ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΡΠ»ΡΠΌΠ°Π·Π΅Π½ΠΈΠ»Π°, ΠΌΠ΅ΡΠ΅Π½Π½ΠΎΠ³ΠΎ ΡΡΠΎΡΠΎΠΌ-18, Π½ΠΎΠ²ΠΎΠ³ΠΎ ΡΠ°Π΄ΠΈΠΎΠ»ΠΈΠ³Π°Π½Π΄Π° Π΄Π»Ρ ΠΏΠΎΠ·ΠΈΡΡΠΎΠ½Π½ΠΎΠΉ ΡΠΌΠΈΡΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠΎΠΌΠΎΠ³ΡΠ°ΡΠΈΠΈ
ΠΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΡ
ΠΠΏΠ΅ΡΠ²ΡΠ΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΊΠΈΠ½Π΅ΡΠΈΠΊΠΈ ΠΈΠ·ΠΎΡΠΎΠΏΠ½ΠΎΠ³ΠΎ 19F/18F-o6MeHa Π² ΠΌΠΎΠ»Π΅ΠΊΡΠ»Π΅ ΡΠ»ΡΠΌΠ°Π·Π΅Π½ΠΈΠ»Π°. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΏΡΠΎΡΠ΅ΠΊΠ°Π½ΠΈΠ΅ ΠΈΠ·ΠΎΡΠΎΠΏΠ½ΠΎΠ³ΠΎ I9F/I8F-ΠΎΠ±ΠΌΠ΅Π½Π° ΠΏΠΎΠ΄ΡΠΈΠ½ΡΠ΅ΡΡΡ ΠΊΠΈΠ½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΌΡ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Π±ΠΈΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠΉ ΡΠ΅Π°ΠΊΡΠΈΠΈ. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ ΠΊΠΎΠ½ΡΡΠ°Π½ΡΡ ΡΠΊΠΎΡΠΎΡΡΠΈ ΠΈΠ·ΠΎΡΠΎΠΏΠ½ΠΎΠ³ΠΎ 19F/, 8F-o6MeHa Π² Π΄ΠΈΠΌΠ΅ΡΠΈΠ»ΡΠΎΡΠΌΠ°ΠΌΠΈΠ΄Π΅ ΠΏΡΠΈ ΡΠ°Π·Π½ΡΡ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΠ°Ρ ΡΠ°ΡΡΡΠΈΡΠ°Π½Ρ ΡΠ½Π΅ΡΠ³ΠΈΡ Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ ΠΈΠ·ΠΎΡΠΎΠΏΠ½ΠΎΠ³ΠΎ l9F/18F-o6MeHa, ΡΠ½ΡΠ°Π»ΡΠΏΠΈΡ ΠΈ ΡΠ½ΡΡΠΎΠΏΠΈΡ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠ΅ΡΠ΅Ρ ΠΎΠ΄Π½ΠΎΠ³ΠΎ… Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΠΠΠΠΠΠΠ
- 2. ΠΠΠΠΠ ΠΠΠ’ΠΠ ΠΠ’Π£Π Π«
- 2. 1. ΠΠΠ’ ΠΊΠ°ΠΊ ΡΠ½ΠΈΠΊΠ°Π»ΡΠ½ΡΠΉ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΈΠΉ ΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΌΠ΅ΡΠΎΠ΄
- 2. 2. ΠΠ½Π°ΡΠ΅Π½ΠΈΠ΅ ΡΠ°Π΄ΠΈΠΎΡ ΠΈΠΌΠΈΠΈ Π² ΡΠ°Π·Π²ΠΈΡΠΈΠΈ ΠΠΠ’
- 2. 3. Π€ΡΠΎΡ-18 — ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΉ ΡΠ°Π΄ΠΈΠΎΠ½ΡΠΊΠ»ΠΈΠ΄ Π΄Π»Ρ ΠΠΠ’
- 2. 3. 1. ΠΠΠ’ ΡΠ°Π΄ΠΈΠΎΠΈΠ·ΠΎΡΠΎΠΏΡ
- 2. 3. 2. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΠΎΡΠ°-18 Π² ΠΌΠΈΡΠ΅Π½ΠΈ ΡΠΈΠΊΠ»ΠΎΡΡΠΎΠ½Π°
- 2. 3. 3. Π‘ΡΡΠ°ΡΠ΅Π³ΠΈΠΈ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ Π Π€Π Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΡΡΠΎΡΠ°
- 2. 3. 4. ΠΡΠ½ΠΎΠ²Π½ΡΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ ΡΡΠΎΡΠ°-18 Π² ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ
