Закономерности изменений выхода молекул аденозиндифосфата из клеток крови при их сдвиговой деформации в условиях окислительного стресса.
Коррекция антиоксидантами
Диссертация
На основе результатов настоящей работы были разработаны и научно обоснованы: новые представления о механизмах выхода молекул аденозиндифосфата из клеток крови при их сдвиговой деформацииэкспериментальная технология, которая позволяет моделировать изменения функционального состояния цитоплазматических мембран клеток крови, путем контроля уровня инициированной пероксидации липидов… Читать ещё >
Содержание
- ЧАСТЬ ПЕРВАЯ (обзор литературы)
- 1. 1. ОСОБЕННОСТИ МОЛЕКУЛЯРНОЙ СТРУКТУРЫ ЦИТОПЛАЗМАТИЧЕСКИХ МЕМБРАН КЛЕТОК И ИХ МЕХАНИЧЕСКИЕ СВОЙСТВА
- 1. 1. 1. Липидно-белковый бислой
- 1. 1. 2. Белковый цитоскелет мембраны эритроцита
- 1. 1. 3. Деформации мембраны
- 1. 1. 4. Роль деформаций цитоплазматических мембран в регуляции функций клеток
- 1. 2. БИОЛОГИЧЕСКАЯ РОЛЬ СВОБОДНО-РАДИКАЛЬНЫХ РЕАКЦИЙ ЧАСТЬ ВТОРАЯ (собственные исследования)
- 2. 1. МАТЕРИАЛЫ И МЕТОДЫ ИССЛЕДОВАНИЙ
- 2. 2. ОСОБЕННОСТИ ТЕХНОЛОГИИ ЭКСПЕРИМЕНТОВ ПО ИССЛЕДОВАНИЮ ВЫХОДА АДФ ИЗ КЛЕТОК КРОВИ ПРИ ИХ СДВИГОВОЙ ДЕФОРМАЦИИ IN VITRO, С КОНТРОЛИРУЕМОЙ ВЕЛИЧИНОЙ УСИЛИЯ СДВИГА
- 2. 3. ЗАКОНОМЕРНОСТИ ИЗМЕНЕНИЙ ВЫХОДА АДФ ИЗ КЛЕТОК КРОВИ ПРИ ВОЗДЕЙСТВИИ SHEAR STRESS И СПОСОБНОСТЬ ЭРИТРОЦИТОВ К ДЕФОРМАЦИИ В УСЛОВИЯХ ОКИСЛИТЕЛЬНОГО СТРЕССА
- 2. 4. КОРРЕКЦИЯ АНТИОКСИДАНТАМИ ИЗМЕНЕНИЙ ВЫХОДА МОЛЕКУЛ АДФ ИЗ КЛЕТОК КРОВИ ПРИ ИХ СДВИГОВОЙ ДЕФОРМАЦИИ В УСЛОВИЯХ ОКИСЛИТЕЛЬНОГО СТРЕССА ОБСУЖДЕНИЕ РЕЗУЛЬТАТОВ
- 1. 1. ОСОБЕННОСТИ МОЛЕКУЛЯРНОЙ СТРУКТУРЫ ЦИТОПЛАЗМАТИЧЕСКИХ МЕМБРАН КЛЕТОК И ИХ МЕХАНИЧЕСКИЕ СВОЙСТВА
- ВЫВОДЫ
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