Экспрессия некоторых СС-и СХС-хемокинов и их рецепторов у больных ишемической болезнью сердца

113 Выводы.

1. Показатели экспрессии мРНК хемокинов эотаксин, эотаксин-2, 1Ь-8, М1Р-1а, МПМр, КАЫТЕБ, а также мРНК хемокиновых рецепторов: ССЮ, ССЮ, СС115, СХСЮ, СХСЮ. в периферической крови у больных ишемической болезнью сердца снижены по сравнению со здоровыми лицами.

2. Экспрессия мРНК хемокинового рецептора ССЮ и хемокина М1Р-1а в периферической крови, а также экспрессия мРНК хемокина М1Р-1р в тканях поверхностной вены бедра у больных ишемической болезнью сердца ассоциирована с длительностью заболеванияэкспрессия мРНК хемокина М1Р-1р и хемокиновых рецепторов СХСЮ, СХСК2 в тканях внутренней грудной артерии и аорты, а также экспрессия мРНК хемокиновых рецепторов ССЮ и ССЫЗ в тканях аорты — с уровнем общего холестеринаэкспрессия мРНК хемокиновых рецепторов ССЮ, ССЮ, ССЯ5, СХСЮ, СХСЯ2 в тканях внутренней грудной артерии, мРНК хемокинового рецептора СХСЮ в периферической крови, в тканях аорты ассоциирована с фракцией выброса левого желудочка.

3. Дополнительное назначение к стандартной терапии ишемической болезни сердца со-3 ПНЖК в дозе 2,0 г/сут в течение 14 дней приводит к восстановлению исходно сниженной экспрессии мРНК хемокиновых рецепторов ССЮ, ССЮ, СС115 в плазме крови.

4. У больных ишемической болезнью сердца со-3 ПНЖК в дозе 2,0 г/сут в течение 14 дней приводит к увеличению экспрессии мРНК хемокиновых рецепторов ССЮ, ССЮ, СС115 в аорте и большой подкожной вене, внутренней грудной артерии.

5. Применение со-3 ПНЖК в дозе 2,0 г/сут в течение 14 дней до коронарного шунтирования и в раннем послеоперационном периоде сопровождается снижением частоты развития послеоперационной фибрилляции предсердий и меньшей выраженностью гемодинамических нарушений.

Практические рекомендации.

Для снижения риска развития фибрилляции предсердий после коронарного шунтирования у больных ишемической болезнью сердца рекомендуется прием со-3 ПНЖК в дозе 2,0 г в сутки в течение 14 дней перед операцией и в раннем послеоперационном периоде.

Следует воздерживаться от приема препаратов ю-З-ПНЖК в раннем периоде после коронарного шунтирования у больных, получающих терапию непрямыми антикоагулянтами.

1. Алмазов, В, А. Ишемическая болезнь сердца. Эндотелиальная дисфункция у больных с дебютом ишемической болезни сердца в разном возрасте / В. А. Алмазов, O.A. Беркович, М. Ю. Ситникова // Кардиология. 2001. -№ 5. — С. 1−5.

2. Кулешова, Э. В. Влияние операции коронарного шунтирования на ишемию миокарда (по данным холтеровского мониторирования) / Э. В. Кулешова, П. А. Казенов, Н. Л. Лоховинина и др. // Вестн. аритмологии. -2000. № 20. — С.44−48.

3. Оганов, Р. Г. Профилактика сердечно-сосудистых заболеваний: возможности практического здравоохранения / Р. Г. Оганов // Кардиоваскулярная терапия и профилактика. 2002. — № 1. — С.28−30.

4. Оганов, Р. Г. Смертность от сердечно-сосудистых и других неинфекционных заболеваний среди трудоспособного населения России / Р. Г. Оганов, Г. Я. Масленникова // Кардиоваскулярная терапия и профилактика. 2002. — № 3. — С.4−8.

5. Перова, Н. В. Высокоочищенные и высококонцентрированные омега-3 жирные кислоты у больных хронической ИБС и постинфарктным кардиосклерозом / Н. В. Перова, С. Ю. Марцевич, О. В. Литинская и др. // Клиническая фармакология и терапия. 2007. — № 4. — С. 36−40.

6. Серик, С. А. Прои противовоспалительные цитокины у больных с ишемической болезнью сердца при прогрессировании хронической сердечной недостаточности / С. А. Серик, C.B. Степанова, В. И. Волков // Украшський кардюлопчний журнал. 2004. — № 4. С. 18−21.

7. Ситникова, М. Ю. Состояние эндотелия и маркеры хронического воспаления у больных ИБС, осложненной сердечной недостаточностью / М. Ю. Ситникова и др. // Сердечная недостаточность. 2002. — Т. З, № 2 (12).-С. 80−87.

8. Тотолян, А. А. Клетки иммунной системы / А. А. Тотолян, И. С. Фрейдлин. Т.1. — НейтрофилыТ.2. — Моноциты/макрофаги. — СПб.: Наука, 2000.-231с.

9. Тотолян, А. А. Роль хемокинов и их рецепторов в иммунорегуляции / А. А. Тотолян // Иммунология. 2001. — № 5. — С. 7−15.

10. Фрейдлин, И. С. Клетки иммунной системы / И. С. Фрейдлин, А. А. Тотолян. Т.З. — ЛимфоцитыТ.4. — Базофилы и тучные клеткиТ.5. — Эозинофилы. — СПб.: Наука, 2001. — 390с.

11. Чазов, Е. И. Проблемы первичной и вторичной профилактики сердечно-сосудистых заболеваний / Е. И. Чазов // Терапевт, архив. -2002.-Т. 74, № 2.-С. 5−12.

12. Abel, S. The transmembrane CXCchemokine ligand 16 is induced by IFN-and TNFand shed by the activity of the disintegrin-like metalloproteinase AD AMI 0 / S. Abel, C. Hundhausen, R. Mentlein et al. // J. Immunol. 2004. -Vol. 172. — P.6362−6372.

13. Abi-Younes, S. The stromal cell-derived factor-1 chemokine is a potent platelet agonist highly expressed in atherosclerotic plaques / S. Abi-Younes,.

14. A. Sauty, F. Mach et al. // Circ. Res. 2000. — Vol. 86. — P. 131−138.

15. Addison, C.L. The CXC chemokine receptor 2, CXCR2, Is the putative receptor for ELR CXC chemokineinduced angiogenic activity / C.L. Addison, Т.О. Daniel, M.D. Burdick et al. // J. Immunol. 2000. — Vol. 165. — P.5269−5277.

16. Agace, W.W. T-lymphocyte-epithelial-cell interactions: integrin alpha (E) (CD 103) beta (7), LEEP-CAM and chemokines / W.W. Agace, J.M. Higgins,.

17. B. Sadasivan et al. // Curr. Opin. Cell. Biol. 2000. — Vol. 12. -P.563−568.

18. Ansel, K.M. A chemokine-driven positive feedback loop organizes lymphoid follicles / K.M. Ansel, V.N. Ngo, P.L. Hyman et al. // Nature. 2000. — Vol. 406. — P.309−314.

19. Arimilli, S. Chemokines in autoimmune diseases / S. Arimilli, W. Ferlin, N. Solvason et al. // Immunol. Rev. -2000. Vol.177. -P.43−51.

20. Asano, T. Expression of IL-8 in Kawasaki disease / T. Asano, S. Ogawa // Clin. Exp. Immunol. 2000. — Vol. 122. -P.514−519.

