Особенности внутриклеточного транспорта растительных токсинов, используемых в составе иммунотоксинов
Диссертация
Суммируя экспериментальные данные по устойчивости гибридом ТУША и ТА7-серии в свете существующих представлений о внутриклеточном транспорте белков можно представить следующую гипотетическую картину транслокации токсинов родственных вискумину. Растительные РИБП не имеют собственной машины транслокации как дифтерийный токсин и, предполагают, используют клеточные механизмы для выхода в цитозоль… Читать ещё >
Содержание
- Список сокращений
- Глава 1. Обзор литературы
- 1. 1. Токсины растения Viscum album
- 1. 1. 1. Строение токсинов из растения Viscum album
- 1. 1. 2. Ферментативная субъединица
- 1. 1. 3. Связывающая субъединица
- 1. 1. 4. Зона контакта субъединиц
- 1. 2. Внутриклеточный транспорт токсинов
- 1. 2. 1. Интернализация токсинов
- 1. 2. 2. Прохождение токсинов через эндосомальный компартмент
- 1. 2. 3. Формирование и слияние везикул
- 1. 2. 4. Транспорт в аппарате Гольджи
- 1. 2. 5. Ретроградный транспорт в эндоплазматический ретикулум
- 1. 2. 6. Транслокация токсинов
- 1. 2. 7. Альтернативные пути транспорта
- 1. 3. Иммунотоксины в терапии меланомы 1.3.1. Белки меланомы
- 1. 3. 2. Высокомолекулярный меланомо-ассоциированный антиген
- 1. 3. 3. Иммунодиагностика и иммунотерапия меланомы
- 1. 3. 4. Иммунотоксины к меланоме
- 1. 1. Токсины растения Viscum album
- 2. 1. Клетки и антитела
- 2. 2. Выделение токсинов и их субъединиц из растения Ricinus communis
- 2. 3. Выделение токсинов и их субъединиц из растения Viscum album
- 2. 4. Получение гибридом, продуцирующие моноклональные антитела к нативной форме А-субъединицы вискумина
- 2. 5. Получение гибридом, продуцирующие моноклональные антитела к денатурированной форме А-субъединицы вискумина
- 2. 6. Получение и очистка антител
- 2. 7. Изучение взаимодействия антител с антигеном на плате с помощью ТИФА
- 2. 8. Изучение взаимодействия антител с нативной и денатурированной формой антигена с помощью ТИФА
- 2. 9. Конкурентный ТИФА
- 2. 10. Сэндвич-ТИФА на основе монАт MNA-серии
- 2. 11. Определение констант взаимодействия монАт с антигеном в растворе
- 2. 12. Определение взаимодействия монАт с антигеном, сорбированного на плату
- 2. 13. Иммуноблоттинг
- 2. 14. Предсказание и синтез пептидов
- 2. 15. Пептидный ТИФА
- 2. 16. Получение и очистка иммунотоксинов
- 2. 17. Иммунофлюоресценция
- 2. 18. Клеточный ТИФА
- 2. 19. Оценка цитотоксической активности токсинов и иммунотоксинов
- 2. 20. Приготовление аффинной колонки с монАт MF
- 3. 1. Гибридомы, продуцирующие антитела к нативной форме MLA
- 3. 1. 1. Получение гибридом
- 3. 1. 2. Свойства монАТ серии МЧА
- 3. 1. 3. Устойчивость гибридом к цитотоксическому действию вискумина
- 3. 1. 4. Устойчивость гибридомы МИА
- 3. 1. 5. Использование монАТ серии МКА в создании тест-системы
- 3. 2. Гибридомы, продуцирующие антитела к денатурированной форме МЬА
- 3. 2. 1. Получение гибридом
- 3. 2. 2. Свойства антител
- 3. 2. 3. Картирование эпитопов
- 3. 2. 4. Устойчивость гибридом
- 3. 3. Иммунотоксины, направленные к НМУ-МАА
- 3. 3. 1. Получение ИТ
- 3. 3. 2. Специфичность связывания ИТ
- 3. 3. 3. Связывающая активность ИТ
- 3. 3. 4. Оценка цитотоксической активности ИТ
- 3. 3. 5. Использование различных агентов, усиливающих цитотоксичность ИТ
- 3. 3. 6. Очистка ИТ на анти-идиотипической колонке
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