Исследование механизмов индукции цитохрома Р450 подсемейства 2В в печени экспериментальных животных
Диссертация
Цитохром Р450 (CYP), представленный мультигенным суперсемейством, является одним из ключевых ферментов микросомальной монооксигеназной системы, ответственной за метаболизм ксенобиотиков и эндогенных соединений в живых организмах (Ляхович, Цырлов, 1978). Важнейшим свойством множественных форм цитохрома Р450 является их способность к индукции, то есть к усилению ферментативной активности фермента… Читать ещё >
Содержание
- ГЛАВА 1. ОБЗОР ЛИТЕРАТУРЫ
- 1. 1. Цитохром Р450 — ключевой фермент микросомальной монооксигеназной системы. 12 ® 1.1.1 Способность цитохромов Р450 к индукции
- 1. 2. Цитохромы Р450 подсемейства 2В
- 1. 3. Индукция генов CYP2B под действием фенобарбитала
- 1. 3. 1. Механизм активации генов CYP2B под действием фенобарбитала
- 1. 3. 2. Характеристика дистального промотора генов CYP2B
- 1. 3. 3. CAR и другие белки, взаимодействующие с элементами дистального промотора генов СУР2В
- 1. 3. 4. CAR рецептор-опосредованная сигнальная трансдукция и индукция генов CYP2B
- 1. 3. 5. Участие коактиваторов в CAR-опосредованной активации экспрессии генов
- 1. 3. 6. Характеристика проксимального промотора генов CYP2B
- 1. 3. 8. Белки, взаимодействующие с проксимальным промотором генов CYP2B млекопитающих
- 1. 3. 9. Вклад проксимального и дистального промоторов в общий механизм индукции генов CYP2B
- 1. 3. 10. Другие регуляторные элементы генов CYP2B. ft 1.4 Индукция активности CYP2B под действием индукторов ФБ-типа
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