21. Balding, C.E. Th2 dominance in nasal mucosa in patients with Wegener’s granulomatosis / C.E. Balding, A.J. Howie, A.B. Drake-Lee et al. // Clin. Exp. Immunol. 2001. — Vol. 125. — P.332−339.

22. Baltus, T. Oligomerization of RANTES is required for CCR1-mediated arrest but not CCR5-mediated transmigration of leukocytes on inflamed endothelium / T. Baltus, K.S.C. Weber, Z. Johnson et al. // Blood. 2003. -Vol.102. -P.1985;1988.

23. Boisvert, W.A. Interleukin-8 and its receptor CXCR2 in atherosclerosis / W.A. Boisvert, L.K. Curtiss, R.A. Terkeltaub // Immunol. Res. 2000. -Vol.21.-P.129−137.

24. Bone-Larson, C.L. The role of chemokines in the immunopathology of the liver / C.L. Bone-Larson, K.J. Simpson, L.M. Colletti et al. // Immunol. Rev. -2000. Vol.177. -P.8−20.

25. Brandt, E. Platelet-derived CXC chemokines: old players in new games / E. Brandt, A. Ludwig, F. Petersen et al. // Immunol. Rev. 2000. — Vol.177. -P.204−216.

26. Brandtzaeg, P. Regional specialization in the mucosal immune system: primed cells do not always home along the same track / P. Brandtzaeg, I.N. Farstad, G. Haraldsen // Immunol. Today. 1999. — Vol. 20. — P.267−277.

27. Breitfeld, D. Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production / D. Breitfeld, L. Ohl, E. Kremmer et al. // J. Exp. Med. 2000. — Vol. 192. — P. 1545−1552.

28. Burger-Kentischer, A. Expression of macrophage migration inhibitory factor in different stages of human atherosclerosis / A. Burger-Kentischer, H. Goebel, R. Seiler et al.//Circulation. 2002. — Vol. 10. -P.1561−1566.

29. Butcher, E.C. Lymphocyte trafficking and regional immunity / E.C. Butcher, M. Williams, K. Youngman et al. // Adv. Immunol. 1999. — Vol. 72. -P.209−253.

30. Calandra, T. Macrophage migration inhibitory factor: a regulator of innate immunity / T. Calandra, T. Roger // Nat. Rev. Immunol. 2003. — Vol.3. -P.791−800.

31. Calo, L. Prevention of atrial fibrillation by n-3 polyunsaturated fatty acids after coronary artery bypass grafting / L. Calo, L. Bianconi, F. Collivicchi et al. // J. Am. Coll. Cardiol. 2005. — Vol.45. — P. 1723−1728.

32. Campbell, J.J. The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells / J.J. Campbell, G. Haraldsen, J. Pan et al. // Nature. 1999. — Vol.400. — P.776−780.

33. Charbonnier, A.S. Macrophage inflammatory protein 3 is involved in the constitutive trafficking of epidermal langerhans cells / A.S. Charbonnier, N. Kohrgruber, E. Kriehuber et al. // J. Exp. Med. 1999. — Vol.190. — P.1755−1768.

34. Chen, Z. Evidence for a role of macrophage migration inhibitory factor in vascular disease / Z. Chen, M. Sakuma, A.C. Zago et al. // Arterioscler Thromb. Vase. Biol. 2004. — Vol.4. — P.709−714.

35. Cinamon, G. Shear forces promote lymphocyte migration across vascular endothelium bearing apical chemokines / G. Cinamon, V. S hinder, R. Alon // Nat. Immunol. 2001. — Vol. 2. — P.515−522.

36. Clemetson, K.J. Functional expression of CCR1, CCR3, CCR4 and CXCR4 chemokine receptors on human platelets / K.J. Clemetson, J.M. Clemetson, A.E. Proudfoot et al. // Blood. 2000. — Vol. 96. — P. 4046−4054.

37. Combadiere, C. Decreased atherosclerotic lesion formation in CXCRl/apolipoprotein E double knockout mice / C. Combadiere, S. Potteaux, J.L. Gao et al. // Circulation. -2003. Vol. 107. — P. 1009−1016.

38. Coulomb-L'Hermine, A. Expression of the chemokine RANTES in pulmonary Wegener’s granulomatosis / A. Coulomb-L'Hermine, F. Capron, W. Zou et al. // Hum. Pathol. 2001. — Vol. 32. -P.320−326.

39. Cyster, J.G. Chemokines and cell migration in secondary lymphoid organs /.

40. J.G. Cyster // Science. 1999. — Vol. 286. — 2098;2102.i.

41. Damas, J.K. Stromal cell-derived factor-1 in unstable angina: potential antiinflammatory and matrix-stabilizing effects / J.K. Damas, T. Waehre, A. Yndestadt et al. // Circulation. 2002. — Vol. 106. — P.36−42.

42. Dawson, T.C. Abesence of CC chemokine receptor-2 reduces atherosclerosis in apolipoprotein E-deficient mice / T.C. Dawson, W.A. Kuziel T.A. Osahar et al. // Atherosclerosis. 1999. — Vol. 143. — P.205−211.

43. Degryse, B. The nuclear protein HMGB1, a new kind of chemokine? / B. Degryse, M. de Yirgilio // FEBS Lett. 2003. — Vol. 9. — P. l 1−17.

44. Doerschuk, C.M. CD1 l/CD18-dependent andindependent neutrophil emigration in the lungs / C.M. Doerschuk, S. Tasaka, Q. Wang // Am. J. Respir. Cell. Mol. Biol.-2000.-Vol. 23.-P. 13 3−136.

45. Downey, G.P. Regulation of neutrophil activation in acute lung injury / G.P. Downey, Q. Dong, J. Kruger et al. // Chest. 1999. — Vol. 116. — P.46−54.

46. Dwinell, M.B. Regulated production of interferon-inducible T-cell chemoattractants by human intestinal epithelial cells / M.B. Dwinell, N. Lugering, L. Eckmann // Gastroenterology. 2001. — Vol. 120. — P.49−59.

47. Eagle and Guyton et al. ACC/AHA 2004 Guideline Update for Coronary Artery Bypass Graft Surgery. AHA. Электронный ресурс. — Режим доступа: www.americanheart.org.

48. Egashira, К. Importance of monocyte chemoattractant protein-1 pathway in neointimal hyperplasia after periarterial injury in mice and monkeys / K. Egashira, Q. Zhao, C. Kataoka et al. // Circ. Res. 2002. — Vol. 90. — P. l 1 671 172.

49. Erkkila, F.T. Autoantibodies against oxidized low density lipoproteins and cardiolipin in patients with coronary heart disease / F.T. Erkkila, O. Narvanen, S. Lehto et al. // Arterioscler Thromb. Vase. Biol. 2000. — Vol. 20, № 1. -P.204−209.

50. Feng, L. Prevention of prescentic glomerulonephritis by immunoneutralization of the fractalkine receptor CX3CR1 rapid communication / L. Feng, S. Chen, G.E. Garcia et al. // Kidney Int. 1999. -Vol.56. -P.612−620.

51. Fong, A.M. Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow / A.M. Fong, L.A. Robinson, D.A. Steeber et al. // J. Exp. Med. 1998. -Vol.188.-P.1413−1419.

52. Forster, R. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs / R. Forster, A. Schubel, D. Breitfeld et al. // Cell. 1999. — Vol. 99. — P.23−33.

53. Foxman, E.F. Integrating conflicting chemotactic signals. The role of memory in leukocyte navigation / E.F. Foxman, E.J. Kunkel, E.C. Butcher // J. Cell. Biol. 1999. — Vol. 147. — P.77−588.

