Клинико-иммунологическая характеристика больных ревматоидным артритом при различных аллельных вариантах генов ФНО-[А] (-308) и ИЛ-1[В] (+3953)
![Диссертация: Клинико-иммунологическая характеристика больных ревматоидным артритом при различных аллельных вариантах генов ФНО-[А] (-308) и ИЛ-1[В] (+3953)](https://westud.ru/work/3322666/cover.png)
Впервые получены данные о распределении аллельных вариантов гена ИЛ-1р (+3953) ехоп 5 среди жителей Сибирского региона. Установлено, что частота распределения гомозиготного варианта С/С (49,03%) и гетерозиготного варианта С/Т (44,23%) преобладает над частотой гомозиготного варианта Т/Т (6,7%). Впервые получены данные о распределении генотипов генов ИЛ-1Р (+3953) ехоп 5 и промоторного участка… Читать ещё >
Содержание
- СПИСОК СОКРАЩЕНИЙ
- ГЛАВА 1. ОБЗОР ЛИТЕРАТУРЫ
- 1. Ревматоидный артрит. Роль провоспалительных медиаторов в патогенезе
- 1. 1. Патогенетическая характеристика ревматоидного артрита
- 1. 2. Роль локальной и системой продукции провоспалительных цитокинов при ревматоидном артрите
- 2. Особенности анемии при ревматоидном артрите
- 2. 1. Обмен железа при ревматоидном артрите
- 2. 2. Роль эритропоэтина в регуляции кроветворения при ревматоидном артрите
- 2. 3. Роль провоспалительных цитокинов в развитии анемии при ревматоидном артрите
- 3. Полиморфизм генов цитокинов и его влияние на течение и исход различных заболеваний
- 4. Полиморфизм генов ФНО-а и ИЛ-1 |3 при РА в различных популяциях
- 4. 1. Полиморфизм гена ФНО-а при ревматоидном артрите
- 4. 2. Полиморфизм гена ИЛ-1Р при ревматоидном артрите
- 5. Антицитокиновая терапия ревматоидного артрита
- 1. Ревматоидный артрит. Роль провоспалительных медиаторов в патогенезе
- ГЛАВА 2. МАТЕРИАЛЫ И МЕТОДЫ
- ГЛАВА 3. РЕЗУЛЬТАТЫ СОБСТВЕННЫХ ИССЛЕДОВАНИЙ
- 1. Анализ распределения аллельных вариантов и генотипов генов ИЛ-1(3 и ФНО-а среди больных РА и здоровых жителей Сибирского региона
- 2. Уровень продукции ИЛ-1|3 и ФНО-а МНК ПК у больных РА в сравнении со здоровыми лицами и в зависимости от аллельных вариантов генов ИЛ-ip и ФНО-<�х
3. Уровень цитокинов в сыворотке крови, пролиферативная активность МНК ПК и показатели иммунного статуса у больных РА в сравнении со здоровыми донорами и в зависимости от генотипов генов ФНО-а и ИЛ-1 (3.
4. Клинико^иммунологические особенности больных ревматоидным артритом с развитием анемии и без анемии и в зависимости от генотипов исследуемых генов.
ГЛАВА 4. ОБСУЖДЕНИЕ РЕЗУЛЬТАТОВ СОБСТВЕННЫХ ИССЛЕДОВАНИЙ.
ВЫВОДЫ.
Список литературы
- Белошевский В.А., Минаков Э. В. Анемия при хронических заболеваниях//- 1995-Воронеж.
- Верхоеф Г. Е., Применение гемопоэтических ростковых факторов-модификаторов биологического ответа при миелопластических синдромах. // Гематол. и трансфузиол.-1997- № 3, стр.11−13.
- Громова А. Ю. Симбирцев А.С. Полиморфизм генов семейства ИЛ-1 человека.// Цитокины и воспаление.- 2005- &bdquo-том 4, № 2, стр.3−12.
- Гублер Е. В. Вычислительные методы анализа и распознавания патологических процессов.// издательство «Медицина"-1978-, Москва.
- Дворецкий Л.И. Железодефицитные анемии.// РМФ. -1997-, V.5(19), р.1234−1242.
- Долгов В.В., Луговская С. А., Почтарь М. Е., Шевчнко Н. Г., Лабораторная диагностика нарушений обмена железа М, 1996.
- Елкманн В., Фандрей Л., Пагел X., Ингибирование продукции эритропоэтина воспалительными цитокинами.// Гематол. И трансфузиол.- 1997-, № 1, стр.16−19.
- Крысов С.В. Продукция цитокинов эритроидными ядросодержащими клетками фетальной печени человека. Автореф. Канд. Биол. Наук. Новосибирск, -2001- 16 стр.
- Лила A.M. Клинико- иммунологическиеоссобенности течения анемии и некоторых гемобластозов у больных ревматоидным артритом и системной красной волчанкой.//-1998-. Автореферат дис. д-ра мед. наук .СПб.
- П.Лукина Е. А, Сысоева Е. П, Франк Г. А, Лечение рекормоном (рекомбинантный эритропоэтин) больного с панцитопенией в крови и хроническим вирусным гепатитом С. // Тер.арх., -1996-, № 8, стр. 46−48.
