Иммунодиагностика геморрагической лихорадки с почечным синдромом на основе использования рекомбинантного нуклеокапсидного антигена вируса
![Диссертация: Иммунодиагностика геморрагической лихорадки с почечным синдромом на основе использования рекомбинантного нуклеокапсидного антигена вируса](https://westud.ru/work/2525969/cover.png)
Диссертация
В процессе выполнения исследований был предложен новый способ экстракционной очистки рекомбинантного нуклеокапсидного белка вируса ГЛПС, позволяющий существенно повысить степень его гомогенности. Вы-сокоочищенный белок может использоваться не только для производства ди-агностикумов, но и служить основой для создания вакцинных препаратов. Разработанные автором на основе НКБ четыре типа… Читать ещё >
Содержание
- Список сокращений и условных обозначений
- Обзор литературы
- Глава 1. Общая характеристика рода Hantavirus
- Глава 2. Серологическая диагностика ГЛПС
- Собственные исследования
- Глава 3. Материалы и методы исследований
- Глава 4. Оптимизация условий получения очищенного рекомбинантно-р го нуклеокапсидного белка вируса Пумала
- 4. 1. Оценка электрофоретических и иммунохимических свойств рекомбинантного нуклеокапсидного белка, продуцируемого трансформированными бактериями Е. coli (штамм Ml 5)
- 4. 2. Разработка иммуноферментной тест-системы для количественного определения НКБ в составе лизата бактериальных клеток
- 4. 3. Оптимизация условий экстракционной очистки нуклеокапсидного белка из бактерий-продуцентов
- 4. 4. Обсуждение результатов
- Глава 5. Разработка иммуноферментных тест-систем для диагностики
- ГЛПС
- 5. 1. Тест-система для определения IgG к нукпеокапсидному белку вируса Пумала
- 5. 2. Тест-система для определения IgM к нукпеокапсидному белку вируса Пумала
- 5. 3. Выявление вирусного антигена в биологических пробах. v 5.4 Обсуждение результатов
- Выводы
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