Π‘ΡΡΡΠΊΡΡΡΠ½ΠΎ-ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½Π°Ρ ΠΈ Π°Π½ΡΠΈΠ³Π΅Π½Π½Π°Ρ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° Π²ΡΡΠΎΠΊΠΎΠΊΠΎΠ½ΡΠ΅ΡΠ²Π°ΡΠΈΠ²Π½ΡΡ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² ΠΎΠ±ΠΎΠ»ΠΎΡΠ΅ΡΠ½ΡΡ Π±Π΅Π»ΠΊΠΎΠ² Π1 ΠΈ Π2 Π²ΠΈΡΡΡΠ° Π³Π΅ΠΏΠ°ΡΠΈΡΠ° Π‘
ΠΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΡΡ ΠΠΠ‘ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΡΠ΅Π·Π²ΡΡΠ°ΠΉΠ½ΠΎ Π²ΡΡΠΎΠΊΠ°Ρ Π²Π°ΡΠΈΠ°Π±Π΅Π»ΡΠ½ΠΎΡΡΡ Π΅Π³ΠΎ ΠΎΠ±ΠΎΠ»ΠΎΡΠ΅ΡΠ½ΡΡ Π±Π΅Π»ΠΊΠΎΠ². ΠΡΠ΄Π΅Π»ΡΡΡ Π΄Π²Π° Π³ΠΈΠΏΠ΅ΡΠ²Π°ΡΠΈΠ°Π±Π΅Π»ΡΠ½ΡΡ ΡΡΠ°ΡΡΠΊΠ° ΠΎΠ±ΠΎ-Π»ΠΎΡΠ΅ΡΠ½ΠΎΠ³ΠΎ Π±Π΅Π»ΠΊΠ° Π2, ΠΊΠΎΡΠΎΡΡΠ΅ ΡΠ²Π»ΡΡΡΡΡ ΠΈΠΌΠΌΡΠ½ΠΎΠ΄ΠΎΠΌΠΈΠ½Π°Π½ΡΠ½ΡΠΌΠΈΠ°Π½ΡΠΈΡΠ΅Π»Π° ΠΏΡΠΎΡΠΈΠ² Π½ΠΈΡ ΡΠΏΠΎΡΠΎΠ±Π½Ρ Π½Π΅ΠΉΡΡΠ°Π»ΠΈΠ·ΠΎΠ²Π°ΡΡ ΠΏΡΠΎΠ½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΠ΅ Π²ΠΈΡΡΡΠ° Π² ΠΊΠ»Π΅ΡΠΊΡ. ΠΠ΄Π½Π°ΠΊΠΎ ΡΡΠΈ Π°Π½ΡΠΈΡΠ΅Π»Π° ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½Ρ Π»ΠΈΡΡ ΠΊ ΠΎΠ΄Π½ΠΎΠΌΡ ΠΈΠ»ΠΈ Π½Π΅ΡΠΊΠΎΠ»ΡΠΊΠΈΠΌ ΠΊΠ²Π°Π·ΠΈΠ²ΠΈΠ΄Π°ΠΌ Π²ΠΈΡΡΡΠ° ΠΈ Π½Π΅ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°ΡΡ Π·Π°ΡΠΈΡΡ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ° ΠΎΡ ΠΈΠ½ΡΡ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ … Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅
- 2. ΠΠ±ΠΎΠ»ΠΎΡΠ΅ΡΠ½ΡΠ΅ Π±Π΅Π»ΠΊΠΈ Π²ΠΈΡΡΡΠ° Π³Π΅ΠΏΠ°ΡΠΈΡΠ° Π‘ ΠΈ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Ρ ΡΠΎΠ·Π΄Π°Π½ΠΈΡ Π²Π°ΠΊΡΠΈΠ½Ρ
- 2. 1. Π‘ΡΡΠΎΠ΅Π½ΠΈΠ΅ Π³Π΅Π½ΠΎΠΌΠ° ΠΈ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΡ Π²ΠΈΡΡΡΠ½ΠΎΠΉ ΡΠ°ΡΡΠΈΡΡ Π³Π΅ΠΏΠ°ΡΠΈΡΠ° Π‘
- 2. 2. ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠ΅ ΠΌΠΎΠ΄Π΅Π»ΠΈ Π΄Π»Ρ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ Π²ΠΈΡΡΡΠ° Π³Π΅ΠΏΠ°ΡΠΈΡΠ° Π‘
- 2. 3. ΠΠΎΠ»Π΅ΠΊΡΠ»Ρ Π½Π° ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠΈ ΠΊΠ»Π΅ΡΠΊΠΈ-Ρ
ΠΎΠ·ΡΠΈΠ½Π° — ΠΏΡΠ΅Π΄ΠΏΠΎΠ»Π°Π³Π°Π΅ΠΌΡΠ΅ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΡ Π΄Π»Ρ Π²ΠΈΡΡΡΠ° Π³Π΅ΠΏΠ°ΡΠΈΡΠ° Π‘