- 2. 3. 5. ΠΡΠΎΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π½ΡΠΊΠ»Π΅ΠΎΡΠΈΠ»ΡΠ½ΠΎΠ΅ Π·Π°ΠΌΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΊΠ°ΠΊ ΠΌΠ΅ΡΠΎΠ΄ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ ΡΡΠΎΡΠ°-18 Π² Π°ΡΠ΅Π½Ρ
- 2. 3. 6. ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΈΠ·ΠΎΡΠΎΠΏΠ½ΠΎΠ³ΠΎ 19F/18F-o6MeHa Π΄Π»Ρ ΡΠΈΠ½ΡΠ΅Π·Π°, ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ ΠΌΠ΅ΡΠ΅Π½Π½ΡΡ ΡΡΠΎΡΠΎΠΌ
- 2. 4. Π£Π½ΠΈΠΊΠ°Π»ΡΠ½ΡΠ΅ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΠΠ’ Π² in vivo ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡΡ
Π»ΠΈΠ³Π°Π½Π΄-ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ½ΡΡ
Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠΉ
- 2. 4. 1. Π€Π°ΡΠΌΠ°ΠΊΠΎΠΊΠΈΠ½Π΅ΡΠΈΠΊΠ° ΠΠΠ’ ΡΠ°Π΄ΠΈΠΎΠ»ΠΈΠ³Π°Π½Π΄ΠΎΠ²
- 2. 5. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π±Π΅Π½Π·ΠΎΠ΄ΠΈΠ°Π·Π΅ΠΏΠΈΠ½ΠΎΠ²ΡΡ
ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ² ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΠΠ’
- 2. 5. 1. ΠΠΠΠ ΠΈ Π±Π΅Π½Π·ΠΎΠ΄ΠΈΠ°Π·Π΅ΠΏΠΈΠ½ΠΎΠ²ΡΠ΅ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΡ
- 2. 5. 2. [ΠΏΠ‘]Π€Π»ΡΠΌΠ°Π·Π΅Π½ΠΈΠ» — ΡΠ°Π΄ΠΈΠΎΠ»ΠΈΠ³Π°Π½Π΄ Π΄Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΠΠ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΠΠ’
- 2. 5. 3. ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π΄ΠΈΠΎΠ»ΠΈΠ³Π°Π½Π΄Ρ Π΄Π»Ρ ΠΠΠ Π² ΡΠ΄Π΅ΡΠ½ΠΎΠΉ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½Π΅
- 2. 5. 4. Π Π°Π΄ΠΈΠΎΠ»ΠΈΠ³Π°Π½Π΄Ρ Π΄Π»Ρ ΡΠ΅Π½ΡΡΠ°Π»ΡΠ½ΡΡ Π±Π΅Π½Π·ΠΎΠ΄ΠΈΠ°Π·Π΅ΠΏΠΈΠ½ΠΎΠ²ΡΡ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ², ΠΌΠ΅ΡΠ΅Π½Π½ΡΠ΅ ΡΡΠΎΡΠΎΠΌ
- 3. 1. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΠΎΡΠ°-18 ΠΈ [ F]ΡΡΠΎΡΠΈΡΡΡΡΠΈΡ Π°Π³Π΅Π½ΡΠΎΠ²
- 3. 2. ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΌΠ΅ΡΠΊΠΈ ΡΡΠΎΡΠ°-18 Π² ΠΌΠΎΠ΄Π΅Π»ΡΠ½ΡΠ΅ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ
- 3. 2. 1. Π Π°Π΄ΠΈΠΎΡΡΠΎΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΌΠΎΠ΄Π΅Π»ΡΠ½ΡΡ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ
- 3. 2. 2. ΠΠΎΠ½ΠΊΡΡΠ΅Π½ΡΠ½ΠΎΠ΅ ΡΠ°Π΄ΠΈΠΎΡΡΠΎΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅
- 3. 2. 3. ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΡΡΠΎΡΠ°-18 Π² Π°ΡΠΎΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΠ΅ ΠΊΠ°ΡΠΈΠΎΠ½ Π΄ΠΈΠ°Π·ΠΎΠ½ΠΈΡ
- 3. 3. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΠ΅Π°ΠΊΡΠΈΠΈ ΠΈΠ·ΠΎΡΠΎΠΏΠ½ΠΎΠ³ΠΎ l9F/18F-o6MeHa Π² ΠΌΠΎΠ»Π΅ΠΊΡΠ»Π΅ ΡΠ»ΡΠΌΠ°Π·Π΅Π½ΠΈΠ»Π°
- 3. 3. 1. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΡΠ°Π΄ΠΈΠΎΡΡΠΎΡΠΈΡΡΡΡΠ΅Π³ΠΎ Π°Π³Π΅Π½ΡΠ°
- 3. 3. 2. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΡΠ»ΡΠΌΠ°Π·Π΅Π½ΠΈΠ»Π°, ΠΌΠ΅ΡΠ΅Π½Π½ΠΎΠ³ΠΎ ΡΡΠΎΡΠΎΠΌ
- 3. 3. 3. ΠΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΠΈ Π°Π½Π°Π»ΠΈΠ· [ F]ΡΠ»ΡΠΌΠ°Π·Π΅Π½ΠΈΠ»Π°
- 3. 3. 4. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΡΡΠΈ ΡΠ»ΡΠΌΠ°Π·Π΅Π½ΠΈΠ»Π° Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ Π½ΡΠΊΠ»Π΅ΠΎΡΠΈΠ»ΡΠ½ΠΎΠ³ΠΎ ΡΠ°Π΄ΠΈΠΎΡΡΠΎΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ
- 3. 3. 5. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ Ρ ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠΈΠ½Π΅ΡΠΈΠΊΠΈ ΠΈΠ·ΠΎΡΠΎΠΏΠ½ΠΎΠ³ΠΎ 19F/18 °F ΠΎΠ±ΠΌΠ΅Π½Π° Π² ΠΌΠΎΠ»Π΅ΠΊΡΠ»Π΅ ΡΠ»ΡΠΌΠ°Π·Π΅Π½ΠΈΠ»Π°
- 3. 3. 6. ΠΡΠΈΡΡΠΊΠ° [18Π ]ΡΠ»ΡΠΌΠ°Π·Π΅Π½ΠΈΠ»Π° ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠ²Π΅ΡΠ΄ΠΎΡΠ°Π·Π½ΠΎΠΉ ΡΠΊΡΡΡΠ°ΠΊΡΠΈΠΈ
- 3. 4. Π‘ΠΈΠ½ΡΠ΅Π· [18Π ]ΡΠ»ΡΠΌΠ°Π·Π΅Π½ΠΈΠ»Π° Π±Π΅Π· Π΄ΠΎΠ±Π°Π²Π»Π΅Π½ΠΈΡ Π½ΠΎΡΠΈΡΠ΅Π»Ρ ΠΈΠ· Ro
- 3. 5. Π‘ΠΈΠ½ΡΠ΅Π· ΠΌΠΎΠ΄Π΅Π»ΡΠ½ΡΡ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ ΠΈ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ-ΠΏΡΠ΅Π΄ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΈΠΊΠΎΠ²
- 3. 6. ΠΠΎΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Ρ [ Π ]ΡΠ»ΡΠΌΠ°Π·Π΅Π½ΠΈΠ»ΠΎΠΌ
- 3. 6. 1. In Vitro Π°Π²ΡΠΎΡΠ°Π΄ΠΈΠΎΠ³ΡΠ°ΡΠΈΡ
- 3. 6. 2. ΠΠΠ’ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ
- 3. 6. 3. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΠ·ΠΌΠ° [ Π ]ΡΠ»ΡΠΌΠ°Π·Π΅Π½ΠΈΠ»Π° Π² ΠΊΡΠΎΠ²ΠΈ. Π» 4 Π ΠΠΠ£ΠΠ¬Π’ΠΠ’Π« Π ΠΠΠ‘Π£ΠΠΠΠΠΠ
- 4. 1. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ [ Π ]ΡΠ»ΡΠΌΠ°Π·Π΅Π½ΠΈΠ»Π° ΠΏΠΎ ΡΠ΅Π°ΠΊΡΠΈΠΈ ΠΈΠ·ΠΎΡΠΎΠΏΠ½ΠΎΠ³ΠΎ F/ F ΠΎΠ±ΠΌΠ΅Π½Π°
