Фотодинамическая инактивация ионных каналов, образованных мини-грамицидином в бислойной липидной мембране
Диссертация
Последующие работы, выполненные в этой группе и еще нескольких группах, позволили понять структурные аспекты регуляции работы, т. е. открывания и закрывания, ионных каналов. За это свойство отвечает расположенная на противоположной стороне от ионного фильтра часть молекулы белка, которая имеет возможность осуществлять механические движения в ответ на приложение трансмембранного электрического… Читать ещё >
Содержание
- СПИСОК СОКРАЩЕНИЙ
- X. ОБЗОР ЛИТЕРАТУРЫ
- 1. 1. Структура и функция грамицидина А
- 1. 1. 1. Структура грамицидина, А в органических растворителях
- 1. 1. 2. Структура грамицидина в липидных мембранах и мембрано-подобных средах
- 1. 1. 3. Ионный канал грамицидина, А в бислойных липидных мембранах
- 1. 2. Мини-грамицидин — укороченный аналог грамицидина А
- 1. 3. Фотосенсибилизированная инактивация ионных каналов в бислойных липидных мембранах
- 1. 3. 1. Основы фотодинамической терапии
- 1. 1. Структура и функция грамицидина А
- 1. 3. 3. Изучение кинетики распада-образования канала грамицидина, А методом сенсибилизированной фотоинактивации
- 1. 3. 4. Метод определения констант формирования и распада каналов грамицидина в мембране, основанный на фотодинамическом воздействии
- 3. 1. Одиночные каналы мини-грамицидина в липидной мембране
- 3. 1. 1. Изучение ионофорной активности мини-грамицидина в БЛМ на уровне одиночных каналов
- 3. 1. 2. Влияние толщины мембраны на образование одиночных каналов мини-грамицидина
- 3. 2. Зависимость электрического тока от концентрации ковалентного димера мини-грамицидина
- 3. 3. Изучение свойств ионных каналов мини-грамицидина методом сенсибилизированной фотоинактивации
- 3. 3. 1. Сравнение фоточувствительности мини-грамицидина и его ковалентного димера
- 3. 3. 2. Исследование кинетики фотоинактивации мини-грамицидина и его ковалентного димера в БЛМ
- 3. 3. 3. Исследование влияния толщины мембраны на характерное время фотоинактивации мини-грамицидина
- 3. 3. 4. Влияние толщины мембраны на характерное время фотоинактивации ковалентного димера мини-грамицидина
- 3. 4. Факторы, влияющие на характерное время фотоинактивации мини-грамицидина
- 3. 5. Влияние спонтанной кривизны липидов мембраны на ионофорную активность мини-грамицидина
- 3. 6. Изучение зависимости характерного времени фотоинактивации от величины индуцированного тока через мембрану для мини-грамицидина
- 3. 7. Ионофорная активность мини-грамицидина и грамицидина, А в липосомах
- 3. 8. Сравнение действия мини-грамицидина и грамицидина, А на выделенные митохондрии
- 3. 9. Действие мини-грамицидина и грамицидина, А на эритроциты
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