V. 20. N° 17. P. 4613−4620.
- Tam W.L., Lim C.Y., Han J. et al. T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways // Stem Cells 2008. V. 26. N° 8. P. 2019−2031.
- Tanaka S., Kunath T., Hadjantonakis AK. et al. Promotion of trophoblast stem cell proliferation by FGF4 // Science 1998. V. 282. № 5396. P. 2072−2075.
- Tesar P.J., Chenoweth J.G., Brook F. A et al. New cell lines from mouse epiblast share defining features with human embryonic stem cells // Nature 2007. V. 448. № 7150. P. 196−199.
- Theunissen T.W., Costa Y., Radzisheuskaya A et al. Reprogramming capacity of Nanog is functionally conserved in vertebrates and resides in a unique homeodomain // Development 2011. V. 138. № 22. P. 4853−4865.
- Theunissen T.W. and Silva J.C. Switching on pluripotency: a perspective on the biological requirement of Nanog // Philos. Trans. R. Soc. Lond. B. Biol. Sci. 2011. V. 366. № 1575. P. 2222−2229.
- Theunissen T.W., van Oosten AL., Castelo-Branco G. et al. Nanog overcomes reprogramming barriers and induces pluripotency in minimal conditions // Curr. Biol. 2011. V. 21. N° 1. P. 65−71.
- Thomson J. A, Itskovitz-EIdor J., Shapiro S.S. et al. Embryonic stem cell lines derived from human blastocysts // Science 1998. V. 282. № 5391. P. 1145−1147.
- Thomson M., Liu S.J., Zou L.N. et al. Pluripotency factors in embryonic stem cells regulate differentiation into germ layers // Cell 2011. V. 145. № 6. P. 875−889.
- Triglia T., Peterson M.G. and Kemp D.J. A procedure for in vitro amplification of DNA segments that he outside the boundaries of known sequences // Nucleic Acids Res 1988. V. 16. № 16. P. 8186.
- Tropepe V., Hitoshi S., Sirard C. et al. Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism // Neuron 2001. V. 30. N° 1. P. 65−78.
- Tsirigos A and Rigoutsos I. Alu and bl repeats have been selectively retained in the upstream and intronic regions of genes of specific functional classes // PLoS Comput Biol 2009. V. 5. N° 12. P. el000610.
- Tutter AV, Kowalski M.P., Baltus G. A et al. Role for Medl2 in regulation of Nanog and Nanog target genes // J. Biol. Chem. 2009. V. 284. № 6. P. 3709−3718.
- Vallier I., Alexander M. and Pedersen JR. A Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells // J. Cell Sci. 2005. V. 118. № Pt 19. P. 4495−4509.
- Wang C. and Song B. Cell-type-specific expression of the platelet-derived growth factor alpha receptor: a role for GATA-binding protein // Mol. Cell. Biol. 1996. V. 16. № 2. P. 712−723.
- Wang J., Rao S., Chu J. et al. A protein interaction network for pluripotency of embryonic stem cells // Nature 2006. V. 444. N° 7117. P. 364−368.
- Wang Y, Smedberg J.L., Cai K.Q. et al. Ectopic expression of GATA6 bypasses requirement for Grb2 in primitive endoderm formation // Dev. Dyn. 2011. V. 240. No 3. P. 566 576.
- Wei Z., Yang Y., Zhang P. et al. Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming // Stem Cells 2009. V. 27. N° 12. P. 2969−2978.
- Wernig M., Meissner A, Foreman R. et al. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state // Nature 2007. V. 448. N° 7151. P. 318−324.
- Wray J., Kalkan T., Gomez-Lopez S. et al. Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation // Nat Cell Biol 2011. V. 13. № 7. P. 838−845.
- WuD.Y. and Yao Z. Functional analysis of two Spl/Sp3 binding sites in murine Nanog gene promoter // Cell Res. 2006. V. 16. N° 3. P. 319−322.
- Wu Q., Chen X., Zhang J. et al. Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells // J. Biol. Chem. 2006. V. 281. № 34. P. 24 090−24 094.
- Wysocka J., Myers M.P., Laherty C.D. et al Human Sin3 deacetylase and trithorax-related Setl/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1 // Genes Dev. 2003. V. 17. № 7. P. 896−911.
- Xu R.H., Sampsell-Barron TL., Gu F. et al NANOG is a direct target of TGFbeta/activin-mediated SMAD signaling in human ESCs // Cell Stem Cell 2008. V. 3. № 2. P. 196 206.
- Yamaguchi S., Kimura H., Tada M. et al Nanog expression in mouse germ cell development // Gene Expr Patterns 2005. V. 5. № 5. P. 639−646.