- 2. 3. 1. ΠΠΈΠΏΠΎΠΏΡΠΎΡΠ΅ΠΈΠ½Ρ Π½ΠΈΠ·ΠΊΠΎΠΉ ΠΈ ΠΎΡΠ΅Π½Ρ Π½ΠΈΠ·ΠΊΠΎΠΉ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΠΈ ΠΈ ΠΈΡ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΡ
- 2. 3. 2. SR-B1 ΠΈ CD81 Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ² Π΄Π»Ρ Π²ΠΈΡΡΡΠ° Π³Π΅ΠΏΠ°ΡΠΈΡΠ° Π‘
- 2. 3. 3. ΠΡΠΈΠ°Π»ΠΎΠ³Π»ΠΈΠΊΠΎΠΏΡΠΎΡΠ΅ΠΈΠ½ΠΎΠ²ΡΠΉ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡ
- 2. 3. 4. ΠΠ΅ΠΊΡΠΈΠ½Ρ DC-SIGN ΠΈ L-SIGN
- 2. 3. 5. ΠΠ»ΠΈΠΊΠΎΠ·Π°ΠΌΠΈΠ½ΠΎΠ³Π»ΠΈΠΊΠ°Π½Ρ
- 2. 4. Π‘ΡΡΡΠΊΡΡΡΠ° ΠΈ ΡΡΠ½ΠΊΡΠΈΠΈ ΠΎΠ±ΠΎΠ»ΠΎΡΠ΅ΡΠ½ΡΡ
Π±Π΅Π»ΠΊΠΎΠ² Π1 ΠΈ Π2 Π²ΠΈΡΡΡΠ° Π³Π΅ΠΏΠ°ΡΠΈΡΠ° Π‘
- 2. 4. 1. ΠΠ±ΡΠ°Ρ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° ΡΡΡΡΠΊΡΡΡΡ ΠΎΠ±ΠΎΠ»ΠΎΡΠ΅ΡΠ½ΡΡ Π±Π΅Π»ΠΊΠΎΠ²
- 2. 4. 2. ΠΠ°ΡΠΈΠ°Π±Π΅Π»ΡΠ½ΠΎΡΡΡ ΠΎΠ±ΠΎΠ»ΠΎΡΠ΅ΡΠ½ΡΡ Π±Π΅Π»ΠΊΠΎΠ²
- 2. 4. 3. Π‘ΡΡΡΠΊΡΡΡΠ° ΠΈ ΡΡΠ½ΠΊΡΠΈΠΈ ΡΡΠ°Π½ΡΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π½ΡΡ Π΄ΠΎΠΌΠ΅Π½ΠΎΠ² ΠΎΠ±ΠΎΠ»ΠΎΡΠ΅ΡΠ½ΡΡ Π±Π΅Π»ΠΊΠΎΠ² Π1 ΠΈ Π
- 2. 4. 4. ΠΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ Π΄ΠΈΡΡΠ»ΡΡΠΈΠ΄Π½ΡΡ ΡΠ²ΡΠ·Π΅ΠΉ ΠΈ ΡΠΎΠ»Π΄ΠΈΠ½Π³ ΠΎΠ±ΠΎΠ»ΠΎΡΠ΅ΡΠ½ΡΡ Π±Π΅Π»ΠΊΠΎΠ² Π1 ΠΈ Π
- 2. 4. 5. ΠΠ»ΠΈΡΠ½ΠΈΠ΅ Π³Π»ΠΈΠΊΠΎΠ·ΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΎΠ±ΠΎΠ»ΠΎΡΠ΅ΡΠ½ΡΡ Π±Π΅Π»ΠΊΠΎΠ² Π½Π° ΠΈΡ ΡΡΡΡΠΊΡΡΡΡ ΠΈ ΡΡΠ½ΠΊΡΠΈΠΈ
- 2. 4. 6. ΠΠ΅ΡΠ΅ΡΠΎΠ΄ΠΈΠΌΠ΅Ρ Π1Π
- 2. 4. 7. ΠΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ Π²ΠΈΡΠΈΠΎΠ½Π° ΠΈ Π²ΡΡΠ²ΠΎΠ±ΠΎΠΆΠ΄Π΅Π½ΠΈΠ΅ Π²ΠΈΡΡΡΠ½ΠΎΠΉ ΡΠ°ΡΡΠΈΡΡ Π²ΠΎ Π²Π½Π΅ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ΅ ΠΏΡΠΎΡΡΡΠ°Π½ΡΡΠ²ΠΎ
- 2. 4. 8. Π£ΡΠ°ΡΡΠΊΠΈ ΠΎΠ±ΠΎΠ»ΠΎΡΠ΅ΡΠ½ΡΡ Π±Π΅Π»ΠΊΠΎΠ², ΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΡΠ΅ Π·Π° ΡΠ°ΡΠΏΠΎΠ·Π½Π°Π²Π°Π½ΠΈΠ΅ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΡΡ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ² Π²ΠΈΡΡΡΠ° Π³Π΅ΠΏΠ°ΡΠΈΡΠ° Π‘
