Дифференциация пород крупного рогатого скота по гену BoLa-DRB3 главного комплекса гистосовместимости и ISSR-маркерам
Показана генетическая устойчивость ярославской породы к лейкозу и маститу, обусловленная высоким содержанием BoLA-DRB3-anneneii, ассоциированных с устойчивостью к лейкозу и низким содержанием аллеля BoLA-DRB3.2*23, ассоциированного с высоким риском заболеваемости маститом. Суммарная частота аллелей устойчивости к лейзозу у ярославской породы (18,1%) в 3 раза выше, чем у иранской породы Систани… Читать ещё >
Содержание
- 1. В ведение
- 2. Обзор литературы 5 2.1 .Структура, функции и полиморфизм главного комплекса гистосовместимости (гкг)
- 2. 1. 1. Главный комплекс гистосовместимости: история вопроса, функция, номенклатура
2.1.2.Структура главного комплекса гистосовместимости В 2.1.3 .Главный комплекс гистосовместимости крупного рогатого скота (BoLA) 11 2.1.4.Методы изучения главного комплекса гистосовместимости и полиморфизм генов класса II
2.2.Полиморфизм гена BoLA-DRB3 и его ассоциации с различными заболеваниями крупного рогатого скота 22 2.2.1 .Полиморфизм гена BoLA-DRB
2.2.2.Ассоциации BoLA-DRB3 с заболеваниями
2.3.Дифференциация пород крупного рогатого скота по ДНК-маркерам
3.Материалы и методы исследования
4.Результаты и их обсуждение 51 4.1.Дифференциация пород крупного рогатого скота по аллелям гена BoLA-DRB
4. 2. Распределение аллелей гена BoLA-DRB3, ассоциированных с болезнями, в исследованных породах крупного рогатого скота 59 4.3 .Дифференциация пород крупного рогатого скота с использованием молекулярного мультилокусного анализа 66 4.3.1.Спектры ISSR-полиморфизма у крупного рогатого скота 67 4.3.Дифференциация пород крупного рогатого скота по GA-ISSR-маркеру
4.3.3. Дифференциация пород крупного рогатого скота по AG-ISSR-маркеру
4.3.4.Характеристика (GA)9C-ISSR- и (AG)9C-ISSR-MapKepoB и возможности их использования для дифференциации пород крупного рогатого скота
5. Выводы
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- Я благодарю О. Е. Лазебного за неоценимую помощь в статистической обработке результатов, Г. Н. Полухину за помощь и внимание в течение 3 лет аспирантуры.
- Выражаю искреннюю благодарность своей супруге Ш. Мораднасаб за постоянное внимание, помощь и терпение.