- Насонов Е.Л. Почему необходима ранняя диагностика и лечение ревматоидного артрита?// РМЖ,-2002.- том 10 № 22.
- Насонова В.А. Ревматоидный артрит. Современная концепция патогенетической терапии.// Справочник по ревматологии 2-е изд. Л., Медицина, .-1983.- с. 25.
- Н.Натан Д. Г., Зифф К. А., Регуляция кроветворения. // Гематол. и трансфузиол., — 1994-, № 2, стр. 3−11.
- Смольникова М. В. Коненков В.И. Клиническая иммуногенетика заболеваний человека.// Мед. Иммунология Т. З, № 3−2001.- стр 379−389.
- Талыбов Ф. Ю. Кубанцева И.В. Жеребцов Л. А. и др. Плазмаферез в комплексном лечении ревматоидного артрита, осложненного анемией и нарушением свертывания крови. // Клин. Мед.- 1993-, № 5 стр. 48−50.
- Талыбов Ф.Ю. Плазмаферез в лечении анемии у больных ревматоидным артритом.// Ревматология — 1985- V.l.p. 75−76.
- Шевченко Н.Г. Лабораторная диагностика обмена железа (лекция).//Клин. лаб. диагн.-1997- V. 4, р. 25−32.
- Ярилин А. А. Основы иммунологии.//издательство «Медицина» -1999-, Москва.
- Adam Z., Krahulowa М., Spelda S et al.// Scr. Med.- 1995-, Vol 68, № 5−6, p.207−218.
- Aoki I, Homori M, Nakahara K, Higashi K, Ishikawa K. Effects of rhIL-1 alpha, rhIL-1 beta, and rhIL-1 receptor antagonist on erythroid progenitors (CFU-E and BFU-E) in human bone marrow // Exp.Hematol.-1995.-V.23.-N.3.-P.217−225.
- Arend W.P. The balance between IL-1 and IL-1 Ra in disease.//Cytokine Growth Factor Rev., -2002, — Vol 13, № 4−5, p.323−340.
- Arend W.P., Dayer J-M. Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis.// Arthritis Rheum. -199 033, p. 305−315.
- Barber RC, Aragaki CC, Rivera-Chavez FA, Purdue GF, Hunt JL, Horton JW. TLR4 and TNF-alpha polymorphisms are associated with an increased risk for severe sepsis following burn injury.// J Med Genet.-2004 Vol. 41(11), p.808−13.
- Baumann H., Gauldie J. The acute phase response.// Immunol. Today -1994.-V. 15, p. 74−80.
- Bayer A.N., Dessypris E.N., Goldwasser E., Krantz S.B. Bluynted erythropoietin responce to anaemia in rheumatid arthritis.// Br. J.Haematol.- 1987- V. 66, p. 559−564.
- Bazrafshani M.R., Hajeer A.H., Wer Oilier, Thornhill M.H. IL-1B and IL-6 gene polymorphisms encode significant risk for the development of recurrent aphthous stomatiyis (RAS)// Genes and immunity -2002-Vol.3-P. 302−305.
- Benczik M, Gaffen SL. The interleukin (IL)-2 family cytokines: survival and proliferation signaling pathways in T lymphocytes.// Immunol Invest. -2004 -V.33(2), p. 109−42.
- Bender S, Haubeck H.D., Van de Leur E. Interleukin-1 beta induces synthesis and secretion of interleukin-6 in human chondrocytes.// FEBS Lett -1990.- V.263,p. 321−324.
- Berczi I, Nagy E, Kovacs K, Horvath E. Regulation of humoral immunity in rats by pituitary hormones.// Acta Endocrinol.-1981-Vol. 98 p.506−13.
- Bidwell J, Keen L, Gallagher G, Kimberly R, Huizinga T, McDermott MF, Oksenberg J, McNicholl J et all. Cytokine gene polymorphism in human disease: on-line databases.// Genes and Immunity -1999-, V. 1. p.3−19.
- Bjarnason L. Enteroscopic diagnosis of small bowel ulceration — patients receiving much nonsteroidal anti-inflammatory drugs. In: Pounder R.E. (ed.) Resent advances in gastroenterology.// Edinburg: Churchill Livingstone -1988- V. 7, p. 23−46.
- Blake D.R., Hall N.D., Bacon P.A. et al. The importance of iron in rheumatoid disease.// Lancet -1981- V. 2 p. 1142−1144.
- Blick M., Sherwin S.A., Rosenblum M., Gutterman J: Phase Istudy of recombinant tumor necrosis factor in cancer patients.// Cancer Res -1987.- V. 47, p. 2986−2989.
- Bourantas K., Tsiara S., Konstantinidou P. et al.// J. exp. clin. Cancer Res- 1996-, Vol.15 № 4, p.371−374.
- Воусе B.F., Aufdemorte T.B., Garret R., Yates A.J.P., Mundy G.R. Effect of interleukin-1 on bone turnover in normal mice.// Endocrinology-1989.-V. 125, p. 1142−1150.
- Boyd H. K., Lappin T.R., Bell A.L. Evidence for impaired erythropoietin response to anaemia in rheumatoid disease.// Br. J.Rheumatol.- 1991- V. 30, p. 255−259.
