Частота спонтанных и индуцированных hprt-мутаций в лимфоцитах, их модуляция антиоксидантами и молекулярный анализ

Список литературы

1. Экоцид в СССР, Мерри Фешбах, Альфред Френдли-младший, Москва 1992.
2. Фогель Ф., Мотульски А., Генетика человека, «Мир», Москва, 1990.
3. Дубинин Н.П., 1994, Некоторые проблемы современной генетики, Из-во: Наука, Москва
4. Шевченко В.А., 1996, Оценка генетического риска облучения популяции человека, в кн.: Последствия Чернобыльской катастрофы: Здоровье Человека, Москва 1996, стр.: 50−67
5. Albertini R.J., J.A. Nicklas, J.P. O’Neill and S.H. Robinson, 1990, In Vivo somatic mutations in humans: measurement and analysis, Annu. Rev. Genet., 24, 305−326
6. Garner R.C., P.B. Farmer, G.T. Steel and A.S. Wright, Editors, Human Carcinogen Exposure, Biomonitoring and Risk Assessment, Oxford Univercity Press, 1991.
7. Albertini R.J., 1982, Studies with T-lymphocytes: An Approach to Human Mutagenicity Monitoring, In: Banbury Report, 13, Indicators of Genotoxic Exposure, pp. 393−412.
8. Umar A. and T.A. Kunkel, 1996, DNA replication fidelity, mismatch repair and genome instability in cancer cells, Eur. J. Biochem., 238 (2), 297−307.
9. Lindahl Т., 1993, Instability and decay of the primary structure of DNA, Nature, 362, 709−715.
10. Modrich P. and R. Lahue, 1996, Mismatch repair in replication fidelity, genetic recombination, and cancer biology, Annu. Rev. Biochem., 65, 101−133.
11. Mullaart E., P.H.M. Lohman, F. Berends, J. Vijg, 1990, DNA damage metabolism and aging, Mutat. Res., 237, 189−210.
12. Barnett Y.A., C.M. King, 1995, An investigation of antioxidant status, DNA repair capacity and mutation as a function of age in humans, Mutat. Res., 338, 115−128.
13. Vishwanath R. and P. Shannon, 1997, Do sperm cell age? A review of the physiological changes in sperm during storage at ambient temperature. Reprod. Fertil. Dev., 9(3), 321−331.
14. Gaulden M.E., 1992, Maternal age effect: the enigma of Down syndrome and other trisomic conditions, Mutat. Res., 296, 69−88.
15. Hemminki K., A. Dipple, D.E.G. Shuker, F.F. Kadlubar, D. Segerback, H. Bartsch, Editors, DNA adducts, IARC Scientific Publications, No 125, Lyon, 1994.
16. Grzybowska E., K. Hemminki, J. Szeliga, M. Chorazy, 1993, Seasonal variation of aromatic DNA adducts in human lymphocytes and granulocytes, Carcinogenesis, 14, 2523−2526.
17. Albertini R.J., Castle K.L., and W.R. Borcherding, 1982, T-cell cloning to detect the mutant 6-thioguanine-resistant lymphocytes present in human peripheral blood, Proc. Natl. Acad. Sci. USA, 79, 6617−6621.
18. O’Neill J.P., L.M. Sullivan, and R.J. Albertini, 1990, In vitro induction, expression and selection of thioguanine-resistant mutants with human T-lymphocytes, Mutat. Res., 240, 135−142.
19. Hakoda M., M. Akijama, S. Kyoizumi, A.A. Awa, M. Yamakido, M. Otake, 1988, Increased somatic cell mutant frequency in atomic bomb survivors, Mutat Res., 201, 39−48.
20. Sanderson B J., J.L. Dempsey, A.A. Morley, 1984, Mutations in human lymphocytes: effect of X- and UV-irradiation, Mutat. Res., 140, 223−227.
21. Langlois R.G., W.L. Bigbee, R.H. Jensen, 1986, Measurements of the frequency of human erythrocytes with gene expression loss phenotypes in the glycophorin A locus, Hum. Genet., 74, 353−362.