54. Garton, K.J. Tumor necrosis factor-converting enzyme (ADAMI7) mediates the cleavage and shedding of fractalkine (CX3CL1) / K.J. Garton, P.J. Gough, C.P. Blobel et al. // J. Biol. Chem. 2001. — Vol. 276. — P.37 993−38 001.

55. Gear, A.R. Adenosine diphosphate strongly potentiates the ability of the chemokines MDC, TARC, and SDF-1 to stimulate platelet function / A.R. Gear, S. Suttitanamonglcol, D. Viisoreanu et al. // Blood. 2001. — Vol. 97. -P.937−945.

56. Gear, A.R. Platelet chemokines and chemokine receptors: linking hemostasis, inflammation, and host defense / A.R. Gear, D. Camerini // Microcirculation. -2003. Vol. 10. — P.335−350.

57. George, J. Anti-oxidized ow density lipoprotein antibody determination as a predictor of restenosis following percutaneous transluminal coronary angioplasty / J. George, D. Harats, E. Bakshi et al. // Immunol. Lett. 1999. -Vol.68, № 2−3.-P.263−266.

58. Gerber, B.O. Functional expression of the eotaxin receptor CCR3 in T lymphocytes co-localizing with eosinophils / B.O. Gerber, M.P. Zanni, M. Uguccioni et al. // Curr. Biol. 1997. — Vol.7. — P.836−843.

59. Gerszten, R.E. MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions / R.E. Gerszten, E.A. Garcia-Zepeda, Y.C. Lim et al. //Nature. 1999. — Vol.398. -P.718−723.

60. Gerszten, R.E. MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions / R.E. Gerszten, E.A. Garcia-Zepeda, Y.C. Lim // Nature. 1999. — Vol.398. — P.718−723.

61. Glabinski, A.R. Chemokine monocyte chemoattractant protein-1 is expressed by astrocytes after mechanical injury to the brain / A.R. Glabinski, V. Balasingam, M. Tani et al. // J. Immunol. 1996. — Vol.156. — P.4363−4368.

62. Glabinski, A.R. Sentries at the gate: chemokines and the blood-brain barrier / A.R. Glabinski, RM. Ransohoff// J. Neurovirol. 1999. — Vol.5. — P.623−634.

63. Goddard, S. Differential expression of chemokines and chemokine receptors shapes the inflammatory response in rejecting human liver transplant / S. Goddard, A. Williams, C. Morland et al. // Transplantation. 2001. — Vol. 72. -P. 1957;1967. ' «.

64. Goldman, S. Internal mammary artery and safenous vein graft patency: effects of aspirin / S. Goldman, J. Copeland, T. Moritz // Circulation. 1990. — Vol. 82, № 4.-P. 273−242.

65. Gonzalo, J.A. Critical involvement of the chemotactic axis CXCR4/stromal cell-derived factor-1 alpha in the inflammatory component of allergic airway disease / J.A. Gonzalo, C.M. Lloyd, A. Peled et al. // J. Immunol. 2000. -Vol. 165. -P.499−508.

66. Gonzalo, J.A. Mouse monocyte-derived chemokine is involved in airway hyperreactivity and lung inflammation / J.A. Gonzalo, Y. Pan, C.M. Lloyd // J. Immunol. 1999. — Vol.163. — P.403−411.

67. Gosset, P. Production of chemokines and proinflammatory and antiinflammatory cytokines by human alveolar macrophages activated by IgE receptors / P. Gosset, I. Tillie-Leblond, S. Oudin et al. // J. Allergy Clin. Immunol. 1999. — Vol.103. -P.289−297.

68. Gough, P.J. A disintegrin and metalloproteinase 10-mediated cleavage and shedding regulates the cell surface expression of CXC chemokine ligand 16 / P.J. Gough, K.J. Garton, P.T. Wille et al. // J. Immunol. 2004. — Vol.172. -P.3678−3685.

69. Grewe, M. A role for Thl and Th2 cells in the immunopathogenesis of atopic dermatitis / M. Grewe, C.A. Bruijnzeel-Koomen, E. Schopf et al. // Immunol. Today. 1998. — Vol.19. — P.359−361.

70. Grimaldi, J.C. Depletion of eosinophils in mice through the use of antibodies specific for C-C chemokine receptor 3 (CCR3) / J.C. Grimaldi, N.X. G. Yu Grunig et al. // J. Leukoc. Biol. 1999. — Vol.65. — P.846−853.

71. Gro’ne, H.J. Met-RANTES reduces vascular and tubular damage during acute renal transplant rejection: blocking monocyte arrest and recruitment / H.J. Gro’ne, C. Weber, K.S. Weber et al. // FASEB J. 1999. — Vol.13. -P.1371−1383.

72. Gu, L. Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice / L. Gu, Y. Okada, S.K. Clinton et al. // Mol. Cell. 1998. — Vol.2. — P.275−281.

73. Gunn, M.D. A B-cell-homing chemokine made in lymphoid follicles activates Burkitt’s lymphoma receptor-1 / M.D. Gunn, V.N. Ngo, K.M. Ansel et al. // Nature. 1998.-Vol. 391.-P.799−803.

74. Gunn, M.D. A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and Chemotaxis of naive T lymphocytes / M.D. Gunn, K. Tangemann, C. Tarn et al. // Proc. Natl. Acad. Sei. USA. 1998. — Vol. 95. — P.258−263.

75. Gunn, M.D. Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization / M.D. Gunn, S. Kyuwa, C. Tarn et al. // J. Exp. Med. 1999. — Vol.189. -P.451−460.

76. Guo, J. Transplantation of monocyte CC-chemokine receptor 2-deficient bone marrow into ApoE3-Leiden mice inhibits atherogenesis / J. Guo, M. Van Eck, J. Twisk et al. // Arterioscler Thromb. Vase. Biol. 2003. — Vol. 23. -P.447−453.

77. Gurevich, V.S. Influenza, autoimmunity and atherogenesis / V.S. Gurevich // Autoimmun Rev. 2005 — Vol. 4, № 2. — P. 101−115.

78. Gutierrez-Ramos, J.C. Non-redundant functional groups of chemokines operate in a coordinate manner during the inflammatory response in the lung / J.C. Gutierrez-Ramos, C. Lloyd, M.L. Kapsenberg et al. // Immunol. Rev. -2000.-Vol. 177.-P.31−42.

79. Hamann, A. Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo / A. Hamann, D.P. Andrew, D. Jablonski-Westrich et al. // J. Immunol. 1994. — Vol. 152. — P.3282−3293.

80. Han, C.I. Circulating bone marrow cells can contribute to neointimal formation / C.I. Han, G.R. Campbell, J.H. Campbell // J. Vase. Res. 2001. -Vol. 38.-P.l 13−119.

81. Hancock, W. W. Requirement of the chemokine receptor CXCR3 for acute, allograft rejection / W.W. Hancock, B. Lu, W. Gao et al. // J. Exp. Med. -2000. Vol. 192. — P. 1515−1520.

82. Hannan, K.M. Troglitazone stimulates repair of the endothelium and inhibits neointimal formation in denuded rat aorta / K.M. Hannan, R.J. Dilley, S.T. De Dios et al. // Arterioscler Thromb. Vase. Biol. 2003. — Vol.23. — P.762−768.

83. Hansson, G.K. Immune mechanisms in atherosclerosis / G.K. Hansson // Arterioscler Thromb. Vase. Biol. 2001. — Vol.21. — P. l876−1890.

84. Haque, N. CC chemokine 1−309 is the principal monocyte chemoattractant induced by apolipoprotein (a) in human vascular endothelial cells / N. Haque, X. Zhang, D. French et al. // Circulation. 2000. — Vol.102. — P.786−792.