- 2. 4. 9. ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΠΎΠ±ΠΎΠ»ΠΎΡΠ΅ΡΠ½ΡΡ Π±Π΅Π»ΠΊΠΎΠ² Π½Π° ΡΠ΅Π³ΡΠ»ΡΡΠΈΡ Π±ΠΈΠΎΡΠΈΠ½ΡΠ΅Π·Π° Π±Π΅Π»ΠΊΠΎΠ² ΠΊΠ»Π΅ΡΠΊΠΈ-Ρ ΠΎΠ·ΡΠΈΠ½Π°
- 2. 5. ΠΠ½ΡΠΈΠ³Π΅Π½Π½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΠΎΠ±ΠΎΠ»ΠΎΡΠ΅ΡΠ½ΡΡ Π±Π΅Π»ΠΊΠΎΠ² Π²ΠΈΡΡΡΠ° Π³Π΅ΠΏΠ°ΡΠΈΡΠ° Π‘
- 2. 6. ΠΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Ρ ΡΠΎΠ·Π΄Π°Π½ΠΈΡ Π²Π°ΠΊΡΠΈΠ½Ρ ΠΏΡΠΎΡΠΈΠ² Π²ΠΈΡΡΡΠ° Π³Π΅ΠΏΠ°ΡΠΈΡΠ° Π‘
- 2. 7. 3. Π°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅
- 3. 1. Π₯ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ΅Π°Π³Π΅Π½ΡΡ ΠΈ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡ
- 3. 2. Π Π°ΡΡΠ²ΠΎΡΠΈΡΠ΅Π»ΠΈ
- 3. 3. ΠΠ±ΠΎΡΡΠ΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠ½ΠΎΠ΅ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΠ΅
- 3. 4. ΠΠ΅ΡΠΎΠ΄Ρ
- 3. 4. 1. Π‘ΠΈΠ½ΡΠ΅Π· ΠΏΠ΅ΠΏΡΠΈΠ΄ΠΎΠ²
- 3. 4. 1. 1. Π‘Π½ΡΡΠΈΠ΅ Fmoc-Π·Π°ΡΠΈΡΡ Ρ N-ΠΊΠΎΠ½ΡΠ΅Π²ΠΎΠΉ Π°ΠΌΠΈΠ½ΠΎΠ³ΡΡΠΏΠΏΡ
- 3. 4. 1. 2. ΠΡΠΈΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠ΅ Fmoc-Π·Π°ΡΠΈΡΠ΅Π½Π½ΡΡ Π°ΠΌΠΈΠ½ΠΎΠΊΠΈΡΠ»ΠΎΡ ΠΊ ΡΠ²ΠΎΠ±ΠΎΠ΄Π½ΡΠΌ Π°ΠΌΠΈΠ½ΠΎΠ³ΡΡΠΏΠΏΠ°ΠΌ Π½Π° ΠΈΠ³Π»Π°Ρ
- 3. 4. 1. 3. ΠΡΠ΅ΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ N-ΠΊΠΎΠ½ΡΠ΅Π²ΡΡ Π°-Π°ΠΌΠΈΠ½ΠΎΠ³ΡΡΠΏΠΏ ΠΏΠ΅ΠΏΡΠΈΠ΄ΠΎΠ²
- 3. 4. 1. 4. ΠΠΈΠΎΡΠΈΠ½ΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ N-ΠΊΠΎΠ½ΡΠ΅Π²ΡΡ Π°-Π°ΠΌΠΈΠ½ΠΎΠ³ΡΡΠΏΠΏ ΠΏΠ΅ΠΏΡΠΈΠ΄ΠΎΠ²
- 3. 4. 1. 5. Π‘Π½ΡΡΠΈΠ΅ Π·Π°ΡΠΈΡ Ρ Π±ΠΎΠΊΠΎΠ²ΡΡ Π³ΡΡΠΏΠΏ Π°ΠΌΠΈΠ½ΠΎΠΊΠΈΡΠ»ΠΎΡΠ½ΡΡ ΠΎΡΡΠ°ΡΠΊΠΎΠ² ΠΏΠ΅ΠΏΡΠΈΠ΄Π° ΠΈ ΡΠ½ΡΡΠΈΠ΅ ΠΏΠ΅ΠΏΡΠΈΠ΄Π° Π² ΡΠ°ΡΡΠ²ΠΎΡ ΠΏΠ΅ΠΏΡΠΈΠ΄ΠΎΠ² Ρ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ½ΠΎΠ³ΠΎ Π½ΠΎΡΠΈΡΠ΅Π»Ρ
- 3. 4. 1. 6. ΠΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ ΡΡΠ»ΡΡΠΎΠΊΡΠΈΠ΄Π½ΡΡ Π³ΡΡΠΏΠΏ ΠΏΠ΅ΠΏΡΠΈΠ΄Π°
- 3. 4. 2. Π’Π΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π±ΠΈΠΎΡΠΈΠ½ΠΈΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΠΏΠ΅ΠΏΡΠΈΠ΄ΠΎΠ² Π½Π° Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Ρ Π³Π΅ΠΏΠ°ΡΠΈΠ½ΠΎΠΌ