22. Grant S.G., and W.L. Bigbee, 1993, In vivo somatic mutation and segregation at the human glycophorin A (GPA) locus: phenotypic variation encompassing both gene-specific and chromosomal mechanisms, Mutation Res., 288, 163−172.
23. Janatipour M., K.J. Trainor, R. Kutlaka, D.R. Turner, and A.A. Morley, 1988, Mutations in human lymphocytes studied by an HLA selection system, Mutat. Res., 198, 221−226.
24. Kushiro J., Y. Hirai, Y. Kusunoki, K. Dohi, N. Nakamura, and M. Akiyama, 1992, Development of a flowcytometric HLA-A locus mutation assay for human peripheral blood lymphocytes, Mutat. Res., 272, 17−29.
25. Pandolfi P.P., 1998, Knoking in and out genes and trans genes: the use of the engineered mouse to study normal and aberrant hemopoiesis, Semin. Hematol., 35(2), 136−148.
26. Neuberger M.S., M.R. Ehrenstein, N. Klix, C.J. Jolly, J. Yelamos, C. Rada, C. Milstein, 1998, Monitoring and interpreting the intrinsic features of somatic hypermutation, Immunol. Rev., 162, 107−116.
27. Hanford M.G., B.C. Rashton, L.C. Goven, R.A. Farber, 1998, Microsatellite mutation in cancer cell lines deficient or proficient in mismatch perair, Oncogene, 16, 2389−2393.
28. DubrovaY.E., V.N. Nesterov, N.G. Krouchinsky, V.A. Ostapenko, R. Neumann, D.L. Neil, A.J. Jeffreys, 1996, Human minisatellite mutation rate after Chernobyl accident, Nature, 380 (6576), 683−686.
29. Lodish H., D. Baltimore, A. Berk, S.L. Zipursky, P. Matsudaira, J. Darnell, 1995, Molecular Cell Biology, Chapter 17: Cellular Energetics, 739−777, Third Edition, Scientific American Books.
30. Ames B.N., M.K. Shigenaga, T.M. Hagen, 1993, Oxidants, antioxidants, and the degenerative diseases of aging, Proc. Natl. Acad. Sci. USA, 90, 7915−7922.
31. Wolf R., D. Wolf, V. Ruocco, 1998, Vitamin E: the radical protector, J.Eur. Acad.Dermatol., 10, 103−117.
32. Чережанова JI.B., Е.Б. Котлярова, К. П. Гарина, 1983, Влияние а-токоферола на семена пшеницы при комбинированном воздействи с мутагеном, Цитология и Генетика, 17, 5, 40−45.
33. Berstein R.L., R. Mahurin, В.М. Hovard, 1979, Apparent antimutagenesis dy some natural products, Microb. Genet. Bull., 47, 16−19.
34. Odin A.P., 1997, Vitamins as antimutagens: advantages and some possible mechanisms of antimutagenic action, Mutat. Res., 386, 39−67.
35. Rock C.L., 1997, Carotenoids: biology and treatment, Pharmacol. Ther., 75 (3), 185−197.
36. Banhegyi G., L. Braun, M. Csala, F. Puskas, J. Mandl, 1997, Ascorbate metabolism and its regulation in animals, Free Radic. Biol. Med., 23(5), 793−803
37. Sram R.J., L. Dobias, A. Postarkova, P. Rossner, L. Janka, 1983, Effect of ascorbic acid profilaxis on the frequency of chromosomal aberration in the peripheral lymphocytes of coal-tar workers, Mutat. Res., 120, 181−186.
38. Sram R.J., M. Cerna, N. Hola, 1986, Effect of ascorbic acid and profilaxis in groups occupationally exposed to mutagens, in: C. Ramel and B. lambert (Eds.), Genetic Toxicology of Environmental Chemicals, Part B, Liss, New York, 327−335.
39. Orr W.C. and R.S. Sohal, 1994, Extension of life-span by overexpression of superoxide dismutase and catalase in drosophila melanogaster, Science, 263, 1128−1130.
40. Przedborski S., E.A. Schon, 1998, Loss of ROS a radical response, Nature Genetics, 18 (2), 99−100.
41. King C.M., H.E. Bristow-Craig, E.S. Gillespie, Y.A. Barnett, 1997, In vivo antioxidant status, DNA damage, mutation and DNA repair capacity in cultured lymphocytes from healthy 75- to 80-year-old humans, Mutat. Res., 377, 137−147.