85. Harris, W. Red blood cell omega-3 fatty acids in acute coronary syndrome patients / W. Harris, K. Reid, S. Sands et al. // Circulation. 2007. -Vol.115, № 8. — P.267.

86. Harrison, J.K. Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia / J.K. Harrison, Y. Jiang, S. Chen et al. // Proc. Natl. Acad. Sei. USA. 1998. -Vol.95.-P.10 896−10 901.

87. Heil, M. Collateral artery growth (arteriogenesis) after experimental arterial occlusion is impaired in mice lacking CC-chemokine receptor-2 / M. Heil, T. Ziegelhoeffer, S. Wagner et al. // Circ. Res. 2004. — Vol. 94. — P.671−677.

88. Hermanowski-Vosatka, A. Enzymatically inactive macrophage migration inhibitory factor inhibits monocyte chemotaxis and random migration / A. Hermanowski-Vosatka, S.S. Mundt, J.M. Ayala et al. // Biochemistry. 1999. -Vol. 38. -P.2841−12 849.

89. Hogaboam, C.M. Exaggerated hepatic injury due to acetaminophen challenge in mice lacking C-C chemokine receptor 2 / C.M. Hogaboam, C.L. Bone-Larson, M.L. Steinhauser et al. // Am. J. Pathol. 2000. — Vol. 156. -P.1245−1252.

90. Hogaboam, C.M. Novel CXCR2-dependent liver regenerative qualities of ELR-containing CXC chemokines / C.M. Hogaboam, C.L. Bone-Larson, M.L. Steinhauser et al. // FASEB J. 1999. — Vol. 13. — P.1565−1574.

91. Homey, B. Chemokines in allergy / B. Homey, A. Zlotnik // Curr. Opin. Immunol. 1999. — Vol. 11. P.626−634.

92. Homey, B. Cutting edge: the orphan chemokine receptor G proteincoupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27.

93. CTACK/ALP/ILC) / B. Homey, W. Wang, H. Soto et al. // J. Immunol. -2000. Vol. 164. — P. 3465−3470.

94. Hoogewerf, A.J. Glycosaminoglycans mediate cell surface oligomerization of chemokines / A.J. Hoogewerf, G.S. Kuschert, A.E. Proudfoot et al. // Biochemistry. 1997.-Vol.36.-P.13 570−13 578.

95. Horvath, C. Targeting CCR2 or CD18 inhibits experimental in-stent restenosis in primates: inhibitory potential depends on type of injury and leukocytes targeted / C. Horvath, F.G. Welt, M. Nedelmann et al. // Circ. Res.- 2002. Vol.90. — P.488−494.

96. Huang, D. Chemokines and chemokine receptors in inflammation of the nervous system: manifold roles and exquisite regulation / D. Huang, Y. Han, M.R. Rani et al. // Immunol. Rev. 2000. — Vol.177. — P.52−67.

97. Hub, E. Binding of RANTES, MCP-1, MCP-3, and MIP-lalpha to cells in human skin / E. Hub, A. Rot // Am. J. Pathol. 1998. — Vol.152. — P.749−757.

98. Huo, Y. Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E / Y. Huo, A. Schober, B. Forlow et al. // Nature Med. 2003. — Vol.9. — P.61−67.

99. Huo, Y. The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium / Y. Huo, C. Weber, S.B. Forlow et al. //J. Clin. Invest.-2001.-Vol.108. -P.1307−1314.

100. Imai, T. Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4 / T. Imai, D. Chantry, C.J. Raport et al. // J. Biol. Chem.- 1998. Vol.273. — P. 1764−1768.

101. Iwaguro, H. Endothelial progenitor growth factor gene transfer for vascular regeneration / H. Iwaguro, J. Yamaguchi, C. Kalka et al. // Circulation. -2002. Vol.105. — P.732−738.

102. Jia, G.Q. Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation I G.Q. Jia, J.A. Gonzalo, C. Lloyd et al. // J. Exp. Med. 1996. — Vol.184. — P. 1939;1951.

103. Jinquan, T. Eotaxin activates T cells to chemotaxis and adhesion only if induced to express CCR3 by IL-2 together with IL-4 / T. Jinquan, S. Quan, G. Feili et al. // J. Immunol. 1999. — Vol.162. — P.4285−4292.

104. John, A. CXC chemokines in angiogenesis / A. John, P. Belperio et al. // J. of Leukocyte Biology. 2000. — Vol. 68. — P. 123−126.

105. Johnston, B. Chronic inflammation upregulates chemokine receptors and induces neutrophil migration to monocyte chemoattractant protein-1 / B. Johnston, A.R. Burns, M. Suematsu // J. Clin. Invest. 1999. — Vol.103. -P.1269−1276.

106. Karpus, W.J. Chemokine regulation of experimental autoimmune encephalomyelitis: temporal and spatial expression patterns govern disease pathogenesis / W.J. Karpus, RM. Ransohoff // J. Immunol. 1998. — Vol.161. -P.2667−2671.

107. Kelner, G.S. Lymphotactin: a cytokine that represents a new class of chemokine / G.S. Kelner, J. Kennedy, K.B. Bacon et al. // Science. 1994. -Vol. 266. -P.1395−1399.

108. Kim, C.H. Bonzo/CXCR6 expression defines type 1-polarized T-cell subsets with extralymphoid tissue homing potential / C.H. Kim, E.J. Kunkel, J. Boisvert et al. // J. Clin. Invest. 2001. — Vol.107. — P.595−601.

109. Kim, C.H. Chemokines: signal lamps for trafficking of T and B cells for development and effector function / C.H. Kim, H.E. Broxmeyer // J. Leukoc. Biol. -1999. Vol.65. -P.6−15.

110. Kim, C.H. Differential chemotactic behavior of developing T cells iniresponse to thymic chemokines / C.H. Kim, L.M. Peius, J.R. White // Blood. 1998. — Vol.91. — P. 4434−4443.

111. Kim, Y. Enhanced airway Th2 response after allergen challenge in mice deficient in CC chemokine receptor-2 (CCR2) / Y. Kim, S. Sung, W.A. Kuziel et al. // J. Immunol. -2001. Vol.166. -P.5183−5192.

112. Klimov, A.N. Antioxidative activity of high density lipoproteins in vivo / A.N. Klimov, V.S. Gurevich, A.A. Nikiforova et al. // Atherosclerosis. -1993.-Vol.100.-P.13−18.

113. Knoller-Hansen, L. The Angiotensin-Converting Enzyme Inhibition Post-Revascularization Study (APRES) / L. Knoller-Hansen, R. Steffesnsen, P. Grande // J. Am. Coll. Cardiol. 2000. — Vol.35. — P.8881−8888.

114. Kunkel, E.J. Leukocyte arrest during cytokine-dependent inflammation in vivo / E.J. Kunkel, J.L. Dunne, K. Ley // J. Immunol. 2000. — Vol.164. -P.3301−3308.

115. Kuschert, G.S. Glycosaminoglycans interact selectively with chemokines and modulate receptor binding and cellular responses /G.S. Kuschert, F. Coulin, C.A. Power //Biochemestry. 1999. — Vol.38. -P.12 959−12 968.

116. Kuziel, W.A. CCR5 deficiency is not protective in the early stages of atherogenesis in apoE knockout mice / W.A. Kuziel, T.C. Dawson, M. Quinones // Atherosclerosis. 2003. — Vol.167. — P.25−32.

