Экспрессия гена CTR1 у млекопитающих при разных состояниях метаболизма меди и IN SILICO анализ его белкового продукта
Диссертация
На основе гидропатического профиля, основываясь на предположении, что трансмембранные домены (ТМД) находятся в мембране в конформации а-спирали, была построена модель расположения ТМД, при котором гомотримерный канал образуется 6 ТМД (ТМД2 и ТМДЗ), тогда как оставшиеся ТМД1, будучи существенно более гидрофобными, не участвуют в образовании медьпроводящей поры. Рассчитанные размеры поры совпадают… Читать ещё >
Содержание
- 1. Обзор литературы
- 1. 1. Физико-химические свойства и биологическая роль ионов меди
- 1. 1. 1. Медь как химический элемент
- 1. 1. 2. Ионы меди Си+ и Си2т
- 1. 1. 3. Биохимические процессы, протекающие с участием ионов меди
- 1. 1. 4. Метаболическая система меди
- 1. 2. Роль CTR1 в метаболизме меди
- 1. 2. 1. Импорт ионов меди через плазматическую мембрану клетки
- 1. 2. 2. Семейство белков CTR
- 1. 2. 3. Экспрессия гена CTR1 млекопитающих в клеточных культурах
- 1. 2. 4. Биохимическая характеристика и внутриклеточная локализация белка CTR1 млекопитающих
- 1. 2. 5. Функция и экспрессия гена CTR1 позвоночных
- 1. 2. 6. Регуляция экспрессии гена CTR
- 1. 2. 7. Изучение связывания ионов меди с доменами CTR
- 1. 2. 8. Участие CTR1 в транспорте платиносодержащих противоопухолевых препаратов (ППП)
- 1. 1. Физико-химические свойства и биологическая роль ионов меди
- 2. 1. Оборудование
- 2. 2. Материалы
- 2. 3. Компьютерные методы
- 2. 4. Экспериментальные методы
- 2. 4. 1. Получение материала для выделения тотальной РНК
- 2. 4. 2. Выделение тотальной РНК
- 2. 4. 3. Обратная транскрипция, сопряжённая с полимеразной цепной реакцией
- 2. 4. 4. Электрофоретический анализ нуклеиновых кислот
- 2. 4. 5. Полуколичественный метод определения квазистационарного уровня мРНК
- 2. 4. 6. Иммуноблотинг
- 2. 4. 7. Измерение концентрации меди
- 2. 4. 8. Измерение концентрации церулоплазмина
- 3. 1. Связь экспрессии гена CTR1 с метаболизмом меди в различных органах крысы и статусом меди в крови
- 3. 1. 1. Экспрессия гена CTRI и статус меди в печени
- 3. 1. 2. Экспрессия гена CTR1 и статус меди в отделах мозга
- 3. 1. 3. Экспрессия гена CTR1 и статус меди в лактирующей молочной железе
- 3. 1. 4. Экспрессия гена CTR1 и статус меди в сердце
- 3. 1. 5. Экспрессии гена CTR1 в печени и мозгу новорожденных и взрослых крыс при дефиците оксидазного ЦП в крови
- 3. 1. 6. Возможная роль меди в импорте цисплатина с участием CTR
- 3. 1. 7. Экспрессии гена CTR1 в опухолях и в печени животных с растущими опухолями 73 3.2. In silico анализ продуктов гена CTR1 разных видов
- 3. 2. 1. Экзон-интронная организация генов семейства CTR
- 3. 2. 2. Филогенетический анализ белков семейства CTR
- 3. 2. 3. Анализ аминокислотных последовательностей белков семейства CTR
- 3. 2. 4. Анализ аминокислотной последовательности CTR1 человека
- 3. 2. 5. Анализ N-концевого экстрацеллюлярного домена CTR1 человека и дрожжей
- 3. 2. 6. Модель олигомерного комплекса CTR1 в мембране
- 3. 2. 7. Связывание меди НСН С-концевым мотивом CTR1 млекопитающих
- 3. 2. 8. Сравнение способностей С-концевого мотива CTR1 НСН связывать ионы Cu (I) и Ag (I)
- 3. 2. 9. Докинг N- и С-концевых медьевязывающих мотивов CTR1 млекопитающих с их предполагаемыми донорами и акцепторами меди
- 3. 2. 10. Анализ регуляторных г/мс-элементов гена CTR
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