42. Shacter E., R.L. Lopez, E.J. Beecham, S. Janz, 1990, DNA damage induction by phorbol ester-stimulated neutrophils is augmented by extracellular cofactors. Role of histidine and metals, J. Biol. Chem., 265 (1), 6693−6699.
43. Yamashina K., B.E. Miller, G.H. Heppner, 1986, Macrophage-mediated induction of drug-resistant variants in a mouse mammary tumor cell line, Cancer Res., 46 (5), 2396−2401.
44. Beasley R.P., 1988, Hepatitis B virus. The major etiology of hepatocellular carcinoma, Cancer, 61 (10), 1942−1956.
45. Tabor E., K. Kobayashi, 1992, Hepatitis C virus, a causative infectious agent of non-A, non-B hepatitis: prevalence and structure summary of a conference on hepatitis C virus as a cause of hepatocellular carcinoma, J. Natl. Cancer, 84 (2), 86−90.
46. Peto R., A.D. Lopez, J. Boreham, M. Thun, CJr. Heath, 1992, Mortality from tobacco in developed countries: inderect estimation from mational vital statistics, Lancet, 339(8804), 1268−1278.
47. Harman D., 1956, Aging: a theory based on free radical and radiation chemistry, J. Gerontol., 11, 298−300.
48. Gerschman R., D.L. Gilbert, S.W. Nye, P. Dwyer, W.O. Fenn, 1954, Oxigen poisoning and X-irradiation: a mechanism in common, Science, 19, 623−629.
49. Harman D., 1994, Free-radical theory of aging. Increasing the functional life span, Ann. NY Acad. Sci., 717, 1−15.
50. Sohal R.S., The free radical hypothesis of aging: an appraisal of the current status, Aging Clin. Exp. Res., 5, 3−17.
51. Wallace D.C., M.D. Broun, S. Melov, B. Graham, M. Lott, 1998, Mitochondrial biology, degenerative diseases and aging, Biofactors, 7 (3), 187 190.
52. Hudson E.K., N. Tsuchiya, R.G. Hansford, 1998, Age-associated changes in mitochondrial mRNA expression and translation in the Wistar rat heart, Mech. Ageing Dev., 103(2), 179−193.
53. Sohal R.S., R.G. Allen, 1990, Oxidative stress as a causal factor in differentiation and aging: a unifying hypothesis, Exp. Gerontol., 25 (6), 499 522.
54. Salas-Vidal E., H. Lomeli, S. Castro-Obregon, R. Cuervo, D. Escalante-Alcalde, L. Covarrubias, 1998, Reactive oxygen species participate in the control of mouse embryonic cell death, Exp. Cell Res., 238 (1), 136−147.
55. Medvedev Z.A., 1990, An attempt at a rational classification of theories of aging, Biol. Rev., 65, 375−398.
56. Eker A.R.M. 1983, Photorepair process, in: G. Montagnoli (Ed) Molecular Models of Photoresponsiveness, Plenum Press, New York, pp. 109−132.
57. Lindahl T., 1982, DNA repair enzymes, Annu. Rev. Biochem.,-51, 61−87.
58. Kanaar R. and J.H. Hoeijmakers, 1997, Recombination and joining: different means to the same ends, Genes Funct., 1 (3), 165−174.
59. Lindahl T., P. Karran, R.D. Wood, 1997, DNA excision repair pathways, Cur. Opinion in Gen. & Devel., 7, 158−169.
60. Krokan H.E., R. Standal, G. Slupphaug, 1997, DNA glycosylases in the base excision repair of DNA, Biochem. J., 325, 1−16.
61. Bohr V.A., 1991, Gene specific DNA repair, Carcinogenesis, 12 (11), 19 831 992.
62. Toft N.J., Arends M.J., 1998, DNA mismatch repair and colorectal cancer, J. Pathol., 185(2), 123−129.
63. Tsukamoto Y., H. Ikeda, 1998, Double-strand break repair mediated by DNA end-joining, Genes Cells, 3 (3), 135−144.
64. Evans M.K., B.G. Taffe, C.C. Harris, V.A. Bohr, 1993, DNA strand bias in the repair of the p53 gene in normal human and xeroderma pigmentosum group C fibroblasts, Cancer Res., 53 (22), 5377−5381.