117. Lamblin, C. Bronchial neutrophilia in patients with noninfectious status asthmaticus / C. Lamblin, P. Gosset, I. Tillie-Leblond et al. // Am. J. Respir. Crit. Care Med. 1998. — Vol.157. — P.394−402.

118. Lan, H.Y. The pathogenic role of macrophage migration inhibitory factor in immunologically. induced kidney disease in the rat / H.Y. Lan, M. Bacher, N. Yang et al.//J. Exp. Med. 1997.-Vol.185. — 1455−1465.

119. Lapidot, T. Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells / T. Lapidot, I. Petit // Exp. Hematol. 2002. — Vol.30. — P.973−981.

120. Laudanna, C. Role of Rho in chemoattractant-activated leukocyte adhesion through integrins / C. Laudanna, J.J. Campbell, E.C. Butcher // Science. -1996. Vol.271. — P.981 -983.

121. Legler, D.F. B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5 / D.F. Legler, M. Loetscher, R.S. Roos et al. // J. Exp. Med. -1998. Vol.187. — P.655−660.

122. Lesnik, P. Decreased atherosclerosis in CX3CRl/mice reveals a role for fractalkine in atherogenesis / P. Lesnik, C.A. Llaskell, I.F. Charo // J. Clin. Invest. 2003. — Vol.111. P.333−340.

123. Ley, K. Pathways and bottlenecks in the web of inflammatory adhesion molecules and chemoattractants / K. Ley // Immunol. Res. 2001. — Vol. 24. -P.87−95.

124. Libby, P. Inflammation in atherosclerosis / P. Libby // Nature. 2002. -Vol.420.-P.868−874.

125. Lin, S.G. De novo expression of macrophage migration inhibitory factor in atherogenesis in rabbits / S.G. Lin, X.Y. Yu, Y.X. Chen et al. // Circ. Res. -2000. Vol.87. -P.1202−1208.

126. Liptay, M.J. Neointimal macrophages colocalize with extracellular matrix gene expression in human atherosclerotic pulmonary arteries / M.J. Liptay, W.C. Parks, R.P. Mecham et al. // J. Clin. Invest. 1993. — Vol. 91. — P.588−594.

127. Lloyd-Jones, D.M. Lifetime risk of developing coronary heart disease / D.M. Lloyd-Jones, M.G. Larson, A. Beiser et al. // Lancet. 1999. — Vol.353. -P.89−92.

128. Loetscher, M. Chemokine receptor specific for IP 10 and mig: structure, function, and expression in activated T-lymphocytes / M. Loetscher, B. Gerber, P. Loetscher et al. // J. Exp. Med. 1996. — Vol.184. — P.963−969.

129. Loetscher, M. Lymphocyte-specific chemokine receptor CXCR3: regulation, chemokine binding and gene localization / M. Loetscher, P. Loetscher, N. Brass et al. // Eur. J. Immunol. 1998. — Vol.28. — P.3696−3705.

130. Loetscher, P. CCR5 is characteristic of Thl lymphocytes / P. Loetscher, M. Uguccioni, L. Bordoli et al. // Nature. 1998. — Vol. 391. — P.344−345.

131. Loetscher, P. Chemokines and their receptors in lymphocyte traffic and HIV infection / P. Loetscher, B. Moser, M. Baggiolini // Adv. Immunol. 2000. -Vol. 74. — P.127−180.

132. Loetscher, P. Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes / P. Loetscher, M, Seitz, M. Baggiolini et al. // J. Exp. Med. 1996. — Vol. 184. — P.569−577.

133. Lomize, A.L. Structural organization of G-protein-coupled receptors / A.L. Lomize, I.D. Pogozheva, H.I. Mosberg // J. Comput. Aided. Mol. Des. -1999.-Vol. 13. P.325−353.

134. Lukacs, N.W. Mast cells produce ENA-78, which can function as a potent neutrophil chemoattractant during allergic airway inflammation / N.W. Lukacs, C.M. Hogaboam, S. L. Kunkel et al. // J. Leukoc. Biol. 1998. -Vol.63.-P.746−751.

135. Lukacs, N.W. Role of chemokines in asthmatic airway inflammation / N.W. Lukacs, K.K. Tekkanat // Immunol. Rev. 2000. — Vol.177. — P.21−30.

136. Lundahl, J. Monocyte and neutrophil adhesion to matrix proteins is selectively enhanced in the presence of inflammatory mediators / J. Lundahl, C.M. Skold, G. Hallden et al. // Scand. J. Immunol. 1996. — Vol.44. -P.143−149.

137. Luster, A.D. Chemokines regulate lymphocyte homing to the intestinal mucosa / A.D. Luster // Gastroenterology. 2001. — Vol.120. — P.291−294.

138. Ma, Q. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice / Q. Ma, D. Jones, P.R. Borghesani et al. // Proc. Natl. Acad. Sci. USA. 1998. — Vol.95. -P.9448−9453.

139. Mach, F. Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells / F. Mach, A. Sauty, A.S. Iarossi et al. // J. Clin. Invest. 1999. — Vol.104. — P. 1041−1050.

140. Mack, M. Chondroitin sulfate A released from platelets blocks RANTES presentation and RANTES-dependent firm adhesion of leukocytes / M. Mack, J. Pfirstinger, C. Weber et al. // Eur. J. Immunol. 2002. ~ Vol.32. — P.1012−1020.

141. Mackay, C.R. Follicular homing T helper (Th) cells and the Thl/Th2 paradigm / C.R. Mackay // J. Exp. Med. 2000. — Vol.192. — P.31−34.

142. Marquez, G. Chemokines: the times they are a-changin' / G. Marquez, A. Martinez // J. Clin. Invest. 2001. — Vol. 107. — P.791−792.

143. Marra, F. Increased expression of monocyte chemotactic protein-1 during active hepatic fibrogenesis: correlation with monocyte infiltration / F. Marra, R. DeFranco, C. Grappone et al. // Am. J. Pathol. 1998. — Vol.152. -P.423−430.

144. Matloubian, M. A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo / M. Matloubian, A. David, S. Engel et al. // Nat. Immun. -2000. Vol.1. -P.298−304.

145. Melter, M. Expression of the chemokine receptor CXCR3 and its ligand IP-10 during human cardiac allograft rejection / M. Melter, A. Exeni, M.E. Reinders et al. // Circulation. 2001. — Vol.104. — P. 2558−2564.

146. Minami, M. Expression of SR-PSOX, a novel cell-surface scavenger receptor for phosphatidylserine and oxidized LDL in human atheroscleroticlesions / M. Minami, N. Kume, T. Shimaoka // Arterioscler Thromb. Vase. Biol. -2001. -Vol.21.-P.1796−1800.

147. Morgan, S.J. Reduced leukocyte adhesion response and absence of slow leukocyte rolling in interleukin-8 receptor-deficient mice / S.J. Morgan, M.W. Moore, G. Cacalano et al. // Microvasc. Res. 1997. — Vol. 54. — P. 188−191.

148. Mori, T. Omega-3 fatty acids and inflammation / T. Mori, L. Beilin // Current Atherosclerosis Reports. 2004. — Vol. 6, № 6. — P.461−667.

149. Moser, B. Expression of transcripts for two interleukin 8 receptors in human phagocytes, lymphocytes and melanoma cells / B. Moser, L. Barella, S. Mattei et al. // Biochem. J. 1993. — Vol. 294. — P.285−292.

150. Murphy, P.M. Chemokine receptors: cloning strategies / P.M. Murphy // Methods. 1996. — Vol. 10. — P. 104−118.

151. Nagasawa, T. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1 / T. Nagasawa, S. Hirota, K. Tachibana et al. // Nature. 1996. — Vol. 382. -P.635−638.

