Влияние белка CRABP1 на биологические характеристики трансформированных клеток мезенхимального происхождения, ассоциированные с опухолевой прогрессией
![Диссертация: Влияние белка CRABP1 на биологические характеристики трансформированных клеток мезенхимального происхождения, ассоциированные с опухолевой прогрессией](https://westud.ru/work/2704881/cover.png)
Предшественники малых шпилечных РНК к кодирующей последовательности CRABP1 были заклонированы в лентивирусный вектор pLKO. l puro по сайтам Agel и EcoRI. В данной работе использовались следующие последовательности малых шпилечных РНК: shA 5' TCTATATCAAGACATCCACCACTCGAGTGGTGGATGTCTTGATATAGAT TTTG3'- ShB 5' CACAAGAATTTATGTCCGGGACTCGAGTCCCGGACAT AAATTCTTGTGTTTTTG3', shC 5' CGGACGC AAGTGCAGGAGTTTCTCG… Читать ещё >
Содержание
- Список использованных сокращений
1. Обзор литературы. Функции белка CRABP1 в норме и при опухолевой трансформации: регуляция метаболизма и биологической активности ретиноевой кислоты.
1.1 Введение.
1.2 Функции ретиноевой кислоты в организме.
1.3 Рецепторы ретиноевой кислоты: RAR- и RXR-белки.
1.4 Метаболизм и транспорт ретиноевой кислоты.
1.5 Строение и внутриклеточные функции белка CRABP1.
1.6 Роль CRABP1 в патогенезе промиелоцитарного лейкоза.
1.7 Экспрессия CRABP1 в развитии солидных опухолей.
Список литературы
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