65. Scicchitano D.A., I. Mellon, 1997 Transcription and DNA damage: a link to a kink, Environ. Health Perspect., 105 (1), 145−153.
66. Lehmann A.R., 1998, Dual functions of DNA repair genes: molecular, cellular, and clinical implications, Bioessays, 20 (2), 146−155.
67. Seegmiller J.E., F.M. Rosenbloom, W.N. Kelley, 1967, Enzyme defect association with a sex-linked human neurological disorder and excessive purine synthesis, Science, 155, 1682−1684.
68. Lesch M., W.L. Nyhan, 1964, A familial disorder of uric acid metabolism and central nervous system function, Am. J. Med., 36, 561−570.
69. Strauss G.H. and R.J. Albertini, 1979, Enumeration of 6-thioguanine resistant peripheral blood lymphocytes in man as potential test for somatic cell mutation arising in vivo, Mutat. Res., 61, 353−359.
70. Albertini R.J., R.L. Kastle, W.R. Borcherding, 1982, T-cell cloning to detect the mutant 6-thioguanine-resistant lymphocytes present in human peripheral blood, Proc. Natl. Acad. Sci. USA, 79 (21), 6617−6621.
71. O’Neill J.P., L.M. Sullivan and R.J. Albertini, 1990, In vitro induction, expression and selection of thioguanine-resistant mutants with human T-lymphocytes, Mutat. Res., 240, 135−142.
72. Zhang X.B., C. Urlando, K.S. Tao, J.A. Heddle, 1995, Factors affecting somatic mutation frequencies in vivo, Mutat. Res., 338, 189−201.
73. Jones I.M., C.B. Thomas, B. Tucker, C.L. Thompson, P. Pleshanov, I. Yorobtsova, D.H. Moorell, Impact of age and environment on somatic mutation at the hprt gene of T lymphocytes in human, Mutat. Res., 338, 129 139.
74. Migeon B.R., Non-random X chromosome inactivation in mammalian cells, Cytogenet. Cell Genet., 80 (1−4), 142−148.
75. Edwards A., H. Voss, P. Rice, A. Civitello, J. Stegemann, C. Schwager, J. Zimmermann, H. Erfle, C.T. Caskey, W. Ansorge, 1990, Automated DNA sequencing of the human hprt locus, Genomics, 6 (4), 593−608.
76. Eads J.C., G. Scapin, Y. Xu, C. Grudmeyer, and J.C. Sacchettini, 1994, The crystal structure of human HPRT with bound GMP, Cell, 78, 325−334.
77. Morley A.A., K.J. Trainor, R. Seshadri, and R.G. Ryall, 1983, Measurement of in vivo mutations in human lymphocytes, Nature, 302, 155−156.
78. Yang T.P., P.I. Patel, A.C. Chinault, J.T. Stout, L.G. Jackson, B.M. Hildebrand, C.T. Caskey, 1984, Molecular evidence for new mutation at the hprt lokus in Lesch-Nyhan patients, Nature, 310, 412−414.
79. Andersson B., S. Fait, B. Lambert, 1992, Strand specificity for mutation induced by (+)-anti BPDE in the hprt gene in human T-lymphocytes, Mutat. Res., 269, 129−140.
80. Gocke E.F., M.T. Eckhardt, M.T. King, D. Wild, 1983, Autoradiographic detection of 6-TG-resistant lymphocytes of mice: a novel system in somatic mutagenesis testing, Mutation Res., 113, 455−465.
81. Dempsey, J.L. and A.A. Morley (1986), Measurement of in vivo mutant frequency in lymphocytes in the mouse, Environ. Mutagen., 8, 385−391.
82. O’Neill J.P., L.M. Sullivan, R.J. Albertini, 1990, In vitro induction, expression and selecrion of thioguanine-resistant mutants with human T-lymphocytes, Mutat. Res., 240 (2), 135−142.
