Иммуногистохимическая и морфометрическая характеристика клеток и межклеточных отношений лобной коры головного мозга человека при острой и хронической ишемии
Диссертация
Появление большого объема информации о структуре нервной ткани сопряжено с необходимостью увеличения точности морфометрической оценки структурно-функционального состояния клеток и межклеточных синапсов с помощью комплексного использования методов автоматизированного компьютерного анализа изображений, морфометрии, иммуногистохимии, а так же с ускорением соответствующего системного статистического… Читать ещё >
Содержание
- Глава 1. СТРУКТУРНО-ФУНКЦИОНАЛЬНЫЕ ИЗМЕНЕНИЯ КОРЫ БОЛЬШОГО МОЗГА ЧЕЛОВЕКА ПРИ ИШЕМИИ (современное состояние проблемы)
- 1. 1. Особенности строения лобной коры головного мозга человека
- 1. 2. Механизмы повреждения, адаптации и восстановления коры большого мозга млекопитающих при ишемии и в постишемическом периоде
- 1. 3. Актуальные методологические проблемы и перспективные направления изучения структурно-функционального состояния головного мозга человека
- Глава. 2, МАТЕРИАЛ И МЕТОДЫ ИССЛЕДОВАНИЯ
- 2. 1. Дизайн исследования
- 2. 2. Объект и предмет исследования
- 2. 3. Методы исследования
- 2. 3. 1. Гистологические методы
- 2. 3. 2. Иммуногистохимические методы
- 2. 3. 3. Морфометрический и автоматизированный компьютерный анализ коры большого мозга
- 2. 4. Статистический анализ
- Глава 3. ОСОБЕННОСТИ ИСПОЛЬЗОВАНИЯ ПРОГРАММЫ mageJ 1.46 ДЛЯ ИДЕНТИФИКАЦИИ КЛЕТОК И МОРФОМЕТРИЧЕСКОГО АНАЛИЗА ЦИТОАРХИТЕКТОНИКИ КОРЫ БОЛЬШОГО МОЗГА ЧЕЛОВЕКА
- 3. 1. Анализ распределения различных структур 8-битного изображения коры большого мозга по оттенкам серого
- 3. 2. Идентификация размеров и формы различных морфотипов пирамидных нейронов на фронтальных срезах
- 3. 2. 1. Гиперхромные несморщенные и сморщенные нейроны
- 3. 2. 2. Нормохромные нейроны
- 3. 2. 3. Гипохромные и вакуолизированные нейроны
- 3. 2. 4. Дискриминация ядер нейронов и глиальных клеток при окраске ЭАР
- 3. 3. Морфометрический анализ клеток коры большого мозга человека на 24-ми битовых изображениях
- Глава 4. СТРУКТУРНО-ФУНКЦИОНАЛЬНЫЕ ИЗМЕНЕНИЯ ЛОБНОЙ КОРЫ БОЛЬШОГО МОЗГА ПРИ ОСТРОЙ И ХРОНИЧЕСКОЙ ИШЕМИИ ПО ДАННЫМ ГИСТОЛОГИЧЕСКОГО ИССЛЕДОВАНИЯ И МОРФОМЕТРИЧЕСКОГО АНАЛИЗА
- 4. 1. Клеточные морфотипы и комплексы клеток в лобной коре большого мозга человека в норме и при ишемии
- 4. 2. Морфометрический анализ пирамидных нейронов в различных слоях лобной коры по данным автоматизированного морфометрического анализа
- 4. 3. Содержание реактивно измененных пирамидных нейронов в различных слоях лобной коры
- Глава 5. СТРУКТУРНО-ФУНКЦИОНАЛЬНЫЕ ИЗМЕНЕНИЯ ЛОБНОЙ КОРЫ БОЛЬШОГО МОЗГА ПРИ ОСТРОЙ И ХРОНИЧЕСКОЙ ИШЕМИИ ПО ДАННЫМ ИММУНОГИСТОХИМИЧЕСКОГО ИССЛЕДОВАНИЯ И МОРФОМЕТРИЧЕСКОГО АНАЛИЗА
- 5. 1. Нейроны
- 5. 2. Глиальные клетки
- 5. 3. Синапсы
- Глава 6. СОПОСТАВЛЕНИЕ РЕЗУЛЬТАТОВ ГИСТОЛОГИЧЕСКОГО И ИММУНОГИСТОХИМИЧЕСКОГО МОРФОМЕТРИЧЕСКОГО ИССЛЕДОВАНИЯ
- 6. 1. Нейроны
- 6. 2. Нейроглиальные отношения
- 6. 3. Межнейронные (синаптические) отношения
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