- Brennan F.M., Field M., Chu C.Q., Feldman M., Maini R.N. Cytokine expression in rheumatoid arthritis.// Br.J.Rheumatology -1991.-V.30, Suppll, p. 76−80.
- Bresnihan B, Alvaro-Gracia JM, Cobby M, et al. Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist.//Arthritis Rheum -1998.-V.41, p.2196−204.
- Brinkman BM, Giphart MJ, Verhoef A et al. Tumor necrosis factor alpha-308 gene variants in relation to major histocompatibility complex alleles and Felty’s syndrome.// Hum Immunol-1994- V.41, p. 259−266.
- Brinkman BM, Kaijzel EL, Huizinga TW et al. Detection of a C-insertion polymorphism within the human tumor necrosis factor alpha (TNFA) gene. //Hum Genet -1995-V. 96, p. 493.
- Buchs N., di Giovine FS., Silvestri Т., et al. IL-1B and IL-lRa gene polymorphisms and disease severity in rheumatoid arthritis: interaction with their plasma levels.//Genes Immun.-2001.-V.2.-P.222−228.
- Bush KA, Farmer KM, Walker JS, Kirkham BW. Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgGl Fc fusion protein.// Arthritis Rheum -2002.- V. 46, p. 802−805.
- Chabaud M, Durand JM, Buchs N, Fossiez F, Page G, Frappart L, Miossec P. Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium.// Arthritis Rheum-1999.- V. 42, p.963−970.
- Chabaud M, Fossiez F, Taupin JL, Miossec P. Enhancing effect of IL-17 on IL-l-induced IL-6 and leukemia inhibitory factor production by rheumatoid arthritis synoviocytes and its regulation by Th2 cytokines.// J Immunol-1998.-V. 161, p. 409 414.
- Chabaud M, Garnero P, Dayer JM, Guerne PA, Fossiez F Miossec P. Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis.// Cytokine-2000.- V.12, p.1092−1099.
- Chantry D., Weinars C.G., Maini R.N., Feldman M. Mechanism of immune complex mediated damage: Induction of interleukin-1 by immune complexes and synergy with inter feron-gamma and tumor necrosis factor a.// Eur.J.Immunol.-1989.-V.19,p. 189−192.
- Cohen S, Hurd E, Cush J, et al. Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist, in combination with methotrexate.// Arthritis Rheum -2002.-V. 46 p.614−24.
- Collins A.J., Notarianni L.J., Dixon A.S.J. Acute gastric microbleeding after aspirin ingestion, compared with similardose of fenbufen by measuremend ofhaemoglobin in gastric aspirates.// J. Pharm. Pharmacol.- 1983-V. 35, p. 610−612.
- Correa PA, Gomez LM, Cadena J, Anaya JM. Autoimmunity and tuberculosis. Opposite association with TNF polymorphism.// J Rheumatol. -2005- V.32(2), p.219−24.
- Corrigall VM, Panayi GS. Autoantigens and immune pathways in rheumatoid arthritis.// Crit Rev Immunol.-2002.-V. 22(4), p. 281−93.
- Cotes P.M., Brozovic В., Mansell M. et al. Radioimmunoassay of erythropoietin in human serum: validation and application of an assay system.// Exp. Heamatol.-1980- V. 8, p.292.
- D’Alfonso S, Richiardi PM. A polymorphic variation in a putative regulation box of the TNFA promoter region.//Immunogenetics- 1994- V.39, p. 150−154.
- Dai C.-H., Price J.O., Brunner T. Fas Ligand Is in Human Erythroid Colony-Forming Cells and Interacts With Fas Inducedby Interferon у to Produce Erythroid Cell Apoptosis.//
- Blood.- 1998.-V. 91. p. 1235−1242.
- De Maria R., Testa U., Luchetti L. Apoptotic Role of Fas/Fas Ligand System in the Regulation of Erythropoiesis.// Blood-1999-.V. 93. p. 796−803.
- De Sousa M., Dynesius-Trentham R., Mota-Garsia F. Activation of the synovium by iron in rats. // Arthr. and Rheum. -1987- V. 30, p. 510.
- Denz H., Fuchs D., Huber H., Nachbaur D., Reibnegger G., Thaler J., Werner E.R., Wachter H: Correlation between neopterin, interferon- gamma and haemoglobin in patients with haematological disorders.// Eur. J. Haematol-1990-, V. 44, p.186−189.
- Dinarello C.A., Moldawer L.L. Proinflammatory and Antiinflammatory Cytokines in Rheumatoid Arthritis.// Amgen Inc.-1999.-p. 190.
- Djouadi K., Nedelec В., Tamouza R. et al. Interleukin 1 gene cluster polymorphisms in multiplex families with spondylarthropathies//Cytokine.-2001 .-V. 13. p.98−103.
- Drakesmith H., Chain В., Beverley P. How can dendritic cells cause autoimmune disease?//Immunol. Today. -2000.-Vol.21. N5.-p.214−217.
- Dudler J, Renggli-Zulliger N, Busso N, Lotz M, So A. Effect of interleukin 17 on proteoglycan degradation in murine knee joints.// Ann Rheum.Dis.-2000- V.59, p. 529−532.