83. Yang J.L., V.M. Maher, and J.J. McCormick, 1989, Amplification and direct nucleotide sequencing of cDNA from the lysate of low numbers of diploid human cells, Gene, 83, 347−354.
84. Osterholm A.-M., S. Falt, B. Lambert, S.-M. Hou, 1995, Classification of mutations at the human hprt-locus in T-lymphocytes of bus maintenance workers by muliplex -PCR and reverse transcriptase-PCR analysis, Carcinogenesis, 16, 1909−1912.
85. Beyer W.H. (Ed.), i966, CRC Handbook of tables for probability and statistics, 2nd., CRC Press, Boca Raton, FL.
86. Snedecor G.W., W. G Cochran, 1967, Sampling from the binominal distribution. In Snedecor G.W. and W.G. Cochran, Statistical Methods, 6th Edn., The Iowa State University Press, IA, pp223−227.
87. Jones, I.M., K. Burkhart-Schuly and A.V. Carraro (1985), A method to quanttify spontaneous and in vivo induced thioguanine-resistant mouse lymphocytes, Mutation Res., 147, 97−105.
88. Dempsey, J.L. and A.A. Morley (1986), Measurement of in vivo mutant frequency in lymphocytes in the mouse, Environ. Mutagen., 8, 385−391.
89. Grdina, D.J., Y. Kataoka, I. Basis and J. Perrin, (1992) The radioprotector WR-2721 reduced neutron-induced mutations of the HPRT locus in mouse splenocytes when administered prior to the following irradiation, Cancirogenesis, 13, 811−814.
90. Albertini, R.J., L.M. Sullivan, J.K. Berman, C.J. Greene, J.A. Stewart, J.M. Silveira and J.P. O’Neill (1988), Mutagenecity monitoring in humans by autoradiographic assay for mutant T-lymphocytes, Mutation Res., 204, 481−492.
91. Albertini, R.J., J.A. Nicklas, J.P. O’Neill and S.H. Robison (1990), In vivo somatic mutations in humans: measurement and analysis, Annu. Rev. Genet., 24, 305−326
92. Morley A.A., S. Cox and R. Holliday, 1982 Human lymphocytes resistant to 6-thioguanine increase with age, Mech. Ageing Dev., 19, 21−26.
93. Trainor, K.J., D.J. Wigmore, A. Chrysostomu, J.I.Dempsey, R. Seshardi and A.A. Morley, 1984, Mutation frequency in human lymphocytes increases with age, Mech. Ageing Dev., 27, 83−86.
94. Dempsey, J.L., M. Pfeiffer and A.A. Orley, 1993, Effect of dietary restriction on in vivo somatic mutation in mice, Mutation Res., 292, 141−146.
95. Saderson, B.J.S., Dempsey J.L., Morley A.A., 1984, Mutations in human lymphocytes: Effect of X- and UV-irradiation. Mutation Res., 140, 223−227
96. Cochrane, J.E. and Skopek T.R., 1994, Mutagenicity of butadiene and its epoxide metabolites: 2. Mutation spectra of butadiene and diepoxybutane at hprt locus in splenic T-cells from exposed B6C3F1 mice. Cfrcinogenesis, 15, 719 723
97. O’Neill J.P., L.M. Sullivan and R.J. Albertini, 1990, In vitro induction, expression and selection of thioguanine-resistant mutants with human T-lymphocytes, Mutat. Res., 240, 135−142.
98. Albertini R.J., K.L. Castle and W.R. Borcherding, 1982, T-cell cloning to detect the mutabt 6-TG-resistant lymphocytes present in human peripheral blood, Proc. Natl. Acad. Sci. USA, 79, 6617−6621.
99. Albertini R.J., J.P.O'Neill, J.A. Nicklas, N.H. Heintz, P.C. Kelleher, 1985, Alterations of the hprt gene in human in vivo-derived 6-TG-resistant T-lymphocytes, Nature, 318, 369−371.
100. IARC, 1994, Some industrial chemicals, Monographs on the evaluation of carcinogenic risks to humans. International Agency for Research on Cancer, Lyon.