152. Nelken, N.A. Monocyte chemoattractant protein-1 in human atheromatous plaques / N.A. Nelken, S.R. Coughlin, D. Gordon et al. // J. Clin. Invest. -1991. Vol.88. — P. l 121−1127.

153. Nelson, P.J. Chemokines and allograft rejection: narrowing the list of suspects / P.J. Nelson, A.M. Krensky // Transplantation. 2001. — Vol.72. -P.1195−1197.

154. Ni, W. New anti-monocyte chemoattractant protein-1 gene therapy attenuates atherosclerosis in apolipoprotein E-knockout Mice / W. Ni, K. Egashira, S. Kitamoto et al. // Circulation. 2001. — Vol.103. — P.2096;2101.

155. Nilsson, G. Mast cell migratory response to interleukin-8 is mediated through interaction with chemokine receptor CXCR2/interleukin-8RB / G. Nilsson, J.A. Mikovits, D.D. Metcalfe et al. // Blood. 1999. — Vol.93. -P.2791−2797.

156. Noris, M. Interleukin-6 and RANTES in Takayasu arteritis: a guide for therapeutic decisions? / M. Noris, E. Daina, S. Gamba et al. // Circulation. -1999.-Vol. 100. -P.55−60.

157. Ommen, S. Atrial arrhytmias after cardiothoracic surgery / S. Ommen, J. Odell, M. Stanton et al. //N. Engl. J. Med. 1997. — Vol. 336. — P. 1429−1434.

158. Oosterga, M. Effects of quinapril on clinical outcome after coronary bypass grafting (the QUOVADIS study) / M. Oosterga, A. Voors, V. Pinto et al. // J. Am. Coll. Cardiol. 2001. — Vol.87. — P.542−546.

159. Ostermann, G. JAM-1 is a ligand of the 2 integrin LFA-1 involved in transendothelial migration of leukocytes / G. Ostermann, K.S.C. Weber, A. Zeraecke et al. //Nature Immunol. 2002. — Vol.3. — P. 151−158.

160. Page, R.D. TreeView: an application to display phylogenetic trees on personal computers / R.D. Page // Comput. Appl. Biosci. 1996. — Vol.12. -P.357−358.

161. Pattison, J.M. RANTES chemokine expression in transplant-associated accelerated atherosclerosis / J.M. Pattison, P.J. Nelson, P. Huie et al. // J. Heart Lung. Transplant. 1996. — Vol.15. — P. 1194−1199.

162. Peled, A. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4 / A. Peled, I. Petit, O. Kollet et al. // Science. -1999. Vol. 283. -P.845−848.

163. Piali, L. The chemokine receptor CXCR3 mediates rapid and shearresistant adhesion-induction of effector T lymphocytes by the chemokines IP 10 and Mig / L. Piali, C. Weber, G. LaRosa et al. // Eur. J. Immunol. 1998. -Vol.28. -P.961−972.

164. Plater-Zyberk, C. Effect of a CC chemokine receptor antagonist on collagen induced arthritis in DBA/1 mice / C. Plater-Zyberk, A.J. Hoogewerf, A.E. Proudfoot et al. // Immunol. Lett. 1997. — Vol.57. — P. 117−120.

165. Ponomaryov, T. Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function / T. Ponomaryov, A. Peled, I. Petit et al. // J. Clin. Invest. 2000. — Vol.106. — P. 1331−1339.

166. Porreca, E. Monocyte chemotactic protein 1 (MCP-1) is a mitogen for cultured rat vascular smooth muscle cells / E. Porreca, C. Di Febbo, M. Reale et al. // J. Vase. Res. 1997. — Vol.34. — P.58−65.

167. Predel, H. Implications of pulsatile stretch on growth of saphenous vein and mammary artery smooth muscle / H. Predel, Z. Yang, L. von Segesser et al. // Lancet. 1992. — Vol.340. — P.878−882.

168. Proudfoot, A.E. The strategy of blocking the chemokine system to combat disease / A.E. Proudfoot, C.A. Power, T.N. Wells // Immunol. Rev. 2000. -Vol.177.-P.246−256.

169. Qin, S. The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions / S. Qin, J.B. Rottman, P. Myers et al. //J. Clin. Invest. 1998. — Vol.101. -P.746−754.

170. Ralston, D.R. Antineutrophil cytoplasmic antibodies induce monocyte IL-8 release. Role of surface proteinase-3, alpha 1-antitrypsin, and Fcgamma receptors / D.R. Ralston, C.B. Marsh, M.P. Lowe // J. Clin. Invest. 1997. -Vol.100.-P.1416−1424.

171. Ransohoff, R.M. Astrocyte expression of mRNA encoding cytokines IP-10 and JE/MCP-1 in experimental autoimmune encephalomyelitis / R.M. Ransohoff, T.A. Hamilton, M. Tani et al. // FASEB J. 1993. — Vol.7. -P.592−600.

172. Rauscher, F.M. Aging, progenitor cell exhaustion, and atherosclerosis / F.M. Rauscher, P.J. Goldschmidt-Clermont, B.H. Davis et al. // Circulation. -2003.-Vol.108.-P.457−463.

173. Reape, T.J. Chemokines and atherosclerosis / T.J. Reape, P.H. Groot // Atherosclerosis. 1999. — Vol.147. — P.213−225.

174. Reape, T.J. Expression and cellular localization of the CC chemokines PARC and ELC in human atherosclerotic plaques / T.J. Reape, K. Rayner, C.D. Manning et al. // Am. J. Pathol. 1999. — Vol.154. — P.365−374.

175. Ren, Y. Macrophage migration inhibitory factor: roles in regulating tumor cell migration and expression of angiogenic factors in hepatocellular carcinoma / Y. Ren, H.T. Tsui, R.T. Poon et al. // Int. J. Cancer. 2003. -Vol.107. -P.22−29.

176. Richardson, R.M. Regulation of human interleukin-receptor A: identification of a phosphorylation site involved in modulating receptor functions / R.M. Richardson, R.A. DuBose, H. Ali et al. // Biochemistry. 1995. — Vol.34. -P.14 193−14 201.

177. Rodriguez-Frade, J.M. The chemokine monocyte chemoattractant protein-1 induces functional responses through dimerization of its receptor CCR2 / J.M.

178. Rodriguez-Frade, A J. Vila-Coro, A.M. de Ana et al. // Proc. Natl. Acad. Sei. USA. 1999. — Vol.96. — P.3628−3633.

179. Rollins, J.B. Chemokines and atherosclerosis: what Adam Smith has to say about vascular disease / J.B. Rollins // J. Clin. Invest. 2001. — Vol.108. -P.1269−1271.

180. Roque, M. CCR2 deficiency decreases intimal hyperplasia after arterial injury / M. Roque, W.J. Kim, M. Gazdoin et al. // Arterioscler Thromb. Vase. Biol. -2002. Vol. 22. — P.554−559.

181. Rossi, D.L. Lungkine, a novel CXC chemokine, specifically expressed by lung bronchoepithelial cells / D.L. Rossi, S.D. Hurst, Y. Xu et al. // J. Immunol. 1999. — Vol. 162. — P.5490−5497.

182. Rot, A. RANTES and macrophage inflammatory protein 1 alpha induce the migration and activation of normal human eosinophil granulocytes / A. Rot, M. Krieger, T. Brunner et al. // J. Exp. Med. 1992. — Vol. 176. — P. 14 891 495.

183. Rothenberg, M.E. Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia / M.E. Rothenberg, J.A. MacLean, E. Pearlman et al. // J. Exp. Med. 1997. — Vol.185. — P.785−790.