- Ergegard G., Hallgren R., Caro J. Serum erythropoietin in rheumatoid arthritis and other imflammatory arthritidis. Relatoinship to anaemia and the effect of anti-inflammatory treatment.// Br. J. Haematol.- 1987- V. 65, p. 479−483.
- Fabris M, Di Poi E, Sacco S, Damante G, Sinigaglia L, Ferraccioli G. TNF- alpha gene polymorphisms in rheumatoid arthritis patients treated with anti-TNF-alpha agents: preliminary results.// Reumatismo-2002.-V. 54(1), p.19−26.
- Fabris M, Tolusso B, Di Poi E, Assaloni R, Sinigaglia L, Ferraccioli G. Tumor necrosis factor-alpha receptor II polymorphism in patients from southern Europe with mild-moderate and severe rheumatoid arthritis.// J rheumatol.-2002.-V. 29(9), p.1847−50.
- Fang XM, Schroder S, Hoeft A, Stuber. Comparison of two polymorphisms of the interleukin-1 gene family: interleukin-1 receptor antagonist polymorphism contributes to susceptibility to severe sepsis.// Crit Care Med. -1999 V.27(7), p. 1330−4.
- Farah D., Sturrock R.D., Russell R.I. Peptic ulcer in rheumatoid arthritis.// Ann. Rheum. Dis. -1988- V. 47, p. 478−480.
- Feldman M., Brennan F., Maini R.N. Role of cytokines in rheumatoid arthrit.// Amgen Inc.-1996.-V. 14, p.397−440.
- Finch C.A. Huebers H. Perspectives in iron metabolism.// N. Engl. J.Med. -1982- V.306, p. 1520−1528.
- Firestein G. S Starving the synovium: angiogenesis and inflammation in rheumatoid arthritis.//Arthritis Rheum -1996.- V. 39, p.1781−1790.
- Firestein, G. S., Alvaro- Gracia, J. M. & Maki
- Quantitative analysis of cytokinegene expression in rheumatoid arthritis.//J. Immunol.-1990.-V. 144, p. 3347−3353.
- Fong KY, Boey ML, Koh WH, Feng PH. Cytokine concentrations in the synovial fluid and plasma of rheumatoid arthritis patients: correlation with bony erosions.// Clin Exp Rheumatol.-1994.-V. 12(1), p.55−8.
- Fuchs D., Zangerle R., Artner- Divorzak E, WeissG, Fritsch P., Tilz G.P., Dierich M.P., Wachter H: Association between immune activation, changes of iron metabolism and anaemia in patients with HIV infection.// Eur J. Haematol.-1993-, V. 50, p. 90−94.
- Genovese MC, Bathon JM, Martin RW, et al. Etanercept versus methotrexate in patients with early rheumatoid arthritis: two-year radiographic and clinical outcomes.// Arthritis Rheum.-2002.-V. 46, p. 1443−50.
- Grimaldi L.M., Casadei V.M., Ferri C. Et al. Associationof early-oncet AlzheimerAs desease with an interleukin-1 alpha gene polymorphism.// Ann.neurol., -2000 -Vol.47p. 361−365.
- Groopamn J. E, Molina J-M, Scadden D.T. Hematopoietic growth factors.// N.Engl.J. Med.-1989.- V. 321, p. 1449−1459.
- Guasch J. F., Bertina R.M., Reitsma P.H. Five novel intragenic dimorphisms in the human interleukin-1 genes combine to high informativity// Cytokine-1996-Vol.8,№ 8.-P.598−602.
- Gudbjornsson В., Hallgren R., Wide L., Birgergard G. Response of anaemia in rheumatoid arthritis to treatment with subcutaneous recombianat human erythropoietin. // Ann.Rheum. Dis. -1992- V.51, p. 747−752.
- Hamann A, Mantzoros C, Vidal-Puig A, Flier JS. Genetic variability in the TNF-alpha promoter is not associated with type II diabetes mellitus (NIDDM).// Biochem Biophys Res Commun -1995- V.211, p. 833−839.
- Hansen T.M., Hansen N.E. Serum ferritin as indicator of iron responsive anaemia in patients with rheumatoid arthritis.// Ibid. -1986- V. 45, p. 596−602.
- Hansen T.M., Hansen N.E., Birgens H.S., et al. Serum ferritin and assessment of iron deficiency in rheumatoid arthritis.// Scand J. Rheumatol.- 1983- V.12, p. 353−359.
- Harada S, Yamamura M, Okamoto H, Morita Y, Kawashima M, Aita T, Makino H. Production of interleukin-7 and interleukin-15 by fibroblast-like synoviocytes from patients with rheumatoid arthritis.// Arthritis Rheum. -1999- V. 42(7) p.1508−16.
- Haworth C, Brennan FM, Chantry D, Turner M, Maini RN, Feldmann M. Expression of granulocyte-macrophage colony-stimulating factor in rheumatoid arthritis: regulation by tumor necrosis factor-alpha.// Eur J Immunol.-1991.- V. 21, p. 2575−9.
- Hernandez-Pacheco Guadalupe, Flores-Dominguez Carmina, Rodriguez-Perez Jose Manuel, at al. Tumor necrosis factor-alfapromoter polymorphisms in Mexican patients withrheumatic heart disease// Journal of Autoimmunity-2003-Vol.21-P. 59−63.