101. Bastlova, T., P. Vodicka, P. Peterkova, K. Hemminki, B. Lambert, 1995, Styrene oxide induced HPRT mutations, DNA adducts and DNA strand breaks in cultured human T-lymphocytes, Carcinogenesis, 16, 2357−2362
102. Deubel, W., I.D. Bassukas, W. Schlereth, R. Lorenz, K. Hempel, 1996, Age dependent selection against HPRT deficient T lymphocytes in the HPRT1 heterozygous mouse, Mutat. Res., 351, 67−77.
103. Lesch, M., W.L. Nyhan, 1964, A familial disorder of uric acid metabolism and central nervous system function, Am. J. Med, 36,561−567.
104. Engle S.J., D.E. Womer, P.M. Davies, G. Bovin, A. Sahota, H.A. Simmonds, P.J. Stambrook, J.A. Tischfield, 1996, HPRT-APRT-deficient mice are not a model for lesch-nyhan syndrome, Hum. Mol. Genet., 5 (10), 1607−1610.
105. Cariello N.F. and T.R. Skopek, 1993, Analysis of mutations occuring at the human hprt locus, J. Mol. Biol., 231, 41−57.
106. Steen A-M., K.G. Meyer, L. Recio, 1997, Analysis of hprt mutations occuring in human TK6 lymphoblastoid cells following exposure to 1,2,3,4-diepoxybutane, Mutagenesis, 12, 2, 61−67.
107. Slonina N., E. Neronova, T. Kharchenko, A. Nikiforov, 1997, Increased level of chromosomal aberration in lymphocytes of Chernobyl liquidators 6−10 years after the accident, Mutat. Res., 379 (2), 121−125.
108. Moore D.H., J.D. Tucker, I.M. Jones, R.G. Langlois, P. Pleshanov, I. Vorobstova, R. Jensen, 1997, A study of the effect of exposure on cleanup workers at the Chernobyl nuclear reactor accident using multiple end points, Radiat. Res., 148 (5), 463−475.
109. Bochkov N.P. and N.P. Kuleshov, 1972, Age sensitivity of human chromosomes to alkylating agents, Mutatin Res., 14, 3, 345−353
110. Джохадзе Т.А., Т.А. Лежава, 1994, Изучение структурных мутаций хромосом, индуцированных солями тяжелых металлов, при старении in vivo и in vitro, Генетика, 30, 12, 1630−1632.
111. Donner D.B., N.Y. Holbrook, 1990, Alterations in gene expression with aging. In: Handbook of the Biology of Aging, 3-rd edition, Eds.: E.L. Schneider, J.W. Rowe, Acad. Press, San Diego, pp. 97−115.
112. Austad S.N., 1997, Why We Age?, Published by John Wiley & Sons, Inc., New York, Toronto.
113. Medvedev Z.A., 1990, An attempt at a rational classification of theories of ageing, Biol. Rev., 65, 375−398
114. NCR, Mammalian Models for Research on Aging: A report of the Institute of Lab. Animal Resources Committee on Animal Models for Research on Aging, 1981, Natl. Acad. Press, Washington D.C.
115. Balachandra Dass S., S.F. Ali, R.H. Heflich, D.A. Casciano, 1997, Frequency of spontaneous and induced micronuclei in the peripheral blood of aging mice, Mutation Res., 381, 105−110
116. Gerschman R., D.L. Gilbert, S.W. Nye, P. Dwyer, W.O. Fenn, 1954, Oxigen poisoning and X-irradiation: a mechanism in common, Science, 19, 623−629.
117. Orr C., R.S. Sohal, 1994, Extension of Life-span by overexpression of superoxide dismutase and catalase in Drosophilia melanogaster, Science, 263, 1128−1130.
118. Ames B.N., M.K. Shigenada, and T.M. Hagen, 1993, Oxidants, antioxidants, and degenerative diseases of aging, Proc. Natl. Acad. Sci. USA, 90, 7915−7922.
119. Swartz H.M. and K. Mader, 1995, Free radical in aging: theories, facts, and artifacts. In K. Esser and G.M. Martin (eds.), Molecular Aspekts of Aging, Wiley, Chichester, pp. 77−97.
120. Beckman K.B. and B.N. Ames, 1998, The free radical theory of aging matures, Physiol. Rev., 78 (2), 547−581.
121. Stadtman E.R., 1995, The status of oxidatively modified proteins as a marker of aging. In K. Esser and G.M. Martin (eds.), Molecular Aspekts of Aging, Wiley, Chichester, pp. 129−143.