184. Rubbert, A. Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry / A. Rubbert, C. Combadiere, M. Ostrowski et al. // J. Immunol. 1998. — Vol.160. — P.3933−3941.

185. Sallusto, F. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes / F. Sallusto, D. Lenig, C.R. Mackay et al. //J. Exp. Med. 1998. — Vol.187. -P.875−883.

186. Sallusto, F. Mobilizing dendritic cells for tolerance, priming, and chronic inflammation / F. Sallusto, A. Lanzavecchia // J. Exp. Med. 1999. -Vol.189.-P.611−614.

187. Sallusto, F. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation / F. Sallusto, P. Schaerli, P. Loetscher et al. // Eur. J. Immunol. 1998. — Vol.28. — P.2760−2769.

188. Sallusto, F. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells / F. Sallusto, C.R. Mackay, A. Lanzavecchia // Science. 1997. -Vol. 277. — P.2005;2007.

189. Sallusto, F. Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells / F. Sallusto, E. Kremmer, B. Palermo et al. // Eur. J. Immunol. 1999. — Vol. 29. — P.2037;2045.

190. Sallusto, F. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions / F. Sallusto, D. Lenig, R. Forster et al. // Nature. 1999. — Vol.401. -P.708−712.

191. Sallusto, F. Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression / F. Sallusto, A. Lanzavecchia // Immunol. Rev. 2000. — Vol.177. — P. 134−140.

192. Sata, M. Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis / M. Sata, A. Saiura, A. Kunisato et al. // Nat. Med. 2002. — Vol.8. — P.403−409.

193. Scha’fer, A. Novel role of the membrane bound chemokine fractalkine in platelet activation and adhesion / A. Scha’fer, C. Schulz, M. Eigenthaler et al. //Blood. -2003. Vol.103. — P.407−412.

194. Schaerli, P. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function / P. Schaerli, K. Willimann, A.B. Lang et al. // J. Exp. Med. 2000. — Vol. 192. — P. 1553−1562.

195. Schober, A. Crucial role of stromal cell-derived factor-1 in neointima formation after vascular injury in apolipoprotein E-deficient mice / A. Schober, S. Knarren, M. Lietz et al. // Circulation. 2003. — Vol.108. -P.2491−2497.

196. Schroder, J.M. Role of eosinophil-chemotactic C-C chemokines in cutaneous inflammation / J.M. Schroder, N. Noso, M. Sticherling et al. // J. Leukoc. Biol. 1996. — Vol.59. — P. 1−5.

197. Schwartz, D. Role of GRO family of chemokines in monocyte adhesion to MM-LDL-stimulated endothelium / D. Schwartz, A. Andalibi, L. Chaverri-Almada et al. // J. Clin. Invest. 1994. — Vol.94. — P. 1968;1973.

198. Sheikine, Y. Chemokines and atherosclerosis / Y. Sheikine, G. Hansson // Ann. Med. 2004. — Vol.36. — P.98−118.

199. Shibahara, T. Characterization of epithelial chemoattractants for human intestinal intraepithelial lymphocytes / T. Shibahara, J.N. Wilcox, T. Couse et al. // Gastroenterology. 2001. — Vol.120. — P.60−70.

200. Simonini, A. IL-8 is an angiogenic factor in human coronary atherectomy tissue / A. Simonini, M. Moscucci, D.W. Muller et al. // Circulation. 2000. -Vol.101.-P.1519−1526.

201. Simper, D. Smooth muscle progenitor cells in human blood / D. Simper, P.G. Stalboerger, C.J. Panetta et al. // Circulation. 2002. — Vol. 106. -P.l 199−1204.

202. Sorensen, T.L. Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients / T.L. Sorensen, M. Tani, J. Jensen et al.//J. Clin. Invest. 1999. — Vol. 103.-P.807−815.

203. Stary, H.C. A Definition of Advanced Types of Atherosclerotic Lesions and a Histological Classification of Atherosclerosis / H.C. Stary, A.B. Chandler, R.E. Dinsmore et al. // Circulation. 1995. — Vol.92. — P.1355−1374.

204. Stary, H.C. Changes in components and structure of atherosclerotic lesions developing from childhood to middle age in coronary arteries / H.C. Stary // Basic. Res. Cardiol. 1994. — Vol.89. — P. 17−32.

205. Steinberg, D. Atherogenesis in perspective: hypercholesterolemia and inflammation as partners in crime / D. Steinberg // Nat. Med. 2002. — Vol.8. -P.1211−1217.

206. Strauss, B.H. Extracellular matrix remodeling after balloon angioplasty injury in a rabbit model of restenosis / B.H. Strauss, R.J. Shisholm, F.W. ICeely et al. // Circ. Res. 1994. — Vol. 75. — P.650−658.

207. Sun, H. Crystal structure at 2.6-A resolution of human macrophage migration inhibitory factor / H. Sun, J. Bernhagen, R. Bucala et al. // Proc. Natl. Acad. Sci USA. 1996. — Vol. 93. -P.5191−5196.

208. Syrbe, U. Thl/Th2 subsets: distinct differences in homing and chemokine receptor expression? / U. Syrbe, J. Siveke, A. Hamann et al. // Springer Semin Immunopathol. 1999. — Vol.21. — P.263−285.

209. Tachibana, K. The chemokine receptor CXCR4 is essential for vascularization of the gastrointestenial tract / K. Tachibana, S. Hirota, H. Iizasa et al.//Nature. 1998. — Vol.393. — P.591−594.

210. Tanaka, K. Diverse contribution of bone marrow cells to neointimal hyperplasia after mechanical vascular injuries / K. Tanaka, M. Sata, Y. Hirata et al. // Circ. Res. 2003. — Vol.93. — P.783−790.

211. Tanaka, Y. Selective expression of liver and activation-regulated chemokine (LARC) in intestinal epithelium in mice and humans /.Y. Tanaka, T. Imai, M. Baba et al. // Eur. J. Immunol. 1999. — Vol.29. — P.633−642.

212. Thelen, M. PI 3-kinase-dependent and independent chemotaxis of human neutrophil leukocytes / M. Thelen, M. Uguccioni, J. Bosiger // Biochem. Biophys. Res. Commun. 1995.-Vol.217.-P. 1255−1262.

213. Tilton, B. G-protein-coupled receptors and Fcgammareceptors mediate activation of Akt/protein kinase B in human phagocytes / B. Tilton, M. Andjelkovic, S.A. Didichenko et al. // J. Biol. Chem. 1997. — Vol.272. -P.28 096−28 101.

214. Tsou, C.L. Tumor necrosis factor-converting enzyme mediates the inducible cleavage of fractalkine / C.L. Tsou, C.A. Haskell, L.F. Charo // J. Biol. Chem.- 2001. Vol. 276. — P.44 622−44 626.

215. Turner, L. RANTES-activated human T lymphocytes. A role for phosphoinositide 3-kinase / L. Turner, S.G. Ward, J. Westwick // J. Immunol.- 1995. Vol. 155. — P.2437−2444.

216. Uguccioni, M. Increased expression of IP-10, IL-8, MCP-1, and MCP-3 in ulcerative colitis / M. Uguccioni, P. Gionchetti, D.F. Robbiani et al. // Am. J. Pathol. 1999.-Vol. 155.-P.331−336.

217. Unutmaz, D. The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern is conserved between human and mouse / D. Unutmaz, W. Xiang, M.J. Sunshine et al. // J. Immunol. -2000. Vol.165. — P.3284−3292.