- Higuchi T, Seki N, Kamizono S et al. Polymorphism of the 5.-flanking region of the human tumor necrosis factor (TNF)-alpha gene in Japanese.// Tissue Antigens- 1998- V.51. p. 605−612.
- Hohler Т., Kruger A., Gerken G., Schneider P.M., Meyer zum Buschenefelde K.H., Rittner C.A. A tumor necrosis factor-alfa promoter polymorphism is associated with chronic hepatitis В infection.// -1998, — Vol.111, p. 579−582.
- Hohler Т., Schaper Т., Schneider P.M. et al. Association of different TNF-a promoter allele frequencies with ankylosing spondylitis in HLA-D27 positive individuals // Arthritis and Rheumatism.-1998.-V.41 (8).-P.l 489−1493.
- Hulkkonen J., Laippala P., Hurme M., A rare allele combination of the interleukin-1 gene complex is associated with high interleukin-1 beta plasma levels in healthy individuals.// Eur. Cytokine Netw., -2000, — Vol lip. 251−255.
- Hurme M., Santtila S., IL-1 receptor antagonist (IL-IRa) plasma levels are co-ordinately regulated by both IL-IRa and IL-lbeta genes.//Eur.J.Immunol.-1998 -Vol.28, p. 2598−2602.
- Husby G, Williams R.C. Synovial localization of tumor necrosis factor in patients with rheumatoid arthritis.// J Autoimmun.-1988.- V. 1. p. 363−371.
- Hutchinson I.V., Pravica V., Hajeer A., Sinnott P.J., Identification of high and low responders to allografts. //Rev Immunogenetics.-1999.-Vol. 1 .-p. 323−333.
- Ishikawa F., Miyazono K., Hellman U., Drexler D., Wernstedt C., Hagiwara К et al. Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor.// Nature-1989.-V. 338, p.557−61.
- Kahle P, Saal JG, Schaudt K, Zacher J, Fritz P, Pawelec G. Determination of cytokines in synovial fluids: correlation with diagnosis and histomorphological characteristics of synovial tissue.// Ann Rheum Dis.-1992.- V.51(6), p.731−4.
- Kaijzel EL, Van Dongen H, Bakker AM, Breedveld FC, Huizinga TW, Verweij CL. Relationship of polymorphisms of the Interleukin-1 gene cluster to occurrence and severity of rheumatoid arthritis.// Tissue Antigens.-2002.- V.59(2) p. 122−6.
- Katsikis P.D., Chu C-Q., Brennan F.M., Feldmann M Immunoregulatory role of interleukin 10 in rheumatoid arthritis.// J. Exp Med. -1994.- V. 179, p.1517−1527.
- Kehlen A, Thiele K, Riemann D, Langner J. Expression, modulation and signalling of IL-17 receptor in fibroblast-like synoviocytes of patients with rheumatoid arthritis.// Clin Exp Immunol.-2002.- V. 127 p.539−546.
- Kendall R., Wasti A., Harvey A. et al. The relationship of haemoglobin to serum erythropoietin concentrations in the anaemia of rheumatoid arthritis: The effect of oral prednisolone.// Br. J. Rheumatol.- 1993-, V. 32. p. 204−208.
- Kern J.A., Lamb R.J., Reed J.C., et al. Dexametasone inhibition of interleukin 1 beta production by human monocytes.// J.Clin.Invest.-1988.-V81. p.237−244.
- Krantz SB. Pathogenesis and Treatment of the Anaemia of Chronic Disease. //The Amer.J. of the Med. Scient.- 1994- V.307. p. 353−359.
- Lacraz S., Nicod L., Galve-de Rochemonteix В., Baumberger C., Dayer J-M., Welgus H.G., Suppression of metalloproteinase biosynthesis in human alveolar macrophages by interleukin-4.// J. Clin.Invest.-1992- V. 90, p. 382−388.
- Lazarus M., Hajeer A.H., Turner D., Sinnott P., Worthington J., Oilier W.E., Hutchinson I.V. Genetic variation in the interleukin-10 gene promoter and systemic lupus erythematosus.//!. Rheumatol.- 1997.-Vol.24.-p.2314−23 17.
- Lewthwaite J, Blake SM, Hardingham ТЕ, Warden PJ, Henderson B. The effect of recombinant human interleukin 1receptor antagonist on the induction phase of antigeninduced arthritis in the rabbit.// J Rheumatol. -1994.-V 21, p.467−72.
- Lopex A.F., Nicola N.A., Burgess A.W. Activation of granulocyte cytotoxic function by purified mouse colony-stimulating factors J. Immunol.-1983.- V. 131 p. 2983−2988.
- Lorenzo J.A. The role of cytokines in the regulation of local bone resorption.// Crit. Rev.Immunol.-1991.- V. 11, p. 195 213.
- Louis E, Franchimont D, Piron A et al. Tumour necrosis factor (TNF) gene polymorphism influences TNF-alpha production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans.// Clin Exp Immunol.- 1998-V.113, p.401−406.
- Ma Suk Ling, Leung Sang Tang Nelson, Chiu Wa Lam Linda, Fung Kum Chiu Helen. Lack of Association of the Interleukin-1 p gene polymorphism with Alzheimer’s disease in a Chinese population// Dement Geriatr Cogn Disord -2003-Voll6-P. 265−268.