122. Sohal R.S. and W.C. Orr, 1995, Is oxidative stress a casual factor in aging? In K. Esser and G.M. Martin (eds.), Molecular Aspekts of Aging, Wiley, Chichester, pp. 109−127.
123. Stadtman E.R. and B.S. Berlett, 1997, Reactive Oxygen mediated protein oxidation in aging and disease, Chem. Res. Toxicol., 10, 485−494.
124. Mullaart E., P.H. Lohman, F. Berends and J. Vijg, 1990, DNA damage metabolism and aging, Mutatin Res., 237, 189−210.
125. Bohr V.A. and R.M. Anson, 1995, DNA damage, mutation and fine structure DNA repair in aging, Mutation Res., 338, 25−34.
126. Ames B.N., L.S. Gold, W.C. Willett, 1995, The causes and prevention of cancer, Proc. Natl. Acad. Sci. USA, 92, 5258−5265.
127. Anisimov V.N., 1994, Age related mechanisms of susceptibility to cancer. In I.S. Fentiman, S. Monfardini (eds.), Cancer in elderly, Oxford University Press, Oxford, pp. 1−10.
128. Gutler R.G., 1984, Antioxidants, aging and longevity. In W.A. Pryor (Eds.), Free radical in biology, Academic Press, New York, pp. 371−437.
129. Bezlepkin V.G., N.P. Sirota, A.I. Gaziev, 1996, The prolongation of survival in mice by dietary antioxidants depends on their age by the start of feeding this diet, Mech. Aging. Dev., 92 (2−3), 227−234.
130. Orr W.C. and R.S. Sohal, 1994, Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster, Science, 263, 1128−1130.
131. Kohn R.R., 1971, Effect of antioxidants on life span of C57BL mice, J. Gerontology, 26, 378−380.
132. Comfort A., I. Youhotsky-Gore and K. Pathmanathan, 1971, Effect of ethoxyquin on the longevity of C3H mice, Nature, 229, 254−255.
133. Boone C.W. and L.W. Wattenberg, 1994, Current strategies of cancer chemoprevention: 13th cancer seminar, Cancer Res., 54, 3315−3318.
134. Keloff G.J., C.W. Boone, V.E. Steele, R.J. Fay, R.A. Luber, J.A. Crowell, and C.C. Sigman, 1994, Mechanistic consideration in chemopreventive drug development, J. Cell. Biochemistry, syuppL, 20, 1−24.
135. Meyskens F.L. and K.N. Prasad (Eds.), 1986, Vitamins and cancer, Human cancer prevention by vitamins and micronutrients, Humana Press, Clifton, New Jersey.
136. Hayatsu H., S. Arimoto and T. Negishi, 1988, Dietary inhibitors of mutagenesis and carcinogenesis, Mutation Res., 202, 429−446.
137. Bronzetti G., H. Hayatsu, S. De Flora, M.D. Waters and D.M. Shankel (Eds.), 1992, Antimutagenesis and anticarcinogenesis mechanisms 3, Plenum, New York.
138. El-Nahas, S.M., F.E. Mattar and A.A. Mohamed, 1993, Radioprotective effect of vitamins C and E, Mutation Res., 301,143−147
139. Kuroda Y., A.K. Jaim, H. Tezuka and T. Kada, 1992, Antimutagenisity in cultured mammalian cells, Mutation Res., 267, 201−209/
140. Odin A.P., 1997, Vitamins as antimutagens: Advantages and some possible mechanisms of antimatagenic action, Mutation Res., 386, 39−67.
141. Simic M.G. and D.S. Bergtold, 1991, Dietary modlation of DNA damage in human, Mutation Res., 250, 17−24.
142. Branda R.F., R.J. Albertini, 1995, Effect of dietary components on hprt mutant frequencies in human T-lymphocytes, Mutation Res., 346, 121−127.
143. Barnett Y.A., C.M. King, 1995, An investigation of antioxidant status, DNA repair capacity and mutation as a function of age in human, Mutation Res., 338, 115−128.