218. Veillard, N.R. Antagonism of RANTES receptors reduces atherosclerotic plaque formation in mice / N.R. Veillard, B. Kwak, G. Pelli et al. // Circ. Res. -2004. Vol. 94. — P.253−261.

219. Veillard, N.R. Crucial role for both chemokines receptors CCR2 and CXCR3 in atherogenesis / N.R. Veillard, B. Lu, G. Pelli et al. // Eur. Heart. J.-2003.-Vol. 24.-P.337.

220. Vicari, A.P. TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development / A.P. Vicari, DJ. Figueroa, J.A. Hedrick // Immunity. 1997. — Vol.7. — P.291−301.

221. Von Andrian, U.H. T-cell function and migration. Two sides of the same coin / U.H. Von Andrian, C.R. Mackay // N. Engl. J. Med. 2000. — Vol. 343. — P.1020−1034.

222. Von der Thusen, J.H. Interleukins in atherosclerosis: molecular pathways and therapeutic potential / J.H. Von der Thusen, J. Kuiper, T.J. van Berkel et al. //Pharmacol. Rev. -2003. Vol. 55. — P. 133−166.

223. Von Hundelshausen, P. RANTES deposition by platelets triggers monocyte arrest on inflamed and atherosclerotic endothelium / P. Von Hundelshausen, K.S.C. Weber, Y. Huo et al. // Circulation. 2001. — Vol.103. — P. 1772−1777.

224. Wakasugi, K. Two distinct cytokines released from a human aminoacyl-RNA synthetase / K. Wakasugi, P. Schimmel // Science. 1999. — Vol.284. -P.147−151.

225. Wang, J.M. Chemokines, receptors, and their role in cardiovascular pathology / J.M. Wang, S. Su, W. Gong et al. // Int. J. Clin. Lab. Res. 1998. — Vol.28.-P.83−90.

226. Wang, N. Interleukin-8 is induced by cholesterol loading of macrophages and expressed by macrophage foam cells in human atheroma / N. Wang, I. Tabas, R. Winchester et al. // J. Biol. Chem. 1996. — Vol. 271. — P.8837−8842.

227. Wang, X. Interferon-inducible protein-10 involves vascular smooth muscle cell migration, proliferation, and inflammatory response / X. Wang, T.L. Yue, E.H. Ohlstein et al. // J. Biol. Chem. 1996. — Vol. 271. — P.24 286−24 293.

228. Weber, C. Novel mechanistic concepts for the control of leukocyte transmigrationspecialization of integrins, chemokines and junctional molecules / C. Weber // J. Mol. Med. 2003. — Vol.81. — P.4−19.

229. Weber, C. Specialized roles of the chemokine receptors CCR1 and CCR5 in recruitment of monocytes and Thl-like/CD45RO T cells / C. Weber, K.S.C. Weber, C. Klier et al. // Blood. 2001. — Vol.97. — P. 1144−1146.

230. Wells, T.N. Chemokine receptors and their antagonists in allergic lung disease / T.N. Wells, A.E. Proudfoot // Inflamm. Res. 1999. — Vol. 48. -P.353−362.

231. Werner, N. Intravenous transfusion of endothelial progenitor cells reduces neointima formation after vascular injury / N. Werner, S. Junk K. Laufs et al. // Circ. Res. 2003. — Vol. 93. — P. 17−24.

232. Wilcox, J.N. Local expression of inflammatory cytokines in human atherosclerotic plaques / J.N. Wilcox, N.A. Nelken, S.R. Coughlin et al. // J. Atheroscler Thromb. 1994. — Vol. 1. — P. 10−13.

233. Wilson, P.W.F. Prediction of coronary heart disease using risk factor categories / P.W.F. Wilson, R.B. D’Agostino, D. Levy et al. // Circulation. -1998. Vol.97. — P. 1837−47.

234. Wu, D. G protein-coupled signal transduction pathways for interleukin-8 / D. Wu, G.J. LaRosa, M.I. Simon // Science. 1993. — Vol. 261. — P.101−103.

235. Wuttge, D.M. CXCL16/SR-PSOX is an interferon-regulated chemokine and scavenger receptor expressed in atherosclerotic lesions / D.M. Wuttge, X. Zhou, Y. Sheikine et al. // Arterioscler Thromb. Vase. Biol. 2004. — Vol. 24.-P.750- 755.

236. Yamaguchi, J. Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization / J. Yamaguchi, K.F. Kusano, O. Masuo et al. // Circulation. 2003. — Vol.11, № 9. -P.1322−1322.

237. Yamaguchi, Y. Monocyte chemoattractant protein-1 enhances expression of intercellular adhesion molecule-1 following ischemia-reperfusion of the liver in rats / Y. Yamaguchi, T. Matsuda, K. Okabe et al. // Hepatology. 1998. -Vol. 27. — P.727−734.

238. Yamaguchi, Y. Neutrophil elastase and oxygen radicals enhance monocyte chemoattractant protein-expression after ischemia/reperfusion in rat liver / Y. Yamaguchi, F. Matsumura, J. Liang et al. // Transplantation. 1999. — Vol. 68.-P. 1459−1468.

239. Yawalkar, N. Enhanced expression of eotaxin and CCR3 in atopic dermatitis / N. Yawalkar, M. Uguccioni, J. Scharer et al. // J. Invest. Dermatol. 1999. — Vol. 113. — P.43−48.

240. Yokoyama, M. Fish oil bolsters statin reduction of coronary events / M. Yokoyama//Lancet. 2007. — Vol. 369. — P. 1090−1098.

241. Yoshida, R. Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7 / R. Yoshida, T. Imai, K. Hieshima et al. // J. Biol. Chem. 1997. — Vol.72. -P.13 803−13 809.

242. Yoshida, R. Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7 / R. Yoshida, M. Nagira, M. Kitaura et al. //J. Biol. Chem. 1998. — Vol. 273. -P.7118−7122.

243. Yoshie, O. Novel lymphocytespecific CC chemokines and their receptors / O. Yoshie, T. Imai, H. Nomiyama // J. Leukoc. Biol. 1997. — Vol. 62. -P.634−644.

244. Yu, X. Elevated expression of monocyte chemoattractant protein 1 by vascular smooth muscle cells in hypercholesterolemic primates / X. Yu, S. Dluz, D.T. Graves et al. // Proc. Natl. Acid. Sci. USA. 1992. — Vol. 89. -P.6953−6957.

245. Yue, T.L. Interleukin-8: a mitogen and chemoattractant for vascular smooth muscle cells / T.L. Yue, X. Wang, C.P. Sung et al. // Cire. Res. 1994. -Vol. 75.-P.1−7.

246. Zeiffer, U. Neointimal smooth muscle cells support increased monocyte arrest in flow by constitutively enhanced expression of P-selectin and chemonkines / U. Zeiffer, A. Schober, M. Lietz et al. // Cire. Res. 2004. -Vol. 94. — P.776−784.

247. Zernecke, A. Combinatorial model of chemokine involvement in glomerular monocyte recruitment: role of CXCR2 in infiltration during nephrotoxic / A. Zernecke, K.S. Weber, L.P. Erwig et al. // J. Immunol. 2001. — Vol. 166. -P.5755−5762.

248. Zingoni, A. The chemokine receptor CCR8 is preferentially expressed in Th2 but not Thl cells / A. Zingoni, H. Soto, J.A. Hedrick et al. // J. Immunol. 1998.-Vol. 161. — P.547−551.

249. Zlotnik, A. Chemokines: a new classification system and their role in immunity / A. Zlotnik, O. Yoshie // Immunity. 2000. — Vol. 12. — P. 121 127.