- 4. 2. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΠ΅Π°ΠΊΡΠΈΠΈ ΠΈΠ·ΠΎΡΠΎΠΏΠ½ΠΎΠ³ΠΎ 19F/18F-o6MeHa Π² ΠΌΠΎΠ»Π΅ΠΊΡΠ»Π΅ ΡΠ»ΡΠΌΠ°Π·Π΅Π½ΠΈΠ»Π°. Ρ. 4.2.1 ΠΠ°Π²ΠΈΡΠΈΠΌΠΎΡΡΡ Π²ΡΡ
ΠΎΠ΄Π° [ Π ]ΡΠ»ΡΠΌΠ°Π·Π΅Π½ΠΈΠ»Π° ΠΎΡ ΡΠ°ΡΡΠ²ΠΎΡΠΈΡΠ΅Π»Ρ ΠΈ ΡΠ°Π΄ΠΈΠΎΡΡΠΎΡΠΈΡΡΡΡΠ΅Π³ΠΎ Π°Π³Π΅Π½ΡΠ°
- 4. 2. 2. ΠΠ°Π²ΠΈΡΠΈΠΌΠΎΡΡΡ Π²ΡΡ ΠΎΠ΄Π° [ Π ]ΡΠ»ΡΠΌΠ°Π·Π΅Π½ΠΈΠ»Π° ΠΎΡ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΡ
- 4. 2. 3. ΠΠ°Π²ΠΈΡΠΈΠΌΠΎΡΡΡ Π²ΡΡ ΠΎΠ΄Π° [l8F]OM3 ΠΎΡ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ Π€ΠΠ
- 4. 2. 4. ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΠΏΠ΅ΡΠ΅ΠΌΠ΅ΡΠΈΠ²Π°Π½ΠΈΡ ΡΠ΅Π°ΠΊΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠΌΠ΅ΡΠΈ, ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΡ ΡΠ»Π΅Π΄ΠΎΠ² Π²ΠΎΠ΄Ρ ΠΈ Π½ΠΎΡΠΈΡΠ΅Π»Ρ (ΡΡΠΎΡ-19) ΠΈΠ·ΠΎΡΠΎΠΏΠ½ΡΠΉ l9F/I8Fo6MeH Π² ΠΌΠΎΠ»Π΅ΠΊΡΠ»Π΅ ΡΠ»ΡΠΌΠ°Π·Π΅Π½ΠΈΠ»Π°
- 4. 2. 5. ΠΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ^ Π ]ΡΠ»ΡΠΌΠ°Π·Π΅Π½ΠΈΠ»Π° Ρ ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ
- 4. 2. 6. ΠΡΠΈΡΡΠΊΠ° [ Π ]ΡΠ»ΡΠΌΠ°Π·Π΅Π½ΠΈΠ»Π° ΡΠ²Π΅ΡΠ΄ΠΎΡΠ°Π·Π½ΠΎΠΉ ΡΠΊΡΡΡΠ°ΠΊΡΠΈΠ΅ΠΉ
- 4. 2. 7. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΊΠΈΠ½Π΅ΡΠΈΠΊΠΈ ΠΈΠ·ΠΎΡΠΎΠΏΠ½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π° Π² ΠΌΠΎΠ»Π΅ΠΊΡΠ»Π΅ ΡΠ»ΡΠΌΠ°Π·Π΅Π½ΠΈΠ»Π°
- 4. 3. ΠΠΎΠ½ΠΊΡΡΠ΅Π½ΡΠ½ΠΎΠ΅ Π½ΡΠΊΠ»Π΅ΠΎΡΠΈΠ»ΡΠ½ΠΎΠ΅ ΡΠ°Π΄ΠΈΠΎΡΡΠΎΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠ»ΡΠΌΠ°Π·Π΅Π½ΠΈΠ»Π°, Ro 152 344 ΠΈ ΡΡΠ΄Π° ΠΌΠΎΠ΄Π΅Π»ΡΠ½ΡΡ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ
- 4. 5. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ [18Π ]ΡΠ»ΡΠΌΠ°Π·Π΅Π½ΠΈΠ»Π° Ρ Π²ΡΡΠΎΠΊΠΎΠΉ ΡΠ΄Π΅Π»ΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ ΠΈΠ· Ro
- 4. 6. 1. In Vitro Π°Π²ΡΠΎΡΠ°Π΄ΠΈΠΎΠ³ΡΠ°ΡΠΈΡ
- 4. 6. 2. ΠΠΠ’ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅
- 4. 6. 3. ΠΠ½Π°Π»ΠΈΠ· ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠΎΠ² Π² ΠΏΠ»Π°Π·ΠΌΠ΅ ΠΊΡΠΎΠ²ΠΈ
- 4. 7. ΠΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ [|8Π ]ΡΠ»ΡΠΌΠ°Π·Π΅Π½ΠΈΠ»Π° Π² ΠΠΠ’
Π‘ΠΏΠΈΡΠΎΠΊ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
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