- 3. 4. 3. ΠΠΎΠ½ΡΡΠ³Π°ΡΠΈΡ ΠΏΠ΅ΠΏΡΠΈΠ΄ΠΎΠ² Ρ Π±Π΅Π»ΠΊΠ°ΠΌΠΈ-Π½ΠΎΡΠΈΡΠ΅Π»ΡΠΌΠΈ
- 3. 4. 3. 1. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠ° ΠΏΠ΅ΠΏΡΠΈΠ΄Π° Ρ Π±Π΅Π»ΠΊΠΎΠΌ-Π½ΠΎΡΠΈΡΠ΅Π»Π΅ΠΌ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π³Π»ΡΡΠ°ΡΠΎΠ²ΠΎΠ³ΠΎ Π°Π»ΡΠ΄Π΅Π³ΠΈΠ΄Π°
- 3. 4. 3. 2. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠ° ΠΏΠ΅ΠΏΡΠΈΠ΄Π° Ρ Π±Π΅Π»ΠΊΠΎΠΌ-Π½ΠΎΡΠΈΡΠ΅Π»Π΅ΠΌ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ N- Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈΡΡΠΊΡΠΈΠ½ΠΈΠΌΠΈΠ΄Π½ΠΎΠ³ΠΎ ΡΡΠΈΡΠ° 3-ΠΌΠ°Π»Π΅ΠΈΠΌΠΈΠ΄ΠΎΠ±Π΅Π½Π·ΠΎΠΉΠ½ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ
- 3. 4. 3. 3. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠ° ΠΏΠ΅ΠΏΡΠΈΠ΄Π° Ρ Π±Π΅Π»ΠΊΠΎΠΌ-Π½ΠΎΡΠΈΡΠ΅Π»Π΅ΠΌ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π΄ΠΈΠΌΠ΅ΡΠΈΠ»ΡΡΠ±Π΅ΡΠΈΠΌΠΈΠ΄Π°ΡΠ°
- 3. 4. 3. 4. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠ° ΠΏΠ΅ΠΏΡΠΈΠ΄Π° Ρ Π±Π΅Π»ΠΊΠΎΠΌ-Π½ΠΎΡΠΈΡΠ΅Π»Π΅ΠΌ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ 1-ΡΡΠΈΠ»-3'(3'-Π΄ΠΈΠΌΠ΅ΡΠΈΠ»Π°ΠΌΠΈΠ½ΠΎΠΏΡΠΎΠΏΠΈΠ»)ΠΊΠ°ΡΠ±ΠΎΠ΄ΠΈΠΈΠΌΠΈΠ΄
- 3. 4. 3. 5. ΠΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½Π°Ρ ΠΈ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π΅Π½Π½Π°Ρ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠΎΠ²
- 3. 4. 4. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΠ²ΠΎΡΠΎΡΠΎΠΊ ΠΈ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² ΠΈΠΌΠΌΡΠ½ΠΎΠ³Π»ΠΎΠ±ΡΠ»ΠΈΠ½ΠΎΠ² ΠΎΡ ΠΈΠΌΠΌΡΠ½ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
- 3. 4. 5. Π’Π΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠ²ΠΎΡΠΎΡΠΎΠΊ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π°