- MacKay K., Milicic A., Lee D., Tikly M., Laval S., Shatford J., Wordsworth P. Rheumatoid arthritis susceptibility and interleukin 10: a study of two ethnically diverse populations.// Rheumatology -2003.- V.42 p.149−153.
- Manus S.W., Beck- Schroeder S., Zanjani E.D.: Suppression of normal human erytropoiesis by gamma interferon in vitro. Role of monocytes and T lymphocytes.// J. Clin. Invest. -1985-, V.75,p.1496−1503.
- Martinez A, Fernandez-Arquero M, Pascual-Salcedo D et al. Primary association of tumor necrosis factor-region genetic markers with susceptibility to rheumatoid arthritis.// Arthritis Rheum.//- 2000-V.43, p. 1366−1370.
- Means R.T., Dessypris E.N. Krantz S.B.: Inhibition of human erytroid colony-forming units by interleukin-1 is mediated by gamma-interferon.//J. Cell Physiol -1992.- V. 150, p. 59−64.
- Means R.T., Dessypris E.N. Krantz S.B.: Inhibition of human erytroid colony-forming units by tumor necrosis factor requires accessory cells.//J. Clin. Invest.-1990.- V. 86, p. 538 541.
- Means R.T., Kranz S. B. Progress in understanding the pathogenesis of anaemia of chronic disease.// Blood.- 1992- V. 7, p. 1639−1647.
- Means R.T., Olsen N.J., Kranz S.B., et al. Treatment of the anaemia of rheumatoid arthritis with recombiant human erythropoietin: clinical and in vitro studies.// Arthritis and Rheum.- 1989-, V. 32, p. 638−642.
- Means R.T.Jr., Krantz S.B. Ingibition of human erythroid colony-forming units by interferon can be corrected by recombinant human erythropoietin. -1991- V. 78, p. 2564−2567.
- Miller B. A, Olivieri N, Hope S. M, Perrine SP. Interferon-gamma modulates fetal hemoglobin synthesis in sickle cell anemia and thalassemia.// J Interferon Res.- 1990-V.10(4).p. 357−66.
- Miller B. A, Perrine S. P, Antognetti G. Gamma-interferon alters globin gene expression in neonatal and adult erythroid cells.// Blood. -1987- V. 69(6). p. 1674−81.
- Miller R. K., Altz- Smith M. Usefulness of serum ferritin in detecting irondeficiency in rheumatoid arthritis (RA).// Arth. And Rheum. -1982-, V. 25, p. 144.93
- Miossec R., Chomarat P., Dechanet J. Interleukin-4 inhibits bone resorption through an effect on osteoclasts andproinflammatory cytokines in an ex vivo model of boneresorption in rheumatoid arthritis.// Arthritis Rheum. -1994.-V.37, p. 1715−1722.
- Mira J-P, Cariou A., Grail F., at al. Association of TNF2, a TNF-a Promoter polymorphism, with septic shock susceptibility and mortality// JAMA -1999-Vol.282 № 6, P.561−568.
- Moghaddam A., Zhang H-T., Fan T-P., Hu D-E., LeesVC., ley H et al. Thymidine phosphorylase is angiogenic and promotes tumor growth.// Proc Natl Acad Sci USA -1995.-V. 92, p. 9 981 002.
- Morikava K., Oseko F., Morikava S.,// Leuk. And Lymph.-1995-, V.18, p. 429−433.
- Mugnier B, Balandraud N, Darque A, Roudier C, Roudier J, Reviron D. Polymorphism at position -308 of the tumor necrosis factor alpha gene influences outcome of infliximab therapy in rheumatoid arthritis.// Arthritis Rheum.- 2003-V.48(7), p. l849−52.
- Nagy E, Berczi I. Immunodeficiency in hypophysectomised rats.// Acta Endocrinol.-1978-V. 89, p.530−7.
- Patino-Garcia A., Sotillo-Pineiro E., Modesto C., Sierrasesumaga L. Screening of the human tumornecrosis factor-alfa (TNF-alfa) gene promoter polymorphisms by PCR-DGGE analysis//Mutat.Res.-1999.-V.406. p. 121−125.
- Pettersson Т., Rosenlof K., Friman C. et al. Successful treatment of the anaemia of rheumatoid arthritis with subcutaneously administered recombianat human erythropoietin.// Scand. J. Rheumatol.- 1993-, V. 22. p. 188−193.
- Pinctus Т., Olsen N.J., Russell L.J., et al. Anaemia in rheumatoid arthritis (RA): Correction using recombinant erythropoietin (EPO).// Arthr. And Rheum.- 1989- V. 32(suppl.) p. 49.
- Pincus Т., Olsen N.J., Russell I.J., et al. Multicenter study of recombianat human erythropoietin in correction of anaemia in rheumatoid arthritis.// Am. J.Med.- 1990- V. 89, p. 161−168.
- Pincus Th., Callahan L.F., Early nortality in RA: predicted by poor clinical stayus.// Bui. Rheum. Dis.- 1992.- V.41(4) p.17.
