Экспрессия некоторых СС-и СХС-хемокинов и их рецепторов у больных ишемической болезнью сердца
![Диссертация: Экспрессия некоторых СС-и СХС-хемокинов и их рецепторов у больных ишемической болезнью сердца](https://westud.ru/work/3609242/cover.png)
Серик, С. А. Прои противовоспалительные цитокины у больных с ишемической болезнью сердца при прогрессировании хронической сердечной недостаточности / С. А. Серик, C.B. Степанова, В. И. Волков // Украшський кардюлопчний журнал. 2004. — № 4. С. 18−21. Дополнительное назначение к стандартной терапии ишемической болезни сердца со-3 ПНЖК в дозе 2,0 г/сут в течение 14 дней приводит к восстановлению… Читать ещё >
Содержание
- Список сокращений
- Глава 1. Обзор литературы
- 1. 1. Система хемокинов и хемокиновых рецепторов и ее участие в воспалительном процессе
- 1. 2. Современные представления об иммунопатогенезе атеросклероза
- 1. 3. Влияние препаратов для лечения ишемической болезни сердца на процессы воспаления
- 1. 4. Применение со-3-полиненасыщенных жирных кислот у больных ишемической болезнью сердца
- Глава 2. Материалы и методы исследования
- 2. 1. Общая характеристика обследованных пациентов
- 2. 1. 1. Характеристика пациентов, получающих терапию со-3 полиненасыщенными жирными кислотами
- 2. 2. Методы исследования
- 2. 2. 1. Методика определения липидного спектра сыворотки крови
- 2. 2. 2. Методика выделения РНК из тканей
- 2. 2. 3. Методика выделения РНК из периферической крови
- 2. 2. 4. Определение мРНК хемокинов и хемокиновых рецепторов методом ЫТ-РСЯ
- 2. 2. 5. Методика проведения холтеровского мониторирования электрокардиограммы
- 2. 2. 6. Методика выполнения эхокардиографического исследования сердца
- 2. 3. Статистическая обработка
- 2. 1. Общая характеристика обследованных пациентов
- Глава 3. Показатели экспрессии хемокинов и их рецепторов у больных ишемической болезнью сердца
- 3. 1. Показатели экспрессии хемокинов и их рецепторов в периферической крови больных ишемической болезнью сердца
- 3. 2. Показатели экспрессии хемокинов и их рецепторов в тканях аорты
- 3. 3. Показатели экспрессии хемокинов и их рецепторов в тканях внутренней грудной артерии
- 3. 4. Показатели экспрессии хемокинов и их рецепторов в тканях лучевой артерии
- 3. 5. Показатели экспрессии хемокинов и их рецепторов в тканях поверхностной вены бедра
- Глава 4. Клинические эффекты со-3 полиненасыщенных жирных кислот у больных ишемической болезнью сердца при коронарном шунтировании
- Глава 5. Влияние со-3 полиненасыщенных жирных кислот на синтез хемокинов и хемокиновых рецепторов у больных ишемической болезнью сердца
- 5. 1. Влияние со-3 полиненасыщенных жирных кислот на синтез хемокинов и их рецепторов в периферической крови пациентов с ишемической болезнью сердца
- 5. 2. Влияние со-3 полиненасыщенных жирных кислот на синтез хемокинов и их рецепторов в тканях аорты у пациентов с ишемической болезнью сердца
- 5. 3. Влияние со-З полиненасыщенных жирных кислот на синтез хемокинов и их рецепторов во внутренней грудной артерии у пациентов с ишемической болезнью сердца
- 5. 4. Влияние со-З полиненасыщенных жирных кислот на синтез хемокинов и их рецепторов в лучевой артерии у пациентов с ишемической болезнью сердца
- 5. 5. Влияние со-З полиненасыщенных жирных кислот на синтез хемокинов и их рецепторов в тканях большой подкожной вены у пациентов с ишемической болезнью сердца
- Глава 6. Обсуждение
- Выводы
Экспрессия некоторых СС-и СХС-хемокинов и их рецепторов у больных ишемической болезнью сердца (реферат, курсовая, диплом, контрольная)
113 Выводы.
1. Показатели экспрессии мРНК хемокинов эотаксин, эотаксин-2, 1Ь-8, М1Р-1а, МПМр, КАЫТЕБ, а также мРНК хемокиновых рецепторов: ССЮ, ССЮ, СС115, СХСЮ, СХСЮ. в периферической крови у больных ишемической болезнью сердца снижены по сравнению со здоровыми лицами.
2. Экспрессия мРНК хемокинового рецептора ССЮ и хемокина М1Р-1а в периферической крови, а также экспрессия мРНК хемокина М1Р-1р в тканях поверхностной вены бедра у больных ишемической болезнью сердца ассоциирована с длительностью заболеванияэкспрессия мРНК хемокина М1Р-1р и хемокиновых рецепторов СХСЮ, СХСК2 в тканях внутренней грудной артерии и аорты, а также экспрессия мРНК хемокиновых рецепторов ССЮ и ССЫЗ в тканях аорты — с уровнем общего холестеринаэкспрессия мРНК хемокиновых рецепторов ССЮ, ССЮ, ССЯ5, СХСЮ, СХСЯ2 в тканях внутренней грудной артерии, мРНК хемокинового рецептора СХСЮ в периферической крови, в тканях аорты ассоциирована с фракцией выброса левого желудочка.
3. Дополнительное назначение к стандартной терапии ишемической болезни сердца со-3 ПНЖК в дозе 2,0 г/сут в течение 14 дней приводит к восстановлению исходно сниженной экспрессии мРНК хемокиновых рецепторов ССЮ, ССЮ, СС115 в плазме крови.
4. У больных ишемической болезнью сердца со-3 ПНЖК в дозе 2,0 г/сут в течение 14 дней приводит к увеличению экспрессии мРНК хемокиновых рецепторов ССЮ, ССЮ, СС115 в аорте и большой подкожной вене, внутренней грудной артерии.
5. Применение со-3 ПНЖК в дозе 2,0 г/сут в течение 14 дней до коронарного шунтирования и в раннем послеоперационном периоде сопровождается снижением частоты развития послеоперационной фибрилляции предсердий и меньшей выраженностью гемодинамических нарушений.
Практические рекомендации.
Для снижения риска развития фибрилляции предсердий после коронарного шунтирования у больных ишемической болезнью сердца рекомендуется прием со-3 ПНЖК в дозе 2,0 г в сутки в течение 14 дней перед операцией и в раннем послеоперационном периоде.
Следует воздерживаться от приема препаратов ю-З-ПНЖК в раннем периоде после коронарного шунтирования у больных, получающих терапию непрямыми антикоагулянтами.
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