144. King C.M., H.E. Bristow-Craig, E.S. Gillespie, Y.A. Barnett, 1997, In vivo antioxidant status, DNA damage, mutation and DNA repair capacity in cultured lymphocytes from healthy 75- to 80-year-old humans, Mutation Res., 377, 137−147.
145. Ames B.N., M.K. Shigenaga and T.M. Hagen, 1993, Oxidants, antioxidants, and the degenerative diseases of aging, Proc. Natl. Acad. Sei. USA, 90, 79 157 922.
146. Longnecker M.P., P.A. Newcomb, R. Mittendorf, E.R. Greenberg, W.C. Willett, 1997, Intake of carrots, spinach, and supplements containing vitamin A in relation to risk of breast cancer, Cancer Epid., Biom. and Prev., 6, 887−892.
147. Ushakova T., H. Melkonyan, L. Nikonova, V. Gogvadze, A. Zhykova, A. Gaziev, R. Bradbury, 1996, The effect of dietary supplements on gene expression in mice tissues, Free Radical Biol. And Med., 20, 279−284.
148. Edvards A., H. Voss, P. Rice, A. Civitello, J. Stegemann, C. Schwager, J. Zimmermann, H. Erfle, C.T. Caskey and W. Ansorge, 1990, Automated DNA sequencing of the human hprt locus, Genomics, 6, 593−608.
149. Cariello N.F., 1994, Software for the analysis og mutations at the human hprt gene, Mutation Res., 312, 173−185.
150. Burkhart-Schultz K., C.L. Thompson and I.M. Jones, 1996, Spectrum of somatic mutation at the hypoxanthine phosphoribosyltransferase (hprt) gene of healthy people, Carcinogenesis, 17, 9, 1871−1883.
151. Cooper D.N. and M. Krawczak, 1993, Human gene mutation. Bios. Scientific Publishers, Oxford, UK.
152. Greenblatt M.S., W.P. Bennett, M. Hollstein and C.C. Harris, 1994, Mutations inthe p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis, Cancer Res., 54, 4855−4878.
153. Vogelstein B., K.W. Kinzler, 1993, The multistep nature of cancer, Trends Genet., 9(4), 138−141.
154. Cariello N.F., L. Cui, T.R. Skopek, 1994, In vitro mutational spectrum of alfatoxin B1 in the human HPRT gene, Cancer Res., 54, 4436−4441.
155. Andersson B., S. Fait, and B. Lambert, 1992, Strand specificity for mutations indused by (+)-anti BPDE in the hprt gene in human T-lymphocytes, Mutation Res., 269, 129−140.
156. Bastlova T., B. Andersson, B. Lambert, and A. Kolman, 1993, Molecular analysis of ethylene oxide-induced mutations at the HPRT locus in human diploid fibroblasts, Mutation Res., 287, 283−292.
157. McGregor W.G., Y.M. Maher, and J.J. McCormic, 1994, Kinds and locations of mutations induced in the hprt gene of human T-lymphocytes by 1-nitrosopyrene, including those caused by V (D)J recombinase, Cancer Res., 54, 4207−4213.
158. Vrieling H., J. Venema, M.-L. Van Rooyen, A. Van Hoffen, P. Menichini, A.A. van Zeeland, 1991, Strand specificity for UY-induced DNA repair and mutations in the Chinese hamster HPRT gene, Nucleic Acid Res., 19, 2411−2415
159. Fuskoe J.C., L.J. Zimmerman, A. Fekete, R.W. Setzzer, and B.J.F. Rossiter, 1992, Analysis of X-ray-induced HPRT mutations in CHO cells: Insertions and deletions, Mutation Res., 269, 171−183.
160. Bastlova T" P. Vodicka, K. Peterkova, K. Hemminki, and B. Lambert, 1995, Styrene oxide-induced HPRT mutations, DNA adducts and DNA strand breaks in cultured human lymphocytes, Carcinogenesis, 16, 2357−2362.
161. Vodicka P., L. Vodickova, K. Trejbalova, R.J. Sram, and K. Hemminiki, 1994, Persistence of 06-guanine DNA adducts in styrene-exposed lamination workers determined by 32P-postlabelling, Carcinogenesis, 15, 1949−1953.