- Pociot F., Molvig J., WogensenL., et al. A Tag I polymorphism in the human interleukin-1 beta (IL-1 beta) genecorrelates with IL-1 beta secretion in vitro.//
- Eur.J.Clin.Invest.,-1992, -Vol.22 p.396−402.
- Raefsky E.L. Platanias L.C., Zoumbos N.C., Young N.S. Studies of interferon as a regulator of hematopoietic cell proliferation.// J. Immunol.- 1985-, V.135, p. 2507−2512.
- Rajapakse C. N. A., Holt P.J.L., Perera B. Diagnosis of true iron deficience in rheumatoid arthritis.// Ann. Rheum. Dis.-1980~ V.39, p. 596.
- Richmond J., Gardner D.L., Roy L.M.N, et al. Nature of anaemia in rheumatoid arthritis.III. Changes in the bone marrow and their relation to other features of the disease.// Ann. Rheum.Dis. -1956-, V.15, p. 217−255.
- Rosenwasser L.J. Promoter polymorphisms in the candidate genes, IL-4, IL-9, TGF-beta 1, for atopy and asthma//.Int Arch allergy Immunol.-1999.-Vol.118.-P.268−270.
- Rovensky J, Bakosova J, Payer J, Lukac J, Raffayova H, Vigas M. Increased demand for steroid therapy in hyperprolactinemic patients with rheumatoid arthritis.// Int J Tissue React.- 2001- V. 23(4), p.145−9.
- Rowley D., Gutterige J.M.C., Blake D.R. et al. Lipid peroxidation in rheumatoid arthritis: TBA reactive material and catalytic iron salts in synovial fluid from rheumatoid payients.//Clin. Sci. -1984- V. 66, p. 691−695.
- Sanford В., Krantz MD. Pathogenesis and treatment of the anaemia of chronic disease.// The Am. J. of the Med. Scien.-1994.- Vol.307,5, p. 353−359.
- Senator G.D., Muirden K. D. Concentration of iron in synovial membrane, synovial fluid, and serum in rheumatoid arthritis and other joint diseases. // Ann. Rheum.Dis.- 1968- V. 27, p.49−54.
- Sennikov SV, Krysov SV, Injelevskaya TV, Silkov AN, Grishina LV, Kozlov VA. Quantitative analysis of human immunoregulatory cytokines by electrochemiluminescence method.// J Immunol Methods.-2003.-V.275.-N.1−2.- p. 81−8.
- Sennikov SV, Krysov SV, Injelevskaya TV, Silkov AN, Kozlov VA. Production of cytokines by immature erythroid cells derived from human embryonic liver. // Eur Cytokine Netw.-2001.-V.12.-N.2.-p.274−9.
- Seriolo B, Ferretti V, Sulli A, Fasciolo D, Cutolo M. Serum prolactin concentrations in male patients with rheumatoid arthritis// Ann N Y Acad Sci.-2002 -Vol.-966-P.258−62.
- Shibue T, Tsuchiya N, Komata T et al. Tumor necrosis factor alpha 5.-flanking region, tumor necrosis factor receptor II, andHLA-DRBl polymorphisms in Japanese patients with rheu-matoid arthritis. //Arthritis Rheum. -2000- V.43. p.753−757.
- Smith R.J., Davis P., Thomson A.B.R. et al. Serum ferritin levels in the anaemia of rheumatoid arthritis.// J.Rheumatol.-1977-, V.4, p. 389−392.
- Sugiura Y., Niimi Т., Sato S., Yoshinouchi Т., Banno S., Naniwa Т., Maeda H., Shimizu S., Ueda R. Transforming growth factor betal gene polymorphism in rheumatoid arthritis.// Ann Rheum Dis.—2002.-V.61, p.826−828.
- Taniguchi S, Dai CH, Krantz SB. Specific binding of interferon-gamma to high affinity receptors on human erythroid colony-forming cells.// Exp.hematol.-1997-V. 25. p. 193−198.
- Taniguchi S, Dai CH, Price JO. Interferon gamma downregulates stem cell factor and erythropoietin receptors but not insulin-like growth factor-I receptors in human erythroid colony-forming cells.// Blood.- 1997.-V.90(6). P. 2244−52.
- Tarumi T, Sawada K, Sato N. Interferon-alpha-induced apoptosis in human erythroid progenitors.// Exp Hematol- 1995-V. 23(12).p. 1310−8.
- Uglialoro AM, Turbay D, Pesavento PA et al. Identification of three new single nucleotide polymorphisms in the human tumor necrosis factor-alpha gene promoter.// Tissue Antigens-1998- V.52, p.359−367.
- Van Roon JAG, Glaudemans К A F M, Bijlsma, J W J, Lafeber F P J G. Interleukin 7 stimulates tumour necrosis factorand Thl cytokine production in joints of patients with rheumatoid arthritis.// Ann Rheum Dis.- 2003- Vol.62, p. 113— 119.
- Villiger P.M., Geng Y., Lotz M. Induction of cytokine expression by leukemia inhibitory factor.// J. Clin. Invest.-1993.-V. 91, p. 1575−1581.
- Vinasco J, Beraun Y, Nieto A et al. Polymorphism at the TNF loci in rheumatoid arthritis.// Tissue Antigens -1997-, V. 49. p.74−78.
