Создание стерически стабилизированной иммунолипосомальной системы на основе моноклональных антител с целью специфической доставки биологически активных веществ к клеткам-мишеням
Диссертация
Создание систем, способных осуществлять специфический направленный транспорт биологически активных веществ из системного кровотока к клеткам центральной нервной системы является одной из самых актуальных задач нейрофармакологии. Известно, что инкапсуляция препаратов в различные микроконтейнеры существенно улучшает их фармакокинетические параметры, снижает токсичность, позволяет уменьшать разовые… Читать ещё >
Содержание
- ГЛАВА 1. Обзор литературы
- 1. 1. Направленный транспорт лекарственных средств с помощью липосом
- 1. 2. Глиофибриллярный кислый белок
- ГЛАВА 2. Материалы и методы
- ГЛАВА 3. Получение стерически стабилизированных липосом и их физико-химические характеристики
- 3. 1. Получение ПЭГилированных липосом
- 3. 2. Конъюгирование моноклональных антител с ПЭГилирован- 85 ными липосомами
- 3. 3. Физико-химические характеристики иммунолипосом
- ГЛАВА 4. Иммуноморфологический анализ ПЭГилированных липосом, конъюгированных с моноклональными антителами к GFAP в культуре эмбриональных астроцитов крысы и клеток глиомы Сб
- 4. 1. Иммуноморфологический анализ моноклональных антител к GFAP в культуре эмбриональных астроцитов крысы и клеток глиомы С
- 4. 2. Анализ специфичности связывания ПЭГилированных липосом, конъюгированных с моноклональными анти-GFAP антителами, с клетками глиомы С6 и эмбриональными астроцитами мозга 104 крысы
- ГЛАВА 5. Количественное определение содержания GFAP в сыворотке крови больных глиальными опухолями мозга. 5.1. Определение GFAP в сыворотке крови пациентов со злокачественными глиомами
- 5. 2. Определение GFAP в сыворотке крови пациентов с глиомами низкой степени злокачественности
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