- Yamaguchi S., Kurimoto K., Yabuta Y. et al Conditional knockdown of Nanog induces apoptotic cell death in mouse migrating primordial germ cells // Development 2009. V. 136. № 23. P. 4011−4020.
- Yamanaka Y., Lanner F. and Rossant J. FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst // Development 2010. V. 137. № 5. P. 715−724.
- Yamashita K., Sato A, Asashima M. et al Mouse homolog of SALL1, a causative gene for Townes-Brocks syndrome, binds to A/T-rich sequences in pericentric heterochromatin via its C-terminal zinc finger domains // Genes Cells 2007. V. 12. № 2. P. 171−182.
- Yang J., Corsello T.R. and Ma Y. Stem cell gene SALL4 suppresses transcription through recruitment of DNA methyltransferases // J. Biol. Chem. 2012. V. 287. Na 3. P. 19 962 005.
- Yang J., Gao C., Chai L. et al A novel SALL4/OCT4 transcriptional feedback network for pluripotency of embryonic stem cells // PLoS One 2010. V. 5. № 5. P. el0766.
- Yi F., Pereira I., Hoffman J. A et al Opposing effects of Tcf3 and Tcfl control Wnt stimulation of embryonic stem cell self-renewal // Nat Cell Biol 2011. V. 13. № 7. P. 762−770.
- Yi F., Pereira L. and Merrill B.J. Tcf3 functions as a steady-state limiter of transcriptional programs of mouse embryonic stem cell self-renewal // Stem Cells 2008. V. 26. № 8. P. 1951−1960.
- Ymg Q.L., Nichols J., Chambers I. et al. BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3 // Cell 2003. V. 115. № 3. P. 281−292.
- Ymg Q.L., Wray J., Nichols J. et al. The ground state of embryonic stem cell self-renewal // Nature 2008. V. 453. № 7194. P. 519−523.
- Ymg Y. y Qi X. and Zhao G.Q. Induction of primordial germ cells from murine epiblasts by synergistic action of BMP4 and BMP8B signaling pathways // Proc. Natl. Acad. Sci. U. S. A. 2001. V. 98. № 14. P. 7858−7862.
- Young RA Control of the embryonic stem cell state // Cell 2011. V. 144. № 6. P. 940−954.
- Yii J., Vodyanik MA., Smuga-Otto K. et al. Induced pluripotent stem cell lines derived from human somatic cells // Science 2007. V. 318. № 5858. P. 1917−1920.
- Yuri S., Fujimura S., Nimura K. et al. Sall4 is essential for stabilization, but not for pluripotency, of embryonic stem cells by repressing aberrant trophectoderm gene expression // Stem Cells 2009. V. 27. № 4. P. 796−805.
- Zandstra P.W., Le H.V., Daley G.Q. et al. Leukemia inhibitory factor (LIF) concentration modulates embryonic stem cell self-renewal and differentiation independently of proliferation // Biotechnol. Bioeng. 2000. V. 69. № 6. P. 607−617.
- Zernicka-Goetz M., Morris SA and Bruce AW. Making a firm decision: multifaceted regulation of cell fate in the early mouse embryo // Nat Rev Genet 2009. V. 10. № 7. P. 467−477.
- Zhang P., Andrianakos R., Yang Y. et al. Kruppel-like factor 4 (Klf4) prevents embryonic stem (ES) cell differentiation by regulating Nanog gene expression // J. Biol. Chem. 2010. V. 285. № 12. P. 9180−9189.
- Zwaka T.P. and Thomson J A A germ cell origin of embryonic stem cells? // Development 2005. V. 132. № 2. P. 227−233.
- Васильева Л, А Статистические методы в биологии, медицине и сельском хозяйстве Новосибирск. Институт цитологии и генетики СО РАН, Новосибирский государственный университет, 2007. С.
- Медведев С.П., Елисафенко Е.А, Шевченко А. И. еГ а/. Молекулярно-генетическая организация и особенности экспрессии гена Истод у полёвки МкгоШб гоБз1аетеп (ИопаИ5 II Доклады Академии наук 2009. V. 425. № 5. Р. 688−691.
- Сорокин М. А, Медведев С. П., Шевченко А. И. еГ а1. Экспрессия генов раннего развития у полёвки МлсгоШб го551аетепс1юпаН8 // Генетика 2010. V. 46. № 2. Р. 282−286.
- Шевченко АИ., Демина В. В., Мазурок НА е1 а1. Линии клеток экстраэмбриональной эндодермы обыкновенных полевок рода МгсгоШБ II Генетика 2008. V. 44. N° 11. Р. 1477−1485.