- Vreugdenhil G., Wognum A.W., Van Eijk H. G., Swaak A.J. Anaemia in rheumatoid arthritis: the role of iron, vitamin В12, and Folic acid deficiency, and erythropoietin responsiveness.// Ann.Rheum. Dis.-1990- V. 49, p. 93−98.
- Walters G.O., Miller F.M., Worwood M. Serum ferritin concentration and iron stores in normal subjects.// J. Clin. Pathol.- 1973-, V.26, p. 770−772.
- Wang C. Q, Udupa K. B, Lipschitz D.A. Interferon-gamma exert its negative regulatory effect primarily on the earliest stages of murine erythroid progenitors cell development.// J. Cell Physiol.- 1995.-V. 162. p.134−138.
- Wang J.M., Colella M.S., Allavena P., Mantagani A. Chemotactic activity of human recombinant granulocyte-macrophage colony-stimulating factor.// Immunology -1987.-V.60, p. 439−444.
- Warning P.M., Carroll G.L., Kandiah D.A., Buirski G., Metcalf D. Increased levels of leukemia inhibitory factor in synovial fluid from patients wiyh rheumatoid arthritis and other inflammatory arthritides.// Arthritis Rheum.-1993.-V. 36, p. 911 915.
- Warzocha by Krzysztof, Ribero Patricia, Bienvenu Jacques at al. Genetic polymorphisms in the tumor necrisis factor locus influence non-hodgkin's lymphoma outcome// Blood-1998-Vol.91, № 10-P. 3574−3581.
- Weisbart R.H., Golde D.W., Clark S. C., Wong G.G. Gasson J.C. Human GM-colony-stimulating factor is a neutrophil activator.// Nature -1985.- V. 314, p. 361−365.
- Weisbart R.H., Kacena A., Schuh A., Golde D.W. GM-CSF induces human neutrophil IgA-mediated phagocytosis by an IgA Fc receptor activation mechanism.// Nature -1988.- V. 332, p. 647−648.
- Westendorp RG, Langermans JA, Huizinga TW et al. Genetic influence on cytokine production and fatal meningococcal disease.// Lancet- 1997- V.349, p.170−173.
- Weyand CM, Goronzy JJ The molecular basis of rheumatoid arthritis.// J Mol Med.-1997.-V. 75, p.772−785.
- Wilder RL. Hormones and autoimmunity: animal models of arthritis.// Baillie^re's Clin Rheumatol.- 1996-Vol.lO, p.259−71.
- Williamson DJ, Begley C. G, Vadas M.A., Metcalf D. The detection and initial characterization of colony-stimulating factors in synovial fluid.// Clin.Exp. Immunol.-1988.- V. 72, p. 67−73.
- Wilson AG, de Vries N, van de Putte LB, Duff GW. A tumour necrosis factor alpha polymorphism is not associated with rheumatoid arthritis.// Ann Rheum Dis.- 1995 -V.54(7)p.601−3.
- Wilson AG, di Giovine FS, Blakemore AL Single base polymorphism in the human tumour necrosis factor alpha (TNF alpha) gene detectable by Ncol restriction of PCR product. //Hum Mol Genet -1992- V.l. p.353.
- Witkin S.S., Gerber S., Ledger W.J. Influence of interleukin-1 receptor antagonist gene polymorphism on disease.// Clin. Onfect.Dis., — 2002.- Vol 15, Suppl.l.p. 204−209.
- Wolf S. F, Sieburth D, Sypek J. Interleukin 12: a key modulator of immune function.// Stem Cells- 1994−12(2). P.154−68.
- Wong H.L., Welch G.R., Brandes M.E., Wahl S.M. IL-4 antagonizes induction of Fc gamma RIII (CD16) expression by transforming growth factor-beta on human monocytes.// J Immunol.-1991.-V. 147, p. 1843−1848.
- Yao Z, Painter SL, Fanslow WC, Ulrich D, Macduff BM, Spriggs MK, Armitage RJ. Human IL-17: a novel cytokine derived from T cells.// J mmunol -1995.-V. 155, p.5483−5486.
- Yen JH, Chen CJ, Tsai WC et al. Tumor necrosis factor promoter polymorphisms in patients with rheumatoid arthri-tisin Taiwan.//J Rheumatol.//- 2001 V.28, p.1788−1792.
- Yocum DE, Esparza L, Dubry S, Benjamin JB, Volz R, Scuderi P Characteristics of tumor necrosis factor production in rheumatoid arthritis.// Cell Immunol.-1989- V.22(l) p.131−45.
- Zhao XY, Lee SS, Wong KH, Chan КС, Ma S, Yam WC, Yuen KY, Ng MH, Zheng BJ. Effects of single nucleotide polymorphisms in the RANTES promoter region in healthy and HIV-infected indigenous Chinese.// Eur J Immunogenet. -2004-V. 31(4). P. 179−83.
- Zolil A, Lizziol M. M, Ferlisil E. M, Massafral V., Mironel L, Barini A, Scuderi3 °F, Bartolozzi F and Magarot M. ACTH, Cortisol and Prolactin in Active Rheumatoid Arthritis// Clin Rheumatol -2002- V.21, p.289−293.