- 3. 4. 5. 1. ΠΠ€Π Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π°Π½ΡΠΈΠ³Π΅Π½Π° Π½Π° ΠΏΠΎΠ²Π΅ΡΡ Π½ΠΎΡΡΠΈ ΠΏΠ»Π°Π½ΡΠ΅ΡΠ° ΡΠΈΠ½ΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΠ΅ΠΏΡΠΈΠ΄ΠΎΠ² ΠΈΠ»ΠΈ ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠΎΠ² ΠΏΠ΅ΠΏΡΠΈΠ΄ΠΎΠ²
- 3. 4. 5. 2. ΠΠ€Π Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π½Π° ΠΏΠΎΠ²Π΅ΡΡ Π½ΠΎΡΡΠΈ ΠΏΠ»Π°Π½ΡΠ΅ΡΠ° Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π°Π½ΡΠΈΠ³Π΅Π½Π° ΡΠΈΠ½ΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ Π±ΠΈΠΎΡΠΈΠ½ΠΈΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΠΏΠ΅ΠΏΡΠΈΠ΄ΠΎΠ²
- 3. 4. 5. 3. ΠΠ€Π Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π°Π½ΡΠΈΠ³Π΅Π½Π° ΠΏΠ΅ΠΏΡΠΈΠ΄Π°, ΠΊΠΎΠ²Π°Π»Π΅Π½ΡΠ½ΠΎ ΡΠ²ΡΠ·Π°Π½Π½ΠΎΠ³ΠΎ Ρ ΠΏΠΎΠ²Π΅ΡΡ Π½ΠΎΡΡΡΡ ΠΏΠ»Π°Π½ΡΠ΅Ρ
- 3. 4. 5. 4. ΠΠ€Π Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π°Π½ΡΠΈΠ³Π΅Π½Π° Π½Π° ΠΏΠΎΠ²Π΅ΡΡ Π½ΠΎΡΡΠΈ ΠΏΠ»Π°Π½ΡΠ΅ΡΠ° ΠΎΠ±ΠΎΠ»ΠΎΡΠ΅ΡΠ½ΠΎΠ³ΠΎ Π±Π΅Π»ΠΊΠ° Π2 ΠΈ Π³Π΅ΡΠ΅ΡΠΎΠ΄ΠΈΠΌΠ΅ΡΠ° Π1Π
- 3. 4. 5. 5. ΠΠΎΠ½ΠΊΡΡΠ΅Π½ΡΠ½ΡΠΉ ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ·
- 3. 4. 1. Π‘ΠΈΠ½ΡΠ΅Π· ΠΏΠ΅ΠΏΡΠΈΠ΄ΠΎΠ²
- 4. 1. Π‘ΠΎΡΡΠ°Π²Π»Π΅Π½ΠΈΠ΅ ΡΡΡΡΠΊΡΡΡΠ½ΠΎ-ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ ΠΊΠ°ΡΡΡ ΠΎΠ±ΠΎΠ»ΠΎΡΠ΅ΡΠ½ΡΡ Π±Π΅Π»ΠΊΠΎΠ²
- 4. 2. ΠΠΎΠΈΡΠΊ Π³Π»ΠΈΠΊΠΎΠ·Π°ΠΌΠΈΠ½ΠΎΠ³Π»ΠΈΠΊΠ°Π½-ΡΠ²ΡΠ·ΡΠ²Π°ΡΡΠΈΡ ΡΡΠ°ΡΡΠΊΠΎΠ² Π² Π²ΡΡΠΎΠΊΠΎΠΊΠΎΠ½ΡΠ΅ΡΠ²Π°ΡΠΈΠ²Π½ΡΡ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠ°Ρ ΠΎΠ±ΠΎΠ»ΠΎΡΠ΅ΡΠ½ΡΡ Π±Π΅Π»ΠΊΠΎΠ² ΠΠΠ‘
- 4. 3. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ Π°Π½ΡΠΈΠ³Π΅Π½Π½ΡΡ
ΡΠ²ΠΎΠΉΡΡΠ² Π²ΡΡΠΎΠΊΠΎΠΊΠΎΠ½ΡΠ΅ΡΠ²Π°ΡΠΈΠ²Π½ΡΡ
ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² ΠΎΠ±ΠΎΠ»ΠΎΡΠ΅ΡΠ½ΡΡ
Π±Π΅Π»ΠΊΠΎΠ² ΠΠΠ‘
- 4. 3. 1. ΠΡΠ±ΠΎΡ Π²ΡΡΠΎΠΊΠΎΠΊΠΎΠ½ΡΠ΅ΡΠ²Π°ΡΠΈΠ²Π½ΡΡ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² ΠΎΠ±ΠΎΠ»ΠΎΡΠ΅ΡΠ½ΡΡ Π±Π΅Π»ΠΊΠΎΠ² ΠΠΠ‘ Π΄Π»Ρ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ Π°Π½ΡΠΈΠ³Π΅Π½Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΈ ΡΠΈΠ½ΡΠ΅Π· ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠΈΡ ΠΈΠΌ ΠΏΠ΅ΠΏΡΠΈΠ΄ΠΎΠ²
- 4. 3. 2. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΡΠΈΠ½ΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΉ, Π²ΠΊΠ»ΡΡΠ°ΡΡΠΈΡ ΠΠΠ€ Π΄Π»Ρ ΠΈΠΌΠΌΡΠ½ΠΈΠ·Π°ΡΠΈΠΈ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
- 4. 3. 3. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π°Π½ΡΠΈΠΏΠ΅ΠΏΡΠΈΠ΄Π½ΡΡ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠ°ΠΌ CR3, CR4, CR5 ΠΈ CHR Ρ ΠΊΡΠΎΠ»ΠΈΠΊΠΎΠ²
- 4. 3. 4. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π°Π½ΡΠΈΠΏΠ΅ΠΏΡΠΈΠ΄Π½ΡΡ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠ°ΠΌ CR1, CR5 ΠΈ CHR Ρ ΠΌΡΡΠ΅ΠΉ
- 4. 3. 5. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΡΡΠΈ Π°Π½ΡΠΈΠΏΠ΅ΠΏΡΠΈΠ΄Π½ΡΡ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°ΠΌ ΠΎΠ±ΠΎΠ»ΠΎΡΠ΅ΡΠ½ΡΡ Π±Π΅Π»ΠΊΠΎΠ² ΠΠΠ‘
- 4. 4. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΡΠΈΠ½ΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠ΅ΠΏΡΠΈΠ΄Π½ΡΡ
Π’-Π ΡΠΏΠΈΡΠΎΠΏΠ½ΡΡ
ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΈ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ Π²ΡΡΠΎΠΊΠΎΠΊΠΎΠ½ΡΠ΅ΡΠ²Π°ΡΠΈΠ²Π½ΡΡ
ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² ΠΎΠ±ΠΎΠ»ΠΎΡΠ΅ΡΠ½ΡΡ
Π±Π΅Π»ΠΊΠΎΠ² ΠΠΠ‘
- 4. 4. 1. Π‘ΠΈΠ½ΡΠ΅Π· Π’-Π ΡΠΏΠΈΡΠΎΠΏΠ½ΡΡ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΉ
- 4. 4. 2. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ Π’-Π-ΡΠΏΠΈΡΠΎΠΏΠ½ΡΠΌ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΡΠΌ ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΈΡ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΡΡΠΈ
- 4. 4. 3. ΠΠ·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Π°Π½ΡΠΈ Π’-Π-ΡΠΏΠΈΡΠΎΠΏΠ½ΡΡ Π°Π½ΡΠΈΡΠ΅Π» Ρ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°ΠΌΠΈ ΠΎΠ±ΠΎΠ»ΠΎΡΠ΅ΡΠ½ΡΡ Π±Π΅Π»ΠΊΠΎΠ² ΠΠΠ‘
Π‘ΠΏΠΈΡΠΎΠΊ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
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